Article
Materials Science, Biomaterials
Peng Xie, Qiao Jin, Yifan Li, Jinbo Zhang, Xiang Kang, Jialin Zhu, Xinzhan Mao, Peiguo Cao, Chaoyong Liu
Summary: This study reports a triple action nanoplatinum drug based on artesunate and cantharidin, which enhances ROS generation, induces DNA damage, and inhibits DNA repair to achieve a high-efficiency killing effect in a single tumor cell.
BIOMATERIALS SCIENCE
(2021)
Article
Engineering, Biomedical
Xiaohui Xiao, Yupeng Wang, Jieyao Chen, Peng Qin, Peiyao Chen, Dongfang Zhou, Yue Pan
Summary: This study presents a self-targeting nano-assembly strategy based on platinum(IV)-lactose amphiphilic prodrug for synergistic and safe chemoradiotherapy of hepatocellular carcinoma (HCC). The nano-assembly targets HCC cells and releases cisplatin to induce DNA damage and cell apoptosis. Under X-ray irradiation, the assembly enhances the cell-killing effect of radiotherapy.
Article
Biophysics
Ping-Hsuan Wu, Pei-Fen Cheng, Watchareeya Kaveevivitchai, Teng-Hao Chen
Summary: Manipulating Fenton chemistry in tumor microenvironment (TME) for the generation of reactive oxygen species is an effective strategy for chemodynamic therapy. Here, a nanozyme MOF-Pt(IV)@GOx was developed by covalently grafting a prodrug of cisplatin (Pt(IV) prodrug) onto a ferric metal-organic framework (MOF) and loading it with a biocatalyst glucose oxidase (GOx). The system achieved synergistic trimodal therapy consisting of ferroptosis, starvation therapy, and chemotherapy, by enhancing GOx loading and chemotherapy, reducing Fe(III) to Fe(II) for Fenton reaction, converting Pt(IV) prodrug to cisplatin, and promoting intracellular acidity and H2O2 supply in TME.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Yue Yu, Liping Sun, Yanfei Tang, Huixia Zhu, Huai Wang, Hua Xiao, Feng Wang, Wei Tao
Summary: Encapsulating cisplatin in calcium phosphate nanoparticles is challenging due to its low solubility and weak binding affinity. This study presents a unique strategy using a polymer bearing numerous carboxyl side groups and incorporating redox-sensitive cisplatin prodrugs for encapsulation in CPNPs. The encapsulated CPNPs showed enhanced stability and efficacy against cancerous cells compared to free cisplatin and the prodrug alone.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Ran Zhang, Yueyue Zhang, Liumei Tang, Yixing Xu, Hao Li, Xueping Jiang, Xiangdong Xin, Zhongzheng Gui
Summary: A series of Pt(IV) prodrugs containing a microtubule inhibitor paclitaxel were synthesized and evaluated for their antitumor activity. One of the prodrugs, named Ptxplatin, effectively entered cancer cells and induced DNA damage, cell cycle arrest, and inhibition of cell migration. Furthermore, Ptxplatin caused mitochondrial dysfunction and triggered endoplasmic reticulum stress, ultimately leading to cancer cell death.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemistry & Molecular Biology
Zhe Li, Xiao-Jing Ding, Xin Qiao, Xiao-Meng Liu, Xin Qiao, Cheng-Zhi Xie, Rui-Ping Liu, Jing-Yuan Xu
Summary: The combination of immune- and chemo-therapy is a promising approach for cancer treatment. In this study, the researchers developed multi-functional Pt(IV) prodrugs by conjugating thalidomide with oxidized cisplatin to investigate the anti-tumor effect. The results showed that the Pt(IV) prodrugs demonstrated remarkable cytotoxicity and inhibited tumor growth through regulating key proteins and disrupting PD-1/PD-L1 signaling pathway.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Jie Yu, Xidong He, Zigui Wang, Sha Liu, Dengyuan Hao, Xiaoyuan Li, Yubin Huang
