Article
Environmental Sciences
Siyu Xia, Xinhong Zhu, Yuepei Yan, Tao Zhang, Guoliang Chen, Daoxi Lei, Guixue Wang
Summary: This study revealed the neurotoxic and developmental toxicity of antimony on zebrafish embryos, primarily affecting neurotransmitter systems and oxidative stress, thereby altering behavior. The findings advance the understanding of antimony-induced neurotoxicity, environmental issues, and health hazards.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Jiayi Li, Huijie Jiang, Pengfei Wu, Siyu Li, Bing Han, Qingyue Yang, Xiaoqiao Wang, Biqi Han, Ning Deng, Bing Qu, Zhigang Zhang
Summary: Chronic exposure to deltamethrin induces inflammation and apoptosis in quail cerebrums through oxidative stress linked to inhibition of the Nrf2/TLR4 signaling pathway.
ENVIRONMENTAL POLLUTION
(2021)
Article
Marine & Freshwater Biology
Xin Chen, Tiantong Qiu, Peng Xiao, Wenhua Li
Summary: Isoflucypram has been found to have teratogenic effects on retinogenesis in zebrafish, causing abnormalities in retinal development and increased retinal cell apoptosis. This SDHI fungicide also demonstrates toxic effects on non-target aquatic organisms, highlighting the need for further investigation.
AQUATIC TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhong-Shang Xia, Er-Wei Hao, Yan-ting Wei, Xiao-Tao Hou, Zhang-mei Chen, Man Wei, Zheng-Cai Du, Jia-Gang Deng
Summary: The study demonstrated that genipin treatment inhibited hatching rates and body length, induced pericardial edema, cardiotoxicity, hepatotoxicity, and nephrotoxicity in zebrafish embryos/larvae. Genipin also increased oxidative stress and apoptosis in zebrafish, indicating a potential developmental toxicity mechanism associated with oxidative stress and apoptosis increase.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elif Unal, Ekrem Sulukan, Onur Senol, Alper Baran, Hayrunnisa Nadaroglu, Meryem Kankaynar, Tuba Kiziltan, Saltuk Bugrahan Ceyhun
Summary: In this study, the antioxidant capacity of carob pods water extract (CPWE) against deltamethrin (DM)-induced oxidative stress was investigated using in vitro and in vivo experiments in a zebrafish model. The results showed that exposure to DM during zebrafish development caused significant body malformations, decreased survival rate, reduced eye size, shortened body length, and decreased locomotor activity in the dark period. In addition, DM increased the levels of free oxygen radicals and apoptotic cells, while CPWE application reduced DM-induced toxicity and oxidative stress.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Environmental Sciences
Jiansheng Zhu, Chunlan Liu, Jingyu Wang, Yinyin Liang, Xing Gong, Lianghui You, Chenbo Ji, Shou-Lin Wang, Chao Wang, Xia Chi
Summary: The study found that DIF induced cardiovascular toxicity in zebrafish embryos, resulting in decreased hatching rate, survival rate, heart rate, and increased malformation rate. DIF exacerbated oxidative stress, triggering cardiovascular apoptosis and inhibiting cardiac muscle contraction, which could be restored by the antioxidant N-acetyl-L-cysteine (NAC).
