Review
Biochemistry & Molecular Biology
Mustapha Benkhalifa, Fabien Joao, Cynthia Duval, Debbie Montjean, Molka Bouricha, Rosalie Cabry, Marie-Claire Belanger, Hatem Bahri, Pierre Miron, Moncef Benkhalifa
Summary: After more than four decades of assisted reproductive technology (ART) practice, the failure of in vitro fertilization (IVF) treatments and recurrent implantation failures (RIFs) and repeated pregnancy loss (RPL) remain significant issues. This article reviews different therapeutic options and suggests that immunomodulation and predictive biomarkers may be promising solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Genia Rozen, Peter Rogers, Wan Tinn Teh, Catharyn J. Stern, Alex Polyakov
Summary: RIF is a disorder with an imprecise definition lacking robust scientific basis, presenting significant challenges in diagnosis and treatment. The concept of 'Theoretical Cumulative Implantation Rate' is proposed to determine RIF diagnosis based on objective data. An updated and standardized definition is needed for patient counseling and research planning.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Paul Pirtea, Marcelle I. Cedars, Kate Devine, Baris Ata, Jason Franasiak, Catherine Racowsky, Jim Toner, Richard T. Scott, Dominique de Ziegler, Kurt T. Barnhart
Summary: To date, there is no clear definition and function impairment of recurrent implantation failure (RIF). Therefore, the term RIF is currently used somewhat haphazardly based on clinicians' judgment. International experts in reproductive medicine met in Lugano, Switzerland, in July 2022 to review RIF and determine its diagnosis and management. Rating: 8/10
FERTILITY AND STERILITY
(2023)
Review
Biochemistry & Molecular Biology
Konstantinos Pantos, Sokratis Grigoriadis, Evangelos Maziotis, Kalliopi Pistola, Paraskevi Xystra, Agni Pantou, Georgia Kokkali, Athanasios Pappas, Maria Lambropoulou, Konstantinos Sfakianoudis, Mara Simopoulou
Summary: Recurrent implantation failure (RIF) is a complex condition affecting 10-15% of IVF couples. Dysregulation of interleukins (ILs), which are involved in immune responses, plays a crucial role in the pathogenesis of RIF. Further research is needed to understand the molecular mechanisms of ILs in order to provide evidence-based consultancy and decision making for RIF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Carolina von Grothusen, Caroline Frisendahl, Vijayachitra Modhukur, Parameswaran Grace Lalitkumar, Maire Peters, Omid R. Faridani, Andres Salumets, Nageswara Rao Boggavarapu, Kristina Gemzell-Danielsson
Summary: This study compares the abundance of miRNAs in uterine fluid between healthy fertile women and women with recurrent implantation failure (RIF). The results show that the composition of miRNAs in RIF uterine fluid is different from that of healthy fertile women, and the dysregulated miRNAs are associated with impaired endometrial receptivity and embryo implantation. These findings shed light on the molecular mechanisms behind RIF and may have implications for future biomarker and clinical treatment studies.
HUMAN REPRODUCTION
(2022)
Article
Public, Environmental & Occupational Health
Samira Ghorbani, Parvin Abedi, Khadije Hekmat, Saeed Ghanbari, Narjes Dibavand
Summary: This study aimed to assess the relationship between recurrent implantation failure and sexual function in infertile Iranian women, and found that women with recurrent implantation failure had significantly lower sexual function. Therefore, sexual function issues should be treated as an important component of comprehensive care.
REPRODUCTIVE HEALTH
(2022)
Article
Endocrinology & Metabolism
Chenyi Zhong, Liusijie Gao, Li Shu, Zhen Hou, Lingbo Cai, Jie Huang, Jiayin Liu, Yundong Mao
Summary: Endometriosis activity has a negative impact on the outcomes of IVF/ICSI cycles in patients with recurrent implantation failure (RIF). Patients with controlled endometriosis activity showed higher cumulative live birth rates, emphasizing the importance of medical treatment for improved prognosis in these patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Jiaxing Li, Jia Qi, Guangxin Yao, Qinling Zhu, Xinyu Li, Rui Xu, Zhenyi Zhu, Hanting Zhao, Yuan Wang, Ying Ding, Yun Sun
Summary: SIRT1 plays a crucial role in regulating differentiation and maintaining ROS homeostasis of human ESCs during decidualization. Decreased expression of SIRT1 in RIF patients disrupts ROS balance, leading to inhibition of decidualization and reduced expression of decidual markers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Xavier Santamaria, Carlos Simon
Summary: Unexplained infertility and recurrent implantation failure are diagnoses made based on failed pregnancy attempts, often leading to frustration for patients and caregivers. Evidence suggests that endometrial factors may play a role in these cases, potentially improving treatment outcomes.
SEMINARS IN REPRODUCTIVE MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Aleksandra E. Mrozikiewicz, Marcin Ozarowski, Piotr Jedrzejczak
Summary: Infertility affects 8-12% of reproductive age couples worldwide, with a significant impact on women experiencing recurrent implantation failure (RIF). RIF is a complex condition involving various physiological and molecular mechanisms, with studies suggesting associations with hormone level imbalances, disturbances of angiogenic and immunomodulatory factors, certain genetic polymorphisms, and ethnicity-related inconsistencies. This review highlights the importance of factors contributing to RIF development, potentially paving the way for new diagnostic and therapeutic solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Micah J. Hill
Summary: Recurrent implantation failure presents a challenging clinical dilemma with no consensus diagnostic criteria. Current evidence provides some guidance for clinical investigation and treatment, but further research is needed to establish a consensus diagnosis.
FERTILITY AND STERILITY
(2021)
Review
Obstetrics & Gynecology
Jason M. Franasiak, Diana Alecsandru, Eric J. Forman, Laura C. Gemmell, Jeffrey M. Goldberg, Natalia Llarena, Cheri Margolis, Joop Laven, Sam Schoenmakers, Emre Seli
Summary: Implantation is a critical step in human reproduction, and recurrent implantation failure can result from various factors. Literature discussing this clinical phenomenon is increasing, and there is not a universally agreed-on definition for it.
FERTILITY AND STERILITY
(2021)
Article
Public, Environmental & Occupational Health
Nayna Patel, Nidhi Patel, Sejal Pal, Neelam Nathani, Ramesh Pandit, Molina Patel, Niket Patel, Chaitanya Joshi, Bhavin Parekh
Summary: This study examined the relationship between gut and vaginal microbiota in infertile women. The results showed significant differences in diversity and structure of gut bacteria between the infertile and control groups. The RIF group had an enrichment of Gram-positive bacteria, while the UE group had a relatively higher abundance of Gram-negative bacteria. Mucus-producing genera decreased in the infertile group. Vaginal microbiota was dominated by Lactobacillus, and overgrowth of anaerobic bacteria occurred in the controls.
Article
Obstetrics & Gynecology
Edgardo Somigliana, Andrea Busnelli, Erkan Kalafat, Paola Vigano, Baris Ata
Summary: Most proposed definitions of recurrent implantation failure (RIF) are not statistically based. Recently, statistical approaches have been proposed, but their effectiveness relies on endorsement from the scientific community.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Endocrinology & Metabolism
Junying Ma, Wenyan Gao, Da Li
Summary: Recurrent implantation failure (RIF) is a common problem in couples undergoing in vitro fertilization and embryo transfer. The lack of widely accepted definitions and treatment protocols hampers the progress in predicting and preventing RIF. The possible causes of RIF include immunology, thrombophilias, endometrial receptivity, microbiome, anatomical abnormalities, male factors, and embryo aneuploidy. Individualized treatment aimed at addressing the primary cause is crucial in increasing the implantation rate.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Ercan Bastu, Irem Demiral, Tuba Gunel, Ege Ulgen, Ece Gumusoglu, Mohammad Kazem Hosseini, Ugur Sezerman, Faruk Buyru, John Yeh
REPRODUCTIVE SCIENCES
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Funda Gungor Ugurlucan, Ozlem Dural, Cenk Yasa, Gamze Kirpinar, Suleyman Engin Akhan
Article
Urology & Nephrology
Funda Gungor Ugurlucan, Ipek Evruke, Cenk Yasa, Ozlem Dural, Onay Yalcin
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2020)
Article
Urology & Nephrology
Funda Gungor Ugurlucan, Cenk Yasa, Bahar Yuksel Ozgor, Goksen Ayvacikli, Cansu Gunaydin, Burcin K. Balci, Onay Yalcin
NEUROUROLOGY AND URODYNAMICS
(2020)
Review
Endocrinology & Metabolism
Cenk Yasa, Funda Gungor Ugurlucan
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2020)
Article
Obstetrics & Gynecology
