Article
Chemistry, Multidisciplinary
Qian Wang, Meng Xiao, Dianyu Wang, Xiaoxue Hou, Jie Gao, Jinjian Liu, Jianfeng Liu
Summary: This study introduces a synergistic Pt(IV) prodrug that combines dual responsive behavior and dual drug resistance-related pathways deactivation, effectively overcoming drug resistance and improving the efficacy of anticancer drugs through multiple mechanisms.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Environmental
Haitao Hu, Wenbin Dai, Yuhuang Zhang, Yue Huang, Jun Qian, Qiao Jin, Jian Ji, Zhe Tang
Summary: In this study, glutathione-activatable photosensitizer-conjugated nanoassemblies were fabricated using dual supramolecular self-assembly. The nanoassemblies showed unique properties in acidic tumor microenvironment, including charge conversion and enhanced cellular internalization. The research provides an innovative approach to fabricate drug nanocarriers.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Ran Zhang, Yueyue Zhang, Liumei Tang, Yixing Xu, Hao Li, Xueping Jiang, Xiangdong Xin, Zhongzheng Gui
Summary: A series of Pt(IV) prodrugs containing a microtubule inhibitor paclitaxel were synthesized and evaluated for their antitumor activity. One of the prodrugs, named Ptxplatin, effectively entered cancer cells and induced DNA damage, cell cycle arrest, and inhibition of cell migration. Furthermore, Ptxplatin caused mitochondrial dysfunction and triggered endoplasmic reticulum stress, ultimately leading to cancer cell death.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Juan Sanchez-Camacho, Sonia Infante-Tadeo, Ana C. Carrasco, Stefano Scoditti, A'lvaro Martinez, Fabienne Barroso-Bujans, Emilia Sicilia, Ana M. Pizarro, Luca Salassa
Summary: In this study, two new asymmetric Pt(IV) derivatives were designed and synthesized, which could be effectively activated into toxic Pt(II) species by incubation with nicotinamide adenine dinucleotide, sodium ascorbate, and glutathione in the dark and under light irradiation. One of the derivatives displayed enhanced toxicity in MDA-MB-231 breast cancer cells preincubated with ascorbate, suggesting selective triggering of oxaliplatin generation through redox activation. Covalent binding of the flavin to the Pt complex was shown to be pivotal for this effect.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jatinder Singh, Hyunuk Kim, Ki-Whan Chi
Summary: This review provides a comprehensive insight into the methods and challenges of obtaining non-trivial topologies through template-free, coordination-driven, and non-covalent interaction-directed self-assembly.
Article
Chemistry, Multidisciplinary
Bin Sun, Eva J. J. Meeus, Felix J. J. de Zwart, Eduard O. O. Bobylev, Tiddo J. J. Mooibroek, Simon Mathew, Joost N. H. Reek
Summary: Coordination chemistry is a powerful method for synthesizing supramolecular cages with specific applications. This study successfully synthesized discrete, homochiral (Fe2L3)-L-II cages through chirality-driven self-assembly. The size of these cages can be controlled by stereochemical manipulation of the iron(II) centers, and their formation requires chirality at both the vertices and ligand backbones. The smaller cages exhibit stereoselectivity with only chiral ligands, and their formation is driven by non-covalent interactions.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Andreas Frank, Christian Hils, Melina Weber, Klaus Kreger, Holger Schmalz, Hansooo-Werner Schmidt
Summary: By matching the functional groups of the surface patches on polymer fibers with the corresponding substituents of BTAs, specific superstructures can be induced.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Biomedical
Xiaohui Xiao, Yupeng Wang, Jieyao Chen, Peng Qin, Peiyao Chen, Dongfang Zhou, Yue Pan
Summary: This study presents a self-targeting nano-assembly strategy based on platinum(IV)-lactose amphiphilic prodrug for synergistic and safe chemoradiotherapy of hepatocellular carcinoma (HCC). The nano-assembly targets HCC cells and releases cisplatin to induce DNA damage and cell apoptosis. Under X-ray irradiation, the assembly enhances the cell-killing effect of radiotherapy.
Article
Chemistry, Multidisciplinary
Zaihui Du, Longjiao Zhu, Pengfei Wang, Xinyue Lan, Shenghao Lin, Wentao Xu
Summary: In this study, Ag@Pt nanozymes with excellent peroxidase-like and antibacterial effects were designed and synthesized using nucleic acid and metal ions coordination-driven self-assembly. The adjustable and peroxidase-like enhancing properties of these nanozymes were achieved by regulating functional nucleic acids. The Ag@Pt nanozymes not only have simple and general synthesis approaches, but also possess dual functionality.
Article
Chemistry, Multidisciplinary
Kripa Joseph, Soh Kushida, Emanuel Smarsly, Dris Ihiawakrim, Anoop Thomas, Gian Lorenzo Paravicini-Bagliani, Kalaivanan Nagarajan, Robrecht Vergauwe, Eloise Devaux, Ovidiu Ersen, Uwe H. F. Bunz, Thomas W. Ebbesen
Summary: The research found that vibrational strong coupling can significantly change the molecular supermolecular morphology of self-assembly, affect self-assembly dynamics, and depend on solvent vibration. These findings provide a new tool for controlling supramolecular assemblies, with broad implications for molecular and material science.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Pengge Zhang, Zhixuan Zhou, Wen Long, Yuping Yan, Youshan Li, Ting Fu, Yanlan Liu, Zilong Zhao, Weihong Tan, Peter J. Stang
Summary: This study utilized self-assembly techniques to construct stable and soluble metallacycle nanoparticles for combination chemotherapy. The nanoparticles, loaded with two chemotherapy drugs, were internalized into cancer cells through folate-mediated targeting. The drugs were released in the reducing intracellular environment, leading to a synergistic anticancer effect.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Dongyue An, Yutao Sun, Dongdong Chang, Jiangyu Zhu, Shumin Chen, Xuefeng Lu
Summary: This study reports four novel p-conjugated macrocycles based on electron acceptor units naphthalimide (NMI) with aryl or alkyl substitutions. The self-assembly behaviors of these macrocycles were greatly affected by the different substitutions. Alkyl substituted macrocycles showed aggregation in solution, while aryl substituted macrocycles did not. Furthermore, all the macrocycles exhibited supramolecular encapsulation with C-70, with larger macrocycles showing stronger binding affinity than smaller macrocycles.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Physical
Bohang Wu, Lin Liu, Lu Zhou, Jose Rodrigo Magana, Marco M. R. M. Hendrix, Jiahua Wang, Chendan Li, Peng Ding, Yiming Wang, Xuhong Guo, Ilja K. Voets, Martien A. Cohen Stuart, Junyou Wang
Summary: The study developed a supramolecular polymer based on BTA, which forms stable fibers in the presence of appropriate metal ions; experiments showed that the formation and structure of the fibers were very similar for various transition metal ions, enabling the introduction of different functionalities by choosing different metal ions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Jindiao Wu, Jianan Zhang, Yanjun Liu, Jun Wang, Cheng Zhang, Jiatao Yan, Wen Li, Toshio Masuda, Andrew K. Whittaker, Afang Zhang
Summary: Molecules with C-3 symmetry can self-assemble into supramolecular fibers with enhanced chirality, and the integration of conjugation provides strong aggregation tendency, leading to the formation of supramolecular fibrous bundles.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Jindiao Wu, Jianan Zhang, Yanjun Liu, Jun Wang, Cheng Zhang, Jiatao Yan, Wen Li, Toshio Masuda, Andrew K. Whittaker, Afang Zhang
Summary: Molecules with C-3 symmetry and conjugated diacetylene cores can self-assemble into well-defined supramolecular fibers with enhanced chirality in both organic and aqueous solutions. The integration of symmetry and conjugation provides aggregation tendency through pi-pi stacking, resulting in supramolecular chirality predominantly influenced by steric hindrance from dipeptide pendants.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Baoxuan Huang, Xi Liu, Guoliang Yang, Jia Tian, Zhiyong Liu, Yucheng Zhu, Xiaopeng Li, Guangqiang Yin, Wei Zheng, Lin Xu, Weian Zhang
Summary: A novel organoplatinum(II) metalla-cycle with multimodal treatment capabilities was developed in this study. The metalla-cycle exhibited remarkable trimodal therapeutic effects against cancer cells through chemotherapy, photodynamic therapy, and photothermal therapy.
Article
Chemistry, Multidisciplinary
Xiaotong Zhao, Heng Wang, Boyang Li, Wenyao Zhang, Xiaopeng Li, Wei Zhao, Christoph Janiak, Andrew W. Heard, Xiao-Juan Yang, Biao Wu
Summary: Anion-coordination-driven assembly (ACDA) is a powerful method for constructing anionic supramolecular architectures. Expanding the anion centers to organic tris-carboxylates has shown promising ability in constructing novel topologies with increasing complexity and diversity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Heng Wang, Chenxing Guo, Xiaopeng Li
Summary: This review focuses on the recent development of multidimensional mass spectrometry (MS) in metallo-supramolecular characterization. MS, including electrospray ionization-MS (ESI-MS), tandem MS (MS2), and ion mobility-MS (IM-MS), is emerging as an essential analytical tool for characterization of metallo-supramolecules. It can provide information about the chemical compositions, connectivity, stability, shape, size, as well as kinetic and thermodynamic features of self-assembly processes. The use of MS techniques helps advance the development of metallo-supramolecular chemistry.
Article
Chemistry, Multidisciplinary
Yali Hou, Zeyuan Zhang, Lingzhi Ma, Ruping Shi, Sanliang Ling, Xiaopeng Li, Gang He, Mingming Zhang
Summary: By using self-assembled supramolecular structures, two barrel-shaped metallacages with efficient singlet oxygen generation ability were prepared. These metallacages can be used for visible light-driven photocatalytic oxidation reactions with high yields, showing significant potential for future applications in photocatalysis.
Article
Chemistry, Multidisciplinary
Furong Lin, Shang-Bo Yu, Yue-Yang Liu, Chuan-Zhi Liu, Shuai Lu, Jin Cao, Qiao-Yan Qi, Wei Zhou, Xiaopeng Li, Yi Liu, Jia Tian, Zhan-Ting Li
Summary: This study reports the use of porous polymers for neutralizing heparin anticoagulants. These porous polymers show strong binding affinities towards heparins and demonstrate good neutralization effects. The results suggest that porous polymers can serve as effective heparin reversal agents.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Chen Xu, Quanjie Lin, Chuan Shan, Xin Han, Hao Wang, Heng Wang, Wenjing Zhang, Zhi Chen, Chenxing Guo, Yinghao Xie, Xiujun Yu, Bo Song, Heng Song, Lukasz Wojtas, Xiaopeng Li
Summary: In this study, chiral metallo-supramolecular octahedra were obtained without using chiral sources. The cages exhibited three types of chirality and demonstrated high stability in solution.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Multidisciplinary Sciences
Yuling Xu, Chonglu Li, Xin Ma, Wei Tuo, Le Tu, Xiaopeng Li, Yan Sun, Peter J. Stang, Yao Sun
Summary: In this study, an emissive Ru(II) metallacycle was developed, which can be excited by 808 nm laser and emit at a wavelength of around 1,000 nm. The metallacycle exhibits good optical penetration and reactive oxygen species production properties, and shows broad-spectrum antibacterial activity and low cytotoxicity. In vivo studies demonstrate its potential for precise imaging-guided, photo-triggered treatments.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nanoscience & Nanotechnology
Qian Feng, Tianfeng Yang, Lingzhi Ma, Xiaopeng Li, Hongye Yuan, Mingming Zhang, Yanmin Zhang, Lihong Fan
Summary: This study reports a morpholine-functionalized metallacage for lysosome-targeted cell imaging. The efficient host-guest interactions between the metallacage and dyes prevent aggregation and maintain emission in aqueous solutions. The metallacage is used as a vector to deliver dyes of different colors into lysosomes for targeted imaging.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Feng Su, Shunran Zhang, Zhi Chen, Zeyuan Zhang, Zhikai Li, Shuai Lu, Mingming Zhang, Fang Fang, Shimin Kang, Chenxing Guo, Chenliang Su, Xiujun Yu, Heng Wang, Xiaopeng Li
Summary: Molecular geometry plays a crucial role in determining the structural features, physical properties, and functions of materials, but constructing macromolecules with diverse geometries remains a challenge. Researchers have successfully designed and synthesized tetratopic monomers with unique shapes to produce metallo-macromolecules with clearly defined geometries, which were visualized at the single-molecule level. In studies of structure-property relationships, the helicoid metallo-polymer shows high efficiency and geometry-dependent selectivity in wrapping single-walled carbon nanotubes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Qiangqiang Shi, Hao Yin, Rundi Song, Jie Xu, Jiajia Tan, Xin Zhou, Jie Cen, Zhengyu Deng, Huimin Tong, Chenhui Cui, Yanfeng Zhang, Xiaopeng Li, Zhengbiao Zhang, Shiyong Liu
Summary: In this study, a modular construction method for precise sequence-defined amphiphilic polymers was reported, and direct sequence reading and quantification were achieved using mass spectrometry. In vivo experiments enabled the comparison of the biological properties of different types of polymers.
Editorial Material
Chemistry, Multidisciplinary
Xiujun Yu, Zhi Chen, Xiaopeng Li
Summary: This article presents an intriguing strategy for constructing highly crystalline and non-interpenetrated 3D porphyrinic COFs with scu topology, demonstrating excellent photocatalytic efficiencies.
Article
Chemistry, Multidisciplinary
Zhikai Li, Min Chen, Zhi Chen, You-Liang Zhu, Chenxing Guo, Heng Wang, Yi Qin, Fang Fang, Dong Wang, Chenliang Su, Chuanxin He, Xiujun Yu, Zhong-Yuan Lu, Xiaopeng Li
Summary: Biological systems use non-equilibrium self-assembly to create ordered nanostructures with sophisticated functions. However, constructing artificial non-equilibrium nanoassemblies is challenging due to the lack of control over assembly dynamics and kinetics. In this study, we designed a series of linear polymers with different side groups for coordination-driven self-assembly based on shape-complementarity. The introduction of main-chain confinement effectively slowed down the assembly process of side groups, allowing for the real-time monitoring of the evolution of lychee-like nanostructures. The function related to the non-equilibrium nature was explored through photothermal conversion study.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Le-Ping Zhang, Chuan-Zhi Liu, Ming Liu, Shuai Lu, Shang-Bo Yu, Qiao-Yan Qi, Guan-Yu Yang, Xiaopeng Li, Bo Yang, Zhan-Ting Li
Summary: This study reports a new self-assembly approach, which induces a structurally symmetric molecule to trimerize using CB[10]. The resulting homotrimer exhibits tunable fluorescence and high stability in both water and the solid state.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Sumra Idrees, Zhikai Li, Fang Fang, Huowang He, Irfan Majeed, Yihuan Zhang, Atsuhiro Osuka, Yan Cao, Zhuo Zeng, Xiaopeng Li, Hua-Wei Jiang
Summary: This report demonstrated the synthesis of a one-dimensional tubular assembly comprising porphyrin nanoring subunits. The nanotubes were formed through hydrogen bonding and exhibited well-defined arrays of nanotube bundles. The ordered 1D tubular nanoscale structure was observed using high-resolution transmission electron microscopy.
Article
Chemistry, Multidisciplinary
Zeyuan Zhang, Lingzhi Ma, Fang Fang, Yali Hou, Chenjie Lu, Chaoqun Mu, Yafei Zhang, Haifei Liu, Ke Gao, Ming Wang, Zixi Zhang, Xiaopeng Li, Mingming Zhang
Summary: A porphyrin-based metallacage with effective host-guest properties for polycyclic aromatic hydrocarbons (PAHs) is reported. The metallacage exhibits high association constant and good singlet oxygen generation capacity, enabling the controlled release of encapsulated guests. This study provides a new design motif for stimuli-responsive materials.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
