Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing

Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions

(2017) Kevin P. Cole et al.   SCIENCE

Assessing inter- and intramolecular continuous-flow strategies towards methylphenidate (Ritalin) hydrochloride

(2017) Romaric Gérardy et al.   Reaction Chemistry & Engineering

Use of a “Catalytic” Cosolvent, N ,N -Dimethyl Octanamide, Allows the Flow Synthesis of Imatinib with no Solvent Switch

(2016) Jeffrey C. Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced Reaction Efficiency in Continuous Flow

(2016) Peter D. Morse et al.   ISRAEL JOURNAL OF CHEMISTRY

Custom-Built Miniature Continuous Crystallization System with Pressure-Driven Suspension Transfer

(2016) Yuqing Cui et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Compact and Integrated Approach for Advanced End-to-End Production, Purification, and Aqueous Formulation of Lidocaine Hydrochloride

(2016) Jean-Christophe M. Monbaliu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

(2016) A. Adamo et al.   SCIENCE

A Concise Flow Synthesis of Efavirenz

(2015) Camille A. Correia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

(2015) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

(2015) Marcus Baumann et al.   Beilstein Journal of Organic Chemistry

Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance May 20–21, 2014 Continuous Manufacturing Symposium

(2015) Ian R. Baxendale et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Achieving Continuous Manufacturing for Final Dosage Formation: Challenges and How to Meet Them May 20–21 2014 Continuous Manufacturing Symposium

(2015) Stephen Byrn et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Achieving Continuous Manufacturing May 20–21 2014 Continuous Manufacturing Symposium

(2015) Clive Badman et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

pH-Dependent Liquid–Liquid Phase Separation of Highly Supersaturated Solutions of Weakly Basic Drugs

(2015) Anura S. Indulkar et al.   MOLECULAR PHARMACEUTICS

Continuous Flow Total Synthesis of Rufinamide

(2014) Ping Zhang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

(2013) Salvatore Mascia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts

(2013) David R. Snead et al.   Chemical Science

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

(2012) François Lévesque et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

(2012) Mark D. Hopkin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones

(2011) Monica Viviano et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Novel Process Windows - Gate to Maximizing Process Intensification via Flow Chemistry

(2009) V. Hessel   CHEMICAL ENGINEERING & TECHNOLOGY

Distillation in microchemical systems using capillary forces and segmented flow

(2009) Ryan L. Hartman et al.   LAB ON A CHIP