Article
Nanoscience & Nanotechnology
Ericka Chorniak, Yang Liu, Ren Odion, Wiguins Etienne, Aidan Canning, Smita K. Nair, Paolo Maccarini, Gregory M. Palmer, Brant A. Inman, Tuan Vo-Dinh
Summary: Bladder cancer is a common cancer with a high proportion of late stage diagnoses. This study developed a novel treatment for bladder cancer using a combination of gold nanostar-mediated photothermal therapy and checkpoint inhibitor immunotherapy. The results showed that this combined therapy was more effective than individual treatments. The study also used intravital optical imaging to investigate immune responses and immune cell accumulation in distant tumors following the treatment. The findings suggest that intravital optical imaging is an efficient tool for studying the mechanisms of photoimmunotherapy.
Article
Chemistry, Multidisciplinary
Jing-Ru Feng, Zhi-Rui Zhao, Zhong-Long Xiong, Hao-Sen Kang, Si-Jing Ding, Liang Ma, Li Zhou
Summary: By changing the shape and composition, the plasmon-enhanced optical properties of nanomaterials can be controlled. In this study, Au/PbS/Au nanostars with multiple tips were synthesized using a gentle approach, and their SERS activity, SHG, and photocatalytic performance were explored. The Au/PbS/Au nanostars exhibited broad spectral responses and enhanced local electric fields, leading to improved SERS activity and photocatalytic efficiency.
Article
Chemistry, Multidisciplinary
Caterina Dallari, Claudia Capitini, Martino Calamai, Andrea Trabocchi, Francesco Saverio Pavone, Caterina Credi
Summary: Gold nanoparticles have unique physicochemical and optical functionalities that make them ideal for spectroscopy-based detection techniques, particularly for SERS. By conjugating different moieties to the nanoparticles, their plasmonic properties can be combined with the specific recognition capabilities of antibodies for analysis of biological fluids in clinical settings.
Article
Chemistry, Physical
Yujing Guo, Shuyi Zhu, Haoming Bao, Hao Fu, Hongwen Zhang, Le Zhou, Yue Li, Weiping Cai
Summary: This study demonstrates the significant impact of interfacial defects on the SERS activity and provides important guidance for the design and fabrication of efficient SERS substrates.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Nhat M. Ngo, Hung-Vu Tran, T. Randall Lee
Summary: The emergence of plasmonic nanostars has enabled a wide range of advanced technologies with great potential. Their superior surface-to-volume ratios and intensely amplified electric fields make them ideal for various applications. However, further study and development are still needed due to the nascency of this unique class of nanostructures.
ACS APPLIED NANO MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Dario Mordini, Alexandra Mavridi-Printezi, Arianna Menichetti, Andrea Cantelli, Xinke Li, Marco Montalti
Summary: Fluorescence, and in particular photoluminescence (PL), has advantages in imaging due to its fast and versatile detection methods, low-cost instrumentation, and utilization of light-based electronic devices. However, limitations for bio-application include tissue transparency and autofluorescence, as well as contrast agent biocompatibility. Luminescent gold nanoclusters (AuNCs) with high biocompatibility and PL in the near-infrared region (NIR) address these limitations. The role of ligands in stabilizing AuNCs and their PL properties is crucial for bioimaging applications, with increasing complexity of the ligand structure achieving different functionalities.
Article
Chemistry, Physical
K. Kleszcz, M. Hebda, A. Kyziol, H. Krawiec, K. Kyziol
Summary: This study focused on modifying the Ti6Al7Nb biomedical alloy by chemical and plasma surface activation, followed by the deposition of chitosan layers enhanced with metal nanoparticles. The modified alloy showed minimal toxicity towards MG-63 cell line in vitro, acceptable corrosion resistance, and release of titanium, aluminum, and niobium ions. The chitosan layers proved to uphold satisfactory ion dosages of gold and silver for up to 96h.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Luciana P. Martinez, Santiago Poklepovich-Caride, Julian Gargiulo, Eduardo D. Martinez, Fernando D. Stefani, Paula C. Angelome, Ianina L. Violi
Summary: Obtaining single nanoparticles with complex three-dimensional shapes is currently a challenge. We investigated the optical printing of gold nanostars and found that tuning the laser to the nanostars' resonant frequencies allows for their deposition without reshaping. This research has implications for the fabrication of complex nanoparticle arrays.
Article
Chemistry, Physical
Biswajoy Bagchi, Priyankan Datta, Carmen Salvadores Fernandez, Lulu Xu, Priya Gupta, Wei Huang, Anna L. David, Dimitrios Siassakos, Shervanthi Homer-Vanniasinkam, Manish K. Tiwari
Summary: Researchers have developed a new hydrogel-based, all-soft, self-healing, and stretchable triboelectric nanogenerator (TENG) that exhibits outstanding power generation capability and biocompatibility. The TENG utilizes semi-transparent hydrogel doped with gold nanoparticles as an electrode and Ecoflex as the triboelectric layer, integrating multiple functionalities. The moldable components allow for the fabrication of wearable or implantable self-powered devices that conform to the human body.
Article
Nanoscience & Nanotechnology
Ziqi Wang, Jiayi Zhu, Linlin Chen, Keqin Deng, Haowen Huang
Summary: The urgent need for innovative materials that effectively eliminate bacteria while promoting cell growth has led to the exploration of a nano-hybrid composite called gold-silver-carbon quantum dots (AuAg-CDs), which shows excellent biocompatibility, strong antibacterial activity, and the ability to promote cell proliferation. This composite disrupts bacterial membranes and promotes mammalian cell proliferation, making it a highly promising material for wound healing applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Peng Zhao, Jingyi Sun, Shijun Zhao, Yanan Song, Feng Gao, Hongbin Wang, Qingbin Ni, Ying Wang, Baoliang Sun
Summary: This method utilizes gold nanostars for immunoassay, enabling detection of the subarachnoid hemorrhage biomarker GFAP with very low detection limits and performance equivalent to that of conventional ELISA.
Review
Nanoscience & Nanotechnology
Yang Liu, Ericka Chorniak, Ren Odion, Wiguins Etienne, Smita K. Nair, Paolo Maccarini, Gregory M. Palmer, Brant A. Inman, Tuan Vo-Dinh
Summary: The SYMPHONY therapy combines photothermal ablation with immunotherapy to treat cancer metastasis and prevent cancer recurrence while inducing a cancer vaccine effect.
Article
Optics
Yueming Li, Ying Jiang, Lu Lan, Xiaowei Ge, Ran Cheng, Yuewei Zhan, Guo Chen, Linli Shi, Runyu Wang, Nan Zheng, Chen Yang, Ji-Xin Cheng
Summary: This study reports on a technique called optically-generated focused ultrasound (OFUS) that allows for non-invasive brain stimulation with ultrahigh precision. The researchers demonstrate the effectiveness of OFUS neurostimulation in vitro and in vivo, showing its potential for neuroscience studies and disease treatments.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Pietro Grisoli, Lorenzo De Vita, Chiara Milanese, Angelo Taglietti, Yuri Diaz Fernandez, Margaux Bouzin, Laura D'Alfonso, Laura Sironi, Silvia Rossi, Barbara Vigani, Paola Sperandeo, Alessandra Polissi, Piersandro Pallavicini
Summary: This study successfully prepared PVA films embedded with silver nanoparticles, NIR-absorbing photothermal gold nanostars, or a combination of both. The slow but prolonged release of silver ions from the films exhibited strong antimicrobial effects against bacteria, while the films also showed rapid hyperthermal bactericidal action upon NIR laser irradiation. The biocompatibility of all films was confirmed, with negligible impact on human fibroblast viability observed.
Article
Neurosciences
Lisa Y. Maeng, Dekel Rosenfeld, Gregory J. Simandl, Florian Koehler, Alexander W. Senko, Junsang Moon, Georgios Varnavides, Maria F. Murillo, Adriano E. Reimer, Aaron Wald, Polina Anikeeva, Alik S. Widge
Summary: This study used magnetic nanoparticle (MNP) technology to remotely trigger the release of adrenal hormones and probe the effects of stress on the hypothalamic-pituitary-adrenal (HPA) axis and sympathoadrenal-medullary (SAM) system. The results showed that aversive conditioning reduced corticosterone levels and blunted heart rate increases. MNP-based organ stimulation offers a novel approach for investigating the function of SAM, HPA, and other neuro-endocrine axes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Jin Woong Lee, Sudong Chae, Seungbae Oh, Dai-Hwan Kim, Si Hyun Kim, Seung Jae Kim, Jae-Young Choi, Jung Heon Lee, Si Young Song
Summary: A 3D hydrogel enhanced with Mo3Se3- IMWs was developed for osteogenesis and bone formation, showing improved mechanical properties and biocompatibility. In vivo evaluations revealed significantly improved new bone regeneration compared to the control hydrogel without Mo3Se3- IMW.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Environmental
Do Hyeon Jung, Yunchul Kim, Hui Hun Cho, Byoungsang Lee, Su-Jeong Suh, Jun Hyuk Heo, Jung Heon Lee
Summary: In this study, a simple, rapid, and accurate in-situ cell quantification method using an achromatic colorimetric sensor system is proposed. Machine learning-assisted, saturation-based image analysis is applied for the facile quantification of living cells. Additionally, a 3D-printed cell quantification kit is fabricated.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Nanoscience & Nanotechnology
Hui Hun Cho, Do Hyeon Jung, Jun Hyuk Heo, Chae Yeon Lee, Sang Yun Jeong, Jung Heon Lee
Summary: Gold nanoparticles (AuNPs) have been widely used as transducers for colorimetric sensors in environmental and biological applications, especially in the detection of water pollutants. This review provides an overview of the advantages of AuNP-based colorimetric sensors, including low toxicity, high stability, facile processability, and unique optical properties. The review also discusses the current status and future prospects of using AuNP for water pollutant detection, aiming to promote further research and development in this area.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Syed Farrukh Alam Zaidi, Aiman Saeed, Van-Chuong Ho, Jun Hyuk Heo, Hui Hun Cho, Nasir Sarwar, Nae-Eung Lee, Junyoung Mun, Jung Heon Lee
Summary: A novel strategy for developing chitosan-reinforced anti-freezing gelatin hydrogel for flexible solid-state supercapacitors is reported. The gelatin hydrogel exhibits high mechanical toughness, anti-freezing properties, and excellent flame retardancy, along with excellent electrochemical performance. This study demonstrates the potential use of this hydrogel as a gel polymer electrolyte for supercapacitors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Hyewon Song, Cheol Hyun Park, Sun Hwan Jeong, Jun Hyuk Heo, Jung Heon Lee
Summary: Considering the persistent problem of fire safety in polymeric materials, including polyurethane foam, there is a growing demand for flame retardants (FRs). This study demonstrates the successful coating of PU foam with a layer-by-layer assembly of adenosine triphosphate (ATP) and chitosan (CS) as an effective FR. The coated PU foam exhibited excellent fire retardancy, with a high limiting oxygen index value, reduced heat release rate, and decreased smoke release.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Engineering, Biomedical
Hyungsub Lee, Gwan-Su Yi, Yoonkey Nam
Summary: Researchers cultured clustered neuronal networks using alginate patterning and studied the changes in functional properties during development. They found that clustered networks had more short-range connections compared to random networks and exhibited slower propagation of activation patterns.
BIOMEDICAL ENGINEERING LETTERS
(2023)
Review
Chemistry, Physical
Jun Hyuk Heo, Minchul Sung, Tran Quang Trung, Yullim Lee, Do Hyeon Jung, Hajeong Kim, Sandeep Kaushal, Nae-Eung Lee, Jin Woong Kim, Jung Heon Lee, Soo-Yeon Cho
Summary: Rapid industrial growth has had negative impacts on ecosystems and increased economic and health risks to society. As a result, the design and development of optimized sensors for ecosystem monitoring has become increasingly important. This review provides a comprehensive overview of sensor design strategies for ecosystem monitoring and discusses transducing mechanisms, sensor interfacing strategies, current performance, and future research directions in this field.
Article
Chemistry, Physical
Hui Hun Cho, Riya Dutta, Jang-Kyun Kwak, Changgyun Moon, Min-Jae Kim, Su-Jeong Suh, Dong-Hwan Kim, Jung Heon Lee, Sunkook Kim
Summary: In this study, a digital colorimetric sensor platform is shown to convert a conventional energy system, like gas-insulated switchgear (GIS), into a smart green energy system. The sensor platform includes a colorimetric sensor film (CSF), an array of silicon photodiodes, and a low-power-driven fiber optical photodiode with wireless communication. The photodiode measures the transmitted light of the color-variable CSF when exposed to sulfur dioxide (SO2) gas, a decomposition by-product of sulfur hexafluoride (SF6) gas in GIS. The electrical photocurrent measurement through the CSF is reported to be able to remotely and in real-time monitor the concentration of SO2 gas, showing comparable behavior to UV-Vis absorption measurement. The sensor has a detection limit of 0.78 ppm, sufficient for analyzing GIS insulation deterioration for green energy systems.
Review
Chemistry, Physical
Syed Farrukh Alam Zaidi, Aiman Saeed, Jun Hyuk Heo, Jung Heon Lee
Summary: This review provides a comprehensive overview of incorporating small biomolecules in developing hydrogel-based strain sensors, with a focus on enhancing their multifunctional properties and strain-sensing performance. Firstly, the representative applications and strain-sensing mechanisms of hydrogel-based strain sensors are introduced. Subsequently, the status of the functional properties of the hydrogels and the performance indicators of their strain-sensing abilities are outlined. Finally, multifunctional small biomolecules are described, followed by a comprehensive discussion concerning recent developments regarding their role in enhancing various functional properties and the performance of hydrogel-based strain sensors. Furthermore, the latest trends and perspectives on the future of hydrogel-based strain sensors are also reported.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Review
Chemistry, Physical
Min Jeong Kim, Do Hyeon Jung, Chae Yeon Lee, Seungpyo Hong, Jun Hyuk Heo, Jung Heon Lee
Summary: Due to their unique optical and chemical properties, gold nanorods (AuNRs) are widely used in biomedical applications such as cancer therapy, imaging, and drug delivery. The silica coating on AuNRs enhances their stability and biocompatibility, making them advantageous in biomedical applications. This review focuses on silica-coated AuNRs from a bioapplication perspective, discussing their importance, recent developments, and various engineering strategies for silica coatings in the biomedical field. It is expected to promote further research on next-generation silica-coated AuNRs for biomedical applications.
Review
Chemistry, Physical
Xuelin Jin, Shrute Kannappan, Natalia Diyah Hapsari, Yu Jin, Kyeong Kyu Kim, Jung Heon Lee, Kyubong Jo
Summary: Electron microscopy-based DNA imaging is a powerful tool for observing genomic structures involved in biochemical processes. Existing methods such as heavy metal shadow casting and uranyl acetate staining have limitations due to government regulations and complicated sample preparation. Nanoparticles and nanowires have emerged as promising alternatives, but further development is needed.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
