Mechanisms involved in normal and pathological osteoclastogenesis

MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα

(2017) Seyeon Bae et al.   JOURNAL OF CLINICAL INVESTIGATION

Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects

(2016) Wei Wei et al.   Cell Metabolism

Denosumab: targeting the RANKL pathway to treat rheumatoid arthritis

(2016) Yahui Grace Chiu et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

VAV3Gene Polymorphism Is Associated with Paget's Disease of Bone

(2016) Ricardo Usategui-Martín et al.   Genetic Testing and Molecular Biomarkers

LOX Fails to Substitute for RANKL in Osteoclastogenesis

(2016) Masayuki Tsukasaki et al.   JOURNAL OF BONE AND MINERAL RESEARCH

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

(2016) Jian Luo et al.   NATURE MEDICINE

RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis

(2016) William O'Brien et al.   Arthritis & Rheumatology

RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation

(2015) Lynett Danks et al.   ANNALS OF THE RHEUMATIC DISEASES

The role of osteoclast differentiation and function in skeletal homeostasis

(2015) Kyoji Ikeda et al.   JOURNAL OF BIOCHEMISTRY

Alternative NF-κB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms

(2015) Rong Zeng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Intravenous Immunoglobulin (IVIG) Attenuates TNF-Induced Pathologic Bone Resorption and Suppresses Osteoclastogenesis by Inducing A20 Expression

(2015) Min Joon Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

(2015) Thomas R. Cox et al.   NATURE

DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine–producing metabolic pathway

(2015) Keizo Nishikawa et al.   NATURE MEDICINE

Immune complexes regulate bone metabolism through FcRγ signalling

(2015) Takako Negishi-Koga et al.   Nature Communications

Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

(2014) Zixue Jin et al.   Cell Metabolism

Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis

(2013) Han Kyoung Choi et al.   CELL RESEARCH

Metabolic regulation of osteoclast differentiation and function

(2013) Yoriko Indo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteopetrosis: genetics, treatment and new insights into osteoclast function

(2013) Cristina Sobacchi et al.   Nature Reviews Endocrinology

Combination of Tumor Necrosis Factor α and Interleukin-6 Induces Mouse Osteoclast-like Cells With Bone Resorption Activity Both In Vitro and In Vivo

(2013) Kazuhiro Yokota et al.   Arthritis & Rheumatology

Fyn positively regulates the activation of DAP12 and FcRγ-mediated costimulatory signals by RANKL during osteoclastogenesis

(2012) H.S. Kim et al.   CELLULAR SIGNALLING

TREM2 and  -Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis

(2012) K. Otero et al.   JOURNAL OF IMMUNOLOGY

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8

(2011) Lionel B. Ivashkiv et al.   Annals of the New York Academy of Sciences

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

PGC1β Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss

(2010) Wei Wei et al.   Cell Metabolism

PPARγ in bone homeostasis

(2010) Yihong Wan   TRENDS IN ENDOCRINOLOGY AND METABOLISM

IL-10 Suppresses Calcium-Mediated Costimulation of Receptor Activator NF- B Signaling during Human Osteoclast Differentiation by Inhibiting TREM-2 Expression

(2009) K.-H. Park-Min et al.   JOURNAL OF IMMUNOLOGY

Inhibition of RANK Expression and Osteoclastogenesis by TLRs and IFN-  in Human Osteoclast Precursors

(2009) J.-D. Ji et al.   JOURNAL OF IMMUNOLOGY

Central control of fever and female body temperature by RANKL/RANK

(2009) Reiko Hanada et al.   NATURE

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE

Chloride channels as drug targets

(2009) Alan S. Verkman et al.   NATURE REVIEWS DRUG DISCOVERY

Increased risk of serious infections in women with osteopenia or osteoporosis treated with denosumab

(2009) K. A. Toulis et al.   OSTEOPOROSIS INTERNATIONAL

The Osteoclast: Friend or Foe?

(2008) Deborah V. Novack et al.   Annual Review of Pathology-Mechanisms of Disease

Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

(2008) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

Tyrosine Kinases Btk and Tec Regulate Osteoclast Differentiation by Linking RANK and ITAM Signals

(2008) Masahiro Shinohara et al.   CELL

Osteoimmunology: Interactions of the Bone and Immune System

(2008) Joseph Lorenzo et al.   ENDOCRINE REVIEWS

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

(2008) Antonios O. Aliprantis et al.   JOURNAL OF CLINICAL INVESTIGATION

DAP12 Couples c-Fms Activation to the Osteoclast Cytoskeleton by Recruitment of Syk

(2008) Wei Zou et al.   MOLECULAR CELL