N terminal N-methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties

Switching substitution groups on the in-tether chiral centre influences backbone peptides’ permeability and target binding affinity

(2017) Yixiang Jiang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell

(2017) Kuan Hu et al.   Theranostics

Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase

(2016) Philipp M. Cromm et al.   ACS Chemical Biology

An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide

(2016) Kuan Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction

(2016) Thomas E. Speltz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Investigation of Cellular Uptakes of the In-Tether Chiral-Center-Induced Helical Pentapeptides

(2016) Kuan Hu et al.   BIOCONJUGATE CHEMISTRY

A new GLP-1 analogue with prolonged glucose-lowering activity in vivo via backbone-based modification at the N-terminus

(2016) Xiaohui Bai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

An in-tether sulfilimine chiral center induces helicity in short peptides

(2016) Huacan Lin et al.   CHEMICAL COMMUNICATIONS

Nitrogen Arylation for Macrocyclization of Unprotected Peptides

(2016) Guillaume Lautrette et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enabling N-to-C Ser/Thr Ligation for Convergent Protein Synthesis via Combining Chemical Ligation Approaches

(2016) Chi Lung Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

(2016) Gregory H Bird et al.   Nature Chemical Biology

Macrocyclization of Unprotected Peptide Isocyanates

(2016) Alexander A. Vinogradov et al.   ORGANIC LETTERS

N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA

(2015) Thomas A. Hilimire et al.   ACS Chemical Biology

Hydrocarbon Stapled Peptides as Modulators of Biological Function

(2015) Philipp M. Cromm et al.   ACS Chemical Biology

Diaminodiacid Bridges to Improve Folding and Tune the Bioactivity of Disulfide-Rich Peptides

(2015) Ye Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Macrocyclic Cell Penetrating Peptides: A Study of Structure-Penetration Properties

(2015) Hassan Traboulsi et al.   BIOCONJUGATE CHEMISTRY

α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells

(2015) James W. Checco et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diaminodiacid-Based Solid-Phase Synthesis of Peptide Disulfide Bond Mimics

(2013) Hong-Kui Cui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells

(2013) Elena Miranda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein chemical synthesis by serine and threonine ligation

(2013) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convergent Chemical Synthesis of Proteins by Ligation of Peptide Hydrazides

(2012) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions

(2012) Jayanta Chatterjee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

(2012) Avinash Muppidi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified

(2012) Johannes G. Beck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Effect of Multiple N-Methylation on Intestinal Permeability of Cyclic Hexapeptides

(2011) Oded Ovadia et al.   MOLECULAR PHARMACEUTICS

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

(2011) Tina R White et al.   Nature Chemical Biology

MultipleN-Methylation of MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies

(2010) Lucas Doedens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of HIF-1 inhibitors for cancer therapy

(2009) Barbara Onnis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of Hypoxia Inducible Factor 1—Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix

(2009) Laura K. Henchey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Methylation of Peptides: A New Perspective in Medicinal Chemistry

(2008) Jayanta Chatterjee et al.   ACCOUNTS OF CHEMICAL RESEARCH

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

(2008) Eric Biron et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides

(2008) N. P. Chongsiriwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell line-dependent internalization pathways and intracellular trafficking determine transfection efficiency of nanoparticle vectors

(2007) K DOUGLAS   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS