Article
Biochemistry & Molecular Biology
Feng Tang, Hua Yu, Xia Wang, Jiageng Shi, Zhizhuang Chen, Hao Wang, Ziyu Wan, Qiqi Fu, Xuan Hu, Yisha Zuhaer, Tao Liu, Zhonghua Yang, Jianping Peng
Summary: NCAPG is overexpressed in bladder cancer, and its knockdown can inhibit cell proliferation through the inhibition of the NF-kappa B signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Huangheng Tao, Yixiang Liao, Youji Yan, Zhiwen He, Jiajie Zhou, Xinghuan Wang, Jianping Peng, Shangze Li, Tao Liu
Summary: This study revealed that high expression of BRCC3 in bladder cancer promotes tumorigenesis by targeting the TRAF2 protein, while genetic ablation of BRCC3 significantly blocks proliferation and migration of bladder cancer cells. RNA-Seq analysis shows down-regulation of NF-kappa B signaling in BRCC3-deficient cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Meiying Zhang, Min Zhou, Xia Cai, Yan Zhou, Xueling Jiang, Yan Luo, Yue Hu, Rong Qiu, Yanrong Wu, Yuejin Zhang, Yan Xiong
Summary: Diabetic retinopathy is a common complication in diabetic patients, and inhibiting the VEGF/PKC/ET/NF-kappa B/ICAM-1 signaling pathway has been found to alleviate the pathology of diabetic retinopathy in a rat model.
EUROPEAN JOURNAL OF HISTOCHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Yue Xia, Minghuan Ge, Ling Xia, Guang Shan, Huijun Qian
Summary: This study reveals that the aberrant expression of cathepsin V (CTSV) is associated with a poor outcome in bladder cancer patients. CTSV enhances the inflammatory reaction, thereby promoting the development of bladder cancer. Overexpression of CTSV increases the proliferation and viability of bladder cancer cells, while deletion of CTSV significantly inhibits their proliferation and viability. Furthermore, overexpression of CTSV activates the inflammatory signaling pathway, which can be restored by introducing an NF-kappa B inhibitor.
Article
Medicine, Research & Experimental
Runyi Ye, Dongwei Liu, Hongyu Guan, NiJiati AiErken, Zeng Fang, Yawei Shi, Yunjian Zhang, Shenming Wang
Summary: The study showed that upregulation of AHNAK2 in thyroid carcinoma tissues, especially in metastatic ones, is associated with poor prognosis. Knockdown of AHNAK2 inhibited thyroid carcinoma migration, invasion, and metastasis by reducing activation of the NF-kappa B pathway. This provides a novel target for treating metastatic thyroid carcinoma.
Article
Oncology
Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang, Jianxin Qiu
Summary: ROC1 is up-regulated in BCa tissues and cell lines, with high levels correlated with higher tumor grade, metastasis, and poor prognosis. It promotes BCa invasion and migration by activating NF-κB signaling through enhancing p-IκBα ubiquitination, leading to p65 nuclear translocation and transcription of metastasis-related genes.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Shanshan Wang, Buxin Kou, Mengyin Chai, Yuxue Gao, Xuejun Lin, Ling Yin, Dexi Chen, Xiaoni Liu
Summary: ASPP2 protein plays an important role in hepatitis and hepatocellular carcinoma, and the absence of ASPP2 can activate the NF-kappa B pathway to promote hepatocarcinogenesis.
CANCER GENE THERAPY
(2022)
Article
Oncology
Daichi Nomoto, Yoshifumi Baba, Yang Liu, Hiroyasu Tsutsuki, Kazuo Okadome, Kazuto Harada, Takatsugu Ishimoto, Masaaki Iwatsuki, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Toshiro Moroishi, Yoshihiro Komohara, Tomohiro Sawa, Hideo Baba
Summary: Fusobacterium nucleatum influences the progression of gastrointestinal cancers by invading and occupying cancer cells, impacting gene and protein expression, and activating signaling pathways. This study provides insights into the mechanism of ESCC progression induced by F. nucleatum.
Article
Biochemistry & Molecular Biology
Xin Yang, Maodi Liang, Yihan Tang, Dingling Ma, Menghuan Li, Chenggang Yuan, Yanting Hou, Chaoyue Sun, Jie Liu, Qianqian Wei, Yongsheng Chang, Cuizhe Wang, Jun Zhang
Summary: In the context of obesity, inflammatory cytokines secreted by adipocytes contribute to insulin resistance and play a key role in the development of metabolic syndrome. Our previous study found that the transcription factor KLF7 promotes the expression of p-p65 and IL-6 in adipocytes, but the specific molecular mechanism remains unclear. In this study, we found that the expression of KLF7, PKC?, p-I?B, p-p65, and IL-6 was significantly increased in epididymal white adipose tissue (Epi WAT) of mice fed a high-fat diet (HFD). However, in KLF7 fat conditional knockout mice, the expression of PKC?, p-I?B, p-p65, and IL-6 was significantly decreased in Epi WAT. In 3T3-L1 adipocytes, KLF7 promotes the expression of IL-6 through the PKC?/NF-?B pathway. Furthermore, luciferase reporter and chromatin immunoprecipitation assays confirmed that KLF7 upregulates the expression of PKC? transcripts in HEK-293T cells. Together, our results demonstrate that KLF7 promotes the expression of IL-6 by upregulating PKC? expression and activating the NF-?B signaling pathway in adipocytes.
Article
Agriculture, Multidisciplinary
Hui Wang, Yuan Zhao, Yuntong Zhang, Tianyuan Yang, Shuping Zhao, Ning Sun, Haoyang Tan, Haiyang Zhang, Chuqiao Wang, Honggang Fan
Summary: This study found that chlorogenic acid (CGA) can inhibit liver inflammation caused by chronic stress by upregulating the generation of resolvin D1 (RvD1), thereby alleviating liver injury.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Yuanxin Xing, Yani Lin, Ying Zhang, Jing Hu, Junmei Liu, Yuanyuan Tian, Jian Zhao, Weiwen Chen, Bo Han
Summary: NF-kappa B signaling pathway plays a crucial role in the development and metastasis of lung adenocarcinoma. The lncRNA IKBKBAS acts as a ceRNA by competitively binding miR-4741 and IKK beta mRNA, regulating the activation of NF-kappa B signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Yan Zou, Yunyan Du, Cheng Cheng, Xueqiang Deng, Zimin Shi, Xiongbing Lu, Honglin Hu, Jun Qiu, Weifan Jiang
Summary: FAT10 and HK2 proteins are significantly elevated in bladder cancer tissues compared to normal adjacent tissues, and FAT10 promotes bladder cancer progression by positively regulating HK2 levels.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Jing Luo, Qingjie Ma, Heng Tang, Xi Zou, Xin Guo, Yuzhen Hu, Kejiang Zhou, Rui Liu
Summary: This study demonstrates that leukotriene B4 (LTB4) is upregulated in one-lung ventilation (OLV) rats and plays a role in activating the PLC epsilon-1/TLR4/NF-kappa B pathway, leading to acute lung injury (ALI). Inhibition of LTB4 can alleviate ALI induced by OLV, suggesting a potential therapeutic target for OLV-induced ALI.
Article
Oncology
Guang-Yu Zhong, Jia-Nan Tan, Jing Huang, Sheng-Ning Zhou, Jin-Hao Yu, Lin Zhong, Dong Hou, Shi-Lin Zhi, Jin-Tao Zeng, Hong-Ming Li, Chu-Lian Zheng, Bin Yang, Fang-Hai Han
Summary: This study revealed that LINC01537 promotes gastric cancer metastasis and tumorigenesis by stabilizing RIPK4 and enhancing the NF-kB signaling pathway expression.
Article
Medicine, Research & Experimental
Ting Zhao, Jianming Zeng, Yujie Xu, Zhongping Su, Yulong Chong, Tao Ling, Haozhe Xu, Hui Shi, Minggao Zhu, Qi Mo, Xiaoying Huang, Yingchang Li, Xiaoren Zhang, Hongbin Ni, Qiang You
Summary: This study reveals that CHI3L1 is overexpressed in glioma and plays a crucial role in tumor progression. It enhances the NF-kappa B signaling pathway and interacts with ACTN4 and NFKB1. Additionally, CHI3L1 reprograms the tumor microenvironment and contributes to M2 macrophage polarization. It is also positively correlated with the expression of immune checkpoints and remodels the TME to an immunosuppressive phenotype.
Article
Immunology
Yi Jin, Zhanwang Wang, Dong He, Yuxing Zhu, Xueying Hu, Lian Gong, Mengqing Xiao, Xingyu Chen, Yaxin Cheng, Ke Cao
Summary: The study highlights the significant role of m6A regulators in adrenocortical carcinoma (ACC), showing distinct m6A patterns associated with clinical outcomes and tumor immune microenvironment. By establishing a prognostic model and validating key modifications, the study reveals the potential importance of m6A modifications in ACC development and prognosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lin Zhou, Qing Chen, Jie Wu, Jian Yang, Huancai Yin, Jingjing Tian, Lian Gong, DanDan Kong, Min Tao
Summary: In CRC, downregulation of miR-942-5p inhibits proliferation and invasion of cancer cells, while upregulation of CCBE1 reverses these effects. CCBE1 is identified as a downstream target of miR-942-5p and is inversely correlated with its expression in CRC cells, suggesting that miR-942-5p may serve as a potential clinical biomarker for CRC diagnosis and therapy.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Wenzhi Hao, Jiajia Wu, Naijun Yuan, Lian Gong, Junqing Huang, Qingyu Ma, Huizheng Zhu, Hua Gan, Xiaoli Da, Lijuan Deng, Xiaojuan Li, Jiaxu Chen
Summary: Xiaoyaosan can alleviate anxiety and depression by modulating the gut microbiota, reducing lipopolysaccharide release, and inhibiting excessive activation of the NLRP3 inflammasome in the colon.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Yeyu Zhang, Yuxing Zhu, Mengqing Xiao, Yaxin Cheng, Dong He, Jianye Liu, Liang Xiang, Lian Gong, Zhanwang Wang, Liping Deng, Ke Cao
Summary: The study reveals that TMPO-AS1 is upregulated in bladder cancer and promotes cell proliferation, migration, invasion, and inhibits apoptosis. Mechanistically, TMPO-AS1 interacts with E2F1, leading to E2F1 stabilization and ultimately promoting malignant behaviors in bladder cancer. Additionally, rescue experiments demonstrate that TMPO-AS1 promotes bladder cancer growth in an E2F1-dependent manner.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xingyu Chen, Hua Lan, Dong He, Zhanwang Wang, Runshi Xu, Jing Yuan, Mengqing Xiao, Yao Zhang, Lian Gong, Songshu Xiao, Ke Cao
Summary: This study investigated the relationship between autophagy and the tumor immune microenvironment in ovarian cancer. By clustering and analyzing levels of immune cell infiltration, two subclasses of OC were identified, with cluster A showing higher immune infiltration. The establishment of a risk model and evaluation of its efficiency revealed that patients with low-risk had better overall survival outcomes than high-risk patients. Additionally, potential targets ULK2 and GABARAPL1 were identified in OC for further validation in clinical samples.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xingyu Chen, Runshi Xu, Dong He, Yao Zhang, Haotian Chen, Yuxing Zhu, YaXin Cheng, Rui Liu, Rongrong Zhu, Lian Gong, Mengqing Xiao, Zhanwang Wang, Liping Deng, Ke Cao
Summary: This study identified important genes associated with CD8+ T effector and immune checkpoint signatures in bladder cancer samples, and constructed an IMS scoring system to predict immunotherapy responsiveness. The high IMS score group showed significant immune activation and better prognosis, serving as a powerful biomarker for predicting ICB treatment responsiveness.
Article
Oncology
Jiawei Xiao, Lian Gong, Mengqing Xiao, Dong He, Liang Xiang, Zhanwang Wang, Yaxin Cheng, Liping Deng, Ke Cao
Summary: The study found that LINC00467 is highly expressed in bladder cancer and can promote the progression of bladder cancer by regulating the NF-kappa B signaling pathway. Targeting LINC00467 may provide a new strategy for the treatment of bladder cancer and improve patient prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yi Jin, Zhanwang Wang, Dong He, Yuxing Zhu, Lian Gong, Mengqing Xiao, Xingyu Chen, Ke Cao
Summary: The study found that ferroptosis is closely related to immune processes in UVM, potentially influencing the tumor microenvironment through immune cell infiltration. By establishing a prognostic model and ceRNA network, key molecules related to prognosis were identified, providing new insights into UVM prognosis and tumor microenvironment characteristics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Lian Gong, Hui Liu, Cheng Lv, Lijun Zhao
Summary: A new welding method, ultranarrow gap welding with constrained arc by flux band, was proposed to improve the quality of rail thermite welded joints. Research results showed that different alloying composition content flux bands could significantly enhance the microstructure and mechanical properties of the welded joints. The optimal alloying composition of flux band was found to be 19%.
ADVANCES IN MATERIALS SCIENCE AND ENGINEERING
(2021)
Article
Genetics & Heredity
Ming Zhong, Xiaohua Wang, Enyi Zhu, Lian Gong, Lingyan Fei, Liang Zhao, Keping Wu, Chun Tang, Lizhen Zhang, Zhongli Wang, Zhihua Zheng
Summary: This study systematically investigated the role of pyroptosis in clear cell renal cell carcinoma (ccRCC) and identified different subtypes with varied clinical outcomes, immune signatures, and responses to immunotherapy. Activation of pyroptosis was found to promote tumor progression by facilitating immune cell infiltration. A high pyroptosis-score was associated with an unfavorable immune environment and worse prognosis. The study also constructed a prognostic model based on pyroptosis-related long noncoding RNAs (PRlncRNAs) and explored the relationship between high- and low-risk groups with tumor microenvironment, immune infiltration, and drug therapy.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Panpan Tai, Zhanwang Wang, Xinyu Chen, Aiyan Chen, Lian Gong, Yaxin Cheng, Ke Cao
Summary: COMMD2 is highly expressed in multiple cancer types and affects the prognosis, clinicopathological stage, and molecular or immune subtypes of various tumors. Promoter hypomethylation and mutations in the COMMD2 gene may be associated with its high expression and poor survival. COMMD2 expression is linked to tumor stemness, tumor mutational burden (TMB), microsatellite instability (MSI), immune cell infiltration, immune-checkpoint inhibitors, and drug sensitivity in pan-cancer. The COMMD2 gene co-expression network shows significant interaction with E2F targets, G2-M checkpoint, and mitotic spindle in bladder cancer (BLCA). RNA interference data demonstrate that suppression of COMMD2 prevents proliferation and migration of BLCA and uterine corpus endometrial carcinoma (UCEC) cells.
Article
Medicine, General & Internal
H. Li, L. Yuan, H. Yang, Y. Guo, W. Zheng, K. Fan, S. Deng, L. Gong, H. Xu, Z. Yang, J. Cheng, M. Kang, H. Deng
Summary: This study identified three genetic variants in three Chinese families with familial ALS (FALS), which are associated with oxidative damage and aggregation. The drug N-acetylcysteine was found to rescue the decreased cell viability caused by these variants. These findings provide a potential drug for ALS therapy.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ming Zhong, Enyi Zhu, Na Li, Lian Gong, Hai Xu, Yong Zhong, Kai Gong, Shan Jiang, Xiaohua Wang, Lingyan Fei, Chun Tang, Yan Lei, Zhongli Wang, Zhihua Zheng
Summary: This study aimed to find key diagnostic markers and therapeutic targets for diabetic kidney disease (DKD) through bioinformatics analysis. Four potential diagnostic markers were identified and their reliability was confirmed through experiments. These results contribute to the understanding and treatment of DKD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Lian Gong, Ming Zhong, Kai Gong, Zhanwang Wang, Yong Zhong, Yi Jin, Haotian Chen, Panpan Tai, Xinyu Chen, Aiyan Chen, Ke Cao
Summary: The study found that CCT8 is highly expressed in various cancers and is associated with poor prognosis. The expression level of CCT8 is influenced by promoter region methylation and genetic alteration, and is related to the molecular and immune subtypes of cancers. CCT8 plays a crucial role in the cell cycle and RNA transport, and can significantly inhibit the proliferation and migration of lung adenocarcinoma cells.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Liping Deng, Hongliang Zeng, Xueying Hu, Mengqing Xiao, Dong He, Yao Zhang, Yi Jin, Yibo Hu, Yuxing Zhu, Lian Gong, Zhanwang Wang, Liang Xiang, Rongrong Zhu, Yeyu Zhang, Yaxin Cheng, Xingyu Chen, Shuihan Zhang, Yongbo Peng, Ke Cao
Summary: Se@Albumin NPs, developed through self-assembly, significantly improved CDDP-induced intestinal mucositis in mouse models by regulating gut microbiota. Fecal microbiota transplantation from Se@Albumin NP-treated mice also provided significant protection against CDDP-induced intestinal mucositis in pseudo-aseptic mice.