Ercan Bastu, Hale Goksever Celik, Yucel Kocyigit, Dilara Yozgatli, Cenk Yasa, Selin Ozaltin, Sema Tas, Meryem Soylu, Atahan Durbas, Husnu Gorgen, Faruk Buyru
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2020)
Article
Obstetrics & Gynecology
Fatemeh Azhari, Sadrettin Pence, Mohammad Kazem Hosseini, Burcin Karamustafaoglu Balci, Nazife Cevik, Ercan Bastu, Tuba Gunel
Summary: This study analyzed the expression levels of microRNAs in endometrial samples from recurrent implantation failure patients and healthy controls, and found that certain microRNAs may be involved in the development of RIF. These microRNAs could potentially serve as biomarkers for early diagnosis of RIF patients.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Urology & Nephrology
Cenk Yasa, Funda Gungor Ugurlucan, Ozlem Dural, Onay Yalcin
Summary: The study aimed to externally validate a prediction model for de novo stress urinary incontinence (SUI) after surgical correction of advanced pelvic organ prolapse (POP), but found that the model had poor clinical performance and suggested the need for future prospective studies to improve prediction capacity.
NEUROUROLOGY AND URODYNAMICS
(2021)
Article
Obstetrics & Gynecology
Fuat Eserol, Hale Goksever Celik, Asli Nehir Aytan, Ali Celik, Engin Celik, Faruk Buyru, Ercan Bastu
Summary: A study on 765 patients undergoing IVF treatment showed that performing diagnostic hysteroscopy before fresh or FET does not improve pregnancy rates.
JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION
(2021)
Article
Obstetrics & Gynecology
Cem Demirel, Hale Goksever Celik, Firat Tulek, Kardelen Uzun, Ercan Bastu
Summary: This study aimed to assess whether dual trigger alters the ploidy chance of a blastocyst in PGT-A cycles, and found that dual triggering did not provide additional superiority on blastocyst euploidy rate compared to hCG triggering. Further studies in women with different infertility etiology are needed to evaluate the impact of triggering method on ploidy rates.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Turkan Gursu, Hale Goksever Celik, Alper Eraslan, Berk Angun, Selin Ozaltin, John Yeh, Ercan Bastu
Summary: This study aimed to investigate the effect of endometrial thickness (ENT) change in response to progesterone on pregnancy outcomes in fresh oocyte donation (OD) recipients. The results showed that the change in ENT after 6 days of progesterone administration, whether increased or decreased, did not significantly affect the live birth rate (LBR) and clinical pregnancy rate (CPR) in fresh OD recipients.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Irem Demiral Keles, Tuba Gunel, Bahar Yuksel Ozgor, Ege Ulgen, Ece Gumusoglu, Mohammad Kazem Hosseini, Ugur Sezerman, Faruk Buyru, John Yeh, Ercan Bastu
Summary: This study investigates the genetic profile differences/similarities in the endometrium at the start of the window of implantation (WOI) in women with unexplained infertility (UI) and unexplained recurrent pregnancy loss (uRPL). The researchers found differentially expressed genes (DEGs) and pathways in the endometrium of patients with UI and uRPL. Unexpectedly, there was a close association in gene expression pathways between UI and uRPL, suggesting that uRPL is a clinical subset of UI. However, there were still some different gene expression patterns in the endometrium at the start of WOI in both conditions. The study concludes that more specific genes-pathways are involved in uRPL compared with UI, indicating the potential for developing diagnostic tools for uRPL.
Article
Genetics & Heredity
Turkan Gursu, Alper Eraslan, Berk Angun, Hale Goksever Celik, John Yeh, Ercan Bastu
Summary: This study compared the pregnancy outcomes of using physiologic saline and G-Rinse medium solution for cervical mucus washing in fresh elective single-embryo transfers in women under the age of 37. The results showed that there was no significant difference in clinical pregnancy rate and live birth rate between the two groups.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Urology & Nephrology
Cenk Yasa, Ozlem Dural, Irem Usta, Engin Celik, Ahmet Salduz, Funda Gungor Ugurlucan
UROLOGIA INTERNATIONALIS
(2020)