Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer

Thymoquinone chemosensitizes colon cancer cells through inhibition of NF-κB

(2016) Lida Zhang et al.   Oncology Letters

MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase

(2016) Recep Bayraktar et al.   Oncotarget

FOXM1 regulates expression of eukaryotic elongation factor 2 kinase and promotes proliferation, invasion and tumorgenesis of human triple negative breast cancer cells

(2016) Zuhal Hamurcu et al.   Oncotarget

microRNA Therapeutics in Cancer — An Emerging Concept

(2016) Maitri Y. Shah et al.   EBioMedicine

Regulation and roles of elongation factor 2 kinase

(2015) Christopher G. Proud   BIOCHEMICAL SOCIETY TRANSACTIONS

Natural inhibitors of PI3K/AKT signaling in breast cancer: Emphasis on newly-discovered molecular mechanisms of action

(2015) Yaghoub Safdari et al.   PHARMACOLOGICAL RESEARCH

Thymoquinone enhances cisplatin-response through direct tumor effects in a syngeneic mouse model of ovarian cancer

(2015) Andrew J. Wilson et al.   Journal of Ovarian Research

Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells

(2014) Ugur Akar et al.   Autophagy

Thymoquinone attenuates cisplatin-induced hepatotoxicity via nuclear factor kappa- β

(2014) Abdulrahman L Al-Malki et al.   BMC Complementary and Alternative Medicine

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

(2014) J. C. Liu et al.   EMBO Molecular Medicine

Thymoquinone, A Bioactive Component of Black Caraway Seeds, Causes G1 Phase Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells with Mutant p53

(2014) Kimberly M. Sutton et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Drug target miRNAs: chances and challenges

(2014) Marco F. Schmidt   TRENDS IN BIOTECHNOLOGY

Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies

(2014) Neoh Hun Phuah et al.   Biomed Research International

Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells

(2013) Ahmed A. Ashour et al.   APOPTOSIS

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

(2013) Gabriel Leprivier et al.   CELL

Regulating miRNA by Natural Agents as a New Strategy for Cancer Treatment

(2013) Sajiv Sethi et al.   CURRENT DRUG TARGETS

Inhibition of Elongation Factor-2 Kinase Augments the Antitumor Activity of Temozolomide against Glioma

(2013) Xiao-yuan Liu et al.   PLoS One

Optimal strategies for the treatment of metastatic triple-negative breast cancer with currently approved agents

(2012) F. Andre et al.   ANNALS OF ONCOLOGY

Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats

(2012) Sadiq Umar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

ER Stress Negatively Modulates the Expression of the miR-199a/214 Cluster to Regulates Tumor Survival and Progression in Human Hepatocellular Cancer

(2012) Quanlu Duan et al.   PLoS One

Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer

(2012) Ibrahim Tekedereli et al.   PLoS One

Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-γ pathway

(2011) Chern Chiuh Woo et al.   BIOCHEMICAL PHARMACOLOGY

Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis

(2011) Reelma Velho‑Pereira et al.   CELL BIOLOGY INTERNATIONAL

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway

(2010) Feng Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Triple-Negative Breast Cancer

(2010) Steven J. Isakoff   CANCER JOURNAL

NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors

(2010) Vivian Y. Shin et al.   CARCINOGENESIS

American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer

(2010) M. Elizabeth H. Hammond et al.   JOURNAL OF CLINICAL ONCOLOGY

Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer

(2010) Sanjeev Banerjee et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden

(2010) L Connelly et al.   ONCOGENE

NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy

(2009) Han-Ming Shen et al.   APOPTOSIS

MicroRNAs in Cancer: Small Molecules With a Huge Impact

(2009) Marilena V. Iorio et al.   JOURNAL OF CLINICAL ONCOLOGY

MicroRNA-224is upregulated in HepG2 cells and involved in cellular migration and invasion

(2009) Qiong Li et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin–nicotinamide induced diabetic rats

(2009) Leelavinothan Pari et al.   LIFE SCIENCES

Thymoquinone Triggers Inactivation of the Stress Response Pathway Sensor CHEK1 and Contributes to Apoptosis in Colorectal Cancer Cells

(2008) H. Gali-Muhtasib et al.   CANCER RESEARCH

NF-κB in carcinoma therapy and prevention

(2008) Matthew Brown et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Targeting Nuclear Factor- B Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis

(2008) G. Sethi et al.   MOLECULAR CANCER RESEARCH

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE