Article
Biotechnology & Applied Microbiology
Yafei Yuan, Lipei Shen, Tiankun Liu, Lin He, Dan Meng, Qingsong Jiang
Summary: In this study, researchers developed a novel scaffold material for bone tissue engineering by encapsulating bone marrow mesenchymal stem cells (BMSCs) in alginate chitosan alginate (ACA) microcapsules and compounding them with calcium phosphate bone cement (CPC). The results showed that cells protected by microcapsules had better viability, proliferation, and adhesion compared to cells directly combined with CPC. The composite scaffold also exhibited better new bone formation function and degradability. These findings suggest that BMSCs encapsulated in ACA microcapsules combined with CPC composite scaffolds have promising applications in bone tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Manqi Yan, Yanan Zhao, Yue Dai, Xiaokang Yao, Honglian Dai
Summary: In this study, modified calcium magnesium phosphate bone cement (MCPC) composites were constructed by introducing gelatin solutions. The modified MCPC composites exhibited improved microenvironment, enhanced osteogenic differentiation and biomineralization. When incorporated with 1% and 5% of gelatin, the MCPC composites showed higher mechanical properties and osteogenic ability of BMSCs.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Physical
Shaochun Lv, Tianyu Qu, Hisham Al-Ward, Liting Mu, Hongbin Qiu, Yunlong Zhang
Summary: Bone defects can cause deformities and dysfunctions in the human body. The use of bioactive bone cement for bone regeneration is essential. In this study, bioactive magnesium phosphate bone cement (BMPC) was fabricated and its properties were discussed. The results showed that BMPC had good biocompatibility and degradability, making it a promising orthopedic material.
Article
Cell & Tissue Engineering
Jeroen van de Peppel, Gerben J. Schaaf, Adriana Arruda Matos, Yuan Guo, Tanja Strini, Wenda Verschoor, Amel Dudakovic, Andre J. van Wijnen, Johannes P. T. M. van Leeuwen
Summary: This research suggests that the cell surface glycoprotein CD24 could serve as a selective biomarker for identifying subpopulations of BMSCs with varying osteogenic potential. CD24(pos) cells have increased expression of genes related to cell adhesion, motility, and extracellular matrix, while also showing reduced proliferation compared to CD24(neg) cells.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Engineering, Multidisciplinary
Wenjuan Liu, Zhiguang Huan, Chengtie Wu, Zhihua Zhou, Jiang Chang
Summary: This study developed a composite bone cement with high compressive strength and desirable bioactivity by incorporating calcium silicate bioceramic into magnesium phosphate bone cement. The composite bone cement showed significantly higher compressive strength compared to traditional bone cements and demonstrated apatite mineralization ability and moderate degradation behavior.
COMPOSITES PART B-ENGINEERING
(2022)
Review
Cell Biology
Kevin Woods, Borhane Guezguez
Summary: MSCs are a heterogeneous cell population found in various tissues in the body, with important regulatory functions, especially in the bone marrow where they play a critical role in regulating HSCs. They contribute to maintaining bone integrity and hormonal nutrition supply, as well as regulating the homeostasis and differentiation of the HSC niche through differentiation into different cell types. Research on MSCs helps understand their role in regulating cell interactions and homeostasis in the body.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Kevin Woods, Borhane Guezguez
Summary: Mesenchymal stromal cells (MSCs) are a diverse cell population known for their nutrient-producing and immunomodulatory functions, crucial in regulating hematopoietic stem cells (HSC) in the bone marrow for blood production and immunity. MSCs contribute to bone integrity and hormone supply by differentiating into osteoblasts and adipocytes, playing a key role in the complex interactions of the HSC niche.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biophysics
Zimo Zhou, Da Liu