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Yuxin Shi, Lei Li, Chuansen Wang, Jing Huang, Lixin Feng, Xiqiang Chen, Attila Gabor Sik, Kechun Liu, Meng Jin, Rongchun Wang
Summary: This study investigates the developmental toxicity of Chelerythrine in zebrafish and finds that it leads to a significant increase in mortality and malformation rate, as well as a reduction in hatching rate and body length. Chelerythrine also affects the normal development processes of the heart, liver, and phagocytes in zebrafish, and increases levels of reactive oxygen species (ROS) and apoptosis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Environmental Sciences
Fei Liu, Ying Zhang, Fan Wang
Summary: This study exposed zebrafish embryos to TCS and evaluated its developmental toxicity. The results showed that TCS can induce oxidative stress and apoptosis, potentially through the ROS-p53-caspase dependent pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Shukai Zheng, Qiong Zhang, Xiaoling Shi, Congying Luo, Jiasheng Chen, Wancong Zhang, Kusheng Wu, Shijie Tang
Summary: Polybrominated diphenyl ether flame retardants, specifically 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), have been found to have adverse effects on the development of zebrafish. This study investigated the molecular mechanisms behind these developmental hazards, with a focus on endoplasmic reticulum stress (ERS), oxidative stress, and apoptosis, as well as the behavioral and morphological alterations observed. The findings suggest that exposure to BDE-47 induces ERS, oxidative stress, and apoptosis in zebrafish, leading to behavioral abnormalities and craniofacial malformations. Understanding these mechanisms is crucial for understanding the toxicological effects of environmental contaminants and developing strategies to mitigate their adverse effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Qing Xia, Shuo Gao, Samuel Rajendran Rapael Gnanamuthu, Kaiyan Zhuang, Zhenzhen Song, Yun Zhang, Xue Wang, Pengfei Tu, Jianheng Li, Kechun Liu
Summary: Aconitine (AC) exerts severe toxic effects on zebrafish embryo development, including cardiac, liver, and neurodevelopment impairment, as well as ROS-mediated mitochondrial apoptosis. High-concentration AC exposure results in deficient cardiovascular system and cell apoptosis in the heart and brain regions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mengqi Wan, Ling Huang, Jieping Liu, Fasheng Liu, Guilan Chen, Huiwen Ni, Guanghua Xiong, Xinjun Liao, Huiqiang Lu, Juhua Xiao, Qiang Tao, Zigang Cao
Summary: This study assessed the toxicity of Cyclosporine A on embryonic development using zebrafish as a model organism, revealing its potential to induce cardiac developmental abnormalities by upregulating oxidative stress and Wnt signaling pathway. Treatment with Astaxanthin and an inhibitor of Wnt signaling pathway showed promising results in alleviating the toxic effects caused by CsA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Fisheries
Min Li, Xueqin Wu, Jixing Zou, Yingqian Lai, Jiawen Zhang, Xiumei Chen, Xiaotian Niu, Yidi Kong, Guiqin Wang
Summary: Thymol-supplemented diets alleviate the oxidative stress, immunotoxicity, and apoptosis induced by deltamethrin in Channa argus through the regulation of the NF-KB/Nrf2/p53 pathway.
Article
Fisheries
Min Li, Xueqin Wu, Jixing Zou, Yingqian Lai, Jiawen Zhang, Xiumei Chen, Xiaotian Niu, Yidi Kong, Guiqin Wang
Summary: This study demonstrates that dietary supplementation of thymol alleviates DEL-induced immunotoxicity, oxidative stress, and apoptosis of Channa argus through the NF-kappa B/Nrf2/p53 pathway.
Article
Environmental Sciences
Karoline Felisbino, Nathalia Kirsten, Shayane da Silva Milhorini, Isabela Saragioto Marcal, Karina Bernert, Rafaela Schiessl, Leticia Nominato-Oliveira, Izonete Cristina Guiloski
Summary: This study evaluated the acute toxicity, teratogenic effects, oxidative stress, and neurotoxicity of Dicamba in zebrafish embryos. The results showed that Dicamba could cause developmental delay, teratogenic effects, and oxidative stress. These findings highlight the potential risks of Dicamba exposure during embryonic development and the need for further studies.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Yunlong Meng, Keyuan Zhong, Suping Chen, Yong Huang, You Wei, Juan Wu, Juan Liu, Zhaopeng Xu, Jing Guo, Fasheng Liu, Huiqiang Lu
Summary: The study revealed that exposure to Pendimethalin can reduce heart rate, survival rate, and body length of zebrafish embryos, causing various malformations and affecting antioxidant enzyme activity and the expression of genes related to cardiac development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Gonca Alak, Veysel Parlak, Mehmet Enes Arslan, Arzu Ucar, Muhammed Atamanalp, Hasan Turkez
BIOLOGICAL TRACE ELEMENT RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Gonca Alak, Asli Cilingir Yeltekin, Arzu Ucar, Veysel Parlak, Hasan Turkez, Muhammed Atamanalp
BIOLOGICAL TRACE ELEMENT RESEARCH
(2019)
Article
Chemistry, Multidisciplinary
Gonca Alak, Arzu Ucar, Ash Cilingir Yeltekin, Veysel Parlak, Gizem Nardemir, Merve Kizilkaya, Ismail Hakki Tas, Mustafa Yilgin, Muhammed Atamanalp, Ahmet Topal, Esat Mahmut Kocaman, Telat Yanik
DRUG AND CHEMICAL TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Gonca Alak, Veysel Parlak, Asli Cilingir Yeltekin, Arzu Ucar, Selim Comakli, Ahmet Topal, Muhammed Atamanalp, Mustafa Ozkaraca, Hasan Turkez
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Arzu Ucar, Fatma Betul Ozgeris, Asli Cilingir Yeltekin, Veysel Parlak, Gonca Alak, Mevlut Sait Keles, Muhammed Atamanalp
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2019)
Article
Zoology
Fatih Korkmaz, Veysel Parlak, Ozgur Kaynar, Arzu Ucar, Gonca Alakl, Muhammed Atamanalp
PAKISTAN JOURNAL OF ZOOLOGY
(2019)
Article
Environmental Sciences
Gonca Alak, Ash Cilingir Yeltekin, Fatma Betul Ozgeris, Veysel Parlak, Arzu Ucar, M. Sait Keles, Muhammed Atamanalp
Article
Food Science & Technology
Gonca Alak, Kubra Guler, Arzu Ucar, Veysel Parlak, Esat Mahmut Kocaman, Telat Yanik, Muhammed Atamanalp
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2019)
Article
Chemistry, Multidisciplinary
Arzu Ucar, Fatma Betul Ozgeris, Veysel Parlak, Asli Cilingir Yeltekin, Esat Mahmut Kocaman, Gonca Alak, Muhammed Atamanalp
Summary: Insecticides, particularly Fipronil, have high neurotoxicity on aquatic organisms and can lead to oxidative stress and apoptosis in fish brain tissue even at low concentrations. The enzyme activities in the brain tissue were affected, with SOD-CAT-GPX-PON and arylesterase being inhibited while MDA and MPO levels varied depending on the concentration of the insecticide.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Toxicology
Veysel Parlak, Bunyamin Ozgeris, Arzu Ucar, Asli Cilingir Yeltekin, Fatma Betul Ozgeris, Ozge Caglar, Gonca Alak, Hasan Turkez, Muhammed Atamanalp
Summary: This study evaluated the hematological, oxidative, and genotoxic damage potentials of 3-Benzoylpyridine (3BP) on rainbow trout. The results showed that 3BP caused hematological and oxidative alterations as well as genotoxic damage in rainbow trout.
TOXICOLOGY MECHANISMS AND METHODS
(2022)
Article
Biochemistry & Molecular Biology
Gonca Alak, Arzu Ucar, Veysel Parlak, Muhammed Atamanalp
Summary: This paper discusses the threats to existing water resources posed by global warming, drought, and industrialization, with a focus on the impact of microplastics on the aquatic ecosystem and detection methods.
CHEMISTRY AND ECOLOGY
(2022)
Article
Chemistry, Applied
Gonca Alak, Asli Cilingir Yeltekin, Mine Kokturk, Mehmet Salih Nas, Veysel Parlak, Mehmet Harbi Calimli, Arzu Ucar, Muhammed Atamanalp
Summary: This study explores the interactions between PdCu@f-MWCNT nanoparticles and zebrafish, and assesses their ecotoxicological risk. The chemical and morphological structures of the nanomaterials are analyzed, and their effects on zebrafish are investigated through biochemical analyses and examination of malformation defects. The results show that the nanoparticles have dose-dependent adverse effects on embryonic development, survival rate, and incidence of malformation in zebrafish.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Arzu Ucar, Mehmet Enes Arslan, Asli Cilingir Yeltekin, Fatma Betul Ozgeris, Ozge Caglar Yildirim, Veysel Parlak, Gonca Alak, Hasan Turkez, Muhammed Atamanalp
Summary: The unique features of nanoparticles have led to new applications in various fields. However, the release of nanoparticles into the environment raises concerns. This study evaluated the toxicity of magnetite nanoparticles on aquatic organisms and found that treatment with boron mineral can alleviate the harmful effects.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mine Kokturk, Fatma Betuel Ozgeris, Muhammed Atamanalp, Arzu Ucar, Suleyman Ozdemir, Veysel Parlak, Hunkar Avni Duyar, Gonca Alak
Summary: Microplastic (MP) pollution has become a health concern, but research on the oxidative stress response to MPs in natural environments is limited. This study evaluated the identification and characterization of MPs in turbot tissues and their impact on biomarkers. Results showed that MPs cause oxidative damage in tissues and had the highest impact on the liver. The potential transmission of MPs from turbot tissues to humans was also examined.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Fisheries
Gonca Alak, Veysel Parlak, Arzu Ucar, Asli Cilingir Yeltekin, Fatma Betul Ozgeris, Ozge Caglar, Muhammed Atamanalp, Hasan Turkez
TURKISH JOURNAL OF FISHERIES AND AQUATIC SCIENCES
(2020)