期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 13, 期 10, 页码 1231-1247出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201800102
关键词
alkynes; C-C coupling; C-H activation; cross coupling; transition metals
C-C triple bonds are amongst the most versatile functional groups in synthetic chemistry. Complementary to the Sonogashira coupling the direct metal-catalyzed alkynylation of C-H bonds has emerged as a highly promising approach in recent years. To guarantee a high regioselectivity suitable directing groups (DGs) are necessary to guide the transition metal (TM) into the right place. In this Focus Review we present the current developments in DG-mediated C(sp(2))-H and C(sp(3))-H modifications with terminal alkynes under oxidative conditions and with electrophilic alkynylation reagents. We will discuss further modifications of the alkyne, in particular subsequent cyclizations to carbo- and heterocycles and modifications of the DG in the presence of the alkyne.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据