Summary: Porous tantalum-based biomaterials have been widely used in bone defect repair due to their unique properties and excellent biocompatibility. BMSCs, as an important type of stem cells, have shown great potential in regulating the effects of porous tantalum. This study reviews the characteristics of porous tantalum-based biomaterials and the regulatory mechanisms on BMSCs, and discusses the feasibility of seeding BMSCs in porous tantalum-based biomaterials for tissue repair.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Azmeer Sharipol, Maggie L. Lesch, Celia A. Soto, Benjamin J. Frisch
Summary: This study developed a modular murine bone marrow microenvironment-on-chip that can maintain functional hematopoietic stem cells in vitro. The chip model has a better representation of the human bone marrow, which contributes to a deeper understanding of bone marrow pathophysiology.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qiaoyun Liu, Changjiang Liu, Weixing Wang, Liangjie Yuan, Yu Wang, Xinzeyu Yi, Zhenyu Pan, Aixi Yu
Summary: Bioinspired strontium magnesium phosphate cements (SMPCs) with excellent mechanical strengths and high biocompatibilities were prepared using a new, facile and environmentally friendly precursor method. The SMPC-2, containing 0.5 mol strontium, showed higher degradation rate and biological activity than magnesium phosphate cements and other SMPCs. The synergistic effect of strontium and magnesium ion release from SMPC-2 created a conducive environment for cell proliferation, mineralized calcium deposition and new bone formation, demonstrating the utility of these biologically compatible cements for bone tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Jiawen Wang, Ziqing Cheng, Duanjing Chen, Guangyue Li, Jie Chen, Kai Wang, Ling Xu, Jiao Huang
Summary: Magnesium phosphate cement (MPC) has been modified to be porous by using calcium carbonate and citric acid as foaming agents. The resulting MPC with 3% CaCO3/CA showed improved physicochemical properties and enhanced biocompatibility. In animal experiments, 3%CaCO3/CA-MPC exhibited better bone regeneration compared to the blank group, and slightly lower regeneration compared to the Bio-Oss(R) group. This study suggests that porous MPC foamed with calcium carbonate and CA is a promising material for bone regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Yanan Zhao, Suchun Yu, Xiaopei Wu, Honglian Dai, Wenbin Liu, Rong Tu, Takashi Goto
Summary: In this study, gelatine microspheres were incorporated into magnesium phosphate-based bone cements to improve their physicochemical properties, biocompatibility, biodegradation, and drug release behavior. The results demonstrated that the gelatine microspheres enhanced the setting time, compression strength, macroporosity, and sustained drug release of the composites. This innovative approach shows promise for developing biocompatible bone cements with improved properties.
MATERIALS & DESIGN
(2021)
Article
Engineering, Biomedical
Xiaomei Wang, Yongfeng Zhu, Bin Mu, Aiqin Wang
Summary: To address the poor mechanical strength and bioactivity of magnesium phosphate bone cements (MPCs), clay minerals were incorporated to fabricate MPCs composite. The resulting MPCs composite showed appropriate setting time, high mechanical strength, and good thermal stability. In particular, the MPCs composite containing 3.0 wt.% of sepiolite exhibited the highest compressive strength and the best thermal stability.
BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Ling Yu, Tian Gao, Wei Li, Jian Yang, Yinchu Liu, Yanan Zhao, Ping He, Xuefeng Li, Weichun Guo, Zhengfu Fan, Honglian Dai
Summary: Magnesium phosphate bone cement (MPC) is an artificial bone substitute with degradable properties and biocompatibility. By functionally modifying MPC with a CMCS/SA gel network, we improved its mechanical strength and optimized the interface for bone in-growth. The 2% CMCS/SA composite showed favorable physicochemical properties and promoted osteoblast cell attachment, proliferation, and osteogenic differentiation.
BIOACTIVE MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Zhikun Wang, Zhonghan Zhao, Bo Gao, Lingli Zhang
Summary: Exosomes are important substances in the skeletal microenvironment and play a role in bone remodeling by regulating cell proliferation and differentiation. Studying the role of exosomes in the skeletal microenvironment can provide a theoretical basis for the clinical treatment of bone-related metabolic diseases, and may also improve the bone tumor microenvironment and alleviate drug resistance in patients.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
