The concept of alpha-synuclein as a prion-like protein: ten years after

Potential Modes of Intercellular α-Synuclein Transmission

(2017) Dario Valdinocci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

‘Prion-like’ propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum

(2017) Dorian Sargent et al.   JOURNAL OF NEUROCHEMISTRY

Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes

(2017) Jinar Rostami et al.   JOURNAL OF NEUROSCIENCE

Parkinson's Disease Is Not Simply a Prion Disorder

(2017) D. James Surmeier et al.   JOURNAL OF NEUROSCIENCE

Prying into the Prion Hypothesis for Parkinson's Disease

(2017) Patrik Brundin et al.   JOURNAL OF NEUROSCIENCE

The prion model for progression and diversity of neurodegenerative diseases

(2017) Barbara E Stopschinski et al.   LANCET NEUROLOGY

Solving the conundrum of insoluble protein aggregates

(2017) Sonia George et al.   LANCET NEUROLOGY

Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage

(2017) Veronica Lindström et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice

(2017) Emily J. Koller et al.   Molecular Neurodegeneration

Aging and Parkinson's disease: Different sides of the same coin?

(2017) Timothy J. Collier et al.   MOVEMENT DISORDERS

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

(2017) Hisham Abdelmotilib et al.   NEUROBIOLOGY OF DISEASE

Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions

(2017) Amulya Nidhi Shrivastava et al.   NEURON

Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders

(2017) Masato Hasegawa et al.   PHARMACOLOGY & THERAPEUTICS

Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

(2017) Poonam Thakur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

(2017) Brian Spencer et al.   Acta Neuropathologica Communications

Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein

(2017) Trevor Tyson et al.   Scientific Reports

α-Synuclein-carrying extracellular vesicles in Parkinson’s disease: deadly transmitters

(2016) Dimitry A. Chistiakov et al.   ACTA NEUROLOGICA BELGICA

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections

(2016) Ayse Ulusoy et al.   ACTA NEUROPATHOLOGICA

Proteopathic Strains and the Heterogeneity of Neurodegenerative Diseases

(2016) Lary C. Walker   Annual Review of Genetics

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease

(2016) Nolwen L. Rey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ɑ-Synuclein strains and the variable pathologies of synucleinopathies

(2016) Wouter Peelaerts et al.   JOURNAL OF NEUROCHEMISTRY

Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance

(2016) Dena G. Hernandez et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation

(2016) Sara Breid et al.   JOURNAL OF VIROLOGY

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein

(2016) N. L. Rey et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Review: Parkinson's disease: from synaptic loss to connectome dysfunction

(2016) Arianna Bellucci et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice

(2015) Michael Helwig et al.   BRAIN

 -synuclein assemblies sequester neuronal  3-Na+/K+-ATPase and impair Na+ gradient

(2015) A. N. Shrivastava et al.   EMBO JOURNAL

A53T Human  -Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration

(2015) L. Chen et al.   JOURNAL OF NEUROSCIENCE

Alpha-synuclein propagation: New insights from animal models

(2015) Benjamin Dehay et al.   MOVEMENT DISORDERS

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

(2015) Eve Peeraer et al.   NEUROBIOLOGY OF DISEASE

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons

(2015) A K Reeve et al.   Cell Death & Disease

Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism

(2015) Valerie R. Osterberg et al.   Cell Reports

Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury

(2015) Ayse Ulusoy et al.   Acta Neuropathologica Communications

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

(2015) Maria E. Bernis et al.   Acta Neuropathologica Communications

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice

(2014) Amanda N. Sacino et al.   ACTA NEUROPATHOLOGICA

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease

(2014) Anke A. Dijkstra et al.   MOVEMENT DISORDERS

Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

(2014) He-Jin Lee et al.   Nature Reviews Neurology

Intramuscular injection of  -synuclein induces CNS  -synuclein pathology and a rapid-onset motor phenotype in transgenic mice

(2014) A. N. Sacino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organization of Monosynaptic Inputs to the Serotonin and Dopamine Neuromodulatory Systems

(2014) Sachie K. Ogawa et al.   Cell Reports

Pathological alpha-synuclein propagates through neural networks

(2014) Masami Masuda-Suzukake et al.   Acta Neuropathologica Communications

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

(2013) Nolwen L. Rey et al.   ACTA NEUROPATHOLOGICA

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Caudo-rostral brain spreading of α-synuclein through vagal connections

(2013) Ayse Ulusoy et al.   EMBO Molecular Medicine

Alpha-synuclein transfers from neurons to oligodendrocytes

(2013) Juan F. Reyes et al.   GLIA

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

(2013) S. J. Chinta et al.   JOURNAL OF INTERNAL MEDICINE

Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD

(2013) Chongwang Chang et al.   NEUROSCIENCE LETTERS

Transmission of multiple system atrophy prions to transgenic mice

(2013) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicles as mediators of neuron-glia communication

(2013) Carsten Frühbeis et al.   Frontiers in Cellular Neuroscience

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

(2013) Amanda N Sacino et al.   Acta Neuropathologica Communications

γ-Synuclein: Seeding of α-Synuclein Aggregation and Transmission between Cells

(2012) Irina Surgucheva et al.   BIOCHEMISTRY

Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation

(2012) Igor F. Tsigelny et al.   FEBS Journal

Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease

(2012) M. F. Keller et al.   HUMAN MOLECULAR GENETICS

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

α-Synuclein Oligomers: an Amyloid Pore?

(2012) Martin T. Stöckl et al.   MOLECULAR NEUROBIOLOGY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease

(2012) J. M. Milber et al.   NEUROLOGY

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

(2012) Mitsuko Watabe-Uchida et al.   NEURON

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo

(2012) Elodie Angot et al.   PLoS One

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

(2011) Anne-Laure Mougenot et al.   NEUROBIOLOGY OF AGING

Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat

(2011) Jeffrey H. Kordower et al.   NEUROBIOLOGY OF DISEASE

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Parkinson's Disease

(2009) Christopher H. Hawkes et al.   Annals of the New York Academy of Sciences

Formation and development of Lewy pathology: a critical update

(2009) Kurt A. Jellinger   JOURNAL OF NEUROLOGY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural insights on physiological functions and pathological effects of α-synuclein

(2008) Marco Bisaglia et al.   FASEB JOURNAL

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Research in motion: the enigma of Parkinson's disease pathology spread

(2008) Patrik Brundin et al.   NATURE REVIEWS NEUROSCIENCE