Article
Multidisciplinary Sciences
Yi Zhou, Yijing Su, Shiying Li, Benjamin C. Kennedy, Daniel Y. Zhang, Allison M. Bond, Yusha Sun, Fadi Jacob, Lu Lu, Peng Hu, Angela N. Viaene, Ingo Helbig, Sudha K. Kessler, Timothy Lucas, Ryan D. Salinas, Xiaosong Gu, H. Isaac Chen, Hao Wu, Joel E. Kleinman, Thomas M. Hyde, David W. Nauen, Daniel R. Weinberger, Guo-li Ming, Hongjun Song
Summary: This study identified molecular characteristics of immature dentate granule cells (imGCs) in the adult human hippocampus using single-nucleus RNA sequencing, revealing common molecular hallmarks across the lifespan and age-dependent transcriptional dynamics. The study also showed a decreased number of imGCs in Alzheimer's disease and demonstrated neurogenesis in the adult human hippocampus.
Article
Biology
Nicholas P. Vyleta, Jason S. Snyder
Summary: Adult-born granule neurons in the hippocampus exhibit enhanced excitability and plasticity during immature stages, which is believed to contribute to their unique roles in learning and memory. Our findings reveal hyper-excitability in the presynaptic terminals of mossy fibers onto CA3 pyramidal neurons, and suggest rapid functionality in immature neurons. Electrophysiological recordings in mouse hippocampal slices demonstrate faster maturation of action potential waveforms in the presynaptic bouton of adult-born granule neurons compared to the soma.
COMMUNICATIONS BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Gabriel Berdugo-Vega, Shonali Dhingra, Federico Calegari
Summary: This article reviews a wealth of research in cellular, anatomical, behavioral, and computational studies on the mammalian hippocampus, aiming to understand the fundamental mechanisms underlying cognition. Despite accumulating knowledge on how the hippocampus processes and stores information for learning and memory, our understanding of hippocampal cognitive function remains incomplete. The article discusses the structural separability of the two blades of the dentate gyrus in the hippocampus and proposes a model that suggests differences in connectivity and adult neurogenesis in the two blades may contribute to subtly different cognitive functions.
Review
Computer Science, Artificial Intelligence
Dhireesha Kudithipudi, Mario Aguilar-Simon, Jonathan Babb, Maxim Bazhenov, Douglas Blackiston, Josh Bongard, Andrew P. Brna, Suraj Chakravarthi Raja, Nick Cheney, Jeff Clune, Anurag Daram, Stefano Fusi, Peter Helfer, Leslie Kay, Nicholas Ketz, Zsolt Kira, Soheil Kolouri, Jeffrey L. Krichmar, Sam Kriegman, Michael Levin, Sandeep Madireddy, Santosh Manicka, Ali Marjaninejad, Bruce McNaughton, Risto Miikkulainen, Zaneta Navratilova, Tej Pandit, Alice Parker, Praveen K. Pilly, Sebastian Risi, Terrence J. Sejnowski, Andrea Soltoggio, Nicholas Soures, Andreas S. Tolias, Dario Urbina-Melendez, Francisco J. Valero-Cuevas, Gido M. van de Ven, Joshua T. Vogelstein, Felix Wang, Ron Weiss, Angel Yanguas-Gil, Xinyun Zou, Hava Siegelmann
Summary: Biological organisms learn from interactions with their environment, and artificial systems also need the ability to learn throughout their lifetime. This article introduces biological mechanisms and artificial models and mechanisms for lifelong learning, and discusses opportunities to bridge the gap between natural and artificial intelligence.
NATURE MACHINE INTELLIGENCE
(2022)
Article
Biochemistry & Molecular Biology
Daniel G. Blackmore, Fabrice Turpin, Tishila Palliyaguru, Harrison T. Evans, Antony Chicoteau, Wendy Lee, Matthew Pelekanos, Nghia Nguyen, Jae Song, Robert K. P. Sullivan, Pankaj Sah, Perry F. Bartlett, Jurgen Gotz
Summary: The study reveals that scanning ultrasound combined with microbubbles can fully restore LTP induction in the aged mouse brain, while ultrasound treatment alone can also improve LTP and spatial learning deficits in aged mice. This non-invasive therapeutic approach may enhance cognition in elderly humans.
MOLECULAR PSYCHIATRY
(2021)
Article
Cell & Tissue Engineering
Ya-Dong Li, Yan-Jia Luo, Ling Xie, Dalton S. Tart, Ryan N. Sheehy, Libo Zhang, Leon G. Coleman, Xian Chen, Juan Song
Summary: Patients with Alzheimer's disease (AD) show memory loss, depression, and anxiety, along with impaired adult hippocampal neurogenesis (AHN). This study demonstrates that optogenetic stimulation of the hypothalamic supramammillary nucleus (SuM) enhances AHN in AD mouse models, improving memory and emotion deficits. Activation of SuM-enhanced adult-born neurons (ABNs) triggers synaptic plasticity and microglia phagocytosis, providing insights into the signaling mechanisms involved.
Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Neurosciences
Kylie A. Huckleberry, Rebecca M. Shansky
Summary: Neurogenesis in the dentate gyrus contributes to the formation of a heterogeneous DG with specialized adult-born neurons. More research is needed to consider the unique functions of adult-born neurons and to address critical gaps in current studies.
Article
Neurosciences
Megane Missaire, Nicolas Fraize, Jean-Christophe Comte, Bruno Truchet, Regis Parmentier, Paul-Antoine Salin, Gael Malleret
Summary: Long-term storage of information in memory relies on long-term synaptic plasticity processes. Studies have shown synaptic changes after training in long-term/reference memory and working memory tasks. Consolidation of long-term information leads to delayed synaptic potentiation, while optimal information processing into working memory triggers synaptic depression.
Article
Neurosciences
Lyles R. Clark, Sanghee Yun, Nana K. Acquah, Priya L. Kumar, Hannah E. Metheny, Rikley C. C. Paixao, Akivas S. Cohen, Amelia J. Eisch
Summary: This study discusses the impact of mild traumatic brain injuries (mTBIs) on the process of adult hippocampal DG neurogenesis. The results show that mTBI induces transient increases in neurogenesis in the ipsilateral hippocampal region, but not in the contralateral hemisphere. These findings are important for understanding the functional implications of TBI-induced neurogenesis and potential neuron replacement or repair after TBI.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Cell Biology
Luka Culig, Xixia Chu, Vilhelm A. Bohr
Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.
AGEING RESEARCH REVIEWS
(2022)
Article
Multidisciplinary Sciences
Can Dong, Antoine D. Madar, Mark E. J. Sheffield
Summary: The study found that CA1 and CA3 play different roles in spatial memory processing. Place fields in CA1 emerge rapidly but tend to shift backwards from trial-to-trial and remap upon re-exposure to the environment a day later, while place fields in CA3 develop gradually and show more stable trial-to-trial and day-to-day dynamics, indicating distinct functional roles in representing space for each subfield.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Fiorenza Stagni, Beatrice Uguagliati, Marco Emili, Andrea Giacomini, Renata Bartesaghi, Sandra Guidi
Summary: The study suggests that the use of 7,8-DHF can improve or restore overall brain proliferation potency in prenatal Ts65Dn mice, with mild long-term effects. However, further research is needed to determine if treatment can extend into the neonatal period to achieve sustained improvement in brain development in adulthood.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Blanca Marin Bosch, Aurelien Bringard, Maria G. Logrieco, Estelle Lauer, Nathalie Imobersteg, Aurelien Thomas, Guido Ferretti, Sophie Schwartz, Kinga Igloi
Summary: The study reveals that moderate intensity exercise enhances hippocampal memory performance and increases levels of endocannabinoids and BDNF, suggesting a synergistic modulation of underlying neural plasticity mechanisms.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Nicholas P. Vyleta, Jason S. Snyder
Summary: Studies suggest that adult-born neurons display slow development of LTP at LPP synapses, but gradually increase over a period of 3-4 months, indicating a presynaptic mechanism. This new form of neuron plasticity may be relevant for maintaining cognitive function in aging.
Article
Neurosciences
S. Sartini, D. Lattanzi, P. Ambrogini, M. Di Palma, C. Galati, D. Savelli, E. Polidori, C. Calcabrini, M. B. L. Rocchi, P. Sestili, R. Cuppini
Article
Neurosciences
Dasiel O. Borroto-Escuela, Caitlin M. DuPont, Xiang Li, David Savelli, Davide Lattanzi, Ipsit Srivastava, Manuel Narvaez, Michael Di Palma, Elisa Barbieri, Yuniesky Andrade-Talavera, Riccardo Cuppini, Yuji Odagaki, Miklos Palkovits, Patrizia Ambrogini, Maria Lindskog, Kjell Fuxe
FRONTIERS IN CELLULAR NEUROSCIENCE
(2017)
Article
Neurosciences
Patrizia Ambrogini, Maria Cristina Albertini, Michele Betti, Claudia Galati, Davide Lattanzi, David Savelli, Michael Di Palma, Stefania Saccomanno, Desiree Bartolini, Pierangelo Torquato, Gabriele Ruffolo, Fabiola Olivieri, Francesco Galli, Eleonora Palma, Andrea Minelli, Riccardo Cuppini
MOLECULAR NEUROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Davide Curzi, Stefano Sartini, Michele Guescini, DaviDe lattanzi, Michael Di Palma, Patrizia Ambrogini, David Savelli, Vilberto Stocchi, Riccardo Cuppini, Elisabetta Falcieri
Article
Multidisciplinary Sciences
Erica Cesarini, Liana Cerioni, Barbara Canonico, Gianna Di Sario, Andrea Guidarelli, DaviDe lattanzi, David Savelli, Michele Guescini, Maria Gemma Nasoni, Noemi Bigini, Riccardo Cuppini, Vilberto Stocchi, Patrizia Ambrogini, Stefano Papa, Francesca Luchetti
Article
Nutrition & Dietetics
Stefano Sartini, Davide Lattanzi, Michael Di Palma, David Savelli, Silvia Eusebi, Piero Sestili, Riccardo Cuppini, Patrizia Ambrogini
Article
Biochemistry & Molecular Biology
Patrizia Ambrogini, Davide Lattanzi, Michael Di Palma, Caterina Ciacci, David Savelli, Claudia Galati, Anna Maria Gioacchini, Laura Pietrangelo, Luciana Vallorani, Feliciano Protasi, Riccardo Cuppini
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Multidisciplinary
Dasiel O. Borroto-Escuela, Xiang Li, Alexander O. Tarakanov, David Savelli, Manuel Narvaez, Kirill Shumilov, Yuniesky Andrade-Talavera, Antonio Jimenez-Beristain, Bartosz Pomierny, Zaida Diaz-Cabiale, Riccardo Cuppini, Patrizia Ambrogini, Maria Lindskog, Kjell Fuxe
Review
Biochemistry & Molecular Biology
Patrizia Ambrogini, Michele Betti, Claudia Galati, Michael Di Palma, Davide Lattanzi, David Savelli, Francesco Galli, Riccardo Cuppini, Andrea Minelli
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)