Summary: The development of a functional nano-system combining starvation therapy with Pt-NP based chemotherapy aims to enhance cellular uptake and optimize the oxidative environment for more efficient tumor elimination.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Alessandra Barbanente, Valentina Gandin, Chiara Donati, Carmela Ilaria Pierro, Giovanni Natile, Nicola Margiotta
Summary: Platinum-based drugs have been successful in treating solid tumors, but toxicity and resistance limit their outcomes. Natural products, such as 10-HDA found in royal jelly, are being explored as safe and easily available anti-cancer drugs. In this study, the researchers aimed to combine the functionality of 10-HDA with platinum to develop new compounds with potential anti-cancer activity. The synthesized compounds were characterized and tested for their cytotoxicity against human tumor cell lines. The results showed that some of the new compounds exhibited promising activity against specific tumor cell lines.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Dongbo Guo, Josh Haipeng Lei, Dade Rong, Tesen Zhang, Bohan Zhang, Zikang Tang, Han-Ming Shen, Chu-Xia Deng, Songnan Qu
Summary: This study reports a novel orange light-triggered anti-tumor therapeutic agent based on photoactivatable Pt(IV)-coordinated carbon dots. These carbon dots release cytotoxic Pt(II) species and promote hydroxy radical generation under orange light, efficiently killing cancer cells.
Review
Chemistry, Multidisciplinary
Larasati Larasati, Witri Wahyu Lestari, Maulidan Firdaus
Summary: The conversion of cisplatin Pt(II) into a Pt(IV) complex is a strategy to overcome resistance and side effects. Ligands with bioactivity could target specific cancer cells and enhance cellular uptake. Self-assembled MOFs with high porosity can load drugs and enable controlled release. Combined with prodrugs, MOFs could generate a triple-acting anticancer agent for enhanced treatment.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2022)
Article
Pharmacology & Pharmacy
Yuanlei Fu, Ying Kong, Xiangping Li, Dongfang Cheng, Yuqian Hou, Yan Li, Tongfang Li, Yani Xiao, Qiuyan Zhang, Rong Rong
Summary: In this study, a novel Pt(IV) prodrug of oxaliplatin (OXA) was synthesized and prepared as self-assembled micellar nanoparticles (PEG-OXA NPs). In vitro experiments showed that PEG-OXA NPs rapidly released biologically active OXA within 5 minutes in tumor cells while remaining extremely stable in whole blood or plasma. Pharmacokinetic results demonstrated that PEG-OXA NPs had a longer drug circulation time and improved antitumor efficacy compared to free OXA solution. These findings suggest that PEG-OXA NPs have the potential to be a desirable self-delivery platform for platinum drugs in anticancer therapeutics.
Article
Engineering, Biomedical
Xiao Ma, Yangjia Liu, Hanmei Wu, Jinxiu Tan, Wenying Yi, Zhenjie Wang, Zhiqiang Yu, Xuefeng Wang
Summary: We present a novel method for the treatment of ovarian cancer using a self-assembly based nano-system. The self-assembling nanoparticles, called TPNPs, were prepared by linking cisplatin and tolfenamic acid to linoleic acid. TPNPs showed superior cellular uptake and tumor aggregation, enhanced apoptosis and tumor growth inhibition by inhibiting COX-2 in the mice xenograft model of ovarian cancer, and reduced systemic toxicity compared to cisplatin. These findings suggest that TPNPs are a promising antitumor drug with high drug load.
