Computationally designed libraries for rapid enzyme stabilization

Computational Enzyme Design

(2013) Gert Kiss et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Computational design gains momentum in enzyme catalysis engineering

(2013) Hein J. Wijma et al.   FEBS Journal

Rational Introduction of Disulfide Bond to Enhance Optimal Temperature of Lipomyces starkeyi α-Dextranase Expressed in Pichia pastoris

(2013) Lin Chen   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Navigating the protein fitness landscape with Gaussian processes

(2013) P. A. Romero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies

(2012) Aleksandr E. Miklos et al.   CHEMISTRY & BIOLOGY

GRID: A high-resolution protein structure refinement algorithm

(2012) Mohsen Chitsaz et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

A Study on the Effect of Surface Lysine to Arginine Mutagenesis on Protein Stability and Structure Using Green Fluorescent Protein

(2012) Sriram Sokalingam et al.   PLoS One

Automated selection of stabilizing mutations in designed and natural proteins

(2012) B. Borgo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods

(2012) Russell S. Komor et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Increasing Sequence Diversity with Flexible Backbone Protein Design: The Complete Redesign of a Protein Hydrophobic Core

(2012) Grant S. Murphy et al.   STRUCTURE

Assessment of flexible backbone protein design methods for sequence library prediction in the therapeutic antibody Herceptin-HER2 interface

(2011) Mariana Babor et al.   PROTEIN SCIENCE

Computational design and selections for an engineered, thermostable terpene synthase

(2011) Juan E. Diaz et al.   PROTEIN SCIENCE

Computational protein design with explicit consideration of surface hydrophobic patches

(2011) Ron Jacak et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Thermostabilization of Bacillus circulans xylanase: Computational optimization of unstable residues based on thermal fluctuation analysis

(2010) Jeong Chan Joo et al.   JOURNAL OF BIOTECHNOLOGY

Manipulating the Stereoselectivity of Limonene Epoxide Hydrolase by Directed Evolution Based on Iterative Saturation Mutagenesis

(2010) Huabao Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thermostabilization of an esterase by alignment-guided focussed directed evolution

(2010) Helge Jochens et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Role of conformational sampling in computing mutation-induced changes in protein structure and stability

(2010) Elizabeth H. Kellogg et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Stability effects of mutations and protein evolvability

(2009) Nobuhiko Tokuriki et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Strategies for successful recombinant expression of disulfide bond-dependent proteins in Escherichia coli

(2009) Ario de Marco   Microbial Cell Factories

In the light of directed evolution: Pathways of adaptive protein evolution

(2009) J. D. Bloom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational stabilization of enzymes by computational redesign of surface charge–charge interactions

(2009) Alexey V. Gribenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Algorithm for backrub motions in protein design

(2008) I. Georgiev et al.   BIOINFORMATICS

Backrub-Like Backbone Simulation Recapitulates Natural Protein Conformational Variability and Improves Mutant Side-Chain Prediction

(2008) Colin A. Smith et al.   JOURNAL OF MOLECULAR BIOLOGY

Hot Water-Promoted Ring-Opening of Epoxides and Aziridines by Water and Other Nucleopliles

(2008) Zhi Wang et al.   JOURNAL OF ORGANIC CHEMISTRY