Article
Cell Biology
Yong-Xing Du, Ying Zhou, Xiao-Hao Zheng, Yun-Jie Duan, Zong-Ting Gu, Ye-Feng Yin, Cheng-Feng Wang
Summary: This study investigated the subcellular localization and expression of NOP14 in pancreatic cancer, and confirmed its role in promoting cell proliferation. It also identified miR17-5p as a downstream target of NOP14 and found that NOP14 activated a set of genes through E2F4 to promote tumor proliferation.
Article
Oncology
Yang Yao, Chao Liu, Bojun Wang, Xin Guan, Lin Fang, Fei Zhan, Haoxiu Sun, Hengzhen Li, Changjie Lou, Feihu Yan, Xiaolin Lu, Luying Cui, Yuanyu Liao, Shuling Han, Yuanfei Yao, Yanqiao Zhang
Summary: In pancreatic cancer, the expression of HOXB9 is down-regulated, while higher expression of HOXB9 is associated with higher survival rates. Over-expression of HOXB9 inhibits pancreatic cancer cell proliferation by regulating RBL2 and cMyc to block cell cycle progression. DNMT1 in pancreatic cancer inhibits the expression of HOXB9 through methylation of its promoter.
Article
Biochemistry & Molecular Biology
Zhou-Tong Dai, Yuan Xiang, Yuan-yuan Duan, Jun Wang, Jia Peng Li, Hui-Min Zhang, Chao Cheng, Qiong Wang, Tong-Cun Zhang, Xing-Hua Liao
Summary: This study preliminarily explored the mechanism of miR-17/MKL-1 in gastric cancer stem cells, and verified the role of miR-17-5p and MKL-1 in promoting stem cell-like properties of gastric cancer through experiments. It was found that MKL-1 promotes expression by targeting miR-17, CD44 and EpCAM promoters, providing new insights for potential early diagnosis and/or molecular therapy of gastric cancer stem cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Hongzhang Shen, Fuqiang Ye, Dongchao Xu, Liangliang Fang, Xiaofeng Zhang, Juanjuan Zhu
Summary: In this study, we found that the expression of MYEOV gene is associated with poor survival in patients with pancreatic ductal adenocarcinoma (PDAC) and is higher in carcinoma tissues. Elevated levels of MYEOV promote cell proliferation, invasion and migration. Further analysis revealed that MYEOV regulates the expression levels of miR-17-5p and miR-93-5p, and its association with MYC contributes to the progression of PDAC.
CELL DEATH & DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Sijun Liu, Ge Tang, Fengqi Duan, Cheng Zeng, Jianfeng Gong, Yanming Chen, Hongmei Tan
Summary: The study demonstrated that miR-17-5p improves glucose tolerance and pancreatic beta-cell function in diabetic mice, while inhibiting pyroptosis mediated by the TXNIP and NLRP3 inflammasome pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yangyang Xia, Shouzhen Chen, Jianfeng Cui, Yong Wang, Xiaochen Liu, Yangli Shen, Li Gong, Xuewen Jiang, Wenfu Wang, Yaofeng Zhu, Shuna Sun, Jiangxia Li, Yongxin Zou, Benkang Shi
Summary: Hyperactivation of STAT3 is closely related to cancer progression, and BBR has been shown to have anti-tumor effects on BCa cells by inhibiting JAK1-STAT3 signaling through upregulation of miR-17-5p, which may serve as a potential therapeutic option for BCa treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Daniel Sur, Loredana Balacescu, Simona S. Cainap, Simona Visan, Laura Pop, Claudia Burz, Andrei Havasi, Rares Buiga, Calin Cainap, Alexandru Irimie, Ovidiu Balacescu
Summary: The study focused on investigating miRNAs in colorectal cancer patients, finding that elevated levels of miR-17-5p and miR-185-5p in plasma may predict treatment response, while overexpression of miR-125b-5p in plasma exosomes may be correlated with a more aggressive CRC phenotype.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mengyan Wang, Mingna Zhao, Qiaomei Guo, Jiatao Lou, Lin Wang
Summary: The study revealed that miR-17-5p promotes osteoclastogenesis in lung cancer through the PI3K/Akt pathway and has negative regulatory effects on PTEN.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Xiaojun Wang, Jiayi Han, Yatian Liu, Jingwen Hu, Ming Li, Xi Chen, Lin Xu
Summary: The study identified that miR-17-5p and miR-4443 are upregulated in ESCC tissues and promote tumor progression by regulating the TIMP2 gene. These two miRNAs may serve as novel molecular targets for ESCC treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shan Li, Qian Zhang, Wen Liu, Chunbo Zhao
Summary: FTX was found to be upregulated in pancreatic cancer cell lines, and silencing FTX led to a decrease in invasion ability and cell viability. Additionally, FTX was shown to bind to miR-513b-5p, promoting invasion and proliferation of pancreatic cancer cells. Knockdown of FTX inhibited tumor growth and increased the expression of miR-513b-5p and apoptosis-related proteins in vivo.
Article
Multidisciplinary Sciences
Hallgeir Selven, Sigve Andersen, Mona Pedersen, Ana Paola Giometti Lombardi, Lill-Tove Rasmussen Busund, Thomas Karsten Kilvaer
Summary: This study investigated the prognostic impact of miR-17-5p and miR-20a-5p in colon cancer. The results showed that high expression of both miR-17-5p and miR-20a-5p is associated with a favorable prognosis and inhibits cell migration.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Xu Liu, Qingqing Wu, Jingwen Wu, Jianxi Liu, Fuli Zheng, Guangxia Yu, Hong Hu, Zhenkun Guo, Siying Wu, Huangyuan Li, Wenya Shao
Summary: Exosomes released from microglia carry circZNRF1, which can reverse the neuronal apoptosis induced by paraquat (PQ) exposure and protect against PQ-induced neuronal degeneration. This discovery offers a novel approach for preventing and treating Parkinson's disease (PD).
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Oncology
Lijie Yang, Tiecheng Yang, Huaqiao Wang, Tingting Dou, Xiaochang Fang, Liwen Shi, Xuanfei Li, Maohui Feng
Summary: This study explores the molecular mechanism of long non-coding RNAs as competing endogenous RNAs in colon cancer. By constructing ceRNA networks and a prognostic risk model, this study identifies DNMBP-AS1 as a potential therapeutic target for colon cancer progression through the miR-93-5p/17-5p/NHLRC3 axis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xuan Ma, Tian Fu, Zhi-Yin Ke, Shen-Lin Du, Xue-Chun Wang, Ning Zhou, Mu-Yi Zhong, Yong-Jun Liu, Ai-Ling Liang
Summary: The study aimed to investigate the regulatory roles of the miR-17-5p/RRM2 axis in gemcitabine resistance in A549/G+ cells. Cell viability was assessed using CCK8 and clonogenic assays. Gene expression levels were analyzed by RT-qPCR and Western blotting. Cell cycle analysis was performed using flow cytometry. The results showed that up-regulating miR-17-5p expression reduced drug resistance and altered cell cycle distribution in gemcitabine-resistant cells. Down-regulating miR-17-5p had the opposite effects in gemcitabine-sensitive cells. The miR-17-5p/RRM2 axis could potentially regulate gemcitabine resistance in A549 cells through the p-PTEN/PI3K/AKT signaling pathway.
Article
Immunology
Chengzhi Wang, Xin Li, Lijuan Zhang, Ying Chen, Ruijie Dong, Jieyou Zhang, Jingyi Zhao, Xiangdong Guo, Guangze Yang, Yan Li, Chao Gu, Qing Xi, Rongxin Zhang
Summary: High expression of miR-194-5p in pancreatic cancer patients is associated with a better survival rate and inhibits the expression of PD-L1. Overexpression of miR-194-5p suppresses the progression of pancreatic cancer, promotes the infiltration of CD8+ T cells in tumor immune microenvironments, and enhances IFN-gamma production of CD8+ T cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Weishen Wang, Ziyun Shen, Jun Zhang, Hao Chen, Xiaxing Deng, Chenghong Peng, Junjie Xie, Zhiwei Xu, Baiyong Shen
Summary: The study found that examining a minimum of 19 lymph nodes is crucial for ensuring quality lymph node detection and long-term survival in patients undergoing distal pancreatectomy for pancreatic ductal adenocarcinoma. The ideal cut-off value for lymph node examination was identified using Kaplan-Meier survival analysis and X-tile software.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Jiabin Jin, Shih-min Yin, Yuanchi Weng, Mengmin Chen, Yusheng Shi, Xiayang Ying, Georgios Gemenetzis, Kai Qin, Jun Zhang, Xiaxing Deng, Chenghong Peng, Baiyong Shen
Summary: This study compared the outcomes of venous resection and reconstruction (VR) in robotic-assisted and open pancreaticoduodenectomy (OPD) in patients with pancreatic ductal adenocarcinoma (PDAC). The results showed similar reconstructed venous patency, postoperative complications, and 90-day mortality between the two groups, but the robotic group had a lower lymph node resection rate.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Multidisciplinary Sciences
Xiaolong Ma, Xuan Cao, Linying Zhu, Ying Li, Xuelong Wang, Baihua Wu, Gang Wei, Lijian Hui
Summary: Cell plasticity, the ability for cells to be reprogrammed, is determined by intrinsic epigenetic attributes such as chromatin organization. Researchers discovered a unique chromatin unit called contiguous compartment-switchable regions (CSRs), which play a crucial role in cell identity conversion. Specifically, CSRs with a switch from compartment B to A had a mosaic status of inactive chromatin and pre-existing accessibility, and this attribute facilitated the binding of inducible factor Foxa3, leading to epigenetic activation and gene expression. This chromatin organization was found in various cell types and involved in multiple reprogramming processes, highlighting the importance of understanding intrinsic chromatin attributes in cell plasticity.
NATIONAL SCIENCE REVIEW
(2022)
Article
Cell Biology
Bishu Zhang, Jiewei Lin, Jiaqiang Zhang, Xuelong Wang, Xiaxing Deng
Summary: This study explored chromatin accessibility and transcription changes in 5-FU resistant colon cancer cells, identifying differentially expressed mRNAs, lncRNAs, and miRNAs related to 5-FU resistance, as well as differentially accessible regions positively correlated with gene expression changes. This analysis identified potential therapeutic targets and regulatory elements associated with 5-FU resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Yihao Liu, Xuelong Wang, Youwei Zhu, Yizhi Cao, Liwen Wang, Fanlu Li, Yu Zhang, Ying Li, Zhiqiang Zhang, Jiaxin Luo, Xiaxing Deng, Chenghong Peng, Gang Wei, Hao Chen, Baiyong Shen
Summary: This study revealed a novel epigenetic regulation mechanism in promoting pro-tumour M2-polarised TAMs in the pancreatic ductal adenocarcinoma (PDAC) tumour microenvironment.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Lingxi Jiang, Xia Wang, Fangfang Ma, Xuelong Wang, Minmin Shi, Qian Yan, Ming Liu, Juan Chen, Chaoran Shi, Xin-yuan Guan
Summary: This study discovered that PITX2C is a newly discovered transcription factor involved in hepatic differentiation and could increase HCC stemness by upregulating key transcriptional factors related to liver development. The expression of PITX2C is associated with tumor size, overall survival rate, AFP, and differentiation in clinical patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Xuelong Wang, Jizhou Yan, Zhao Ye, Zhiqiang Zhang, Sheng Wang, Shuang Hao, Baiyong Shen, Gang Wei
Summary: This study revealed the close connection between 3D genome reorganization, chromatin accessibility, and gene transcription in doxorubicin-resistant breast cancer, providing new insights into the epigenomic mechanisms of doxorubicin resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Xuelong Wang, Huiping Guo, Feifei Yu, Hui Zhang, Ying Peng, Chenghui Wang, Gang Wei, Jizhou Yan
Summary: The study observed cellular remodeling and chromatin remodeling in zebrafish hearts after resection of the ventricular apex, leading to myocardial recovery and tissue regeneration. The interaction of Krt5 with cytoskeleton and BMP4 plays a crucial role in angiogenesis and muscle regeneration.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Lili Wang, Yiling Lai, Jingjing Chen, Xuan Cao, Weilu Zheng, Ling Dong, Yitong Zheng, Fang Li, Gang Wei, Sibao Wang
Summary: In this study, it was discovered that the histone lysine methyltransferase ASH1 in the insecticidal fungus Metarhizium robertsii regulates appressorium turgor generation and cuticle penetration by activating the peroxin gene Mrpex16. The ASH1-PEX16 pathway plays a pivotal role in regulating peroxisome biogenesis and lipolysis, providing insights into the molecular mechanisms underlying fungal pathogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Microbiology
Xuan Cao, Yuhao Wen, Ying Li, Xuying Ma, Qingqing Jing, Lubin Jiang, Gang Wei
Summary: By analyzing the genome structure of Plasmodium falciparum, it has been found that PfSET2 is crucial for the 3D organization of heterochromatin, which keeps var genes in a transcription repressive state. These findings contribute to a better understanding of the regulation of high-order chromatin structure in P. falciparum.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Yuwen Zhang, Xuan Cao, Zehua Gao, Xuying Ma, Qianfeng Wang, Xiaoxuan Xu, Xiumei Cai, Yan Zhang, Zhao Zhang, Gang Wei, Bo Wen
Summary: In this study, researchers discovered that the nuclear matrix protein MATR3 interacts with antisense LINE1 (AS L1) RNAs to form a meshwork through phase separation, which dynamically organizes chromatin spatially. MATR3 and AS L1 RNAs influence each other's nuclear localization. Depletion of MATR3 leads to redistribution of chromatin, particularly chromatin modified by H3K27me3. The meshwork formed by MATR3 and AS L1 RNAs plays a role in gathering chromatin in the nucleus.
Article
Biology
Ge Zhang, Ying Li, Gang Wei
Summary: Multi-omic analysis reveals dynamic changes in three-dimensional chromatin architecture during T helper cell differentiation. The differentiation process leads to widespread changes in transcriptional programs and remodeling of three-dimensional genome architecture. Using multiple assays, we identify alterations in chromatin organization and topologically associated domains during CD4(+) T cell differentiation into Th17 and Th1 cells. We also identify cell-type specific enhancer-promoter loops associated with functional genes in Th cells. Overall, these results provide insights into the epigenetic regulation of T helper cell differentiation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Meng Wang, Chenxing Ji, Yichao Zhang, Zhiqiang Zhang, Yu Zhang, Huiping Guo, Nidan Qiao, Xiang Zhou, Xiaoyun Cao, Zhen Ye, Yifei Yu, Vladimir Melnikov, Wei Gong, Min He, Zhaoyun Zhang, Yao Zhao, Xuelong Wang, Gang Wei, Zhao Ye
Summary: This study aimed to investigate the changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma (GHPA). Through RNA sequencing and ATAC-seq analysis, a series of differentially expressed genes and changes in chromatin accessible regions were identified.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.