The LRRK2 signalling system

Active Interaction Mapping Reveals the Hierarchical Organization of Autophagy

(2017) Michael H. Kramer et al.   MOLECULAR CELL

Autophagy-related gene LRRK2 is likely a susceptibility gene for systemic lupus erythematosus in northern Han Chinese

(2017) Yue-miao Zhang et al.   Oncotarget

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

(2017) Martin Steger et al.   eLife

Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells

(2017) Kenneth Thirstrup et al.   Scientific Reports

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

(2016) G. Ito et al.   BIOCHEMICAL JOURNAL

LRRK2 autophosphorylation enhances its GTPase activity

(2016) Zhiyong Liu et al.   FASEB JOURNAL

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

(2016) Dorien A. Roosen et al.   Molecular Neurodegeneration

Cancer in Parkinson’s disease

(2016) Pawel Tacik et al.   PARKINSONISM & RELATED DISORDERS

Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts

(2016) Giambattista Guaitoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leucine-rich repeat kinase 2 and Parkinson's disease

(2016) Un-Beom Kang et al.   PROTEOMICS

A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy

(2016) Vinicius M. Fava et al.   PLoS Neglected Tropical Diseases

G2385R and I2020T Mutations Increase LRRK2 GTPase Activity

(2016) Dong Hwan Ho et al.   Biomed Research International

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

Cellular processes associated with LRRK2 function and dysfunction

(2015) Rebecca Wallings et al.   FEBS Journal

Architecture of human mTOR complex 1

(2015) C. H. S. Aylett et al.   SCIENCE

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

(2015) Reina N. Fuji et al.   Science Translational Medicine

Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach

(2015) Joanne L. Dunster et al.   PLoS Computational Biology

Higher Frequency of Certain Cancers inLRRK2G2019S Mutation Carriers With Parkinson Disease

(2015) Ilir Agalliu et al.   JAMA Neurology

Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease

(2015) Lorraine V. Kalia et al.   JAMA Neurology

Computational analysis of the LRRK2 interactome

(2015) Claudia Manzoni et al.   PeerJ

Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response

(2015) Wambui S. Wandu et al.   PLoS One

Frequency of the LRRK2 G2019S mutation in late-onset sporadic patients with Parkinson’s disease

(2014) Hsin Fen Chien et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Genetic, Structural, and Molecular Insights into the Function of Ras of Complex Proteins Domains

(2014) Laura Civiero et al.   CHEMISTRY & BIOLOGY

Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China

(2014) D Wang et al.   GENES AND IMMUNITY

The role of the LRRK2 gene in Parkinsonism

(2014) Jie-Qiong Li et al.   Molecular Neurodegeneration

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

(2014) A. Beilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

(2014) Ruth Chia et al.   Nature Communications

Disease Penetrance of Late-Onset Parkinsonism

(2014) Joanne Trinh et al.   JAMA Neurology

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

(2014) Maria D. Cirnaru et al.   Frontiers in Molecular Neuroscience

Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

(2013) Claudia Manzoni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of LRRK2 kinase activity stimulates macroautophagy

(2013) Claudia Manzoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation

(2013) Izabella D. Greene et al.   JOURNAL OF NEUROSCIENCE RESEARCH

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus

(2013) Daniah Trabzuni et al.   PLoS One

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia

(2012) Beomsue Kim et al.   PLoS One

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

(2012) Nicolas Dzamko et al.   PLoS One

Phosphorylation of 4E-BP1 in the Mammalian Brain Is Not Altered by LRRK2 Expression or Pathogenic Mutations

(2012) Alzbeta Trancikova et al.   PLoS One

Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

(2012) Z. Sheng et al.   Science Translational Medicine

Leucine-rich repeat (LRR) proteins: Integrators of pattern recognition and signaling in immunity

(2011) Aylwin Ng et al.   Autophagy

Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity

(2011) Elena V. Nikonova et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition

(2011) Elizabeth A. Doggett et al.   JOURNAL OF NEUROCHEMISTRY

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study

(2011) Owen A Ross et al.   LANCET NEUROLOGY

High frequency and reduced penetrance of lRRK2 g2019S mutation among Parkinson's disease patients in Cantabria (Spain)

(2011) María Sierra et al.   MOVEMENT DISORDERS

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

Association between LRRK2 and 4E-BP1 protein levels in normal and malignant cells

(2011) Santiago Ram�n y Cajal   ONCOLOGY REPORTS

First neuropathological description of a patient with Parkinson’s disease and LRRK2 p.N1437H mutation

(2011) Andreas Puschmann et al.   PARKINSONISM & RELATED DISORDERS

Phosphorylation-Dependent 14-3-3 Binding to LRRK2 Is Impaired by Common Mutations of Familial Parkinson's Disease

(2011) Xianting Li et al.   PLoS One

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue

(2011) Michael J. Devine et al.   PLoS One

LRRK2 signaling pathways: the key to unlocking neurodegeneration?

(2011) Daniel C. Berwick et al.   TRENDS IN CELL BIOLOGY

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

(2010) Nicolas Dzamko et al.   BIOCHEMICAL JOURNAL

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

(2010) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Membrane Localization of LRRK2 Is Associated with Increased Formation of the Highly Active LRRK2 Dimer and Changes in Its Phosphorylation

(2010) Zdenek Berger et al.   BIOCHEMISTRY

Reevaluation of Phosphorylation Sites in the Parkinson Disease-associated Leucine-rich Repeat Kinase 2

(2010) Xiaojie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

(2010) Veronique Daniëls et al.   JOURNAL OF NEUROCHEMISTRY

A comprehensive map of the mTOR signaling network

(2010) Etienne Caron et al.   Molecular Systems Biology

Leucine-Rich Repeat Kinase 2 Gene-Associated Disease: Redefining Genotype-Phenotype Correlation

(2010) Christian Wider et al.   Neurodegenerative Diseases

The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation

(2010) Azad Kumar et al.   PLoS One

Armadillo Motifs Involved in Vesicular Transport

(2010) Harald Striegl et al.   PLoS One

WD40 proteins propel cellular networks

(2010) Christian U. Stirnimann et al.   TRENDS IN BIOCHEMICAL SCIENCES

GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

(2010) Yulan Xiong et al.   PLoS Genetics

Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions

(2009) Elisa Greggio et al.   ASN Neuro

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization

(2009) Saurabh Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

(2008) Yuzuru Imai et al.   EMBO JOURNAL

The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation

(2008) Elisa Greggio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS