Article
Food Science & Technology
Jinghe Sun, Shuang Song, Chunqing Ai, Beiwei Zhu, Jingfeng Yang
Summary: Sulfate-modified abalone polysaccharide (S-AGSP) effectively inhibits SARS-CoV-2 infection by weakening the binding affinity between the virus spike protein and ACE2. S-AGSP shows potential as a therapeutic candidate for COVID-19.
Article
Biochemistry & Molecular Biology
Ana S. Luis, Arnaud Basle, Dominic P. Byrne, Gareth S. A. Wright, James A. London, Chunsheng Jin, Niclas G. Karlsson, Gunnar C. Hansson, Patrick A. Eyers, Mirjam Czjzek, Tristan Barbeyron, Edwin A. Yates, Eric C. Martens, Alan Cartmell
Summary: This study uses structural biology to uncover how sulfatases from the human gut microbiota recognize sulfated glycans. The data reveals that carbohydrate sulfatases are highly selective for the glycan component of their substrate.
NATURE CHEMICAL BIOLOGY
(2022)
Review
Chemistry, Applied
Wenjing Lu, Zhifeng Yang, Juan Chen, Di Wang, Yu Zhang
Summary: This review highlights the antiviral mechanisms of sulfated polysaccharides, suggesting that they may interfere with various steps in the virus life cycle or enhance host immune response. Additionally, the antiviral activity of sulfated polysaccharides is influenced by factors such as degree of substitution, substitution position, molecular weight, and spatial conformation, providing insights for the development of novel therapeutic agents.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Jenny Fjodorova, Robin Held, Gerd Hublik, Jorge M. Esteban Vazquez, Volker Walhorn, Thomas Hellweg, Dario Anselmetti
Summary: Xanthan gum''s thickening properties are correlated with the formation of secondary structures and the coordination of ions on the polymer side chain. Modifying the secondary structures can alter its thickening properties.
Review
Chemistry, Applied
Ji Kang, Xing Jia, Nifei Wang, Meng Xiao, Shuang Song, Shufen Wu, Zhenjing Li, Shujun Wang, Steve W. Cui, Qingbin Guo
Summary: This review compares the structural characteristics of marine sulfated polysaccharides and summarizes their functional and biological activities, as well as the influence of sulfate groups on their properties. The aim is to provide a deeper understanding of marine SPs for their industrial applications in various fields.
FOOD HYDROCOLLOIDS
(2022)
Article
Biology
Valeria Miranda-Arizmendi, Diana Fimbres-Olivarria, Anselmo Miranda-Baeza, Karla Martinez-Robinson, Agustin Rascon-Chu, Yubia De Anda-Flores, Jaime Lizardi-Mendoza, Mayra A. Mendez-Encinas, Francisco Brown-Bojorquez, Rafael Canett-Romero, Elizabeth Carvajal-Millan
Summary: Algae and microalgae are important sources of bioactive compounds, particularly polysaccharides, which have been reported to have beneficial bioactivities for human health. However, the structure of polysaccharides in microalgae is not well explored. The present study extracted a sulfated polysaccharide (CMSP) from Chaetoceros muelleri and analyzed its structure, physicochemical properties, and bioactivities. The CMSP showed antioxidant activity, low glycemic index, and no cytotoxicity in colon cells.
Article
Chemistry, Applied
Severin Eder, Patrick Zueblin, Michael Diener, Mohammad Peydayesh, Samy Boulos, Raffaele Mezzenga, Laura Nystrom
Summary: The study investigates the impact of polysaccharide conformation on ultrafiltration performance, revealing significant deviations between nominal MWCO and apparent M-w due to conformational variations. Results indicate that polysaccharides with different conformations show varied recovery rates during ultrafiltration processes based on experimental data.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Kao Wu, Yi Wan, Xin Li, Hong Qian, Man Xiao, Xuewen Ni, Fatang Jiang, Sheng Chen
Summary: This study analyzed the impact of heating and drying temperatures on the properties of curdlan and KGM/curdlan blend films, revealing that the addition of KGM improved the film-forming properties of curdlan. High heating temperature enhanced molecular interaction in the films, while drying temperature had different effects on different films.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Yufeng Gong, Yongxuan Ma, Peter Chi-Keung Cheung, Lijun You, Lan Liao, Sandra Pedisic, Viktoryia Kulikouskaya
Summary: UV/H2O2 treatment significantly reduced the molecular weight and particle size of GLP, decreased the content of total sugars, uronic acids and proteins, and modified its surface morphology, showing the potential to enhance the anti-inflammatory activity of algal sulfated polysaccharides.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Zhiwei Li, Yuanhao Wei, Yawen Wang, Ran Zhang, Chuanjie Zhang, Caixing Wang, Xuebing Yan
Summary: Highly substituted sulfated alfalfa polysaccharides (SAP) were successfully synthesized via the chlorosulfonic acid (CSA)-pyridine (Pyr) method. The optimized reaction conditions resulted in a maximum degree of substitution of 0.724. SAP exhibited improved water solubility and biological activity, showing better antioxidant activity, antibacterial ability, and promotion of intestinal epithelial cells' viability compared to non-sulfated alfalfa polysaccharides (AP). Furthermore, SAP showed potential in inhibiting obesity.
Article
Biochemistry & Molecular Biology
Md. Akibul Hasan Bakky, Ngoc Tuan Tran, Ming Zhang, Yongsheng Zhang, Huifen Liang, Yilei Wang, Yueling Zhang, Hongyu Ma, Huaiping Zheng, Shengkang Li
Summary: This study characterized the polysaccharide from Gracilaria lemaneiformis and investigated its fermentation by rabbitfish intestinal microbes. The study found that the polysaccharide was mainly composed of galactose and anhydrogalactose, and it enhanced the production of short-chain fatty acids and altered the gut microbiota. The findings suggest that the polysaccharide has prebiotic potential and could be used as a functional feed additive in aquaculture.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Bilal Muhammad Khan, Li-Xin Zheng, Wajid Khan, Aftab Ali Shah, Yang Liu, Kit-Leong Cheong
Summary: This study filled the gap in the physical and chemical characterization of Gracilaria blodgettii polysaccharides, revealing its antioxidant potential and potential applications in the functional food industry.
Article
Chemistry, Applied
Lei Ji, Antonia Orthmann, Leonardo Cornacchia, Jinfeng Peng, Guido Sala, Elke Scholten
Summary: Polysaccharides play a significant role in the sensorial properties of foods due to their lubricating ability. In this study, the lubrication performance of polysaccharides with different characteristics was investigated. The results showed that conformation was a key factor in determining lubrication ability. Rigid rod-like polysaccharides exhibited better lubricating capacity and resistance to changes in pH and ionic strength compared to flexible polysaccharides. The friction behavior of flexible polysaccharides was highly dependent on concentration and sliding speed.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Gustavo Leite Miliao, Lucas de Souza Soares, Douglas Fernando Balbino, Everton de Almeida Alves Barbosa, Gustavo Costa Bressan, Alvaro Vianna Novaes de Carvalho Teixeira, Jane Selia dos Reis Coimbra, Eduardo Basilio de Oliveira
Summary: The study found that the interaction between ovalbumin and chitosan is mainly driven by electrostatic forces and hydrogen bonds at specific pH values. The presence of chitosan alters the secondary structure of ovalbumin, increasing the stability of alpha-helix and random coil structures while decreasing beta-sheet content.
FOOD HYDROCOLLOIDS
(2022)
Review
Biochemistry & Molecular Biology
Francisca Crislandia Oliveira Silva, Arunkumar Malaisamy, Thiago Barbosa Cahu, Maria Isabela Ferreira de Araujo, Paulo Antonio Galindo Soares, Angelioca Thomaz Viera, Maria Tereza dos Santos Correia
Summary: Polysaccharides in plant-exuded gums are complex biopolymers with a wide range of structural variability. These structural features are directly related to the enzymatic degradation of polysaccharides by gut microbiota and their regulatory effects on the host homeostasis system. Molecular docking analysis can be used to study and predict the fermentation potential of polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jinhui Jia, Weiyun Zheng, Chenxi Zhang, Panpan Zhang, Xiaoming Guo, Shuang Song, Chunqing Ai
Summary: This study analyzed the protective effect of fucoidan from Scytosiphon lomentaria (SLF) on dietary fibers deficiency (FF)-induced change of physiological functions in mice. SLF reduced weight gain and low-density lipoprotein cholesterol, increased high-density lipoprotein cholesterol, but had no effect on food intake and body fat mass in FF-treated mice. It also modulated lipid metabolism, protected against FF-induced colon damages, and regulated gut microbiota dysbiosis. This indicates that SLF can be developed as a prebiotic agent to benefit host health.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Agriculture, Multidisciplinary
Ying You, Haoran Song, Linlin Wang, Zhengqi Liu, Xiaoming Guo, Chunqing Ai, Shuang Song, Beiwei Zhu
Summary: The study found that Caulerpa lentillifera polysaccharide (CLP) can effectively reduce lipid digestibility and inhibit lipid absorption to prevent obesity. Pre-prandial administration of CLP showed better effects in lowering body weight and serum lipid levels, while free feeding method was more conducive to increasing the diversity of gut microbiota.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Chemistry, Applied
Weigong Tian, Ying You, Xiaona Sun, Linlin Wang, Lilong Wang, Songtao Wang, Chunqing Ai, Shuang Song
Summary: A photocatalytic degradation method using H2O2 and TiO2 was developed to decrease the average molecular weight of CS into 5 kDa within 6 hours, without removing sulfate groups. Mass spectrometry analysis revealed the presence of glucuronic acid or its derivative, arabinuronic acid, in the degradation product, suggesting a depolymerization mechanism. Moreover, the absorption of CS in rats was enhanced by the degradation, and the excretion profile of the degradation product was similar to that of CS.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Xiaona Sun, Chunqing Ai, Chengrong Wen, Haoran Peng, Jingfeng Yang, Yuna Cui, Shuang Song
Summary: Different molecular weight fucoidans were prepared and compared for their chemical structures and anti-pathogenic microbiota activity. Results showed that fucoidan with higher molecular weight had stronger inhibitory effects on pathogenic bacteria and SARS-CoV-2. In addition, it also exhibited better capability to prevent bacterial adhesion to cells. These findings provide insights into the relationship between structure and activity of fucoidan against pathogenic microbiota.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Lilong Wang, Chunhong Yan, Linlin Wang, Chunqing Ai, Songtao Wang, Caihong Shen, Yuqin Tong, Shuang Song
Summary: This study reveals that Ascophyllum nodosum polysaccharide (ANP) can protect against colonic inflammation by regulating the metabolites of gut microbiota. ANP promotes the production of short-chain fatty acids (SCFAs), betaine, l-carnitine, and aminoimidazole carboxamide ribonucleotide (AICAR) and enhances aminoacyl-tRNA biosynthesis. Furthermore, ANP has an impact on the relative abundances of specific gut bacteria. Overall, these findings suggest that ANP plays a significant role in maintaining intestinal health and reducing colonic inflammation.
Article
Polymer Science
Chen Song, Ying You, Chengrong Wen, Yinghuan Fu, Jingfeng Yang, Jun Zhao, Shuang Song
Summary: Low-molecular-weight carrageenan has advantages in solubility, absorption efficiency, and bioavailability compared to original carrageenan. A photocatalytic degradation method with only TiO2 has been developed to prepare low-molecular-weight carrageenan with high sulfation degree and low viscosity. The study also proposed the degradation rules and provided an effective green method for the degradation of carrageenan.
Article
Food Science & Technology
Chenxi Zhang, Jinhui Jia, Panpan Zhang, Weiyun Zheng, Xiaoming Guo, Chunqing Ai, Shuang Song
Summary: This study evaluated the beneficial effect of Laminaria japonica fucoidan (LJF) on type 2 diabetes mellitus (T2DM) and found that LJF can alleviate symptoms, reduce blood glucose and cholesterol levels, regulate insulin resistance and sensitivity, protect pancreatic islets, and inhibit fat accumulation in T2DM mice. LJF also modulates the gut microbiota and metabolites, leading to changes in metabolism pathways. Therefore, LJF can be used as a prebiotic agent for the prevention and treatment of diabetes and microbiota-related diseases.
Article
Chemistry, Applied
Cui Cao, Lilong Wang, Xueqian Zhang, Chunqing Ai, Zhongfu Wang, Linjuan Huang, Shuang Song, Beiwei Zhu
Summary: The study investigated the utilization of an arabinogalactan from Lycium barbarum (LBP-3) by intestinal Bacteroidetes species. The results showed that Bacteroides caccae and Phocaeicola vulgatus utilized more LBP-3 compared to other species. In addition, different preferences for arabinose and galactose were observed during the fermentation process. The study also identified oligosaccharides produced by B. caccae and P. vulgatus and demonstrated the proliferation of various Parabacteroides species in the presence of B. caccae and P. vulgatus.
Article
Chemistry, Applied
Nan Wang, Jie Tian, Li Guo, Xueting Chen, Bingbing Hu, Shuang Song, Chengrong Wen
Summary: The effects of differently charged anions (NaCl, NaBr, NaI, Na2SO4, and Na3PO4) on the gel properties and structure of the fucoidan/kappa-carrageenan mixed gel (FC) were investigated through various techniques. Cl- and Br- stabilized the gel's conformation, while SO42- and PO43- weakened the gel's strength, and I- softened the gel. With increasing anion concentration, electrostatic repulsion between FUC and KC was enhanced. The addition of anions affected the gel's water migration and microstructure. Overall, this study provides a theoretical basis for the design of FUC-based gels.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Zhengqi Liu, Yuanyuan Hu, Xiaoya Tao, Jinjin Li, Xiaoming Guo, Gang Liu, Shuang Song, Beiwei Zhu
Summary: In this study, the interaction between sea cucumber sulfated polysaccharide (SCSPsj) and Parabacteroides distasonis was investigated. SCSPsj was found to be fermented by P. distasonis, resulting in the production of various microbial metabolites. Additionally, the fermented supernatants of P. distasonis promoted the growth of specific intestinal Bacteroidales strains through cross-feeding.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Acoustics
Geng Cao, Xueting Chen, Bingbing Hu, Zuoqian Yang, Man Wang, Shuang Song, Lei Wang, Chengrong Wen
Summary: This study investigated the rheological properties, microstructure, cooking, and texture characteristics of surimi-wheat noodles under different ultrasonic powers. The results showed that ultrasonic treatment significantly improved the microstructure, cooking properties, and texture characteristics of noodles (<= 24.00 W/L) compared to the fermentation control. The effect of ultrasonic power on the surimi-wheat dough performance was elucidated, and the optimal ultrasound power was obtained, thereby improving the nutritional properties and quality of surimi-wheat noodles.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Food Science & Technology
Jinjin Li, Xiaoming Guo, Zhengqi Liu, Zhihua Yang, Chunqing Ai, Shuang Song, Beiwei Zhu
Summary: In this study, a Gracilaria lemaneiformis slurry (GLS) was used as a stabilizer for oil-in-water emulsions. The microstructures and stability of the emulsions were controlled by adjusting the emulsion formulations. The optimized conditions yielded high internal phase emulsions (HIPEs) with gel-like textures, and the presence of exogenous Ca2+ enhanced the viscoelasticity of the emulsions.
Editorial Material
Food Science & Technology
Shuang Song, Chunqing Ai
Article
Biochemistry & Molecular Biology
Cheng Li, Yang Tian, Jiahuan Pei, Yuyang Zhang, Daokuan Hao, Tianjiao Han, Xiaoqin Wang, Shuang Song, Linjuan Huang, Zhongfu Wang
Summary: Previous research studies have shown that sulfated polysaccharides can inhibit food allergy, but the detailed mechanism remains largely unknown. In this study, the anti-allergic activities of four sulfated polysaccharides were compared using RBL-2H3 cells, and an allergic mouse experiment was used to explore their desensitization effect. Sea cucumber chondroitin sulfate (SCCS) showed significant inhibition of RBL-2H3 cell degranulation and reduced allergic symptoms in mice. SCCS also affected gut microbiota, immune cell differentiation, and the secretion of short chain fatty acids, providing a deeper understanding of its functioning mechanism in alleviating food allergy.
Article
Biochemistry & Molecular Biology
Zhengqi Liu, Chunqing Ai, Xinping Lin, Xiaoming Guo, Shuang Song, Beiwei Zhu
Summary: Sulfated polysaccharides from sea cucumber Stichopus japonicus (SCSPsj) modulate gut microbiota by promoting the growth of probiotics. This study investigated the effects of SCSPsj and Lactobacillus gasseri on gut microbiota-altered mice through gut microbiota and metabolomics analysis. The combination of SCSPsj and L. gasseri effectively ameliorated body weight gain and fat accumulation in mice treated with low-dose penicillin, with a better effect attributed to their synergistic effect.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)