Article
Neurosciences
Marta Gronksa-Peski, J. Tiago Goncalves, Jean M. Hebert
Summary: Research shows that an enriched environment promotes adult neurogenesis by increasing the function of fibroblast growth factor receptor (FGFR) within neurogenic cells. Activation of FGFR by an enriched environment signals through FGFR substrate (FRS) to induce stem cell proliferation and via FRS and phospholipase C gamma to increase the number of adult-born neurons.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Gabriel Berdugo-Vega, Shonali Dhingra, Federico Calegari
Summary: This article reviews a wealth of research in cellular, anatomical, behavioral, and computational studies on the mammalian hippocampus, aiming to understand the fundamental mechanisms underlying cognition. Despite accumulating knowledge on how the hippocampus processes and stores information for learning and memory, our understanding of hippocampal cognitive function remains incomplete. The article discusses the structural separability of the two blades of the dentate gyrus in the hippocampus and proposes a model that suggests differences in connectivity and adult neurogenesis in the two blades may contribute to subtly different cognitive functions.
Article
Neurosciences
Sara Bottes, Baptiste N. Jaeger, Gregor-Alexander Pilz, David J. Jorg, John Darby Cole, Merit Kruse, Lachlan Harris, Vladislav Korobeynyk, Izaskun Mallona, Fritjof Helmchen, Francois Guillemot, Benjamin D. Simons, Sebastian Jessberger
Summary: Researchers identified long-term self-renewing neural stem cells (NSCs) in the adult mouse hippocampus using intravital imaging and single-cell RNA sequencing. They found that Gli1-targeted NSCs exhibit long-term self-renewal, while Ascl1-targeted NSCs have limited proliferative activity before exhaustion. The study revealed the existence of heterogeneous NSC populations with diverse behavioral properties in contributing to neurogenesis in the adult hippocampus.
NATURE NEUROSCIENCE
(2021)
Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Neurosciences
N. M. Weston, A. T. Rolfe, A. H. Freelin, T. M. Reeves, D. Sun
Summary: The hippocampus is susceptible to damage from traumatic brain injury (TBI) and resulting cognitive deficits. Recent studies have shown that TBI can enhance neurogenesis in the hippocampal dentate gyrus (DG), which is related to cognitive recovery, but the specific cellular mechanisms remain unclear. This study investigated changes in long-term potentiation (LTP) within the DG following TBI and found differing patterns of recovery in the total granule cell population and newly born granule cells.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yasuyuki Fujii, Jun Sakata, Fumitaka Sato, Kurumi Onishi, Yuki Yamato, Kazuki Sakata, Shu Taira, Hiroki Sato, Naomi Osakabe
Summary: Recent studies suggest that consumption of polyphenol-rich plant foods may reduce the risk of cognitive decline. A short-term administration of A2 may enhance spatial memory by promoting neurogenesis in the dentate gyrus of adult mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Neurosciences
Gaifen Li, Jia Liu, Yuying Guan, Xunming Ji
Summary: Hypoxia plays a crucial role in regulating various cell functions, including stem cells and neural stem cells. Hypoxia stimulation in specific brain regions can promote proliferation, migration, and maturation of neural stem cells, potentially offering a promising strategy for treating central nervous system diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Behavioral Sciences
Farah Chamaa, Batoul Darwish, Ziad Nahas, Elie D. Al-Chaer, Nayef E. Saade, Wassim Abou-Kheir
Summary: This study demonstrates that sustained activation of the anteromedial thalamic nucleus boosts neurogenesis and improves spatial reference memory. Both single and multiple sessions of deep brain stimulation prompt an increase in novel arm exploration, with multiple sessions having a greater effect starting from week 1.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Clinical Neurology
Sarah Houben, Megane Homa, Zehra Yilmaz, Karelle Leroy, Jean-Pierre Brion, Kunie Ando
Summary: AHN plays a critical role in sustaining hippocampal functions such as learning and memory, and impaired AHN in AD patients may contribute to cognitive deficits. NFTs and amyloid plaques are key neuropathological hallmarks of AD, with abnormal tau protein accumulation impacting AHN. Further research is needed to fully understand the relationship between tau pathology and AHN.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rada Jeremic, Sanja Pekovic, Irena Lavrnja, Ivana Bjelobaba, Marina Djelic, Sanja Dacic, Predrag Brkic
Summary: A growing body of evidence suggests that hyperbaric oxygenation (HBO) can affect the activity of adult neural stem cells (NSCs). In this study, the effects of sensorimotor cortex ablation (SCA) and HBO treatment (HBOT) on neurogenesis in the adult dentate gyrus (DG) were investigated. The results showed that SCA caused significant loss of neurons in the DG, while HBOT prevented the reduction of dendritic arborization and increased proliferation of progenitor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Aikaterini Lampada, Verdon Taylor
Summary: Neurogenesis stops in most areas of the mammalian brain before or shortly after birth, but in certain brain regions, the production of new neurons continues into adulthood. Neural stem cells in these neurogenic zones are situated within niches that govern their activity and fate. Majority of adult brain stem cells are mitotically inactive and can remain dormant for extended periods. The molecular mechanisms regulating neural stem cell maintenance and differentiation are of great interest, with Notch signaling identified as a critical regulator in various tissues, including the nervous system. This review examines the roles of Notch signaling, as well as the functions of different Notch receptors and ligands, in the regulation of adult neurogenesis in mice.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Nanami Kasakura, Yuka Murata, Asuka Shindo, Shiho Kitaoka, Tomoyuki Furuyashiki, Kanzo Suzuki, Eri Segi-Nishida
Summary: The dentate gyrus of the hippocampus plays a regulatory role in stress-related emotional behaviors and neurogenesis. NT-3 is expressed in the adult dentate gyrus and is enhanced under chronic stress conditions in rodents. However, the functional modulation of the dentate gyrus by NT-3 signaling is still unclear.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Natalia A. Simonova, Maxim A. Volgushev, Alexey Y. Malyshev
Summary: The dentate gyrus is a site of neurogenesis in the adult brain where integration of new-generated granule cells into the hippocampal circuitry is crucial for normal function. It has been found that GABA-ergic inputs play a significant role in synaptic plasticity, and non-associative plasticity changes with maturation of newly generated granule cells.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Davide Lattanzi, David Savelli, Marica Pagliarini, Riccardo Cuppini, Patrizia Ambrogini
Summary: Exercise can have long-term effects on the morpho-functional maturation of newborn neurons, enhancing synaptic plasticity and promoting their maturation and integration in the hippocampal circuitry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Katarzyna Bartkowska, Beata Tepper, Krzysztof Turlejski, Ruzanna Djavadian
Summary: This article evaluates the developmental neurogenesis that occurs after birth in both marsupials and eutherians, with a focus on the generation of granule cells during the formation of the olfactory bulb, dentate gyrus, and cerebellum. The importance of immature neurons in the piriform cortex of young mammals is discussed, and the knowledge of adult neurogenesis in the olfactory bulb and dentate gyrus of marsupials is synthesized to determine the essentiality of adult-born neurons in a given area.
Review
Neurosciences
S. M. Ohline, W. C. Abraham
Article
Biochemistry & Molecular Biology
M. Schouten, P. Bielefeld, L. Garcia-Corzo, E. M. J. Passchier, S. Gradari, T. Jungenitz, M. Pons-Espinal, E. Gebara, S. Martin-Suarez, P. J. Lucassen, H. E. De Vries, J. L. Trejo, S. W. Schwarzacher, D. De Pietri Tonelli, N. Toni, H. Mira, J. M. Encinas, C. P. Fitzsimons
MOLECULAR PSYCHIATRY
(2020)
Article
Biotechnology & Applied Microbiology
Jacob T. Cain, Shibi Likhite, Katherine A. White, Derek J. Timm, Samantha S. Davis, Tyler B. Johnson, Cassandra N. Dennys-Rivers, Federica Rinaldi, Dario Motti, Sarah Corcoran, Pablo Morales, Christopher Pierson, Stephanie M. Hughes, Stella Y. Lee, Brian K. Kaspar, Kathrin Meyer, Jill M. Weimer
Article
Neurosciences
Anurag Singh, Owen D. Jones, Bruce G. Mockett, Shane M. Ohline, Wickliffe C. Abraham
