Article
Engineering, Biomedical
Liang Qi, Han Han, Meng-Meng Han, Ying Sun, Lei Xing, Hu-Lin Jiang, Stephen J. Pandol, Ling Li
Summary: Pancreatic fibrosis is caused by excessive deposition of collagen in the pancreas, leading to an imbalance in extracellular matrix (ECM) homeostasis. The dual drug-loaded lipid nanoparticles AT-CC, which are decorated with collagen-binding peptide (CBP) and collagenase I, can target fibrotic pancreas and degrade excess collagen. This allows effective delivery of all-trans-retinoic acid (ATRA) and ammonium tetra-thiomolybdate (TM) into the pancreas, reducing collagen overproduction and collagen cross-linking to restore ECM homeostasis.
Article
Oncology
Ananya Chakraborty, Bithika Halder, Souravi Mondal, Amanda Barrett, Wenbo Zhi, Gabor Csanyi, E. Sabbatini
Summary: Patients with chronic pancreatitis (CP) have a higher risk of pancreatic ductal adenocarcinoma (PDAC). Activated pancreatic stellate cells (PaSCs) in CP contribute to the progression of non-invasive pancreatic intraepithelial neoplasia (PanIN) lesions to invasive PDAC. In this study, we found that NADPH oxidase 1 (Nox1) in activated PaSCs from a mouse model of CP promotes the growth of pancreatic cancer cells by up-regulating Twist1/MMP-9 expression and causing changes in the extracellular matrix composition. Inhibiting Nox1 signaling in activated PaSCs can ameliorate the progression of PDAC in patients with CP.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Ananya Chakraborty, Bithika Halder, Souravi Mondal, Amanda Barrett, Wenbo Zhi, Gabor Csanyi, Maria E. Sabbatini
Summary: Patients with chronic pancreatitis (CP) are at higher risk of pancreatic ductal adenocarcinoma (PDAC) compared to the general population. Activated pancreatic stellate cells (PaSCs) in CP play a role in the progression of non-invasive pancreatic intraepithelial neoplasia (PanIN) to invasive PDAC. In this study, we investigated the role of NADPH oxidase 1 (Nox1) in CP-activated PaSCs and found that Nox1 enhances the growth and invasion of pancreatic cancer cells through Twist1/MMP-9 expression and changes in the extracellular matrix composition. Blocking Nox1 signaling in CP-activated PaSCs can potentially reduce extracellular matrix reorganization and protect neoplastic cells from cellular stresses, thereby ameliorating the progression of PDAC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Min Kyung Kang, Fen Jiang, Ye Ji Kim, Kyoungjin Ryu, Atsushi Masamune, Shin Hamada, Yun-Yong Park, Sang Seok Koh
Summary: CTHRC1, a protein highly expressed in tumors, is predominantly secreted by cancer stroma in pancreatic cancer. It activates pancreatic stellate cells (PSCs) to remodel the cancer extracellular matrix (ECM) and has stronger pro-tumoral effects through PSC activation than through autocrine action. This study unveils PSC activation as the central mechanism underlying the pro-tumoral effects of CTHRC1 and suggests its potential as a therapeutic target for pancreatic cancer.
Article
Veterinary Sciences
Eva Monleon, Oscar Lucia, Antonio Guemes, Borja Lopez-Alonso, Dolores Arribas, Hector Sarnago, Alba Hernaez, Jose Miguel Burdio, Concepcion Junquera
Summary: IRE is a method of non-thermal tissue ablation that irreversibly permeabilizes cell membranes while preserving the extracellular matrix. This study investigated tissue remodeling after IRE in a porcine model and found that IRE led to necrosis followed by reparative tissue formation, characterized by the proliferation of myofibroblast-like cells and reorganization of the extracellular matrix. The events observed in this study suggest that IRE can be used as a model to study liver regeneration after acute injury.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Oncology
Rohit Sarkar, Zhihong Xu, Chamini J. Perera, Minoti Apte
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterized by a collagenous stromal reaction/desmoplasia surrounding tumor cells. Pancreatic stellate cells (PSCs) produce this stroma and promote PDAC progression. Recently, extracellular vesicles (EVs), particularly small extracellular vesicles (exosomes), have gained attention for their roles in cancer progression and diagnosis. This review provides an overview of PDAC, PSCs, their interactions with cancer cells, and the known role of PSC-derived EVs in PDAC progression.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Cell Biology
Daniela Vega-Mendoza, Alicia Canas-Linares, Angel Flores-Alcantar, Roberto Espinosa-Neira, Erika Melchy-Perez, Rosario Vera-Estrella, Constance Auvynet, Yvonne Rosenstein
Summary: The aberrant expression of CD43 in nonhematopoietic malignant tumors has been shown to correlate with poor prognosis, promoting tumor development by enhancing motility, growth, and protection against cell lysis. In lung cancer, CD43 plays a significant role in remodeling the tumor microenvironment through the secretion of specific molecules.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aiting Yang, Xuzhen Yan, Hufeng Xu, Xu Fan, Mengyang Zhang, Tao Huang, Weiyu Li, Wei Chen, Jidong Jia, Hong You
Summary: The deficiency of HSCs-specific Loxl1 can prevent CCl4-induced hepatic fibrosis and reduce fibrosis and inflammation in liver tissue, with ITGA8/FAK/PI3K/AKT/HIF1a being essential for the function and expression of LOXL1. The study suggests novel mechanisms and potential targets for the treatment of fibrosis in the future.
Article
Engineering, Biomedical
Pengkai Wu, Xinping Luo, Meiling Sun, Beicheng Sun, Minjie Sun
Summary: A versatile nanocomplex was developed that improved liver fibrosis therapy by overcoming biological barriers and co-regulating Kupffer cells, extracellular matrix, and hepatic stellate cells.
Review
Oncology
Zoi Piperigkou, Konstantina Kyriakopoulou, Christos Koutsakis, Stylianos Mastronikolis, Nikos K. Karamanos
Summary: Proteolytic enzymes and non-proteolytic enzymatic partners play crucial roles in cancer cell propagation and metastatic potential. This article revisits the functions of major matrix remodeling molecules and discusses their epigenetic regulation mechanisms, pharmacological targeting, and ongoing clinical trials. The importance of targeting matrix remodeling partners for cancer management is explored in relation to tissue homeostasis and ECM turnover.
Review
Cell Biology
Zhilin Zhang, Huan Zhang, Tian Liu, Tian Chen, Daorong Wang, Dong Tang
Summary: Pancreatic cancer is associated with strong therapeutic resistance and poor prognosis, with activated pancreatic stellate cells (PSC) playing a crucial role in the malignant progression. By analyzing PSC population heterogeneity, researchers have identified two subtypes - myofibroblastic and inflammatory PSC - that cooperate to create a microenvironment suitable for cancer cell survival, potentially offering more effective treatment options for pancreatic cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Victor Alfonso Solarte David, Viviana Raquel Guiza-Argueello, Martha L. Arango-Rodriguez, Claudia L. Sossa, Silvia M. Becerra-Bayona
Summary: The absence or damage of tissue is a major cause of diseases, and novel therapeutic alternatives aim to recover lost functions through tissue regeneration. Chronic cutaneous lesions are common wounds that require regenerative medicine and tissue engineering interventions to develop bioactive medical products for proper healing and prevention of complications. The coordination of cells, extracellular matrix (ECM), and biomolecules is crucial in tissue repair and regeneration, with ECM acting as a biological platform for their interactions. Tissue engineering utilizes synthetic polymers and decellularized tissues to mimic native ECM and provide necessary functionalities for cell differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell & Tissue Engineering
Pradyut K. Paul, Rahul Das, Travis J. Drow, Arnaldo H. de Souza, Appakalai N. Balamurugan, Dawn Belt Davis, Jacques Galipeau
Summary: Culture-adapted porcine pancreatic stellate cells (PSCs) have cytoprotective effects and can prolong the viability and function of islets through intercellular communication. These findings contribute to the development of ex vivo diabetes modeling and suggest that a combined islet-PSC tissue engineered implant may significantly improve islet transplantation outcome.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Hongjun Xiao, Yezhen Zhang, Zhaofeng Li, Bin Liu, Dan Cui, Fan Liu, Dafan Chen, Yingfu Liu, Gaoliang Ouyang
Summary: Periostin plays a critical role in the pathogenesis of liver disorders and the development of HCC. This study demonstrates that HSC-derived periostin promotes HCC development by enhancing HSC activation through multiple pathways and by augmenting HCC cell proliferation via the ERK pathway.
JOURNAL OF PATHOLOGY
(2021)
Review
Oncology
Zhengfeng Wang, Ru He, Shi Dong, Wence Zhou
Summary: Pancreatic cancer is a highly malignant gastrointestinal carcinoma with late detection, high mortality rates, poor patient prognosis, and a lack of effective treatments. Pancreatic stellate cells, a significant component of the tumor microenvironment, play a crucial role in modulating this environment and promoting cancer progression. This paper reviews the mechanisms by which pancreatic stellate cells inhibit antitumor immune responses and discusses preclinical studies focusing on these cells, aiming to provide theoretical references for the development of new therapeutic approaches for pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biology
Hodaka Numasaki, Teruki Teshima, Tetsuo Nishimura, Keizo Akuta, Yutaka Ando, Hiroshi Ikeda, Norihiko Kamikonya, Masahiko Koizumi, Tomonari Sasaki, Kenji Sekiguchi, Masao Tago, Atsuro Terahara, Katsumasa Nakamura, Masamichi Nishio, Masao Murakami, Yoshimasa Mori, Kazuhiko Ogawa
JOURNAL OF RADIATION RESEARCH
(2019)
Article
Oncology
Masayoshi Tasaki, Mitsuharu Ueda, Yoshinobu Hoshii, Mayumi Mizukami, Sayaka Matsumoto, Makoto Nakamura, Taro Yamashita, Akihiko Ueda, Yohei Misumi, Teruaki Masuda, Yasuteru Inoue, Tessei Torikai, Toshiya Nomura, Yukimoto Tsuda, Kyosuke Kanenawa, Aito Isoguchi, Masamitsu Okada, Hirotaka Matsui, Konen Obayashi, Yukio Ando
JOURNAL OF PATHOLOGY
(2019)
Article
Gastroenterology & Hepatology
Toshiya Abe, Chiho Koi, Shiro Kohi, Ki-Byung Song, Koji Tamura, Anne Macgregor-Das, Naoki Kitaoka, Miguel Chuidian, Madeline Ford, Mohamad Dbouk, Michael Borges, Jin He, Richard Burkhart, Christopher L. Wolfgang, Alison P. Klein, James R. Eshleman, Ralph H. Hruban, Marcia Irene Canto, Michael Goggins
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Pathology
Anne Macgregor-Das, Jun Yu, Koji Tamura, Toshiya Abe, Masaya Suenaga, Koji Shindo, Michael Borges, Chiho Koi, Shiro Kohi, Yoshihiko Sadakari, Marco Dal Molin, Jose A. Almario, Madeline Ford, Miguel Chuidian, Richard Burkhart, Jin He, Ralph H. Hruban, James R. Eshleman, Alison P. Klein, Christopher L. Wolfgang, Marcia I. Canto, Michael Goggins
JOURNAL OF MOLECULAR DIAGNOSTICS
(2020)
Article
Education & Educational Research
Tatsuya Manabe, Mitsuhiro Takasaki, Takao Ide, Kenji Kitahara, Seiji Sato, Seiji Yunotani, Yoshimi Hirohashi, Akihiro Iyama, Masahiko Taniguchi, Toshiro Ogata, Shuji Shimizu, Hirokazu Noshiro
BMC MEDICAL EDUCATION
(2020)
Article
Biochemistry & Molecular Biology
Christian Dubiella, Benika J. Pinch, Kazuhiro Koikawa, Daniel Zaidman, Evon Poon, Theresa D. Manz, Behnam Nabet, Shuning He, Efrat Resnick, Adi Rogel, Ellen M. Langer, Colin J. Daniel, Hyuk-Soo Seo, Ying Chen, Guillaume Adelmant, Shabnam Sharifzadeh, Scott B. Ficarro, Yann Jamin, Barbara Martins da Costa, Mark W. Zimmerman, Xiaolan Lian, Shin Kibe, Shingo Kozono, Zainab M. Doctor, Christopher M. Browne, Annan Yang, Liat Stoler-Barak, Richa B. Shah, Nicholas E. Vangos, Ezekiel A. Geffken, Roni Oren, Eriko Koide, Samuel Sidi, Ziv Shulman, Chu Wang, Jarrod A. Marto, Sirano Dhe-Paganon, Thomas Look, Xiao Zhen Zhou, Kun Ping Lu, Rosalie C. Sears, Louis Chesler, Nathanael S. Gray, Nir London
Summary: Through screening an electrophilic fragment library, a highly selective and effective Pin1 inhibitor named Sulfopin was developed, showing promising anti-tumor activity by downregulating c-Myc target genes, slowing tumor progression, and improving survival rates in murine models of neuroblastoma and pancreatic cancer.
NATURE CHEMICAL BIOLOGY
(2021)
Review
Neurosciences
Nami Kim, Bin Wang, Kazuhiro Koikawa, Yutaka Nezu, Chenxi Qiu, Tae Ho Lee, Xiao Zhen Zhou
Summary: It has been shown that death-associated protein kinase 1 (DAPK1) plays a critical role in regulating the induction of cis phosphorylated form of tau protein (cis P-tau) after traumatic brain injury (TBI). DAPK1 mediates cis P-tau induction through phosphorylation of Pin1 at Ser71. Genetic deletion of DAPK1 reduces cis Ptau expression, attenuates neuropathology development, and rescues behavioral impairments after TBI.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Oncology
Chika Iwamoto, Kenoki Ohuchida, Tomohiko Shinkawa, Sho Okuda, Yoshiki Otsubo, Takashi Okumura, Akiko Sagara, Kazuhiro Koikawa, Yohei Ando, Koji Shindo, Naoki Ikenaga, Kohei Nakata, Taiki Moriyama, Yoshihiro Miyasaka, Takao Ohtsuka, Masatoshi Eto, Koichi Akashi, Masafumi Nakamura
Summary: This study found that in PDAC, macrophages derived from bone marrow can partially convert into CAF-like cells, acting as a specific subtype that promotes pancreatic cancer growth and invasion. This conversion may represent a novel therapeutic strategy.
Article
Biochemistry & Molecular Biology
Kazuhiro Koikawa, Shin Kibe, Futoshi Suizu, Nobufumi Sekino, Nami Kim, Theresa D. Manz, Benika J. Pinch, Dipikaa Akshinthala, Ana Verma, Giorgio Gaglia, Yutaka Nezu, Shizhong Ke, Chenxi Qiu, Kenoki Ohuchida, Yoshinao Oda, Tae Ho Lee, Babara Wegiel, John G. Clohessy, Nir London, Sandro Santagata, Gerburg M. Wulf, Manuel Hidalgo, Senthil K. Muthuswamy, Masafumi Nakamura, Nathanael S. Gray, Xiao Zhen Zhou, Kun Ping Lu
Summary: Upregulation of Pin1 in PDAC contributes to the desmoplastic and immunosuppressive TME, but targeting Pin1 with available drugs can synergize with immunotherapy and gemcitabine to induce complete elimination of PDAC.
Article
Surgery
Chikanori Tsutsumi, Toshiya Abe, Hirotaka Kuga, So Nakamura, Kazuyoshi Nishihara, Sadafumi Tamiya, Toru Nakano
Summary: A 50-year-old woman was diagnosed with gallbladder ciliated foregut cysts (CFCs) after a gallbladder tumor was detected using abdominal ultrasonography. Despite suspicion of malignancy preoperatively, a rapid intraoperative pathological diagnosis confirmed no malignancy, leading to a final pathological diagnosis of CFC without malignancy. Treatment involved open whole layer cholecystectomy.
CASE REPORTS IN SURGERY
(2021)
Article
Oncology
Toshiro Ogata, Yoshihiko Sadakari, Hiroyuki Nakane, Kazuhiro Koikawa, Hiroki Kanno, Ryo Kohata, Kayoko Endo, Takao Tsukahara, Koichiro Shimonaga, Kazuhisa Kaneshiro, Gentaro Hirokata, Takeshi Aoyagi, Chiyo Tsutsumi, Masahiko Taniguchi
Summary: This study aimed to investigate whether the 5-mFI predicted long-term survival and cause of death in elderly patients who underwent CRC surgery and to determine the risk factors for mortality. The results showed that the 5-mFI score was associated with short- and long-term outcomes and risk factors for mortality unrelated to CRC. Additionally, the 5-mFI score was negatively associated with long-term survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Orthopedics
Sayuri Hayashida, Naoki Ikenaga, Kohei Nakata, So Nakamura, Toshiya Abe, Noboru Ideno, Makoto Endo, Shoko Noguchi, Yoshinao Oda, Masafumi Nakamura
Summary: A case report of a patient with extraskeletal mesenchymal chondrosarcoma undergoing multiple robotic pancreatectomies for recurrent pancreatic metastasis, achieving successful outcomes.
ASIAN JOURNAL OF ENDOSCOPIC SURGERY
(2023)
Article
Surgery
Chikanori Tsutsumi, Toshiya Abe, Tomohiko Shinkawa, Hideyuki Watanabe, Kazuyoshi Nishihara, Toru Nakano
SURGICAL CASE REPORTS
(2020)
Article
Surgery
Chikanori Tsutsumi, Toshiya Abe, Yusuke Sawatsubashi, Sadafumi Tamiya, Daisuke Kakihara, Kazuyoshi Nishihara, Toru Nakano
SURGICAL CASE REPORTS
(2020)
Article
Surgery
Chikanori Tsutsumi, Toshiya Abe, Tomohiko Shinkawa, Kazuyoshi Nishihara, Sadafumi Tamiya, Toru Nakano
SURGICAL CASE REPORTS
(2020)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
