T helper 17.1 cells associate with multiple sclerosis disease activity: perspectives for early intervention

Recognition of viral and self-antigens by T H 1 and T H 1/T H 17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses

(2017) Moira Paroni et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Elevated Levels of Proinflammatory Cytokines in Cerebrospinal Fluid of Multiple Sclerosis Patients

(2017) Timur Khaibullin et al.   Frontiers in Immunology

Immunological and pathological characterization of fatal rebound MS activity following natalizumab withdrawal

(2016) Catherine Larochelle et al.   Multiple Sclerosis Journal

Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration

(2016) Melissa A Lopes Pinheiro et al.   eLife

Immunological and pathological characterization of fatal rebound MS activity following natalizumab withdrawal

(2016) Catherine Larochelle et al.   Multiple Sclerosis Journal

Increased expression of Tbet in CD4+ T cells from clinically isolated syndrome patients at high risk of conversion to clinically definite MS

(2016) Sharee A. Basdeo et al.   SpringerPlus

The role and modulation of CCR6+ Th17 cell populations in rheumatoid arthritis

(2015) Sandra M.J. Paulissen et al.   CYTOKINE

Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation

(2015) M. Paterka et al.   EMBO JOURNAL

GM-CSF promotes migration of human monocytes across the blood brain barrier

(2015) Daphne Y. S. Vogel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins

(2015) Gijsbert P van Nierop et al.   Multiple Sclerosis Journal

Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression

(2015) Andrea Nemecek et al.   Multiple Sclerosis Journal

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

(2015) Nicola Gagliani et al.   NATURE

Multiple sclerosis—a quiet revolution

(2015) Richard M. Ransohoff et al.   Nature Reviews Neurology

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

(2015) Yonghao Cao et al.   Science Translational Medicine

Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins

(2015) Gijsbert P van Nierop et al.   Multiple Sclerosis Journal

Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression

(2015) Andrea Nemecek et al.   Multiple Sclerosis Journal

Regulatory T cells in autoimmune neuroinflammation

(2014) Markus Kleinewietfeld et al.   IMMUNOLOGICAL REVIEWS

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells

(2014) Tilman Schneider-Hohendorf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-1  Promotes the Differentiation of Polyfunctional Human CCR6+CXCR3+ Th1/17 Cells That Are Specific for Pathogenic and Commensal Microbes

(2014) T. Duhen et al.   JOURNAL OF IMMUNOLOGY

Recurrence or rebound of clinical relapses after discontinuation of natalizumab therapy in highly active MS patients

(2014) Per Soelberg Sorensen et al.   JOURNAL OF NEUROLOGY

Fatigue at time of CIS is an independent predictor of a subsequent diagnosis of multiple sclerosis

(2014) Tessel F Runia et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

IL-17 and GM-CSF Expression Are Antagonistically Regulated by Human T Helper Cells

(2014) R. Noster et al.   Science Translational Medicine

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells

(2014) Felix J. Hartmann et al.   Nature Communications

Main features of human T helper 17 cells

(2013) Francesco Annunziato et al.   Annals of the New York Academy of Sciences

IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair

(2013) Gilad Kunis et al.   BRAIN

The CD226/CD155 Interaction Regulates the Proinflammatory (Th1/Th17)/Anti-Inflammatory (Th2) Balance in Humans

(2013) E. Lozano et al.   JOURNAL OF IMMUNOLOGY

First-line natalizumab in multiple sclerosis: rationale, patient selection, benefits and risks

(2013) Jacqueline Ann Nicholas et al.   Therapeutic Advances in Chronic Disease

Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system

(2012) Catherine Larochelle et al.   BRAIN

Predictors of freedom from disease activity in natalizumab treated-patients with multiple sclerosis

(2012) Luca Prosperini et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Clinically isolated syndromes

(2012) David H Miller et al.   LANCET NEUROLOGY

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

(2011) Chris H. Polman et al.   ANNALS OF NEUROLOGY

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE

(2011) Veit Rothhammer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Immune reconstitution inflammatory syndrome in natalizumab-associated PML

(2011) I. L. Tan et al.   NEUROLOGY

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

Elevated Epstein-Barr virus-encoded nuclear antigen-1 immune responses predict conversion to multiple sclerosis

(2009) Jan D. Lünemann et al.   ANNALS OF NEUROLOGY

Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis

(2009) Verena Brucklacher-Waldert et al.   BRAIN

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells

(2009) P. Kivisakk et al.   NEUROLOGY

β1integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity

(2009) Martina Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

(2008) Ingunn M Stromnes et al.   NATURE MEDICINE

Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event

(2008) J.-C. Corvol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA