Article
Pharmacology & Pharmacy
Yan Huang, Gang Wang, Zhan Zhou, Zhengshan Tang, Ningning Zhang, Xiaoyan Zhu, Xin Ni
Summary: The gasotransmitter H2S plays a crucial role in maintaining normal oxygen saturation in the lungs and preventing lung injury, inflammation, and oxidative stress. GYY4137 treatment was effective in ameliorating these conditions in both genetic deficiency and hypoxia-induced mouse models.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Qian Lin, Bin Geng
Summary: This article discusses the significant impact of atherosclerosis on cardiovascular events and global mortality, as well as the role of hydrogen sulfide in plaque stability and its regulation mechanism on different cell populations.
Article
Agriculture, Dairy & Animal Science
Bohao Zhang, Ting Lin, Xu Bai, Xiaoxiao An, Lijun Dai, Jun Shi, Yong Zhang, Xingxu Zhao, Quanwei Zhang
Summary: This study identified differentially expressed proteins (DEPs) associated with hydrogen sulfide metabolism in Holstein cows with clinical mastitis (CM), indicating the important role of cystathionine-gamma-lyase (CTH)/H2S in CM. The findings provide insight into the function and regulatory mechanism of CTH/H2S in Holstein cows and can contribute to the prevention and treatment of CM.
Review
Pharmacology & Pharmacy
Sunil Jamuna Tripathi, Suwarna Chakraborty, Emiko Miller, Andrew A. Pieper, Bindu D. Paul
Summary: The gaseous neurotransmitter hydrogen sulfide (H2S) exerts neuroprotective effects in the brain through post-translational modification of cysteine residues by sulfhydration. It cannot be stored in vesicles due to its gaseous nature and is either synthesized or released from endogenous stores. Sulfhydration has both specific and general neuroprotective effects and is diminished in neurodegenerative disorders, while excessive cellular H2S is linked to certain forms of neurodegenerative disease. This review explores the role of H2S in signaling across various neurodegenerative diseases and age-related neurodegeneration.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Multidisciplinary Sciences
Heng Zhang, Yaqian Huang, Selena Chen, Chaoshu Tang, Guang Wang, Junbao Du, Hongfang Jin
Summary: H2S plays a crucial role in glucose metabolism by affecting insulin secretion, apoptosis of islet β cells, insulin sensitivity, glucose uptake, adipogenesis, lipolysis, and modulation of circadian-clock genes. Further studies are needed to determine whether H2S could be a promising target for diabetes mellitus treatment.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Laura Micheli, Emma Mitidieri, Carlotta Turnaturi, Domenico Vanacore, Clara Ciampi, Elena Lucarini, Giuseppe Cirino, Carla Ghelardini, Raffaella Sorrentino, Lorenzo Di Cesare Mannelli, Roberta D'Emmanuele di Villa Bianca
Summary: In an in vitro model of sarcopenia, impairment in CBS/CSE/H2S signaling occurs, and glucoraphanin, as a natural H2S-releasing molecule, appears to be more effective in preventing muscle damage. Therefore, glucoraphanin supplementation could be an innovative therapeutic approach in the management of sarcopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yaping Niu, Congkuo Du, Changting Cui, Haizeng Zhang, Yue Deng, Jun Cai, Zhenzhen Chen, Bin Geng
Summary: The study identified NW as a novel CSE agonist that enhances CSE generation of H2S, thereby alleviating kidney I/R injury and hypertension. NW shows potential therapeutic merit for cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dalila G. F. Fernandes, Joao Nunes, Catarina S. Tome, Karim Zuhra, Joao M. F. Costa, Alexandra M. M. Antunes, Alessandro Giuffre, Joao B. Vicente
Summary: Gasotransmitters hydrogen sulfide, nitric oxide, and carbon monoxide play critical roles in human physiology by mediating signal transduction through interaction with protein targets. Research shows that S-nitrosation can inhibit hydrogen sulfide production through affecting various protein cysteine residues, highlighting a new mechanism of crosstalk between gasotransmitters.
Article
Biochemistry & Molecular Biology
Sumeet Manandhar, Stephen Chambers, Andrew Miller, Isao Ishii, Madhav Bhatia
Summary: This study investigates the effect of hydrogen sulfide (H2S) on adhesion molecules in endothelial cells of vital organs in mice with sepsis. The researchers found that H2S reduced adhesion molecule expression and liver and lung injury in septic mice. They also validated the use of PAG as a tool to study the Cth/H2S-signaling axis in sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jun Wang, Guanya Jia, Heng Li, Shasha Yan, Jing Qian, Xin Guo, Ge Li, Haizhen Qi, Zhilong Zhu, Yanjun Wu, Weijuan He, Weining Niu
Summary: Oxidation induces the formation of a disulfide bond within the CSE protein, enhancing its H2S-producing activity and promoting cellular H2S production under oxidative stress conditions. The residue Cys255 plays a crucial role in sensing oxidation and forming a disulfide bond with Cys252.
Article
Biochemistry & Molecular Biology
Gopi K. Kolluru, John D. Glawe, Sibile Pardue, Ahmad Kasabali, Shafiul Alam, Saranya Rajendran, Allison L. Cannon, Chowdhury S. Abdullah, James G. Traylor, Rodney E. Shackelford, Matthew D. Woolard, A. Wayne Orr, Nicholas E. Goeders, Paari Dominic, Md Shenuarin S. Bhuiyan, Christopher G. Kevil
Summary: Methamphetamine use has been found to significantly decrease cardiovascular function by reducing the availability of cystathionine gamma lyase (CSE), hydrogen sulfide (H2S), and nitric oxide (NO). This leads to endothelial dysfunction and pathological changes in the heart. Increasing CSE/H2S bioavailability may be a potential therapeutic intervention for attenuating METH-induced cardiovascular disease.
Article
Biochemistry & Molecular Biology
Shuang Zhao, Celine Deslarzes-Dubuis, Severine Urfer, Martine Lambelet, Sebastien Deglise, Florent Allagnat
Summary: This study investigated the expression and regulation of CSE, CBS, and 3-MST enzymes in human saphenous vein and large arteries. The results showed that CSE was negatively regulated by arterial shear stress and inhibited human vascular smooth muscle cell migration.
Article
Nutrition & Dietetics
Jiaxiang Duan, Lunli Xiang, Zhen Yang, Li Chen, Jianteng Gu, Kaizhi Lu, Daqing Ma, Hailin Zhao, Bin Yi, Hongwen Zhao, Jiaolin Ning
Summary: This study found that methionine restriction (MR) can attenuate lipopolysaccharide (LPS)-induced lung injury by regulating cystathionine-gamma-lyase (CSE) expression and hydrogen sulfide (H2S). MR inhibits the activation of TLR4/NF-kappa B/NOD-like receptor protein 3 (NLRP3) pathway, reducing the release of inflammatory mediators and immune cell infiltration.
Article
Biochemistry & Molecular Biology
Yingying Wang, Xiang Ni, Rahuljeet Chadha, Caitlin McCartney, Yannie Lam, Brock Brummett, Geat Ramush, Ming Xian
Summary: Hydrogen sulfide (H2S) plays critical roles in redox biology, and its imbalance can lead to pathological processes. Recent advances in inhibitors and scavengers for H2S have been made, but challenges remain, including potency and specificity of inhibitors, as well as biologically active by-products produced during scavenging. Further development is needed for potent and specific inhibitors, as well as scavengers that generate biocompatible by-products for potential therapeutic applications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Chenghua Luo, Dengyu Ji, Yan Li, Yan Cao, Shangyue Zhang, Wenjing Yan, Ke Xue, Jiayin Chai, Ye Wu, Huirong Liu, Wen Wang
Summary: This study revealed a new mechanism of post-translational modification of Sp1/CSE, investigated the specific effects of homocysteine metabolism disorder on H2S deficiency, and proposed therapeutic strategies involving restoring S-sulfhydration and blocking nitration.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Vladislav V. Makarenko, Ying-Jie Peng, Guoxiang Yuan, Aaron P. Fox, Ganesh K. Kumar, Jayasri Nanduri, Nanduri R. Prabhakar
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2015)
Review
Genetics & Heredity
Jayasri Nanduri, Ying-Jie Peng, Guoxiang Yuan, Ganesh K. Kumar, Nanduri R. Prabhakar
JOURNAL OF MOLECULAR MEDICINE-JMM
(2015)
Review
Physiology
Ganesh K. Kumar, Jayasri Nanduri, Ying-Jie Peng, Nanduri R. Prabhakar
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2015)
Article
Neurosciences
Vladislav V. Makarenko, Gias U. Ahmmed, Ying-Jie Peng, Shakil A. Khan, Jayasri Nanduri, Ganesh K. Kumar, Aaron P. Fox, Nanduri R. Prabhakar
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Neurosciences
Jayasri Nanduri, Ying-Jie Peng, Ning Wang, Shakil A. Khan, Gregg L. Semenza, Ganesh K. Kumar, Nanduri R. Prabhakar
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Biochemistry & Molecular Biology
Guoxiang Yuan, Ying-Jie Peng, Shakil A. Khan, Jayasri Nanduri, Amritha Singh, Chirag Vasavda, Gregg L. Semenza, Ganesh K. Kumar, Solomon H. Snyder, Nanduri R. Prabhakar
Article
Biochemistry & Molecular Biology
Guoxiang Yuan, Ying-Jie Peng, Shakil A. Khan, Jayasri Nanduri, Amritha Singh, Chirag Vasavda, Gregg L. Semenza, Ganesh K. Kumar, Solomon H. Snyder, Nanduri R. Prabhakar
Article
Multidisciplinary Sciences
Ying-Jie Peng, Xiuli Zhang, Anna Gridina, Irina Chupikova, David L. McCormick, Robert J. Thomas, Thomas E. Scammell, Gene Kim, Chirag Vasavda, Jayasri Nanduri, Ganesh K. Kumar, Gregg L. Semenza, Solomon H. Snyder, Nanduri R. Prabhakar
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Neurosciences
Jayasri Nanduri, Ying-Jie Peng, Ning Wang, Shakil A. Khan, Gregg L. Semenza, Nanduri R. Prabhakar
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Physiology
Ying-Jie Peng, Vladislav V. Makarenko, Anna Gridina, Irina Chupikova, Xiuli Zhang, Ganesh K. Kumar, Aaron P. Fox, Nanduri R. Prabhakar
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2019)
Article
Physiology
Ying-Jie Peng, Jayasri Nanduri, Ning Wang, Shakil A. Khan, Matthew E. Pamenter, Nanduri R. Prabhakar
Summary: Naked mole rats exhibit attenuated ventilatory responses to hypoxia and hypercapnia, which may be due to the reduced sensitivity of their carotid bodies. Specifically, the morphology and cellular composition of the naked mole rat carotid bodies differ from those of mice, and the responses of the carotid bodies are regulated by hemeoxygenase and hydrogen sulfide signaling pathways. In contrast, the naked mole rats have increased sensitivity to CO2 compared to mice, and this augmented response is regulated by carbonic anhydrase activity in the carotid bodies.
Article
Multidisciplinary Sciences
Olivia A. Gray, Jennifer Yoo, Debora R. Sobreira, Jordan Jousma, David Witonsky, Noboru J. Sakabe, Ying-Jie Peng, Nanduri R. Prabhakar, Yun Fang, Marcelo A. Nobrega, Anna Di Rienzo
Summary: In Tibetans, noncoding alleles in the EPAS1 gene have strong signatures of positive selection. This study found that high-altitude alleles disrupt the activity of enhancers in the EPAS1 gene, and one specific enhancer, ENH5, is both allele specific and hypoxia dependent. The findings suggest that the pleiotropic adaptive effects of these alleles in multiple cell types underlie the strong selective signal at the EPAS1 gene.
Article
Multidisciplinary Sciences
Ying-Jie Peng, Jayasri Nanduri, Ning Wang, Ganesh K. K. Kumar, Vytautas Bindokas, Bindu D. D. Paul, Xuanmao Chen, Aaron P. P. Fox, Thibaut Vignane, Milos R. R. Filipovic, Nanduri R. R. Prabhakar
Summary: This study shows that hydrogen sulfide (H2S) signaling plays a role in the activation of the carotid body during low oxygen conditions. The persulfidation of olfactory receptor 78 (Olfr78) by H2S is found to be essential for this activation. Mutations in Olfr78, adenylate cyclase 3 (Adcy3), or cyclic nucleotide-gated channel alpha 2 (Cnga2) impair the carotid body and glomus cell responses to H2S and hypoxia.
Review
Physiology
Jayasri Nanduri, Ying-Jie Peng, Ning Wang, Nanduri R. Prabhakar
CURRENT OPINION IN PHYSIOLOGY
(2019)