Review
Biochemistry & Molecular Biology
Hong-Beom Park, Kwang-Hyun Baek
Summary: This review summarizes the role and mechanisms of MAPK signaling pathways in cancer, as well as the functions of E3 ligases and DUBs targeting MAPK signaling components.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Biochemistry & Molecular Biology
Jin Hee Kim, In Gyoung Ju, Namkwon Kim, Eugene Huh, So-Ri Son, Joon Pyo Hong, Yujin Choi, Dae Sik Jang, Myung Sook Oh
Summary: This study aimed to investigate the anti-neuroinflammatory effects of yomogin, isolated from Artemisia iwayomogi. The results showed that yomogin suppressed neuroinflammatory factors and regulated the MAPK pathway, suggesting its potential as a therapeutic candidate for inflammation-mediated neurological diseases.
Article
Oncology
Junpeng Cui, Yang Ge, Wei Sun, Baolin Liu, Chaoliu Dai
Summary: This study investigated the expression and function of CgB in colonic neuroendocrine carcinoma (NEC). It was found that the expression of CgB was significantly upregulated in colonic NEC tissues and promoted cell invasion, migration, as well as epithelial mesenchymal transition (EMT) and stemness. Mechanistically, CgB overexpression activated p38 MAPK and ERK pathways. Overall, CgB contributes to the development of colonic NEC by activating p38 MAPK and ERK pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Plant Sciences
Zahra Ayatollahi, Vaiva Kazanaviciute, Volodymyr Shubchynskyy, Kotryna Kvederaviciute, Manfred Schwanninger, Wilfried Rozhon, Michael Stumpe, Felix Mauch, Sebastian Bartels, Roman Ulm, Salma Balazadeh, Bernd Mueller-Roeber, Irute Meskiene, Alois Schweighofer
Summary: This study reveals the crucial role of different types of MAPK phosphatases in plant stress responses and the tight control of MAPK activities.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Cell Biology
Pauline Esteves, Benoit Allard, Alexis Celle, Isabelle Dupin, Elise Maurat, Olga Ousova, Matthieu Thumerel, Jean-William Dupuy, Thierry Leste-Lasserre, Roger Marthan, Pierre-Olivier Girodet, Thomas Trian, Patrick Berger
Summary: This study shows that asthmatic bronchial smooth muscle (BSM) cells enhance the replication of rhinovirus (RV) in bronchial epithelium through increased production of CCL20. Additionally, these asthmatic BSM cells downregulate the antiviral pathway PKR, leading to increased susceptibility of the bronchial epithelium to RV infection.
Article
Food Science & Technology
Yue Zhao, Qingqing Jiang, Limin Guo, Daming Fan, Mingfu Wang, Yueliang Zhao
Summary: Glycidol is a food contaminant found in refined edible oils and various thermally processed foods, which induces cell cycle arrest, apoptosis, and autophagy in HUVECs. The toxicity effects of glycidol are mediated through activation of the ERK/JNK/p38 signaling pathways, and these effects can be attenuated by apigenin-7 (API-C8) through inhibition of the same pathways.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yoshiaki Soejima, Nahoko Iwata, Yasuhiro Nakano, Koichiro Yamamoto, Atsuhito Suyama, Takahiro Nada, Fumio Otsuka
Summary: The study examined the roles of Clock genes and BMP system in regulating gonadotropin secretion by GnRH using mouse L beta T2 cells. The results showed that LH beta mRNA expression in L beta T2 cells changed over time and was influenced by Bmal1 and Clock. ERK and BMPs were found to be involved in the regulation of LH beta mRNA expression at different stages after GnRH stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Agriculture, Dairy & Animal Science
Meijuan Meng, Xuerui Li, Ran Huo, Nana Ma, Guangjun Chang, Xiangzhen Shen
Summary: This experiment investigated the effects of a high-concentrate diet on mammary gland inflammation and mitochondrial damage in dairy cows. The results showed that the high-concentrate diet induced inflammation in the mammary gland, increased the concentration of Ca2+, upregulated the expression of inflammatory factors, and caused mitochondrial dysfunction via activation of the mitochondrial-associated signaling pathway.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Emma Marie Wilber Hepworth, Shanta D. Hinton
Summary: MAPK signaling pathways are crucial regulators of eukaryotic cell function, with kinases and phosphatases controlling the activation and inhibition of MAPK. Pseudoenzymes also play a significant role in regulating these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jun Yu, Yibo Wu, Hong Li, Hui Zhou, Cong Shen, Tingting Gao, Meng Lin, Xiuliang Dai, Jian Ou, Meiling Liu, Xiaoyan Huang, Bo Zheng, Fei Sun
Summary: The study identified BMI1 as a positive regulator of testosterone production, with the mechanism involving BMI1-mediated gene silencing to inhibit the p38 MAPK pathway and promote steroidogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Matthaeus Metz, James O'Hare, Bob Cheng, Michelle Puchowicz, Christoph Buettner, Thomas Scherer
Summary: In this study, the role of brain insulin signaling in regulating lipolysis was further characterized. It was found that intact hypothalamic MAPK signaling is required for insulin to suppress adipose tissue lipolysis.
MOLECULAR METABOLISM
(2023)
Article
Cell Biology
Yuanxi Yang, Xin Ran, Hefei Wang, Yingsheng Chen, Shuang Hou, Zhanqing Yang, Shoupeng Fu, Juxiong Liu, Guiqiu Hu, Wenjin Guo
Summary: Evodiamine was found to significantly alleviate pathological injury and pro-inflammatory cytokine production in breast tissue, as well as inhibit the activation of inflammation-related pathways.
Article
Biochemistry & Molecular Biology
Hsin-Yu Ho, Ping-Ju Chen, Yi-Ching Chuang, Yu-Sheng Lo, Chia-Chieh Lin, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Picrasidine I exerts anticancer effects in nasopharyngeal carcinoma by modulating HO-1 via the ERK and Akt signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Tae-Won Jang, Jae-Ho Park
Summary: The research demonstrated that the callus of Abeliophyllum distichum has anti-inflammatory effects by inhibiting the MAPK, PI3K/Akt, and NF-kappa B signaling pathways. The presence of acteoside and isoacteoside in CAO contributes to its potential as an anti-inflammatory agent by suppressing the release of inflammation factors in RAW 264.7 cells.
Article
Gastroenterology & Hepatology
Sen Yagi, Shinya Furukawa, Kana Shiraishi, Teruki Miyake, Kazuhiro Tange, Yu Hashimoto, Shogo Kitahata, Tomoe Kawamura, Tomoyuki Ninomiya, Kenichirou Mori, Seiyuu Suzuki, Naozumi Shibata, Hidehiro Murakami, Katsuhisa Ohashi, Aki Hasebe, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa
Summary: This study aimed to evaluate the association between albumin to globulin ratio (AGR) and clinical outcomes among Japanese patients with ulcerative colitis (UC). The results showed that AGR was positively correlated with clinical remission and mucosal healing. Especially in UC patients with low CRP levels, AGR might be a useful marker for assessing mucosal healing.
ANNALS OF COLOPROCTOLOGY
(2023)
Article
Oncology
Atsushi Hiraoka, Takashi Kumada, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Hiroshi Shibata, Tomoko Aoki, Takaaki Tanaka, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Kouji Joko, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Masatoshi Kudo
Summary: This study compared the therapeutic efficacy of atezolizumab plus bevacizumab and lenvatinib as first-line treatment for unresectable hepatocellular carcinoma (u-HCC). The results showed that patients who received atezolizumab plus bevacizumab had a better prognosis in terms of PFS and OS compared to those who received lenvatinib.
Article
Gastroenterology & Hepatology
Sen Yagi, Shinya Furukawa, Teruki Miyake, Kana Shiraishi, Kazuhiro Tange, Yu Hashimoto, Shogo Kitahata, Tomoyuki Ninomiya, Seiyuu Suzuki, Naozumi Shibata, Hidehiro Murakami, Katsuhisa Ohashi, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa
Summary: This study found a significant positive association between complete mucosal healing (MH) and high-density lipoprotein cholesterol (HDL-C) in patients with ulcerative colitis (UC). However, it is still unclear whether medication for dyslipidemia affects this association.
Article
Oncology
Andrea Casadei-Gardini, Margherita Rimini, Toshifumi Tada, Goki Suda, Shigeo Shimose, Masatoshi Kudo, Jaekyung Cheon, Fabian Finkelmeier, Ho Yeong Lim, Lorenza Rimassa, Jose Presa, Gianluca Masi, Changhoon Yoo, Sara Lonardi, Francesco Tovoli, Takashi Kumada, Naoya Sakamoto, Hideki Iwamoto, Tomoko Aoki, Hong Jae Chon, Vera Himmelsbach, Tiziana Pressiani, Margarida Montes, Caterina Vivaldi, Caterina Solda, Fabio Piscaglia, Atsushi Hiraoka, Takuya Sho, Takashi Niizeki, Naoshi Nishida, Christoph Steup, Massimo Iavarone, Giovanni Di Costanzo, Fabio Marra, Mario Scartozzi, Emiliano Tamburini, Giuseppe Cabibbo, Francesco Giuseppe Foschi, Marianna Silletta, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Fujimasa Tada, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Hisashi Kosaka, Atsushi Naganuma, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Valentina Burgio, Mara Persano, Angelo Della Corte, Francesca Ratti, Francesco De Cobelli, Luca Aldrighetti, Stefano Cascinu, Alessandro Cucchetti
Summary: This retrospective multi-center study compared the clinical efficacy and safety of lenvatinib and atezolizumab plus bevacizumab as a first-line treatment for unresectable HCC. The results showed that atezolizumab plus bevacizumab did not have a significant survival advantage over lenvatinib overall. However, lenvatinib had a higher overall survival rate in patients with non-alcoholic steatohepatitis/non-alcoholic fatty liver disease, while atezolizumab plus bevacizumab had a higher overall survival rate in patients with viral hepatitis. After adjusting for population, atezolizumab plus bevacizumab provided better safety profile for most adverse events.
EUROPEAN JOURNAL OF CANCER
(2023)
Correction
Gastroenterology & Hepatology
Takeshi Hatanaka, Satoru Kakizaki, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Noritomo Shimada, Kazuhito Kawata, Hisashi Kosaka, Takaaki Tanaka, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Atsushi Naganuma, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Takashi Kumada
HEPATOLOGY INTERNATIONAL
(2023)
Article
Oncology
Toshifumi Tada, Takashi Kumada, Atsushi Hiraoka, Kazuya Kariyama, Joji Tani, Masashi Hirooka, Koichi Takaguchi, Masanori Atsukawa, Shinya Fukunishi, Ei Itobayashi, Kunihiko Tsuji, Kazuto Tajiri, Hironori Ochi, Toru Ishikawa, Satoshi Yasuda, Chikara Ogawa, Hidenori Toyoda, Takeshi Hatanaka, Takashi Nishimura, Satoru Kakizaki, Kazuhito Kawata, Noritomo Shimada, Fujimasa Tada, Kazuhiro Nouso, Akemi Tsutsui, Hideko Ohama, Asahiro Morishita, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Hisashi Kosaka, Michitaka Imai, Atsushi Naganuma, Shinichiro Nakamura, Yohei Koizumi, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa
Summary: The aim of this study was to investigate whether the neo-GPS could predict prognosis in HCC patients treated with Atez/Bev. The results showed that the neo-GPS was independently associated with overall survival and performed better than the traditional GPS in predicting prognosis.
Article
Oncology
Toshifumi Tada, Takashi Kumada, Atsushi Hiraoka, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Fujimasa Tada, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Hisashi Kosaka, Atsushi Naganuma, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa
Summary: This study aimed to investigate the correlation between the development of adverse events (AEs) and prognosis in patients with unresectable hepatocellular carcinoma (HCC) treated with atezolizumab plus bevacizumab. The results showed that treatment-related hypertension was associated with good outcomes in these patients.
Article
Gastroenterology & Hepatology
Toshifumi Tada, Takashi Kumada, Atsushi Hiraoka, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Fujimasa Tada, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Hisashi Kosaka, Atsushi Naganuma, Tomomitsu Matono, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa
Summary: This study aimed to compare the outcomes of patients with unresectable hepatocellular carcinoma (HCC) who received atezolizumab plus bevacizumab (Atezo/Bev) as either first- or later-line systemic therapy. The results showed that the median progression-free survival time was 7.7 months in the first-line group and 6.2 months in the later-line group. Hypertension of any grade was more common in the first-line group. The analysis adjusted by inverse probability weighting revealed that the later-line group was significantly associated with progression-free survival.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Mamun Al Mahtab, Sheikh Mohammad Fazle Akbar, Julio Cesar Aguilar, Osamu Yoshida, Sakirul Khan, Guillen Nieto Gerardo, Yoichi Hiasa
Summary: This study conducted a clinical trial on a therapeutic vaccine for chronic hepatitis B (CHB) patients. The vaccine showed excellent safety and antiviral potential 5 years after treatment, reducing viral load and protecting the liver. The results of the study demonstrate long-term efficacy of the vaccine for CHB patients.
FRONTIERS IN MEDICINE
(2023)
Article
Clinical Neurology
Takahiro Ushida, Yoichi Katayama, Yoichi Hiasa, Makoto Nishihara, Fumihiro Tajima, Shinsuke Katoh, Hirotaka Tanaka, Takeshi Maeda, Kazunari Furusawa, Yoshihiro Kakehi, Kunika Kikumori, Masanori Kuroha
Summary: The study aimed to confirm the safety and efficacy of mirogabalin in patients with Parkinson's disease and central post-stroke pain, and obtain long-term data for central neuropathic pain. The results showed that mirogabalin demonstrated good safety and efficacy in treating central neuropathic pain.
Article
Gastroenterology & Hepatology
Toshifumi Tada, Takashi Kumada, Atsushi Hiraoka, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Fujimasa Tada, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Hisashi Kosaka, Atsushi Naganuma, Tomomitsu Matono, Tomoko Aoki, Hidekatsu Kuroda, Yutaka Yata, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Masatoshi Kudo
Summary: This study compared the outcomes of patients with intermediate-stage hepatocellular carcinoma (HCC) who received atezolizumab plus bevacizumab (Atezo/Bev) or lenvatinib (LEN) as first-line systemic therapy. The results showed that Atezo/Bev group had longer median progression-free survival (PFS) compared to LEN group, and Atezo/Bev group demonstrated better efficacy in patients with HCC beyond the up-to-seven criteria.
LIVER INTERNATIONAL
(2023)
Article
Immunology
Kana Shiraishi, Osamu Yoshida, Yusuke Imai, Sheikh Mohammad Fazle Akbar, Takahiro Sanada, Michinori Kohara, Takashi Miyazaki, Taizou Kamishita, Teruki Miyake, Masashi Hirooka, Yoshio Tokumoto, Masanori Abe, Julio Cesar Aguilar Rubido, Gerardo Guillen Nieto, Yoichi Hiasa
Summary: This study found that CVP-NASVAC has prophylactic capacity for HB vaccine non-responders. After administration of CVP-NASVAC, patients were able to produce antibodies, and the neutralizing activity in sera was also confirmed. In addition, CVP-NASVAC also induced the generation of specific cytotoxic T lymphocytes.
Article
Oncology
Takeshi Hatanaka, Satoru Kakizaki, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Keisuke Yokohama, Hiroki Nishikawa, Takashi Nishimura, Noritomo Shimada, Kazuhito Kawata, Hisashi Kosaka, Atsushi Naganuma, Yutaka Yata, Hideko Ohama, Hidekatsu Kuroda, Kazunari Tanaka, Takaaki Tanaka, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Masatoshi Kudo, Takashi Kumada
Summary: This retrospective study compared the impact of atezolizumab plus bevacizumab (Atez/Bev) and lenvatinib (LEN) on liver function in patients with hepatocellular carcinoma. The results showed that there was no significant difference in the trend of liver function deterioration between the Atez/Bev and LEN groups. However, caution should be exercised for LEN-treated patients with BCLC advanced stage or those receiving the full dose of LEN.
Article
Oncology
Hideko Ohama, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Tomomitsu Matono, Hiroshi Shibata, Tomoko Aoki, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Masatoshi Kudo, Takashi Kumada
Summary: This retrospective study found no significant differences in terms of progression-free survival (PFS) or overall survival (OS) between CP-B patients treated with Atez/Bev or LEN as initial systemic treatment for uHCC.
Meeting Abstract
Gastroenterology & Hepatology
Yuki Tahata, Hayato Hikita, Satoshi Mochida, Nobuyuki Enomoto, Akio Ido, Hidekatsu Kuroda, Daiki Miki, Masayuki Kurosaki, Yoichi Hiasa, Ryotaro Sakamori, Norifumi Kawada, Taro Yamashita, Goki Suda, Hiroshi Yatsuhashi, Hitoshi Yoshiji, Naoya Kato, Taro Takami, Kazuhiko Nakao, Kentaro Matsuura, Yasuhiro Asahina, Yoshito Itoh, Ryosuke Tateishi, Yasunari Nakamoto, Eiji Kakazu, Shuji Terai, Masahito Shimizu, Yoshiyuki Ueno, Norio Akuta, Takahiro Kodama, Tomohide Tatsumi, Tomomi Yamada, Tetsuo Takehara
JOURNAL OF HEPATOLOGY
(2023)