Article
Medicine, Research & Experimental
Sebastian A. Wohlfeil, Verena Haefele, Bianca Dietsch, Celine Weller, Carsten Sticht, Anna Sophia Jauch, Manuel Winkler, Christian David Schmid, Anna Lena Irkens, Ana Olsavszky, Kai Schledzewski, Philipp-Sebastian Reiners-Koch, Sergij Goerdt, Cyrill Geraud
Summary: This study investigates the efficiency and vascularization patterns of different mouse melanoma cell lines in liver metastasis. The highly and moderately metastatic melanomas are associated with gene clusters involved in cell migration and angiogenesis. Sorafenib shows a strong inhibitory effect on vascularization in liver metastasis of melanoma.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Filipa Lopes-Coelho, Filipa Martins, Sofia A. Pereira, Jacinta Serpa
Summary: Anti-angiogenic therapy aims to fight cancer by disrupting the nutrient and oxygen supply to tumor cells, mainly by targeting vascular endothelial growth factor (VEGF). While some drugs in this category can enhance immune therapy, they often fall short in terms of efficacy. Researchers believe that targeting alternative angiogenic pathways in combination could be a promising solution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Qian Shen, Xue Pan, Yi Li, Junchen Li, Chuanlong Zhang, Xiaochen Jiang, Fudong Liu, Bo Pang
Summary: Curcumin, a natural active ingredient from traditional Chinese medicine (TCM), has multi-target characteristics and extensive pharmacological activities. It has been applied in the treatment of various diseases such as cancer, cardiovascular diseases, nervous system, and autoimmune disorders. Curcumin can modulate lysosomal function through different pathways, affecting tumor proliferation, invasion, metastasis, drug resistance, and immune function. This review provides a reference for the clinical application of curcumin and anti-tumor research targeting lysosomes.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour, Nikolay V. Dokholyan
Summary: The low efficiency of cancer treatment strategies is a major obstacle in developing cancer inhibitors. Peptidomimetics, a new class of agents, have been introduced to overcome the limitations of peptides and have shown effectiveness in inhibiting metastasis, angiogenesis, and cancerous cell growth.
MOLECULAR MEDICINE
(2022)
Review
Oncology
Chenming Zhong, Zijun Xie, Shiwei Duan
Summary: This article summarizes important predictive ncRNA biomarkers reported in cancer patients treated with different immunotherapeutic modalities including monoclonal antibodies, small molecule inhibitors, cancer vaccines, and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilization of immune-modulatory ncRNA biomarkers as predictive tools and therapeutic targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Pablo Fernandez-Tussy, Ruben Rodriguez-Agudo, David Fernandez-Ramos, Lucia Barbier-Torres, Imanol Zubiete-Franco, Sergio Lopez de Davalillo, Elisa Herraez, Naroa Goikoetxea-Usandizaga, Sofia Lachiondo-Ortega, Jorge Simon, Fernando Lopitz-Otsoa, Virginia Gutierrez-de Juan, Misti V. McCain, Maria J. Perugorria, Jon Mabe, Nicolas Navasa, Cecilia M. P. Rodrigues, Isabel Fabregat, Loreto Boix, Victor Sapena, Juan Anguita, Shelly C. Lu, Jose M. Mato, Jesus M. Banales, Erica Villa, Helen L. Reeves, Jordi Bruix, Maria Reig, Jose J. G. Marin, Teresa C. Delgado, Maria L. Martinez-Chantar
Summary: miR-518d-5p modulates sorafenib resistance in HCC through inhibition of c-Jun/PUMA-induced apoptosis, and circulating miR-518d-5p emerges as a potential biomarker for lack of response to sorafenib.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Luciana M. Gutierrez, Matias Valenzuela Alvarez, Yuanzheng Yang, Fiorella Spinelli, Maria Jose Cantero, Laura Alaniz, Mariana G. Garcia, Eugenie S. Kleinerman, Alejandro Correa, Marcela F. Bolontrade
Summary: Osteosarcoma metastatic cells gain in angiogenic-related pathways may relate more to a prosurvival switch than to an advantage feature for lung colonization. Despite higher adhesion and gain in angiogenesis pathways, metastatic cells do not display major angiogenic potential. Antiangiogenic treatments may affect cell survival rather than angiogenesis in OS cells with different metastatic potential.
Review
Pharmacology & Pharmacy
Nehad M. Ayoub, Sara K. Jaradat, Kamal M. Al-Shami, Amer E. Alkhalifa
Summary: Angiogenesis plays a vital role in the growth and spread of solid cancers, but breast cancer has shown poor response to anti-angiogenic drugs. Assessing the angiogenic signaling mechanisms in breast cancer, exploring new drug targets, and improving treatment outcomes through vascular normalization and nanotechnology are important areas of research.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Ji-Hak Jeong, Uttam Ojha, Hyeonha Jang, Soohyun Kang, Sunhee Lee, You Mie Lee
Summary: The study showed that Avastin, a protease inhibitor, suppresses tumor growth and metastasis, as well as inhibits tumor dissemination by regulating angiogenesis and normalizing tumor vasculature. Additionally, Avastin was found to have inhibitory effects on the VEGFR2/PI3K/AKT pathway in endothelial cells of tumor vasculature, and on the I kappa B alpha/NF Kappa B(p65)/MMP-9 pathway in cancer cells, thereby suppressing their migration ability. Moreover, Avastin was found to enhance the integrity of tumor vasculature, improving the drug delivery efficacy of cisplatin and synergistically increasing its anti-tumor activity.
Article
Materials Science, Ceramics
J. G. Santos, H. Lopes, H. Moreno, M. A. Ramirez, F. G. Garcia, A. Z. Simoes
Summary: In this study, NiFe2O4 nanoparticles were prepared using the polymeric precursor method with or without CTAB as a surfactant. The addition of CTAB significantly enhanced the magnetic properties of the nanoparticles and demonstrated anti-angiogenic activity in the study.
CERAMICS INTERNATIONAL
(2021)
Article
Cell Biology
Khuong T L Nguyen, Jhih-Yi Chiou, You-Chi Liu, Fang-Ju Cheng, Yi-Cheng Shen, Chao-Jung Chen, Chih-Hsin Tang, Wei-Chien Huang, Chia-Hung Chen, Chih-Yen Tu
Summary: In this study, it was found that lactic acid promotes resistance to PKC inhibitors by competing for uptake through transporters rather than activating its receptor, which explains the limited response of PKC inhibitors in clinical trials.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Cell Biology
Vanessa Innao, Vincenzo Rizzo, Andrea Gaetano Allegra, Caterina Musolino, Alessandro Allegra
Summary: Multiple myeloma cells acquire drug resistance through reprogramming their metabolic assessment via mitochondrial pathways. Some compounds, such as 2-methoxyestradiol and Artesunate, overcome resistance by increasing oxidative stress, while others restore efficacy through caspase-dependent tools. Each substance improves efficacy rates when used in combination with commonly used antimyeloma drugs.
Review
Medicine, Research & Experimental
Xuan Yan, Zhangyan Zhao, Haicheng Tang
Summary: Lung cancer, a high incidence and mortality malignant tumor in China, is a major cause of death and a significant public health problem. Anti-angiogenesis has become a crucial approach to inhibit tumor development by rebalancing pro- and anti-angiogenic factors. This article reviews the mechanism of blood vessel formation in tumor tissues, the action mechanism of different anti-angiogenic drugs, the combination therapy of anti-angiogenic drugs with other anti-tumor drugs, and the mechanism of anti-angiogenic drug resistance.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiu-Rong Ma, Jun-Jian Lu, Bo Huang, Xing-Yun Lu, Rong-Tao Li, Rui-Rong Ye
Summary: In this study, three heterometallic Ru(II)-Re(I) complexes were designed and synthesized. Cytotoxicity tests showed that these complexes exhibited high phototoxicities against multiple cancer cell lines, with RuRe2 showing the most significant increase in cytotoxicity against human prostate cancer cells under light irradiation. Mechanistic studies revealed that RuRe2-mediated photodynamic therapy induced tumor cell apoptosis and inhibited PC3 cell scratch healing, as well as the expression levels of MMP-2, MMP-9, and VEGFR2. Additionally, RuRe2 exhibited anti-angiogenic activities.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Zhen-Ling Liu, Huan-Huan Chen, Li-Li Zheng, Li-Ping Sun, Lei Shi
Summary: Angiogenesis is a complex process regulated by various molecules and plays a crucial role in tumor growth and metastasis. Targeted therapeutic research based on these molecules has led to the emergence of promising anti-angiogenic strategies in cancer therapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
T. A. Bogush, A. A. Basharina, E. A. Bogush, O. M. Ryabinina, A. S. Tjulandina, S. A. Tjulandin
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2018)
Article
Chemistry, Multidisciplinary
T. A. Bogush, I. A. Mamichev, S. A. Kaliuzhny, B. E. Polotskii, V. T. Zarkua, A. S. Tjulandina, E. A. Bogush, M. M. Davydov
MOSCOW UNIVERSITY CHEMISTRY BULLETIN
(2017)
Article
Biochemistry & Molecular Biology
T. A. Bogush, E. A. Dudko, A. N. Grishanina, V. T. Zarkua, E. A. Bogush, A. A. Basharina, B. E. Polotsky, S. A. Tjulandin, M. M. Davydov, M. I. Davydov
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2017)
Article
Chemistry, Multidisciplinary
T. A. Bogush, I. A. Mamichev, Iu. P. Borisenko, E. A. Bogush, N. O. Vichljantseva, V. Ju. Kirsanov
MOSCOW UNIVERSITY CHEMISTRY BULLETIN
(2018)
Article
Chemistry, Multidisciplinary
T. A. Bogush, S. A. Kalyuzhny, M. R. Chetyrkina, M. A. Yastrebova, A. M. Scherbakov, O. M. Ryabinina, I. A. Mamichev, E. A. Bogush, A. A. Kamensky
MOSCOW UNIVERSITY CHEMISTRY BULLETIN
(2018)
Meeting Abstract
Oncology
E. A. Ponomarenko, I. A. Mamichev, T. A. Bogush, O. M. Ryabinina, J. B. Dyakova, D. V. Novikov, B. E. Polotsky, M. M. Davydov
ANNALS OF ONCOLOGY
(2017)