MATERIALS TODAY BIO
(2023)
Article
Biophysics
Xiao Kuang, Dongxu Chi, Jinbo Li, Chunlin Guo, Yinxian Yang, Shuang Zhou, Cong Luo, Hongzhuo Liu, Zhonggui He, Yongjun Wang
Summary: A disulfide bond inserted Pt(IV) self-assembled nanoplatform with reduction-responsiveness was developed for targeted treatment of malignant tumors, showing prolonged blood circulation, higher tolerated doses, potent anti-tumor efficiency, and low toxicities in normal tissues. This platform offers promising potential for clinical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Inorganic & Nuclear
Jiafan Lin, Jishuai Zhang, Ziqi Ma, Xiaoqin Wu, Fuyi Wang, Yao Zhao, Kui Wu, Yi Liu
Summary: The interaction between a photoactivatable Pt(iv) prodrug and human telomeric DNA was studied. Two major mono-platinated DNA adducts were detected, with trans-[Pt-II(N-3)(py)(2)](+) and trans-[Pt-II(py)(2)](2+) as the bound Pt moieties. The platination sites were found to be G(6) and A(3) in one adduct, and a potential intrastrand crosslink was speculated after G(4) and G(6) in the other adduct. Minor platinated adducts and oxidized DNA adducts were also observed. These results provide valuable chemical information about the photoreaction between photoactivatable Pt(iv) anticancer prodrugs and human telomeric DNA.
DALTON TRANSACTIONS
(2023)
Article
Medicine, Research & Experimental
Tushar Date, Kaushik Kuche, Rohan Ghadi, Pradeep Kumar, Sanyog Jain
Summary: Cisplatin is an anticancer drug with challenges in drug delivery. Cisplatin(IV) prodrug formation can effectively resolve these challenges. The selection of axial ligands plays a key role in determining the therapeutic outcomes. Rational design of cisplatin(IV) derivatives can improve their stability and cellular uptake, reducing side effects and offering potential in resolving cisplatin drug delivery challenges.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Analytical
Liping Zhang, Yun Li, Ganen Mu, Lijun Yang, Chunhua Ren, Zhongyan Wang, Qingxiang Guo, Jianfeng Liu, Cuihong Yang
Summary: The unique fluorescence property of aggregation-induced emission luminogens (AIEgens) makes them ideal for constructing self-assembled peptide-based nanoprobes. This study reveals the key factors influencing the assembly and luminescence of AIEgen-peptides and proposes strategies for efficient assembly and luminescence. Additionally, AIEgen-peptide probes show good selectivity and sensitivity for alkaline phosphatase (ALP) detection. These insights are crucial for guiding the design of AIEgen-conjugated supramolecular materials, especially for applications in enzyme detection, biomarker imaging, diseases therapy, and other biomedical fields.
ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Cui-Cui Zhao, Chuan-Gui Zhang, Xuan Sun, Qingxiang Guo, Jinjian Liu, Yan Liu, Ya-Nan Hao, Guowei Feng, Lijun Yang, Hong Liu, Jianfeng Liu
Summary: The study demonstrated that using paclitaxel-conjugated mifepristone-loaded hydrogel (PM-nano) can effectively inhibit breast cancer metastasis, showing good water solubility and biocompatibility. Additionally, PM-nano inhibits metastasis by impacting glucocorticoid receptor/receptor tyrosine kinase-like orphan receptor 1 and MMPs.
Article
Chemistry, Multidisciplinary
Hongmei Cao, Yang Gao, Haixue Jia, Liping Zhang, Jinjian Liu, Ganen Mu, Han Gui, Yuebing Wang, Cuihong Yang, Jianfeng Liu
Summary: Sepsis is a life-threatening disease with high morbidity and mortality. Antibiotic therapy is challenged by impaired macrophages and drug-resistant bacteria. In this study, a membrane-camouflaged metal-organic framework system was developed for efficient delivery of plasmid DNA to combat sepsis, significantly improving the survival rate of septic mice.
Article
Engineering, Biomedical
Zujian Feng, Yumin Zhang, Chunfang Yang, Xiang Liu, Yini Huangfu, Chuangnian Zhang, Pingsheng Huang, Anjie Dong, Jinjian Liu, Jianfeng Liu, Deling Kong, Weiwei Wang
Summary: A glycopeptide hydrogel inspired by extracellular matrix (ECM) has been designed to accelerate wound healing in radiation-induced skin injury (RSI) by modulating chronic inflammation. The hydrogel replicates ECM components and structure, scavenges reactive oxygen species (ROS), and polarizes macrophages to reduce inflammation. In mouse models, the hydrogel significantly reduces hyperplasia, promotes regeneration and angiogenesis, and decreases proinflammatory cytokine expression, making it superior to current treatment options.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Yang Gao, Yun Li, Hongmei Cao, Haixue Jia, Dianyu Wang, Chunhua Ren, Zhongyan Wang, Cuihong Yang, Jianfeng Liu
Summary: A self-assembled peptide derivative (NSBSO) based on BSO was developed to selectively deplete tumor GSH and inhibit its biosynthesis, leading to ferroptosis and pyroptosis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shi-Qi Dong, Fan Yang, Dong-Xu Zhang, Ling-Mei Wang, Jian-Feng Liu, Ai-Jie Zhang, Hui-Rong Fan
Summary: The study investigated the effects of X-ray radiation on the pharmacokinetics of apatinib in rats and found that radiation decreased plasma exposure, tissue distribution, and excretion of apatinib. This phenomenon may be closely related to changes in metabolic enzymes in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Materials Science, Biomaterials
Dianyu Wang, Jianlan Yue, Qiannan Cao, Jinjian Liu, Lijun Yang, Wen Shen, Wenxue Zhang, Jianfeng Liu
Summary: Multimodality imaging-navigated precise phototherapy has shown promise in preclinical trials for enhancing the efficiency of cancer diagnosis and treatment. However, there is still a need for theranostic agents with sufficient biosafety and efficacy, as well as simple components and preparations, to facilitate the clinical translation of this approach. In this study, a multifunctional nanosystem was developed for FLI/SPECT-guided photothermal/photodynamic therapy of breast cancer, using FDA-approved indocyanine green (ICG) and I-125-labeled glycopeptides. The nanosystem demonstrated stable nanostructure and radiolabel, as well as ROS and hyperthermia generation properties, making it suitable for tumor targeting, multimodality imaging, and phototherapy with high biosafety. The nanosystem showed potential for clinical diagnosis and treatment of breast cancer.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Lijun Yang, Dianyu Wang, Haixue Jia, Cuihong Yang, Yumin Zhang, Hui Li, Jinjian Liu, Jianfeng Liu
Summary: Tumor cells use metabolic reprogramming to create an immunosuppressive tumor microenvironment (TME) and evade the immune system. This study develops a tumor-specific peroxynitrite nanogenerator that disrupts metabolic homeostasis in melanoma cells. The produced peroxynitrite induces a decrease in metabolites in the tricarboxylic acid cycle and reduces lactate production. Mechanistically, peroxynitrite impairs glucose metabolism by affecting the activity of glyceraldehyde-3-phosphate dehydrogenase. These metabolic alterations reverse the immunosuppressive TME and promote antitumor immune responses. When combined with anti-PD-L1, the nanogenerator inhibits both primary and metastatic melanomas without causing toxicity. This research provides a new strategy for enhancing immunotherapy sensitivity.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Qian Wang, Hongmei Cao, Xiaoxue Hou, Dianyu Wang, Zhilong Wang, Yue Shang, Shuqin Zhang, Jinjian Liu, Chunhua Ren, Jianfeng Liu
Summary: A surface-induced self-assembly system (CA-Pt) is developed to overcome hypoxic cancer stem cell-mediated radioresistance by deep penetration, amplified CAIX inhibition, and enhanced cellular uptake. It effectively relieves the hypoxic and acidic microenvironment, promotes the differentiation of hypoxic CSCs, and enhances the DNA damage induced by radiotherapy. This study provides a universal treatment strategy for overcoming tumor radioresistance.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Yusen Hao, Hui Li, Jiajun Guo, Dan Wang, Jiamin Zhang, Jinjian Liu, Cuihong Yang, Yumin Zhang, Guoliang Li, Jianfeng Liu
Summary: Radiotherapy is an important cancer treatment method, but it can cause adverse reactions and injuries to the skin. This study designed an antioxidant heparin-mimetic peptide hydrogel (K16) for repairing radiation-induced skin injuries (RISI). The K16 hydrogel can scavenge excess reactive oxygen species (ROS), prevent radiation damage to DNA, promote cell proliferation, migration, and angiogenesis, and eliminate inflammation at the wound site. In vivo experiments demonstrated that the K16 hydrogel inhibits wound degradation, reduces inflammation, and promotes wound healing. Therefore, the K16 hydrogel has great potential for application in repairing radiation-induced skin injuries.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Hongjing Luo, Hongmei Cao, Haixue Jia, Yuna Shang, Jinjian Liu, Han Gui, Cuihong Yang, Chunhua Ren, Zhongyan Wang, Jianfeng Liu
Summary: Radiotherapy can remodel the tumor microenvironment by inducing immunogenic cell death and inflammation, but it is not effective in generating a systemic antitumor immune response. This study presents a novel strategy to create in situ peptide-based nanovaccines using enzyme-induced self-assembly, in combination with immunogenic cell death. The nanovaccine enhances antigen accumulation in the lymph nodes and cross-presentation by antigen-presenting cells, and promotes the repolarization of macrophages and reduces regulatory T cells and myeloid-derived suppressor cells. The combination of nanovaccines and radiotherapy significantly improves the therapeutic effect on tumors, providing a promising strategy for tumor radioimmunotherapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhongyan Wang, Yuna Shang, Hongjing Luo, Cuihong Yang, Zhimou Yang, Chunhua Ren, Jianfeng Liu
Summary: This study presents a novel strategy of achieving higher hierarchical structures through cooperative self-assembly of hydrophobic tripeptides with reverse sequences, showing a low-to-high hierarchical structure transformation. The cooperation between different sequences also allows different morphological transitions, promoting a more compact molecular arrangement by creating more hydrogen bond interactions and in-register π-π stacking in the anti-parallel β-sheet conformation. This work provides a handy approach for controlled hierarchical assembly and the development of various functional bionanomaterials.
Article
Chemistry, Multidisciplinary
Qian Wang, Hongmei Cao, Xiaoxue Hou, Dianyu Wang, Zhilong Wang, Yue Shang, Shuqin Zhang, Jinjian Liu, Chunhua Ren, Jianfeng Liu
Summary: This study reports a CAIX-targeted induced in situ self-assembly system on the surface of hypoxic cancer stem-like cells (CSCs), which relieves the hypoxic and acidic microenvironment and promotes CSC differentiation to overcome tumor radiotherapy resistance. The constructed peptide-based drug delivery system exhibits deep penetration, amplified CAIX inhibition, and enhanced cellular uptake, showing potential as a universal treatment strategy for overcoming tumor radioresistance.
ADVANCED MATERIALS
(2023)
Retraction
Polymer Science
Minjie Tang, Zheng Yang, Zujian Feng, Junhui Zhou, Jinjian Liu, Jianfeng Liu, Weiwei Wang, Junqiang Zhao, Anjie Dong, Liandong Deng
Article
Engineering, Biomedical
Guang Yang, Da-Yuan Wang, Yong Liu, Fan Huang, Shuang Tian, Yijin Ren, Jianfeng Liu, Yingli An, Henny C. van der Mei, Henk J. Busscher, Linqi Shi
Summary: This study developed a magnetic cascade-reaction container that can generate reactive-oxygen-species for eradicating infectious biofilms. In vitro experiments showed that cascade-reaction containers with coupled glucose-oxidase were effective in killing various bacteria. In vivo experiments demonstrated that cascade-reaction containers could accumulate in abdominal Staphylococcus aureus biofilms in real-time through magnetic targeting. Furthermore, the study found that vancomycin-resistant abdominal S. aureus biofilms could be eradicated using endogenous glucose.
BIOACTIVE MATERIALS
(2022)
