Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes

Microhomology-mediated end joining: Good, bad and ugly

(2018) Ja-Hwan Seol et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A novel role of the Dna2 translocase function in DNA break resection

(2017) Adam S. Miller et al.   GENES & DEVELOPMENT

The motor activity of DNA2 functions as an ssDNA translocase to promote DNA end resection

(2017) Maryna Levikova et al.   GENES & DEVELOPMENT

BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites

(2017) Dharm S. Patel et al.   JOURNAL OF CELL BIOLOGY

The SMX DNA Repair Tri-nuclease

(2017) Haley D.M. Wyatt et al.   MOLECULAR CELL

DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination

(2017) Ronja Biehs et al.   MOLECULAR CELL

Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity

(2017) Marko Vujanovic et al.   MOLECULAR CELL

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers

(2017) Angelo Taglialatela et al.   MOLECULAR CELL

RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks

(2017) Huzefa Dungrawala et al.   MOLECULAR CELL

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

(2017) Arun Mouli Kolinjivadi et al.   MOLECULAR CELL

Regulation of repair pathway choice at two-ended DNA double-strand breaks

(2017) Atsushi Shibata   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Rad51-mediated double-strand break repair and mismatch correction of divergent substrates

(2017) Ranjith Anand et al.   NATURE

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

(2017) Weixing Zhao et al.   NATURE

Public antibodies to malaria antigens generated by two LAIR1 insertion modalities

(2017) Kathrin Pieper et al.   NATURE

Control of structure-specific endonucleases to maintain genome stability

(2017) Pierre-Marie Dehé et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Resolution of single and double Holliday junction recombination intermediates by GEN1

(2017) Rajvee Shah Punatar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A global view of meiotic double-strand break end resection

(2017) Eleni P. Mimitou et al.   SCIENCE

A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination

(2017) H. B. D. Prasada Rao et al.   SCIENCE

A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis

(2017) Markus Löbrich et al.   TRENDS IN BIOCHEMICAL SCIENCES

V(D)J Recombination Exploits DNA Damage Responses to Promote Immunity

(2017) Rahul Arya et al.   TRENDS IN GENETICS

Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA

(2017) Alex N. Zelensky et al.   Nature Communications

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination

(2017) Weiran Feng et al.   Nature Communications

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

(2017) Delphine Lemaçon et al.   Nature Communications

Replication fork reversal triggers fork degradation in BRCA2-defective cells

(2017) Sofija Mijic et al.   Nature Communications

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression

(2017) Jun Hyun Kim et al.   Cell Reports

Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection

(2017) Karina Zadorozhny et al.   Cell Reports

PrimPol—Prime Time to Reprime

(2017) Thomas Guilliam et al.   Genes

The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair

(2016) Julian Lange et al.   CELL

DNA damage tolerance by recombination: Molecular pathways and DNA structures

(2016) Dana Branzei et al.   DNA REPAIR

The MMS22L–TONSL heterodimer directly promotes RAD51‐dependent recombination upon replication stress

(2016) Wojciech Piwko et al.   EMBO JOURNAL

Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex

(2016) Julyun Oh et al.   MOLECULAR CELL

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts

(2016) Rajashree A. Deshpande et al.   MOLECULAR CELL

A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling

(2016) Martin R.G. Taylor et al.   MOLECULAR CELL

Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection

(2016) Roopesh Anand et al.   MOLECULAR CELL

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

EXD2 promotes homologous recombination by facilitating DNA end resection

(2016) Ronan Broderick et al.   NATURE CELL BIOLOGY

Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination

(2016) Stephanie Bregenhorn et al.   NUCLEIC ACIDS RESEARCH

The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation

(2016) T. Robert et al.   SCIENCE

Regulation of Single-Strand Annealing and its Role in Genome Maintenance

(2016) Ragini Bhargava et al.   TRENDS IN GENETICS

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

(2016) Pauline Chanut et al.   Nature Communications

Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases

(2016) Cosimo Pinto et al.   eLife

Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination

(2015) Martin R.G. Taylor et al.   CELL

DNA Sequence Alignment by Microhomology Sampling during Homologous Recombination

(2015) Zhi Qi et al.   CELL

DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination

(2015) Petr Cejka   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

Top3-Rmi1 Dissolve Rad51-Mediated D Loops by a Topoisomerase-Based Mechanism

(2015) Clare L. Fasching et al.   MOLECULAR CELL

HLTF’s Ancient HIRAN Domain Binds 3′ DNA Ends to Drive Replication Fork Reversal

(2015) Andrew C. Kile et al.   MOLECULAR CELL

Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry

(2015) Weixing Zhao et al.   MOLECULAR CELL

Tel1ATM-mediated interference suppresses clustered meiotic double-strand-break formation

(2015) Valerie Garcia et al.   NATURE

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens

(2015) Joshua Tan et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

Heterochromatic breaks move to the nuclear periphery to continue recombinational repair

(2015) Taehyun Ryu et al.   NATURE CELL BIOLOGY

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells

(2015) Jennifer M. Mason et al.   NUCLEIC ACIDS RESEARCH

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of Recombination and Genomic Maintenance

(2015) Wolf-Dietrich Heyer   Cold Spring Harbor Perspectives in Biology

An Overview of the Molecular Mechanisms of Recombinational DNA Repair

(2015) Stephen C. Kowalczykowski   Cold Spring Harbor Perspectives in Biology

Meiotic Recombination: The Essence of Heredity

(2015) Neil Hunter   Cold Spring Harbor Perspectives in Biology

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52

(2015) William A. Gaines et al.   Nature Communications

FBH1 Catalyzes Regression of Stalled Replication Forks

(2015) Kasper Fugger et al.   Cell Reports

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

(2015) Sean M. Howard et al.   PLoS Genetics

High-affinity DNA-binding Domains of Replication Protein A (RPA) Direct SMARCAL1-dependent Replication Fork Remodeling

(2015) Kamakoti P. Bhat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-Organization of Meiotic Recombination Initiation: General Principles and Molecular Pathways

(2014) Scott Keeney et al.   Annual Review of Genetics

Structure–Function Studies of DNA Polymerase λ

(2014) Katarzyna Bebenek et al.   BIOCHEMISTRY

Holliday junction resolution: Regulation in space and time

(2014) Joao Matos et al.   DNA REPAIR

Mlh1-Mlh3, a Meiotic Crossover and DNA Mismatch Repair Factor, Is a Msh2-Msh3-stimulated Endonuclease

(2014) Maria V. Rogacheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells

(2014) Andreas Sturzenegger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TheSaccharomyces cerevisiaeMlh1-Mlh3 Heterodimer Is an Endonuclease That Preferentially Binds to Holliday Junctions

(2014) Lepakshi Ranjha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regression of Replication Forks Stalled by Leading-strand Template Damage

(2014) Sankalp Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability

(2014) Miguel G. Blanco et al.   MOLECULAR CELL

SWR1 and INO80 Chromatin Remodelers Contribute to DNA Double-Strand Break Perinuclear Anchorage Site Choice

(2014) Chihiro Horigome et al.   MOLECULAR CELL

Rad54 Functions as a Heteroduplex DNA Pump Modulated by Its DNA Substrates and Rad51 during D Loop Formation

(2014) William Douglass Wright et al.   MOLECULAR CELL

CtIP Maintains Stability at Common Fragile Sites and Inverted Repeats by End Resection-Independent Endonuclease Activity

(2014) Hailong Wang et al.   MOLECULAR CELL

Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection

(2014) Nodar Makharashvili et al.   MOLECULAR CELL

Topoisomerase II mediates meiotic crossover interference

(2014) Liangran Zhang et al.   NATURE

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

Mechanisms and principles of homology search during recombination

(2014) Jörg Renkawitz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and RMI1

(2014) Nicolas Bocquet et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

(2014) Sarah K Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sustained active site rigidity during synthesis by human DNA polymerase μ

(2014) Andrea F Moon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Top3α Is Required during the Convergent Migration Step of Double Holliday Junction Dissolution

(2014) Stefanie Hartman Chen et al.   PLoS One

Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination

(2014) A. Zahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism and Regulation of Meiotic Recombination Initiation

(2014) Isabel Lam et al.   Cold Spring Harbor Perspectives in Biology

Spatial control of the GEN1 Holliday junction resolvase ensures genome stability

(2014) Ying Wai Chan et al.   Nature Communications

MUS81-EME2 Promotes Replication Fork Restart

(2014) Alessandra Pepe et al.   Cell Reports

Role of Replication Protein A in Double Holliday Junction Dissolution Mediated by the BLM-Topo IIIα-RMI1-RMI2 Protein Complex

(2013) Xiaoyu Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

(2013) Dennis Castor et al.   MOLECULAR CELL

Coordinated Actions of SLX1-SLX4 and MUS81-EME1 for Holliday Junction Resolution in Human Cells

(2013) Haley D.M. Wyatt et al.   MOLECULAR CELL

PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication

(2013) Julie Bianchi et al.   MOLECULAR CELL

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

(2013) Sara García-Gómez et al.   MOLECULAR CELL

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

(2013) Atsushi Shibata et al.   MOLECULAR CELL

Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

(2013) Marenda A. Wilson et al.   NATURE

RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis

(2013) April Reynolds et al.   NATURE GENETICS

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

(2013) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Repriming of DNA synthesis at stalled replication forks by human PrimPol

(2013) Silvana Mourón et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate specificity of the MUS81-EME2 structure selective endonuclease

(2013) A. Pepe et al.   NUCLEIC ACIDS RESEARCH

Nuclease activity of Saccharomyces cerevisiae Dna2 inhibits its potent DNA helicase activity

(2013) M. Levikova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Break-induced replication occurs by conservative DNA synthesis

(2013) R. A. Donnianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Cell-Cycle Kinases Coordinate the Resolution of Recombination Intermediates with Chromosome Segregation

(2013) Joao Matos et al.   Cell Reports

Heteroduplex DNA Position Defines the Roles of the Sgs1, Srs2, and Mph1 Helicases in Promoting Distinct Recombination Outcomes

(2013) Katrina Mitchel et al.   PLoS Genetics

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing

(2012) Jiazhi Hu et al.   CELL

Delineation of Joint Molecule Resolution Pathways in Meiosis Identifies a Crossover-Specific Resolvase

(2012) Kseniya Zakharyevich et al.   CELL

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

(2012) R. Betous et al.   GENES & DEVELOPMENT

Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA Complex: A Mechanism for Disentangling Chromosomes

(2012) Petr Cejka et al.   MOLECULAR CELL

Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress

(2012) Alberto Ciccia et al.   MOLECULAR CELL

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

In vivo genome editing using a high-efficiency TALEN system

(2012) Victoria M. Bedell et al.   NATURE

Single-molecule imaging of DNA pairing by RecA reveals a three-dimensional homology search

(2012) Anthony L. Forget et al.   NATURE

Increased chromosome mobility facilitates homology search during recombination

(2012) Judith Miné-Hattab et al.   NATURE CELL BIOLOGY

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery

(2012) Vincent Dion et al.   NATURE CELL BIOLOGY

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 presynaptic filament stabilization function of the mouse Swi5–Sfr1 heterodimeric complex

(2012) Shang-Pu Tsai et al.   NUCLEIC ACIDS RESEARCH

Rad51 Is an Accessory Factor for Dmc1-Mediated Joint Molecule Formation During Meiosis

(2012) V. Cloud et al.   SCIENCE

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

V(D)J Recombination: Mechanisms of Initiation

(2011) David G. Schatz et al.   Annual Review of Genetics

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombination

(2011) Shannon J. Ceballos et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

(2011) Joao Matos et al.   CELL

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

Processing of homologous recombination repair intermediates by the Sgs1-Top3-Rmi1 and Mus81-Mms4 complexes

(2011) Ian D. Hickson et al.   CELL CYCLE

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

hSWS1·SWSAP1 Is an Evolutionarily Conserved Complex Required for Efficient Homologous Recombination Repair

(2011) Ting Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI

(2011) George-Lucian Moldovan et al.   MOLECULAR CELL

Aberrant chromosome morphology in human cells defective for Holliday junction resolution

(2011) Thomas Wechsler et al.   NATURE

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

(2011) Valerie Garcia et al.   NATURE

Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

(2011) Jie Liu et al.   NATURE

The RecA/RAD51 protein drives migration of Holliday junctions via polymerization on DNA

(2011) M. J. Rossi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

(2011) Petra Langerak et al.   PLoS Genetics

The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination

(2011) Yong Qing et al.   PLoS Genetics

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

(2011) Deniz Simsek et al.   PLoS Genetics

Sister Cohesion and Structural Axis Components Mediate Homolog Bias of Meiotic Recombination

(2010) Keun P. Kim et al.   CELL

Break-induced replication: What is it and what is it for?

(2010) Bertrand Llorente et al.   CELL CYCLE

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

Mechanism of Holliday junction resolution by the human GEN1 protein

(2010) U. Rass et al.   GENES & DEVELOPMENT

Physical Interaction of RECQ5 Helicase with RAD51 Facilitates Its Anti-recombinase Activity

(2010) Sybille Schwendener et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporally and Biochemically Distinct Activities of Exo1 during Meiosis: Double-Strand Break Resection and Resolution of Double Holliday Junctions

(2010) Kseniya Zakharyevich et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

(2010) Hengyao Niu et al.   NATURE

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination

(2010) Muneer G Hasham et al.   NATURE IMMUNOLOGY

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4–ligase IV during chromosomal translocation formation

(2010) Deniz Simsek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks

(2010) Matthew L Nicolette et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

(2010) Tina Thorslund et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

(2010) Rémi Buisson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

(2010) Mieun Lee-Theilen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1–Top3

(2010) Petr Cejka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of RAD51 and RAD54 in regression of a model replication fork

(2010) Dmitry V. Bugreev et al.   NUCLEIC ACIDS RESEARCH

The MRX Complex Plays Multiple Functions in Resection of Yku- and Rif2-Protected DNA Ends

(2010) Diego Bonetti et al.   PLoS One

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

(2010) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion

(2010) W. M. Hicks et al.   SCIENCE

Role for the Mammalian Swi5-Sfr1 Complex in DNA Strand Break Repair through Homologous Recombination

(2010) Yufuko Akamatsu et al.   PLoS Genetics

Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

(2009) Jennifer M. Svendsen et al.   CELL

The BRC Repeats of BRCA2 Modulate the DNA-Binding Selectivity of RAD51

(2009) Aura Carreira et al.   CELL

Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases

(2009) Samira Fekairi et al.   CELL

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination

(2009) R. Prakash et al.   GENES & DEVELOPMENT

Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery

(2009) P. Oza et al.   GENES & DEVELOPMENT

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

(2009) Kasper Fugger et al.   JOURNAL OF CELL BIOLOGY

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

(2009) Beth A. Helmink et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PCNA Is Required for Initiation of Recombination-Associated DNA Synthesis by DNA Polymerase δ

(2009) Xuan Li et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Complex landscapes of somatic rearrangement in human breast cancer genomes

(2009) Philip J. Stephens et al.   NATURE

Multiple functions of MRN in end-joining pathways during isotype class switching

(2009) Maria Dinkelmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

(2009) Anyong Xie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

(2009) Emilie Rass et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad52 promotes second-end DNA capture in double-stranded break repair to form complement-stabilized joint molecules

(2009) A. V. Nimonkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

(2009) S. Kosugi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

(2009) S. M. H. Sy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination

(2008) Louise J. Barber et al.   CELL

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Phosphorylation of the Axial Element Protein Hop1 by Mec1/Tel1 Ensures Meiotic Interhomolog Recombination

(2008) Jesús A. Carballo et al.   CELL

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

(2008) S. Gravel et al.   GENES & DEVELOPMENT

Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis

(2008) A. Sourirajan et al.   GENES & DEVELOPMENT

BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome

(2008) T. R. Singh et al.   GENES & DEVELOPMENT

A Mutation in the Putative MLH3 Endonuclease Domain Confers a Defect in Both Mismatch Repair and Meiosis in Saccharomyces cerevisiae

(2008) K. T. Nishant et al.   GENETICS

RECQ1 Possesses DNA Branch Migration Activity

(2008) Dmitry V. Bugreev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Repair Synthesis Facilitates RAD52-Mediated Second-End Capture during DSB Repair

(2008) Michael J. McIlwraith et al.   MOLECULAR CELL

Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

(2008) Joost van Mameren et al.   NATURE

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE

Identification of Holliday junction resolvases from humans and yeast

(2008) Stephen C. Y. Ip et al.   NATURE

Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis

(2008) Miki Shinohara et al.   NATURE GENETICS

Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease

(2008) K. T. Ehmsen et al.   NUCLEIC ACIDS RESEARCH

Remodeling of DNA replication structures by the branch point translocase FANCM

(2008) K. Gari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics