Article
Engineering, Biomedical
Yuedan Xu, Dongni Shen, Zihuai Zhou, Yi Sun, Xinni Pan, Wei Liu, Chun Hung Chu, Ling Zhang, Matthias Hannig, Baiping Fu
Summary: This study successfully achieved the generation of antibacterial remineralized dentin using a new biomimetic mineralization technology. Through the use of poly-aspartic acid-strontium complexes and phosphate&fluoride solution, mineralization of hydroxyapatite and demineralized dentin was achieved, resulting in dentin with antibacterial capability against Streptococcus mutans.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Zhou Ye, Xiao Zhu, Isha Mutreja, Sunil Kumar Boda, Nicholas G. Fischer, Anqi Zhang, Christine Lui, Yipin Qi, Conrado Aparicio
Summary: The study developed a scaffold with dual function for promoting tissue growth and preventing bacterial infections. The scaffolds were fabricated through intrafibrillar-mineralization of collagen and coating with antimicrobial peptides, demonstrating both antimicrobial properties and cytocompatibility to human cells. The process of scaffold fabrication is versatile and can be used with other biopolymers for controlling mineral load.
BIOACTIVE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Saravanan Sekaran, Selvaraj Vimalraj, Lakshmi Thangavelu
Summary: TNAP is an essential enzyme involved in skeletal tissue mineralization and dephosphorylation of various physiological substrates. It plays vital roles in neuronal development, detoxification, anti-inflammatory processes, bile pH regulation, and maintaining the blood brain barrier. Understanding the mechanisms mediated by TNAP is crucial for minimizing off targeted effects and improving various pathological scenarios.
Article
Biochemistry & Molecular Biology
Zhongcheng Li, Yuhao Zeng, Qian Ren, Longjiang Ding, Sili Han, Die Hu, Ziqian Lu, Luoyao Wang, Yinmo Zhang, Linglin Zhang
Summary: Biomimetic mineralization aims to reverse dental caries through bio-inspired strategies, focusing on both mineralization promotion and collagen protection. This study evaluated the effects of carboxymethyl chitosan (CMC) as a glycosaminoglycan analog for biomimetic modification of collagen. CMC successfully improved the hydrophilicity, calcium absorption capacity, and thermal degradation resistance of collagen. It also inhibited the activity of endogenous matrix metalloproteinases in demineralized dentin. CMC biomodification enhanced cross-linking and intrafibrillar mineralization of collagen, especially in the two-dimensional monolayer reconstituted collagen model. This study provided a comprehensive biomimetic mineralization strategy with collagen protection and expanded the application of chitosan-based materials in dentistry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Multidisciplinary
Ling Wang, Yawen Huang, Kailei Ding, Yixiang Lai, Ruiqi Mao, Fengxiong Luo, Boqing Zhang, Jiayi Zhu, Yujiang Fan, Changchun Zhou, Kefeng Wang, Xingdong Zhang
Summary: Enhanced biomimetic mineralization was achieved through polyphosphate modification of gelatin. The polyphosphorylation was shown to increase the saturation of in-situ mineralization, leading to improved mechanical properties and osteogenesis of the mineralized composite. Combining 3D printing, the scaffolds with enhanced mineralization and macro-controllable porous structure were prepared for better bone regeneration.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Abraham Garcia-Jimenez, Angelica Roman-Guerrero, Cesar Perez-Alonso, Benoit Fouconnier
Summary: This study investigates the effect of pH and ionic strength on the association interactions and phase separations in polyelectrolyte systems. The results show that the structure and phase transitions can be controlled by modifying the ionization degree, pKa, and charge screening. The findings provide insights into the functional properties of complexed polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Materials Science, Multidisciplinary
Yiyuan Li, Yufeng Meng, Yuning Wang, Yun Wang, Zuolin Wang
Summary: Chitosan is a natural cationic polysaccharide with excellent biological properties and potential applications. Mineralized chitosan scaffolds, as ideal biomaterials for repairing hard tissue defects, have made significant progress in the past decade. This study summarizes the structures, properties, preparation methods, and applications of mineralized chitosan scaffolds, and discusses their defects and possible improvement measures.
Article
Materials Science, Multidisciplinary
Pengfei Ma, Wenjing Wu, Yu Wei, Le Ren, Shuxian Lin, Junhua Wu
Summary: The study focuses on creating composite scaffolds using gelatin, chitosan, polyvinyl alcohol, and nano-hydroxyapatite to mimic natural bone structure and properties. These composite scaffolds exhibit improved mechanical strength and biocompatibility, promoting cell growth and adhesion in bone tissue engineering applications.
MATERIALS & DESIGN
(2021)
Article
Soil Science
Jiabao Li, Ting Xie, He Zhu, Jun Zhou, Chaonan Li, Wenjun Xiong, Lin Xu, Yanhong Wu, Zhili He, Xiangzhen Li
Summary: This study investigated the effects of alkaline and acid phosphatase activities on soil P availability in subalpine forests. The results showed that alkaline phosphatase activity played a key role in regulating soil P availability, primarily modulated by soil total N and N:P ratio.
Article
Engineering, Environmental
Naganagouda Goudar, Vinayak N. Vanjeri, Vishram D. Hiremani, Tilak Gasti, Sheela Khanapure, Saraswati P. Masti, Ravindra B. Chougale
Summary: In this study, novel polyelectrolyte complexes were prepared by mixing Tragacanth gum and Chitosan. The properties of the colloidal solution and films were systematically evaluated. The results showed that the water resistance and permeability of the films were significantly improved by ionic crosslinking, and they exhibited excellent antibacterial and antioxidant activities.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Nancy Alvarado, Romina L. Abarca, Cristian Linares-Flores
Summary: The current challenges in the food packaging field involve replacing non-renewable plastic with biopolymers and developing attractive packaging materials for consumers. Polyelectrolyte complexes (PECs) have emerged as a promising candidate in meeting these requirements, with encapsulation, protection, and transportation capabilities. Various biopolymers, such as alginate, cellulose, gelatin, and collagen, have been utilized in PEC formation. This paper reviews the use of chitosan-based PECs in food packaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Konstantinos Loukelis, Foteini Machla, Athina Bakopoulou, Maria Chatzinikolaidou
Summary: This study investigates the impact of kappa-carrageenan on dental pulp stem cells and reveals that its integration in scaffolds significantly enhances the odontogenic potential of DPSCs, supporting dentin-pulp regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Freja Pontan, Helena Hauta-alus, Saara Valkama, Jenni Rosendahl, Maria Enlund-Cerullo, Sture Andersson, Outi Makitie, Elisa Holmlund-Suila
Summary: This study investigated the concentrations of alkaline phosphatase (ALP) and the prevalence of hyperphosphatasemia in healthy children, and their association with vitamin D, growth, infections, and bone parameters. It was found that boys had higher ALP levels than girls, and hyperphosphatasemia was more common at 12 months. Hyperphosphatasemia was associated with body size, growth rate, and bone mineralization, but not with infections.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Konstantinos Makris, Chagigia Mousa, Etienne Cavalier
Summary: Alkaline phosphatases are isoenzymes that catalyze the hydrolysis of organic phosphate esters in the extracellular space. Zinc and magnesium are important co-factors for their biological activity. They are found in various tissues, but most are derived from the liver and bone in the bloodstream. However, their exact physiological function remains largely unknown.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Man Zhao, Juan Han, Jiacong Wu, Yuanyuan Li, Yang Zhou, Lei Wang, Yun Wang
Summary: This study presents a simple method to separate and immobilize histagged enzymes directly from cell lysis solution through a single biomineralization step, without the need for support preparation. The results demonstrate that this approach significantly enhances enzyme activity recovery and separation efficiency, while also exhibiting excellent reusability.
BIOCHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemical Research Methods
Ingrid Amer Cid, Lenny Van Daele, Peter Dubruel, Kristiaan Neyts, Filip Strubbe
Summary: Understanding the adsorption of polymers onto particles is crucial for many technological and biomedical applications. This study investigates the use of single-particle electrophoresis to directly analyze the adsorption kinetics of cationic polymers onto anionic particles. The results show that this technique enables accurate measurement and comparison of the kinetics of polymer adsorption on the single-particle level.
Article
Biochemistry & Molecular Biology
Manon Minsart, Nicolas Deroose, Laurens Parmentier, Sandra Van Vlierberghe, Arn Mignon, Peter Dubruel
Summary: This research focuses on the development of hydrogel-based wound dressings with high mechanical strength and exudate absorption capacities. The synthesized AUP materials show high gel fractions and strong swelling degrees, as well as tunable mechanical properties. They exhibit higher swelling degrees and mechanical resistance compared to commercial dressings. The materials also show excellent biocompatibility and have the potential to compete with commercially available dressings.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Materials Science, Biomaterials
Nathan Carpentier, Luca Urbani, Peter Dubruel, Sandra Van Vlierberghe
Summary: Drug induced liver injury (DILI) is a major reason for drug withdrawal during drug development. Currently, there is a lack of reliable in vitro models that can mimic the liver environment and function. This review discusses different approaches for the development of liver models in tissue engineering.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Biomedical
Ananya Pattnaik, A. Swaroop Sanket, Sanghamitra Pradhan, Rajashree Sahoo, Sudiptee Das, Swarnaprbha Pany, Timothy E. L. Douglas, Rambabu Dandela, Qiang Liu, Jaykumar Rajadas, Sanghamitra Pati, Stefaan C. Smedt, Kevin Braeckmans, Sangram Keshari Samal
Summary: Gradient scaffolds are three-dimensional structures that mimic the biological extracellular matrix with gradual transitions in various properties. They have shown advantages in nutrient and cell penetration, cellular adhesion, viability and differentiation, mechanical stability, and biocompatibility compared to conventional scaffolds. This review explains recent advancements in designing gradient scaffolds and their implications in tissue regeneration applications, as well as discussing the specific utility of gradients in different native tissues.
