Alexander disease: an astrocytopathy that produces a leukodystrophy

Glial fibrillary acidic protein exhibits altered turnover kinetics in a mouse model of Alexander disease

(2017) Laura R. Moody et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocytic modulation of neuronal excitability through K + spatial buffering

(2017) Alba Bellot-Saez et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease

(2017) Alexander A. Sosunov et al.   Acta Neuropathologica Communications

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy

(2016) Eitan Israeli et al.   HUMAN MOLECULAR GENETICS

Alexander Disease

(2016) Ali Tavasoli et al.   JOURNAL OF CHILD NEUROLOGY

Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease

(2016) Michael R. Heaven et al.   JOURNAL OF PROTEOME RESEARCH

Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia

(2016) Nicola B. Hamilton et al.   NATURE

Glutamate signalling: A multifaceted modulator of oligodendrocyte lineage cells in health and disease

(2016) Sonia Spitzer et al.   NEUROPHARMACOLOGY

Lipocalin-2 as a therapeutic target for brain injury: An astrocentric perspective

(2016) Kyoungho Suk   PROGRESS IN NEUROBIOLOGY

Astrocyte pathology in Alexander disease causes a marked inflammatory environment

(2015) Markel Olabarria et al.   ACTA NEUROPATHOLOGICA

Elevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II Alexander disease

(2015) Heather R. Minkel et al.   GLIA

CXCL10 Triggers Early Microglial Activation in the Cuprizone Model

(2015) Tim Clarner et al.   JOURNAL OF IMMUNOLOGY

Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes

(2015) Simona Federica Spampinato et al.   Frontiers in Cellular Neuroscience

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

(2015) Hélène O. B. Gautier et al.   Nature Communications

Nitric oxide mediates glial-induced neurodegeneration in Alexander disease

(2015) Liqun Wang et al.   Nature Communications

Involvement of p38 MAPK in reactive astrogliosis induced by ischemic stroke

(2014) Gourav Roy Choudhury et al.   BRAIN RESEARCH

Direct and Indirect Effects of Immune and Central Nervous System–Resident Cells on Human Oligodendrocyte Progenitor Cell Differentiation

(2014) Craig S. Moore et al.   JOURNAL OF IMMUNOLOGY

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis

(2014) Roy Y. Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model

(2014) Emily Mills Ko et al.   Journal of Neuroinflammation

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition

(2014) Sunita Maharjan et al.   Scientific Reports

Hyaluronan accumulation and arrested oligodendrocyte progenitor maturation in vanishing white matter disease

(2013) Marianna Bugiani et al.   BRAIN

Phenotypic Conversions of "Protoplasmic" to "Reactive" Astrocytes in Alexander Disease

(2013) A. A. Sosunov et al.   JOURNAL OF NEUROSCIENCE

Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition

(2012) Marc Kästle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Homeostatic function of astrocytes: Ca2+ and Na+ signalling

(2012) Vladimir Parpura et al.   Translational Neuroscience

Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability

(2011) Yi-Song Chen et al.   EXPERIMENTAL CELL RESEARCH

Lipocalin-2 Is a Chemokine Inducer in the Central Nervous System

(2011) Shinrye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Misfolding and Oxidative Stress Promote Glial-Mediated Neurodegeneration in an Alexander Disease Model

(2011) L. Wang et al.   JOURNAL OF NEUROSCIENCE

GFAP mutations, age at onset, and clinical subtypes in Alexander disease

(2011) M. Prust et al.   NEUROLOGY

Oligomers of Mutant Glial Fibrillary Acidic Protein (GFAP) Inhibit the Proteasome System in Alexander Disease Astrocytes, and the Small Heat Shock Protein αB-Crystallin Reverses the Inhibition

(2010) Guomei Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alexander Disease Mutant Glial Fibrillary Acidic Protein Compromises Glutamate Transport in Astrocytes

(2010) Rujin Tian et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Fate of Synaptic Input to NG2 Glial Cells: Neurons Specifically Downregulate Transmitter Release onto Differentiating Oligodendroglial Cells

(2010) M. Kukley et al.   JOURNAL OF NEUROSCIENCE

Excitability and Synaptic Communication within the Oligodendrocyte Lineage

(2010) L. M. De Biase et al.   JOURNAL OF NEUROSCIENCE

Electrical stimulation of the medullary pyramid promotes proliferation and differentiation of oligodendrocyte progenitor cells in the corticospinal tract of the adult rat

(2010) Qun Li et al.   NEUROSCIENCE LETTERS

Intermediate filament transcription in astrocytes is repressed by proteasome inhibition

(2009) Jinte Middeldorp et al.   FASEB JOURNAL

Deletion of Astrocyte Connexins 43 and 30 Leads to a Dysmyelinating Phenotype and Hippocampal CA1 Vacuolation

(2009) S. E. Lutz et al.   JOURNAL OF NEUROSCIENCE

Alexander disease: An important mimicker of focal brainstem glioma

(2009) Katherine Van Poppel et al.   PEDIATRIC BLOOD & CANCER

Alexander disease: An important mimicker of focal brainstem glioma

(2009) Stefan Ring et al.   PEDIATRIC BLOOD & CANCER

Tumor-like enlargement of the optic chiasm in an infant with Alexander disease

(2008) Cyril Mignot et al.   BRAIN & DEVELOPMENT

Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice

(2008) Woosung Cho et al.   EXPERIMENTAL CELL RESEARCH

Postmortem analysis following 71 months of deep brain stimulation of the subthalamic nucleus for Parkinson disease

(2008) David A. Sun et al.   JOURNAL OF NEUROSURGERY