Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform

Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart

(2016) Romina Becerra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle

(2016) Jamal Bouitbir et al.   ANTIOXIDANTS & REDOX SIGNALING

Interpretation of the evidence for the efficacy and safety of statin therapy

(2016) Rory Collins et al.   LANCET

The role of acid-base imbalance in statin-induced myotoxicity

(2016) Dhiaa A. Taha et al.   Translational Research

Effects of Statins on First and Recurrent Supraventricular Arrhythmias in Patients With Mild Heart Failure (from the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy)

(2015) Yitschak Biton et al.   AMERICAN JOURNAL OF CARDIOLOGY

Experimental design and analysis and their reporting: new guidance for publication in BJP

(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Statin-Induced Cardioprotection Against Ischemia-Reperfusion Injury: Potential Drug-Drug Interactions. Lesson to be Learnt by Translating Results from Animal Models to the Clinical Settings

(2015) Gilad D. Birnbaum et al.   CARDIOVASCULAR DRUGS AND THERAPY

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition

(2015) Tom J.J. Schirris et al.   Cell Metabolism

Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

(2015) Erik S. Stroes et al.   EUROPEAN HEART JOURNAL

FKBP12.6 Activates RyR1: Investigating the Amino Acid Residues Critical for Channel Modulation

(2014) Elisa Venturi et al.   BIOPHYSICAL JOURNAL

Statin-induced muscle toxicity and susceptibility to malignant hyperthermia and other muscle diseases: a population-based case-control study including 1st and 2nd degree relatives

(2014) Karin Hedenmalm et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Acute effects of simvastatin to terminate fast reentrant tachycardia through increasing wavelength of atrioventricular nodal reentrant tachycardia circuit

(2014) Vahid Khori et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Simvastatin Potently Induces Calcium-dependent Apoptosis of Human Leiomyoma Cells

(2014) Mostafa A. Borahay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhabdomyolysis: Review of the literature

(2014) R. Zutt et al.   NEUROMUSCULAR DISORDERS

Preoperative statin therapy in cardiac surgery: a meta-analysis of 90 000 patients†

(2013) Elmar W. Kuhn et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Mice with RyR1 mutation (Y524S) undergo hypermetabolic response to simvastatin

(2013) Mark Knoblauch et al.   Skeletal Muscle

Statin Use and Musculoskeletal Pain Among Adults With and Without Arthritis

(2012) Catherine Buettner et al.   AMERICAN JOURNAL OF MEDICINE

FKBP12 Activates the Cardiac Ryanodine Receptor Ca2+-Release Channel and Is Antagonised by FKBP12.6

(2012) Elena Galfré et al.   PLoS One

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1

(2011) Jamal Bouitbir et al.   EUROPEAN HEART JOURNAL

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Statins Alter Intracellular Calcium Homeostasis in Malignant Hyperthermia Susceptible Individuals

(2010) T. Metterlein et al.   Cardiovascular Therapeutics

Efflux and uptake transporters as determinants of statin response

(2010) Alice C Rodrigues   Expert Opinion on Drug Metabolism & Toxicology

Ca2+-calmodulin can activate and inactivate cardiac ryanodine receptors

(2009) C Sigalas et al.   BRITISH JOURNAL OF PHARMACOLOGY

DHPR activation underlies SR Ca2+release induced by osmotic stress in isolated rat skeletal muscle fibers

(2009) James D. Pickering et al.   JOURNAL OF GENERAL PHYSIOLOGY

Statin induced myotoxicity: The lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro

(2008) Ine Blankenberg Skottheim et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES