Article
Environmental Sciences
Ozge Temiz
Summary: The study investigated the toxic effects of emamectin benzoate (EMB) in male mice, showing dose-dependent neurotoxic effects and changes in various biomarkers and enzyme activities in the brain tissue.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Toxicology
Muhammed Atamanalp, Veysel Parlak, Fatma Betul Ozgeris, Asli Cilingir Yeltekin, Arzu Ucar, Mevlut Sait Keles, Gonca Alak
Summary: The study revealed that after exposure to pesticides, antioxidant enzyme activities increased in the N-acetyl cysteine treated group, while oxidative stress-related indicators decreased, and the kidney was found to be the most sensitive tissue.
TOXICOLOGY MECHANISMS AND METHODS
(2021)
Article
Biochemistry & Molecular Biology
Vera Belousova, Oxana Svitich, Elena Timokhina, Irina Ignatko, Irina Bogomazova, Svetlana Pesegova, Tatiana Silaeva, Tatiana Kuzmina, Oxana Skorobogatova
Summary: This article presents the hypothesis that premature placenta apoptosis could be a potential cause of preterm birth, supported by evaluating gene expression. The study found that during pregnancy, the expression of apoptosis-related genes in the placenta is low, but the expression of the apoptosis inhibitor XIAP is high. However, at the onset of preterm labor, the expression of apoptosis-related genes increases significantly, potentially initiating preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Peiwei Xu, Zhe Mo, Lizhi Wu, Weizhong Chen, Shengliang He, Yuan Chen, Dandan Xu, Jie Xiang, Zhijian Chen, Xiaoming Lou, Zhen Wang, Xiaofeng Wang
Summary: This study found that residents living near electroplating industries have elevated body burdens of Cd levels, as well as slight renal dysfunction and DNA oxidation damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Asmaa R. Hashim, Dina W. Bashir, Noha A. E. Yasin, Mona K. Galal, S. M. El-Gharbawy
Summary: This study explored the hepatotoxic properties of glyphosate (GLP) on adult albino rats, and the potential ameliorative effects of N-acetylcysteine (NAC). NAC administration before GLP partially mitigated alterations in liver indicators, histopathological findings, and immunohistochemical results.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Ozge Temiz, Dicle Kargin, Hikmet Y. Cogun
Summary: This study revealed the toxic effects of the pesticide thiamethoxam at sublethal concentrations on the liver and brain of Oreochromis niloticus, leading to changes in oxidative stress and genotoxicity. At the cellular level, the antioxidant system and stress proteins played a protective role against the toxic effects caused by thiamethoxam.
WATER AIR AND SOIL POLLUTION
(2021)
Article
Chemistry, Analytical
Duong Song Thai Duong, Chang-Hyun Jang
Summary: We developed a liquid crystal-based assay to monitor paraoxon using a Cu2+ -coated substrate and acetylcholinesterase (AChE). The inhibitory effect of paraoxon on AChE resulted in a homeotropic alignment of the liquid crystal. The proposed sensor platform showed high sensitivity and specificity in quantifying paraoxon, making it a potential screening tool for accurate evaluation of paraoxon and other organophosphorus compounds.
Article
Environmental Sciences
J. C. Balasch, I. Brandts, C. Barria, M. A. Martins, A. Tvarijonaviciute, L. Tort, M. Oliveira, M. Teles
Summary: Exposure to PMMA-NPs elicited mildly antioxidant responses and increased AChE activity in gilthead sea bream fingerlings, while also inhibiting key regulators of muscle development.
MARINE POLLUTION BULLETIN
(2021)
Article
Nutrition & Dietetics
Hinako Nanri, Megumi Hara, Yuichiro Nishida, Chisato Shimanoe, Yun-Shan Li, Hiroshi Kasai, Kazuaki Kawai, Yasuki Higaki, Keitaro Tanaka
Summary: This study aimed to evaluate the association between oxidative balance score (OBS) and urinary levels of 8-hydroxydeoxyguanosine (8-OHdG) among Japanese adults. The findings showed that higher OBSs were significantly associated with lower urinary 8-OHdG levels, suggesting that OBS could be a useful tool for evaluating oxidative stress-related lifestyle factors, including diet.
Article
Public, Environmental & Occupational Health
Lucie Blahova, Tomas Janos, Vicente Mustieles, Andrea Rodriguez-Carrillo, Mariana F. Fernandez, Ludek Blaha
Summary: This study developed a sensitive extraction method for urine matrix, coupled with LC-MS/MS analysis of the biomarker 8-OHdG. The results showed that the concentrations of non-adjusted 8-OHdG significantly decreased in the third trimester and post-delivery urine samples. Additionally, the study found a correlation between the concentrations of 8-OHdG in urine and placenta samples, as well as associations with maternal obesity, mode of delivery, and newborn sex.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Pharmacology & Pharmacy
Zhihui Ding, Jing Zhao, Xufang Wang, Wei Li, Chong Chen, Chen Yong, Yiye Zhu, Fang Tian, Li Liu, Manshu Yu, Enchao Zhou, Liubao Gu, Chunlei Yao, Kun Gao
Summary: This study found that the total extract of Abelmoschus manihot flower can protect renal tubular epithelial cells from uric acid-induced injury by inhibiting the ERK/1/2/caspase-8/caspase-3/NLRP3/GSDME pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Freylan Mena, Adarli Romero, Julian Blasco, Cristiano V. M. Araujo
Summary: As aquatic environments associated with conventional agriculture are exposed to various pesticides, it is important to identify any possible interactions that modify their effects when in a mixture. This study found that the presence of glyphosate attenuated the avoidance response of fish to chlorpyrifos and chlorothalonil, indicating that the ecological risk of exposure may be temporarily masked.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Doaa A. Madkour, Mohamed M. Ahmed, Sahar H. Orabi, Samy M. Sayed, Reda M. S. Korany, Hanem K. Khalifa
Summary: The study demonstrated that Nigella sativa oil (NSO) has a protective effect against emamectin benzoate (EMB) induced neurotoxicity through its antioxidant, anti-inflammatory, and anti-apoptotic activities. The findings suggest NSO as a potential therapeutic agent for EMB-induced neurotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Diego A. Rodriguez, Giovanni Quarato, Swantje Liedmann, Bart Tummers, Ting Zhang, Cliff Guy, Jeremy Chase Crawford, Gustavo Palacios, Stephane Pelletier, Halime Kalkavan, Jeremy J. P. Shaw, Patrick Fitzgerald, Mark J. Chen, Siddharth Balachandran, Douglas R. Green
Summary: This study identifies a molecular mechanism whereby Caspase-8 and FADD suppress spontaneous necroptotic cell death. The absence of Caspase-8 or FADD leads to the activation of RIPK3 and MLKL, resulting in necroptosis. This process relies on the nucleic acid sensor ZBP1 and its associated signaling pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Tzu-Jung Yu, Jun-Ping Shiau, Jen-Yang Tang, Ammad Ahmad Farooqi, Yuan-Bin Cheng, Ming-Feng Hou, Chia-Hung Yen, Hsueh-Wei Chang
Summary: Physapruin A (PHA), a compound extracted from Physalis plants, can induce endoplasmic reticulum stress to regulate proliferation and apoptosis of breast cancer cells, which is associated with oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Arzu Ucar, Veysel Parlak, Fatma Betul Ozgeris, Asli Cilingir Yeltekin, Mehmet Enes Arslan, Gonca Alak, Hasan Turkez, Esat Mahmut Kocaman, Muhammed Atamanalp
Summary: This study investigated the effects of exposure to magnetic nanoparticles on Oncorhynchus mykiss and found that ulexite can mitigate neurotoxicity and inflammation. The impact on the antioxidant system and DNA damage was also analyzed. The results showed that magnetic nanoparticles induced stress in O. mykiss, while ulexite exhibited a positive regulatory effect on this stress response.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Applied
Gonca Alak, Asli Cilingir Yeltekin, Mine Kokturk, Mehmet Salih Nas, Veysel Parlak, Mehmet Harbi Calimli, Arzu Ucar, Muhammed Atamanalp
Summary: This study explores the interactions between PdCu@f-MWCNT nanoparticles and zebrafish, and assesses their ecotoxicological risk. The chemical and morphological structures of the nanomaterials are analyzed, and their effects on zebrafish are investigated through biochemical analyses and examination of malformation defects. The results show that the nanoparticles have dose-dependent adverse effects on embryonic development, survival rate, and incidence of malformation in zebrafish.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Arzu Ucar, Mehmet Enes Arslan, Asli Cilingir Yeltekin, Fatma Betul Ozgeris, Ozge Caglar Yildirim, Veysel Parlak, Gonca Alak, Hasan Turkez, Muhammed Atamanalp
Summary: The unique features of nanoparticles have led to new applications in various fields. However, the release of nanoparticles into the environment raises concerns. This study evaluated the toxicity of magnetite nanoparticles on aquatic organisms and found that treatment with boron mineral can alleviate the harmful effects.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mine Kokturk, Fatma Betuel Ozgeris, Muhammed Atamanalp, Arzu Ucar, Suleyman Ozdemir, Veysel Parlak, Hunkar Avni Duyar, Gonca Alak
Summary: Microplastic (MP) pollution has become a health concern, but research on the oxidative stress response to MPs in natural environments is limited. This study evaluated the identification and characterization of MPs in turbot tissues and their impact on biomarkers. Results showed that MPs cause oxidative damage in tissues and had the highest impact on the liver. The potential transmission of MPs from turbot tissues to humans was also examined.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Muhammed Atamanalp, Mine Kokturk, Fatih Guenduez, Veysel Parlak, Arzu Ucar, Duried Alwazeer, Gonca Alak
Summary: This study aimed to investigate the presence of microplastics (MPs) in freshwater mussel species found in the Beyhan dam lake and characterized them using Fourier transform infrared spectroscopy (FTIR). The study found a significant difference in MP presence between different stations and determined the color, size, shape, and type of the MPs. The presence of MPs in the freshwater mussels suggests their potential as bioindicators for MP pollution in aquatic ecosystems.
Article
Biochemistry & Molecular Biology
Arzu Ucar, Asli Cilingir Yeltekin, Mine Kokturk, Mehmet Harbi Calimli, Mehmet Salih Nas, Veysel Parlak, Gonca Alak, Muhammed Atamanalp
Summary: This study investigated the developmental toxicity of zebrafish treated with different concentrations of PdCu@GO. It was found that PdCu@GO administration decreased hatchability and survival rate, and caused dose-dependent cardiac malformation. Furthermore, reactive oxygen species (ROS) and apoptosis were also affected by nano-Pd exposure.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Public, Environmental & Occupational Health
Cigdem Oter, Asli Cilingir Yeltekin, Sama Ammer Abbas El-Tekreti
Summary: By studying the biological parameters of brain tissue in Carassius auratus, it was found that high dose lithium exposure caused oxidative stress, DNA damage, and apoptosis. It was also found that lithium exposure led to a decrease in acetylcholinesterase activity. The solid phase extraction method using sawdust loaded with magnetite nanoparticles showed a high removal yield of about 96% for lithium.
TOXICOLOGY AND INDUSTRIAL HEALTH
(2023)
Article
Green & Sustainable Science & Technology
Gonca Alak, Mine Kokturk, Muhammed Atamanalp, Esat Mahmut Kocaman, Arzu Ucar, Nurinisa Esenbuga, Sinan Ozcan, Veysel Parlak
Summary: In recent years, the study of plastic levels in aquaculture has expanded to include assessing consumer health risks and ecological monitoring. This study aimed to determine the microplastic load in rainbow trout at various stages of development, from egg to +1 year of age, under routine breeding conditions. The findings showed an increase in microplastic levels as the fish transitioned to external feeding, with the dominant microplastic color being black and blue, and the polymer type being polyethylene. This study model will encourage further research and highlights the potential for microplastic contamination throughout fish production.
Article
Toxicology
Hasan Sac, Asli C. Yeltekin
Summary: The study found that exposure to high concentrations of arsenic in the water caused changes in multiple indicators in the brain tissues of fish, indicating that arsenic can induce oxidative stress.
TOXICOLOGY RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Muhammed Atamanalp, Mine Kokturk, Mahinur Kirici, Arzu Ucar, Muammer Kirici, Veysel Parlak, Ahmet Aydin, Gonca Alak
Summary: This study investigated the presence of microplastic pollution in different fish species in Erzurum, Erzincan, and Bingol. The results showed that microplastics, mainly in the form of fragments and fibers, were found in the gastrointestinal systems of various fish species. Additionally, the study observed oxidative damage and reduced antioxidant levels in fish species exposed to microplastics.
