Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 by Consensus-Guided Mutagenesis

Whole-Cell-Catalyzed Multiple Regio- and Stereoselective Functionalizations in Cascade Reactions Enabled by Directed Evolution

(2016) Aitao Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs

(2016) Vikas Tyagi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Applications of microbial cytochrome P450 enzymes in biotechnology and synthetic biology

(2016) Hazel M Girvan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity

(2015) James B.Y.H. Behrendorff et al.   BIOCHEMICAL JOURNAL

Directed Evolution of a Formate Dehydrogenase for Increased Tolerance to Ionic Liquids Reveals a New Site for Increasing the Stability

(2014) Julie L. L. Carter et al.   CHEMBIOCHEM

Computationally designed libraries for rapid enzyme stabilization

(2014) H. J. Wijma et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures

(2013) Indira Wu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Unusual Cytochrome P450 Enzymes and Reactions

(2013) F. Peter Guengerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Achieving Regio- and Enantioselectivity of P450-Catalyzed Oxidative CH Activation of Small Functionalized Molecules by Structure-Guided Directed Evolution

(2012) Rubén Agudo et al.   CHEMBIOCHEM

The crystal structure of the FAD/NADPH-binding domain of flavocytochrome P450 BM3

(2012) Michael G Joyce et al.   FEBS Journal

Controlled Oxidation of Remote sp3 C–H Bonds in Artemisinin via P450 Catalysts with Fine-Tuned Regio- and Stereoselectivity

(2012) Kaidong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advanced evolutionary molecular engineering to produce thermostable cellulase by using a small but efficient library

(2012) Y. Ito et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes

(2012) M. M. Y. Chen et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Tuning P450 Enzymes as Oxidation Catalysts

(2012) Rudi Fasan   ACS Catalysis

Engineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9

(2011) Andrea Rentmeister et al.   ChemCatChem

P450BM3(CYP102A1): connecting the dots

(2011) Christopher J. C. Whitehouse et al.   CHEMICAL SOCIETY REVIEWS

Cytochrome P450: taming a wild type enzyme

(2011) Sang Taek Jung et al.   CURRENT OPINION IN BIOTECHNOLOGY

In Vitro Evolved Non-Aggregating and Thermostable Lipase: Structural and Thermodynamic Investigation

(2011) Md. Zahid Kamal et al.   JOURNAL OF MOLECULAR BIOLOGY

P450 Fingerprinting Method for Rapid Discovery of Terpene Hydroxylating P450 Catalysts with Diversified Regioselectivity

(2011) Kaidong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli

(2010) Rudi Fasan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Screening of a minimal enriched P450 BM3 mutant library for hydroxylation of cyclic and acyclic alkanes

(2010) Evelyne Weber et al.   CHEMICAL COMMUNICATIONS

Cytochromes P450: exploiting diversity and enabling application as biocatalysts

(2010) Gideon Grogan   CURRENT OPINION IN CHEMICAL BIOLOGY

Position-specific propensities of amino acids in the beta-strand

(2010) Nicholus Bhattacharjee et al.   BMC STRUCTURAL BIOLOGY

A Highly Active Single-Mutation Variant of P450BM3(CYP102A1)

(2009) Christopher J. C. Whitehouse et al.   CHEMBIOCHEM

Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes

(2009) Paul R. Ortiz de Montellano   CHEMICAL REVIEWS

A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds

(2009) Andrew M. Sawayama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8

(2009) Elmar Krieger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Altering the regioselectivity of the subterminal fatty acid hydroxylase P450 BM-3 towards γ- and δ-positions

(2008) Matthias Dietrich et al.   JOURNAL OF BIOTECHNOLOGY

Chemo-enzymatic fluorination of unactivated organic compounds

(2008) Andrea Rentmeister et al.   Nature Chemical Biology

Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites

(2007) Micaela C. Damsten et al.   CHEMICO-BIOLOGICAL INTERACTIONS