JOURNAL OF NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Robert J. Huber, Stephanie M. Hughes, Wenfei Liu, Alan Morgan, Richard Tuxworth, Claire Russell
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Neurosciences
Jodi A. Morrissey, Bruce G. Mockett, Anurag Singh, David Kweon, Shane M. Ohline, Warren P. Tate, Stephanie M. Hughes, Wickliffe C. Abraham
Article
Neurosciences
Jodi A. Morrissey, Erin Bigus, Julie C. Necarsulmer, Vinay Srinivasan, Katie Peppercorn, Daniel J. O'Leary, Bruce G. Mockett, Warren P. Tate, Stephanie M. Hughes, Karen D. Parfitt, Wickliffe C. Abraham
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Medicine, Research & Experimental
Sophie N. Mathiesen, Jasmine L. Lock, Lucia Schoderboeck, Wickliffe C. Abraham, Stephanie M. Hughes
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2020)
Article
Neurosciences
Margaret Ryan, Valerie T. Y. Tan, Nasya Thompson, Diane Guevremont, Bruce G. Mockett, Warren P. Tate, Wickliffe C. Abraham, Stephanie M. Hughes, Joanna Williams
Summary: This study identified key molecular processes underlying the long-term neuroprotective and therapeutic effects of increasing sAPP alpha levels in vivo, including the regulation of GABA receptor signaling, cell survival, and inflammatory responses. Upstream gene regulatory analysis indicated sAPP alpha activation of Interleukin-4, which can counteract inflammatory changes in Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Hannah L. Best, Alison J. Clare, Kirstin O. McDonald, Hollie E. Wicky, Stephanie M. Hughes
Summary: Neuronal ceroid lipofuscinoses (NCLs) are a group of inherited childhood neurodegenerative disorders characterized by neuroinflammation and alterations in the extracellular environment. This study investigated the secretome in the CLN6 variant of NCL and found significant changes that could be partially corrected with gene therapy, suggesting potential biomarkers for disease monitoring. Overall, the secretome plays a role in CLN6 pathogenesis and may serve as an in vitro model for future studies.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
I. Basak, H. E. Wicky, K. O. McDonald, J. B. Xu, J. E. Palmer, H. L. Best, S. Lefrancois, S. Y. Lee, L. Schoderboeck, S. M. Hughes
Summary: Neuronal Ceroid Lipofuscinosis (NCL), also known as Batten disease, is an incurable childhood brain disease caused by mutations in thirteen CLN genes. Mutations in the CLN5 gene lead to a form of variant late-infantile NCL, with widespread protein expression in various tissues. Research on CLN5 helps to understand lysosomal biology and develop efficient therapies for CLN5 Batten disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Neurosciences
Shane M. Ohline, Connie Chan, Lucia Schoderboeck, Hollie E. Wicky, Warren P. Tate, Stephanie M. Hughes, Wickliffe C. Abraham
Summary: sAPP alpha is a regulator of neuronal and memory mechanisms and has neurogenic and neuroprotective effects. The delivery of sAPP alpha can rescue adult hippocampal neurogenesis in an APP/PS1 mouse model of Alzheimer's disease.
Article
Neurosciences
Shane M. Ohline, Xinhuai Liu, Mohamed F. Ibrahim, Bruce M. Mockett, Ruth M. Empson, Wickliffe C. Abraham, Karl J. Iremonger, Peter P. Jones
Summary: This study compared intrinsic excitability and spontaneous synaptic inputs in CA1 hippocampal neurons of aged APPswe/PS1dE9 mice and wildtype control mice. The results showed no change in intrinsic excitability or spontaneous postsynaptic currents between the two groups, but a reduced input resistance and an increase in hyperpolarization-activated sag current were observed. These findings suggest that neuronal hyperexcitability may not be a consistent feature of all AD mouse models.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Indranil Basak, Rhodri Harfoot, Jennifer E. Palmer, Abhishek Kumar, Miguel E. Quinones-Mateu, Lucia Schweitzer, Stephanie M. Hughes
Summary: The research indicates that although SARS-CoV-2 infects neurons at a lower rate and cannot replicate, it may still lead to irregular morphology in neurons and affect mitochondrial proteins and apoptotic and metabolic pathways, potentially causing the development of neurological complications. These findings contribute to understanding the potential mechanisms behind SARS-CoV-2-mediated neuropathology in the human brain.