Article
Agriculture, Multidisciplinary
Yuan Zhao, Chaoran Wang, Tianyuan Yang, Guofeng Feng, Haoyang Tan, Xue Piao, Dongni Chen, Yu Zhang, Wenjign Jiao, Yongping Chen, Jichen Sha, Honggang Fan
Summary: Chronic stress can cause intestinal barrier damage, and MAPK and NF-κB are closely related to it. It has been found that CGA, a dietary polyphenol, can protect the intestines, but its mechanism through regulating MAPK and NF-κB is still unclear. In this experiment, CGA was shown to inhibit chronic stress-induced intestinal damage.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Cell Biology
Hao Chen, Xiaofeng Li, Yingyin Sun, Yan Du, Sha Wu, Yuanyuan Wu, Huiping Liu, Yaru Liu, Yongmei Wang, Qihang Zhao, Shi Yin
Summary: Inflammation is a key factor in the progression of alcohol-associated liver disease (ALD). HAO1, a peroxisomal enzyme, has been found to play a role in ALD. The study found that the expression of HAO1 was decreased in ALD patients and mice fed with ethanol, but increased in peripheral blood monocytes and liver macrophages. Overexpression of HAO1 inhibited inflammation, while knockdown exacerbated the inflammatory response. These findings suggest HAO1 as a potential target for treating ALD.
CELLULAR SIGNALLING
(2022)
Article
Immunology
Zhao Fang, Shuang Li, Feierkaiti Yushanjiang, Gaoke Feng, Shengyu Cui, Shan Hu, Xuejun Jiang, Chengyin Liu
Summary: Cardiac remodeling is a complex process that contributes to heart failure and arrhythmias in cardiovascular diseases. This study explored the protective effect of curcumol on cardiac remodeling and revealed its underlying mechanism. Curcumol attenuated cardiac dysfunction, fibrosis, and hypertrophy in an animal model of cardiac remodeling. It also alleviated cardiac electrical remodeling and inhibited inflammation and apoptosis through the AKT/NF-KB pathway. These findings suggest that curcumol holds potential as a therapeutic agent for cardiac remodeling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Yichun Tong, Caiyun Yu, Zechen Xie, Xianglei Zhang, Zaibin Yang, Tian Wang
Summary: This study investigated the protective effect of trans-anethole (TA) on lipopolysaccharide-induced acute liver inflammation in chickens. The results showed that TA attenuated the increase in inflammatory mediators and improved the levels of anti-inflammatory mediators. Additionally, TA downregulated the expression of inflammation-related genes and proteins in the NF-kB signaling pathway. Overall, TA was found to alleviate acute liver inflammation by blocking NF-kB activation.
Article
Immunology
Qi Guo, Meng Zhang, Yonghui Dong, Ke Liu, Desheng Wang, Jia Zheng
Summary: Isobavachalcone (IBC), an active component isolated from Psoralea corylifolia L., has shown potential therapeutic effects on osteoarthritis (OA) by inhibiting inflammation and cartilage degeneration through the NF-KB signaling pathway. These findings suggest that IBC could be a promising therapeutic drug for treating OA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Davide Di Paola, Daniela Impellizzeri, Tiziana Genovese, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Livia Interdonato, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Marika Cordaro
Summary: Endocrine-disrupting substances (EDS) are common and pose a serious risk to human and animal health. Vinclozolin, a commonly used fungicide, not only affects the reproductive system but also induces lung damage and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Menghui Xu, Ruhao Zhuo, Shengxiang Tao, Yaxu Liang, Chunru Liu, Qingyang Liu, Tian Wang, Xiang Zhong
Summary: This study found that lipopolysaccharide activates the NOD1/NF-κ B pathway through altering m(6)A RNA methylation, promoting the production of inflammatory cytokines and leading to liver inflammation and damage.
Article
Medicine, Research & Experimental
Weixin Zhao, Yixiao Yan, Zhongxiang Xiao, Meihong Wang, Mingjiang Xu, Zhe Wang, Yi Wang, Zaishou Zhuang, Daona Yang, Gaozhi Chen, Guang Liang
Summary: Bicyclol, approved as an anti-inflammatory drug in China, has shown potential in treating non-alcoholic fatty liver disease (NAFLD) by reducing inflammation and improving dyslipidemia, hepatic apoptosis, systemic and hepatic inflammation, and liver fibrosis. Further studies also indicated that Bicyclol may inhibit inflammatory responses by targeting MAPKs and NF-KB signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Jie Cui, Weifeng Tang, Wenqian Wang, La Yi, Fangzhou Teng, Fei Xu, Mihui Li, Mengyu Ma, Jingcheng Dong
Summary: Asthma is a difficult-to-cure disease and there is an urgent need for more reliable and effective medications. Acteoside, a phenylpropanoid glycoside found in various herbs, has been shown to have anti-inflammatory and antioxidant properties. However, there have been few studies on the impact of acteoside on asthma. Therefore, this study aimed to investigate the protective effects of acteoside on asthma and explore the underlying mechanisms both in vivo and in vitro.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biology
An-Hsun Chou, Hung-Chen Lee, Chia-Chih Liao, Huang-Ping Yu, Fu-Chao Liu
Summary: This study investigated the therapeutic effect of curcumin on acetaminophen-induced liver injury in mice. The results showed that curcumin treatment reduced liver enzyme levels, inflammation markers, and oxidative stress, while increasing antioxidant levels. Curcumin also inhibited the activation of signaling pathways involved in liver injury. This highlights the hepatoprotective potential of curcumin against acetaminophen-induced liver injury.
Article
Medicine, Research & Experimental
Ziteng Deng, Dan Li, Xue Yan, Jing Lan, Deping Han, Kai Fan, Jianyu Chang, Yunfei Ma
Summary: This study aims to evaluate the underlying mechanisms of GABA signaling on enteric glial cells (EGCs) and found that GABA receptor activation inhibits the proinflammatory factors secretion of EGCs, promotes EGCs polarization into E2 phenotype, mitigates intestinal damage in LPS-induced mice through modulating inflammatory factors expressions and inhibiting NF-KB pathway, providing potential targets for intestinal inflammatory diseases.
Article
Biochemistry & Molecular Biology
Haoqu Tan, Jinfang Hu, Wei Zuo, Yun Huang, Jian Cui, Fei Gong, Wei Bai
Summary: Recent studies have shown that the receptor for advanced glycation end-products (RAGE) plays a role in liver fibrosis and inflammatory reaction. Specifically, high expression of RAGE has been observed in non-alcoholic fatty liver disease (NAFLD). However, the specific mechanisms of RAGE in NAFLD are not well understood. This study aimed to investigate the role of RAGE in chronic intermittent hypoxia (CIH)-induced NAFLD. The results showed that RAGE and NF-kappa B were upregulated in the liver tissues of CIH-induced NAFLD mice and CIH-exposed hepatocytes. Knockdown of RAGE attenuated hepatocyte injury, lipid deposition, and inflammation induced by CIH. Further analysis revealed that the NF-kB pathway was inhibited by RAGE knockdown, leading to the alleviation of CIH-induced disorders in hepatocytes. In vivo experiments confirmed that depletion of RAGE alleviated CIH-induced NAFLD by inhibiting the NF-kB pathway. These findings suggest that RAGE could be a potential target for the treatment of NAFLD.
Article
Multidisciplinary Sciences
Guoyong Hu, Minjie Zhou, Lina Xu, Donglian Wang
Summary: This study investigates the molecular mechanisms of KLF7 in apoptosis, inflammation, and oxidative stress in H9c2 cells. The results suggest that down-regulation of KLF7 inhibits LPS-induced injury and apoptosis in H9c2 cells, as well as oxidative stress and inflammation. These findings indicate the potential use of KLF7 knockdown as a therapeutic approach for sepsis treatment.
Article
Biochemistry & Molecular Biology
Dongsheng Huang, Lianhui Su, Chaowen He, Licheng Chen, Dongxuan Huang, Jianfeng Peng, Fan Yang, Yahui Cao, Xiaohua Luo
Summary: This study evaluated the protective effects of pristimerin on cigarette smoke-induced chronic obstructive pulmonary disease (COPD). The results showed that pristimerin could reverse the effects of cigarette smoke on lung function, inflammatory cell infiltration, and lung tissue damage. Furthermore, pristimerin could decrease oxidative stress parameters and inflammatory factors levels, and exert its effects by inactivating the NF-KB pathway.
BIOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Xing-Yue Wu, Fei-Yao Wang, Hao-Xiang Chen, Hui-Li Dong, Zhan-Qin Zhao, Li -Fang Si
Summary: This study aimed to explore the mechanism of lung tissue damage caused by heat stress. The results showed that heat stress can damage the integrity of the blood-air barrier and increase permeability, leading to an intensified inflammatory response.