Article
Materials Science, Multidisciplinary
Aysu Arslan, Patrice Roose, Annemie Houben, Heidi Declercq, Sandra Van Vlierberghe, Peter Dubruel
Summary: In this research, the printability of inks formulated with AUP and Laponite was evaluated. The flow behavior of the AUP/Laponite hydrogel inks showed yielding and shear thinning behavior, dependent on the concentrations of AUP and Laponite. The flow behavior inside the printing needle was analyzed to gain insight into printability. The recovery mechanism of the inks was found to have a biexponential behavior, with fast and slow recovery steps.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Engineering, Biomedical
Elanagai Rathinam, Sivaprakash Rajasekharan, Heidi Declercq, Christian Vanhove, Peter De Coster, Luc Martens
Summary: The gene expression profiles and histological outcomes of two different tricalcium silicate-based biomaterials in endodontic revitalisation therapy were compared in immature sheep teeth. Biodentine induced a larger area of neoformed tissue with cellularity and vascularity, showing potential for promoting dentin formation. Further studies with larger sample size are needed to confirm the effect of intracoronal sealing biomaterials on histological outcomes.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Editorial Material
Engineering, Biomedical
Mark Skylar-Scott, Heidi Declercq, Koichi Nakayama
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Physical
S. Das, P. Priyadarshini, S. Senapati, S. Bisoyi, S. K. Samal, R. Naik
Summary: The present report investigates the preparation of Bi-doped ZnTe (Bi:ZnTe) nanosheets (NS) with different Bi contents for optoelectronic applications and antibacterial responses. The flower-like Bi:ZnTe NS assemblies were synthesized by a cation exchange reaction, exhibiting high crystallinity and a hexagonal ZnTe phase. The optical properties of the NS, including absorption edge and photoluminescence (PL), varied with the Bi content. The Bi:ZnTe NS also demonstrated good antibacterial activities.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Subrata Senapati, Ramakanta Naik, Saumya Dash, Ashutosh Mohanty, Kevin Braeckmans, Stefaan C. De Smedt, Sangram Keshari Samal
Summary: Biomass-derived luminescent nitrogen-doped carbon nanosheets were prepared using an eco-friendly and cost-effective green method. The nitrogen-doped carbon nanosheets exhibited intense visible light emission with excitation-dependent behavior, as well as temperature-dependent photoluminescent properties. The nanosheets also showed excitation-dependent emissions in the dispersed state, making them suitable for various biomedical applications. Overall, this study demonstrates the potential of environmentally friendly nitrogen-doped carbon nanosheets for nanoscale temperature sensing, bioimaging, and therapeutic applications.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Review
Chemistry, Analytical
Antonella Battisti, Sangram Keshari Samal, Dario Puppi
Summary: Graphene oxide (GO) is a versatile material obtained by the strong oxidation of graphite. Its remarkable ability to significantly alter the fluorescence of many common fluorophores and dyes has been exploited in the design of novel switch-ON and switch-OFF fluorescence biosensing platforms for the detection of various biomolecules, especially pathological biomarkers and environmental contaminants.
Meeting Abstract
Cell & Tissue Engineering
Mendy Minne, Rebecca Wust, Lisanne Terrie, Lieven Thorrez, Heidi Declercq
TISSUE ENGINEERING PART A
(2023)
Meeting Abstract
Cell & Tissue Engineering
Jasper Smet, Lieven Thorrez, Heidi Declercq
TISSUE ENGINEERING PART A
(2023)
Meeting Abstract
Cell & Tissue Engineering
Rebecca Wust, Lisanne Terrie, Heidi Declercq, Lieven Thorrez
TISSUE ENGINEERING PART A
(2023)
Review
Polymer Science
Itishree Panda, Sangram Keshari Samal, Sanghamitra Pradhan
Summary: Bacterial infection has become a significant clinical challenge due to the overuse of antibiotics and resulting antibiotic resistance. This review focuses on the potential and applications of poly-ionic liquids (PILs) as effective antimicrobial agents in biomedical applications.
JOURNAL OF POLYMER SCIENCE
(2023)
Article
Materials Science, Biomaterials
Lenny Van Daele, Babs van de Voorde, Robin Colenbier, Lobke De Vos, Laurens Parmentier, Louis Van der Meeren, Andre Skirtach, Ruslan I. Dmitriev, Peter Dubruel, Sandra Van Vlierberghe
Summary: Cardiovascular diseases are the leading cause of death worldwide. Poly(alkylene terephthalate)s (PATs) with longer alkyl chain lengths show potential for improving compliance in vascular graft materials. This study investigated the effects of polymer molar mass and alkyl chain length on the surface properties of spin-coated PAT films, as well as endothelial cell adhesion and proliferation. The results showed that higher molar mass and longer alkyl chain lengths increased surface roughness, while no significant trend was observed for wettability. All investigated PATs were non-cytotoxic and supported endothelial cell adhesion and growth, with some PATs even promoting angiogenic maturation.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
