Review
Pharmacology & Pharmacy
Malvina Hoxha, Bruno Zappacosta
Summary: This review examines the connection between fatty acid metabolism and cancer, specifically CRC, providing insights into its pathogenesis and potential in developing novel biomarkers and innovative pharmacological therapies based on the dependency of cancer cells on FAs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Marianna Potenza, Martina Sciarretta, Maria Giovanna Chini, Anella Saviano, Francesco Maione, Maria Valeria D'Auria, Simona De Marino, Assunta Giordano, Robert Klaus Hofstetter, Carmen Festa, Oliver Werz, Giuseppe Bifulco
Summary: This study identified three 1,2,4-oxadiazole compounds as potential multi-target inhibitors in the treatment of inflammatory disorders, with compound 5 showing promising results in in vivo experiments. The results suggest the potential for developing novel anti-inflammatory agents with a favorable pharmacological profile by expanding chemical diversity around the 1,2,4-oxadiazole central core.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Veterinary Sciences
Amanda (Mandi) Nichole Carr, Roy Neville Kirkwood, Kiro Risto Petrovski
Summary: This review discusses the teaching of problem-solving skills in veterinary learners. It emphasizes the need for learners to recognize and define problems before gathering information and determining solutions. A suggested process with 5 elements is proposed to make problem-solving easier. The role of the instructor in facilitating problem-solving activities is also highlighted.
VETERINARY SCIENCES
(2022)
Article
Medicine, General & Internal
Natalie M. Hendrikse, Jordi Llinares Garcia, Thorsten Vetter, Anthony J. Humphreys, Falk Ehmann
Summary: Biomarkers play a crucial role in drug development and clinical practice, with the European Medicines Agency emphasizing the importance of their discovery and use. Early engagement with regulators is crucial for biomarker qualification, and there are opportunities to improve support for developers by EMA. Qualified biomarkers are important for enabling precision medicine in clinical trials.
FRONTIERS IN MEDICINE
(2022)
Article
Physics, Multidisciplinary
A. B. McDonald
Summary: During the COVID-19 pandemic, the DarkSide-20k (DS) Dark Matter international experimental collaboration shifted their research focus and successfully developed MVM, a new ventilator tailored to severe intubated patients. They have produced and authorized 7300 units for the Canadian government, and are considering donating them to other countries in need. In addition, DS members are utilizing photo-electronics innovation to develop a more sensitive PET scanner with better resolution and reduced doses, particularly beneficial for pediatric patients.
EUROPEAN PHYSICAL JOURNAL PLUS
(2022)
Letter
Oncology
Meysam Shirzad, Alireza Abbassian
Summary: This study aimed to increase the number of clinical trials on herbal medicine in traditional Iranian Medicine by adding Iranian Medicine, Traditional Iranian Medicine, or Iranian Traditional Medicine as additional terms in the keywords.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Harald Heinrichs
Summary: This article discusses teaching sustainable development in higher education with a sensory and artistic approach to raise awareness and develop creativity in students. By designing and conducting experimental bachelor courses, the author argues that scientific-artistic co-teaching is an innovative way to teach sustainability topics in a more sensory manner.
Review
Biochemistry & Molecular Biology
Mariya Misheva, Jethro Johnson, James McCullagh
Summary: Oxylipins play crucial regulatory roles in inflammation, with different classes of oxylipins exerting opposite effects during different stages of inflammation. Understanding the role of oxylipins in inflammatory diseases is essential for elucidating disease onset and prevention.
Article
Health Care Sciences & Services
Asger Sand Paludan-Muller, Ingrid Rose Maclean-Nyegaard, Klaus Munkholm
Summary: Reporting bias poses a threat to the transparency and validity of clinical trials, and accessing Clinical Study Reports (CSRs) can mitigate this to some extent. The European Medicines Agency (EMA) publishes clinical data under their Policy 0070, but there are considerable delays in the publications, reducing their potential impact on reporting bias.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
News Item
Biochemistry & Molecular Biology
Mike May
Summary: Designing a new drug is crucial, but finding the right delivery method to reach the target is equally important and can be achieved through various vehicles.
Article
Engineering, Geological
Hengshuo Liu, Harianto Rahardjo, Alfrendo Satyanaga, Hejun Du
Summary: Compared with conventional water-filled tensiometers, polymer-filled osmotic tensiometers can measure a higher matric suction by increasing the osmotic pressure of the water inside. This study found that the long-term pressure decay of osmotic tensiometers is more likely due to the stress relaxation of polymer materials instead of polymer leakage. The proposed osmotic tensiometers can measure matric suction in both low and high ranges with fast response and high accuracy.
Article
Business
Seokbeom Kwon
Summary: This study examines the relationship between interdisciplinarity in knowledge integration for research and its unique knowledge input for technology development. The study finds that interdisciplinarity is positively associated with uniqueness in its contribution to technology development only when the research has funding support. It also finds that interdisciplinarity is positively associated with the non-unique impact of research on technology development regardless of funding support.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2022)
Review
Biotechnology & Applied Microbiology
Jia Gao, Chunyang Liao, Sijin Liu, Tian Xia, Guibin Jiang
Summary: The patch-clamp technique is a significant approach for studying neural excitability and recent advancements in automation have been made, though challenges remain. Nanotechnologies offer opportunities to overcome obstacles and improve intracellular electrophysiological recording systems in neural cells.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Social Issues
Hans Liwang
Summary: This study investigates co-creation between government, industry, and academia in the early phase design of security and defense systems, considering nontechnical system properties and the interactions between technical and social components. The study emphasizes the role of higher education institutions in creating a collaborative space for industry and policy/social/critical sciences, and argues that co-creation can facilitate the articulation of societal challenges and alternative design principles in the early concept design stages.
TECHNOLOGY IN SOCIETY
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Viktoriia Starokozhko, Anne Hess, Wiebke Loebker, Wolfgang Ballensiefen, Eleonora Agricola, Bettina Ziegele, Marko J. Kallio, Laurence O'Dwyer, Yoana Nuevo, Peter G. M. Mol, Anna M. G. Pasmooij
Summary: Improved understanding of regulatory requirements by academic researchers can accelerate the translation of new medical interventions to the clinic. Here, we highlight the recommendations of the 'Strengthening Training of Academia in Regulatory Science' (STARS) project to improve the interaction and knowledge exchange between academics and regulators, and thereby advance academic drug development.
NATURE REVIEWS DRUG DISCOVERY
(2023)
