Article
Pharmacology & Pharmacy
Tao Li, Guangyao Jiang, Xuantao Hu, Daishui Yang, Tingting Tan, Zhi Gao, Zhuoyuan Chen, Cheng Xiang, Shizhen Li, Zhengxiao Ouyang, Xiaoning Guo
Summary: Punicalin inhibits osteoclast formation and bone resorption by suppressing the NF-κB signaling pathway, showing potential in suppressing breast cancer-induced bone metastasis and promoting apoptosis of breast cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Yang Nan, Liyun Guo, Yingwei Zhen, Le Wang, Bingcheng Ren, Xingjie Chen, Yalin Lu, Kai Yu, Yue Zhong, Qiang Huang
Summary: The study found that miRNA-451 regulates the NF-kappa B signaling pathway by targeting IKK beta, inhibiting the growth and invasion ability of glioma cells. Overexpression of miRNA-451 decreased the expression of IKK beta and other proteins, leading to reduced cell proliferation and invasion.
Article
Biochemistry & Molecular Biology
Shenglan Liu, Liangmei He, Junhong Wu, Xinqiang Wu, Lu Xie, Wei Dai, Lingxia Chen, Fuhua Xie, Zhiping Liu
Summary: DHX9 plays a crucial role in promoting proliferation and metastasis in colorectal cancer, making it a potential therapeutic target for prevention and treatment of CRC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Bin Liu, Xin Zheng, Jiajun Li, Peng Yao, Peng Guo, Wei Liu, Gaoping Zhao
Summary: This study demonstrates that atovaquone can inhibit the metastasis and invasion of colorectal cancer by inhibiting the expression of NF-κB (p-P65) and related inflammatory factors. Atovaquone may be a promising drug for the treatment of colorectal cancer metastasis.
Article
Oncology
Anqi Zeng, Xinyue Yu, Bao Chen, Lu Hao, Ping Chen, Xue Chen, Yuan Tian, Jing Zeng, Hua Hua, Ying Dai, Junning Zhao
Summary: The NF-kappa B signaling pathway is overactivated in tumor cells, releasing inflammatory factors and promoting tumor immunosuppression and metastasis. In breast cancer cells, tetrahydrocurcumin (THC) induces apoptosis, inhibits proliferation and migration via the CYP1A1/NF-kappa B signaling pathway, and shows significant tumor growth inhibition and anti-pulmonary metastasis effects in a mouse model.
CANCER CELL INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Yumei Cao, Su'an Tang, Xiaoyu Nie, Zuoqing Zhou, Guangfeng Ruan, Weiyu Han, Zhaohua Zhu, Changhai Ding
Summary: The study identified miR-214-3p as a key regulator in osteoarthritis, impacting ECM metabolism and cell apoptosis in cartilage by modulating the NF-kappa B signaling pathway. Targeting IKKP, decreased miR-214-3p exacerbates OA development, suggesting it as a potential novel therapeutic target for OA.
Article
Neurosciences
Jinwang Ye, Suyue Zhong, Yunsong Deng, Xuanbao Yao, Qiong Liu, Jian-Zhi Wang, Shifeng Xiao
Summary: Class IIa histone deacetylases (HDAC) play a role in inflammation by promoting IKK activation and subsequent NF-kappa B activation. In this study, HDAC7 was found to be elevated in astrocytes after LPS challenge, leading to NF-kappa B activation, pro-inflammatory gene upregulation, and anxiety-like behaviors. Inhibition of HDAC7 attenuated LPS-induced inflammation and anxiety-like behaviors.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, Rumela Chakrabarti
Summary: Research has shown that the Notch ligand Dll1 is crucial for tumor growth, metastasis, and chemoresistance in breast cancer, with NF-kappa B activation playing a role in chemoresistance. Pharmacological blocking of Dll1 or NF-kappa B pathway can sensitize Dll1(+) tumors to chemotherapy, providing potential therapeutic avenues for chemotherapy resistant breast cancer patients.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Zongmeng Zhang, Jinlin Du, Qihua Xu, Yuyu Li, Sujin Zhou, Zhenggang Zhao, Yunping Mu, Allan Z. Zhao, Su-Mei Cao, Fanghong Li
Summary: Chronic inflammation is associated with the development of nasopharyngeal carcinoma (NPC), where resistin, an inflammatory cytokine, plays a role in promoting tumor metastasis. High resistin levels in NPC patients are positively correlated with lymph node metastasis, and resistin induces epithelial-mesenchymal transition (EMT) to facilitate metastasis. The TLR4/p38 MAPK/NF-kappa B signaling pathways are involved in resistin-mediated promotion of NPC metastasis.
Article
Biotechnology & Applied Microbiology
Zhilong Yu, Shanshi Tong, Chenyi Wang, Zizhen Wu, Yingjiang Ye, Shan Wang, Kewei Jiang
Summary: This study successfully synthesized PPy@Fe3O4 nanoparticles and found their potential in combating colorectal cancer cells. The results showed that PPy@Fe3O4 nanoparticles effectively inhibited tumor growth, migration, and invasion, while promoting ferroptosis. The experiments also revealed that PPy@Fe3O4 nanoparticles inhibited colorectal cancer cells by modulating the NF-kappa B signaling pathway. Additionally, the study discovered that Fer-1 inhibitors could reverse the changes in metastasis-associated proteins caused by nanoparticle treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Microbiology
Shuang Jiao, Changyao Li, Hongyang Liu, Mengdi Xue, Qiongqiong Zhou, Longfeng Zhang, Xiaohong Liu, Chunying Feng, Guangqiang Ye, Jia Liu, Jiangnan Li, Li Huang, Tao Xiong, Zhaoxia Zhang, Changjiang Weng
Summary: Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious pathogen that causes significant economic losses to the swine industry worldwide. The nonstructural protein 4 (Nsp4) of PRRSV is shown to inhibit the activation of the nuclear transcription factor kappa B (NF-kappa B) signaling pathway by cleaving the inhibitor kappa B kinase beta (IKK beta). The cleavage of IKK beta by PRRSV Nsp4 is dependent on its 3C-like serine protease activity.
VETERINARY MICROBIOLOGY
(2023)
Article
Oncology
Guodong Tang, Liyun Luo, Jianlei Zhang, Dongfeng Zhai, Danqing Huang, Jiang Yin, Qin Zhou, Qiong Zhang, Guopei Zheng
Summary: The study identified LINC01057 as a regulator of NF-kappa B signaling to promote MES differentiation in GBMs, showing potential as a therapeutic target for MES-subtype GBM.
Article
Cell Biology
Junchen Li, Lixun Huang, Zinan He, Minggui Chen, Yi Ding, Yuying Yao, Youfa Duan, Zixuan Li, Cuiling Qi, Lingyun Zheng, Jiangchao Li, Rongxin Zhang, Xiaoming Li, Jianwei Dai, Lijing Wang, Qian-Qian Zhang
Summary: Andrographolide (Andro), a traditional anti-inflammatory drug, has shown anti-tumor effects in breast cancer treatment by inhibiting cell proliferation and promoting apoptosis via activation of signaling pathways. The study suggests that Andro may exert its potential anti-cancer effects on luminal-like breast cancer by suppressing NF-kappa B expression to regulate miR-21-5p and further promote PDCD4. This indicates that Andro could be a promising antitumor agent for the treatment of luminal-like breast cancer in clinical settings.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Li Yang, Qiang Ma, Jiayu Chen, Xiangcai Kong, Xiaohui Yu, Wei Wang
Summary: The expression of Foxa2 is downregulated in NAFLD, and it ameliorates hepatic steatosis by inhibiting the activation of the NF-KB/IKK signaling pathway.
Article
Endocrinology & Metabolism
Ming Wu, Dewei Kong, Yan Zhang
Summary: Bone metastasis is a major complication in lung adenocarcinoma (ADC) patients, and identifying biomarkers for this disease is crucial. This study found that SPON2 plays a key role in promoting bone metastasis by activating the NF-kappa B pathway in ADC. These findings suggest that SPON2 could be a potential therapeutic target for future drug development.
Article
Oncology
Suneetha Nunna, Ying-Pei Huang, Mahdi Rasa, Anna Krepelova, Francesco Annunziata, Lisa Adam, Sandra Kaeppel, Ming-Hua Hsu, Francesco Neri
Summary: This study discovered that derivatives from natural compounds are more effective in inducing cytotoxicity in colorectal cancer cells. These derivatives can inhibit the growth of cancer cells and induce apoptosis through different mechanisms, while showing no toxicity to healthy cells.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Oncology
Maria Teresa Bochicchio, Valeria Di Battista, Pietro Poggio, Giovanna Carra, Alessandro Morotti, Mara Brancaccio, Alessandro Lucchesi
Summary: Aberrant signaling in myeloproliferative neoplasms can result from genetic alterations, and the cooperation between mutated and normal cells leads to persistent inflammation. Despite hopes for targeted therapies, these diseases remain incurable.
Review
Biochemistry & Molecular Biology
Carla Liaci, Lucia Prandi, Lisa Pavinato, Alfredo Brusco, Mara Maldotti, Ivan Molineris, Salvatore Oliviero, Giorgio R. Merlo
Summary: Long non-coding RNAs (lncRNAs) are widely expressed in the human brain, and may play a role in normal brain development and the molecular pathology of neurodevelopmental disorders. However, their involvement in intellectual disability (ID) and neurodevelopmental disorders is still poorly understood, and only a few genomic alterations have been causally linked to the disease endophenotype. Further investigation into the non-coding genome may uncover novel pathogenic mechanisms and translational opportunities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Dovydas Sirvinskas, Omid Omrani, Jing Lu, Mahdi Rasa, Anna Krepelova, Lisa Adam, Sandra Kaeppel, Felix Sommer, Francesco Neri
Summary: We performed single-cell sequencing of aging mouse colonic epithelium and immune cells, and identified significant aging-associated changes in cell composition and signaling pathways. Our study provides new insights into the normal and age-associated states of the colon.
Letter
Hematology
Giovanna Carra, Emilia Giugliano, Sofia Camerlo, Giorgio Rosati, Enrica Branca, Beatrice Maffeo, Isabella Russo, Rocco Piazza, Daniela Cilloni, Alessandro Morotti
Article
Hematology
Enrico Tiacci, Alessandro Mancini, Monia Marchetti, Gianna Maria D'Elia, Anna Candoni, Alessandro Morotti, Alessandra Romano, Alessandro Gozzetti, Alessandro Broccoli, Luca De Carolis, Riccardo Bruna, Maria Chiara Tisi, Carmine Selleri, Monia Capponi, Daniele Vallisa, Chiara Cattaneo, Matteo Giovanni Della Porta, Alessandro Busca, Brunangelo Falini, Massimo Massaia, Lorenza Bertu, Alessandro Pulsoni, Paolo Rivela, Paolo Corradini, Francesco Passamonti
Summary: Little is known about the course of COVID-19 and the antibody response to infection or vaccination in patients with hairy-cell leukaemia (HCL). In this study of 58 HCL cases, 37 unvaccinated patients developed COVID-19 with a generally favorable outcome, while active leukemia, older age, and comorbidities were associated with a worse course. Seroconversion consistently developed after infection (11 cases) and vaccination (28 cases), except in patients recently treated with anti-CD20 or venetoclax therapy. Vaccination appeared to protect against severe COVID-19 in patients with breakthrough infection.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sofia Camerlo, Jacopo Ligato, Giorgio Rosati, Giovanna Carra, Isabella Russo, Marco De Gobbi, Alessandro Morotti
Summary: Splanchnic vein thrombosis is a rare but potentially life-threatening manifestation of venous thromboembolism that poses challenges in terms of pathology and treatment. It is commonly associated with liver cirrhosis, but can also be caused by myeloproliferative disorders, gastroenterological cancers, abdominal infections, and thrombophilia. Some cases of splanchnic vein thrombosis remain idiopathic. In this review, we discuss the mechanisms of splanchnic vein thrombosis, including new insights on the role of clonal hematopoiesis in the development of idiopathic SVT, which have important implications for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Pathology
Jasna Metovic, Anna Sapino, Isabella Castellano
Article
Cell Biology
Sara Bonzano, Eleonora Dallorto, Ivan Molineris, Filippo Michelon, Isabella Crisci, Giovanna Gambarotta, Francesco Neri, Salvatore Oliviero, Ruth Beckervordersandforth, Dieter Chichung Lie, Paolo Peretto, Serena Bovetti, Michele Studer, Silvia De Marchis
Summary: The nuclear receptor NR2F1 is a strong transcriptional regulator in neural cells. Mutations in the NR2F1 gene cause BBSOAS, a rare neurodevelopmental disorder characterized by vision impairment, intellectual disability, and autistic traits. In this study, the researchers identified a set of nuclear-encoded mitochondrial genes as potential targets under direct NR2F1 control. They demonstrated that NR2F1 loss of function in mice resulted in reduced mitochondrial mass, fragmentation, and downregulation of key mitochondrial proteins in newborn neurons, impairing their generation, survival, and integration. Similar dysregulation was also observed in a BBSOAS mouse model. These findings highlight the role of NR2F1 in the mitochondrial gene expression network in neurons and suggest a connection between mitochondrial dysfunction and BBSOAS pathogenesis.
DISEASE MODELS & MECHANISMS
(2023)
Article
Oncology
Roberto Ruiu, Chiara Cossu, Antonella Iacoviello, Laura Conti, Elisabetta Bolli, Luca Ponzone, Jolanda Magri, Alekya Rumandla, Enzo Calautti, Federica Cavallo
Summary: xCT is dispensable for proper immune system function, thus supporting the safety of xCT targeting in oncology. However, xCT is involved in several processes required for the metastatic seeding of mammary cancer cells, thus broadening the scope of xCT-targeting approaches.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Rheumatology
Sofia Camerlo, Irene Cecchi, Silvia Grazietta Foddai, Massimo Radin, Alice Barinotti, Alessandro Morotti, Dario Roccatello, Savino Sciascia
Summary: This case report highlights the importance of suspecting APS in young patients experiencing unprovoked thrombosis, the critical issue of testing aPL during anticoagulant treatment, and the double nature of aPL-mediated clinical manifestations.
Editorial Material
Medicine, Research & Experimental
Salvatore Oliviero
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Oncology
Enza Di Gregorio, Chiara Romiti, Antonino Di Lorenzo, Federica Cavallo, Giuseppe Ferrauto, Laura Conti
Summary: Breast cancer is the most common cancer in women and the leading cause of cancer-related death. Systemic chemotherapy is the primary choice for treatment, but it causes side effects and requires high drug doses. Nanosystems for drug delivery offer a promising solution to these drawbacks.
Article
Hematology
Giorgio Rosati, Sofia Camerlo, Matteo Dalmazzo, Melissa Padrini, Tiziano Tommaso Busana, Marco De Gobbi, Alessandro Fornari, Alessandro Morotti
Summary: This article presents a case of a BrS patient diagnosed with low-risk APL and treated with ATRA and ATO therapy. The article highlights the challenges encountered by clinicians in the diagnosis and treatment choice for these patients.
HEMATOLOGY REPORTS
(2023)