Long-term exposure to TNF-α leads human skin fibroblasts to a p38 MAPK- and ROS-mediated premature senescence

Human nucleus pulposus intervertebral disc cells becoming senescent using different treatments exhibit a similar transcriptional profile of catabolic and inflammatory genes

(2017) Sotiris-Spyros Vamvakas et al.   EUROPEAN SPINE JOURNAL

17beta-estradiol Attenuates TNF-α-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-κB Pathway

(2017) Pei Li et al.   International Journal of Biological Sciences

Precise role of dermal fibroblasts on melanocyte pigmentation

(2017) Yinjuan Wang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Deregulation of hsa-miR-20b expression in TNF-α-induced premature senescence of human pulmonary microvascular endothelial cells

(2017) Pooi-Fong Wong et al.   MICROVASCULAR RESEARCH

The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway

(2017) Pei Li et al.   Scientific Reports

Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin

(2017) Shafaat Y. Khan et al.   Scientific Reports

Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

(2016) Aleksandra Borodkina et al.   Aging-US

The role of transcription factor Nrf2 in skin cells metabolism

(2015) Agnieszka Gęgotek et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo

(2015) Magnus S. Ågren et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin

(2015) Marco Demaria et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The differential proliferative response of fetal and adult human skin fibroblasts to TGF-β is retained when cultured in the presence of fibronectin or collagen

(2014) Andreas A. Armatas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Induction of heme oxygenase-1 expression protects articular chondrocytes against cilostazol-induced cellular senescence

(2014) KANG MI KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Oxidative Stress-induced Inhibition of Sirt1 by Caveolin-1 Promotes p53-dependent Premature Senescence and Stimulates the Secretion of Interleukin 6 (IL-6)

(2014) Daniela Volonte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The catabolic effect of TNFα on bovine nucleus pulposus intervertebral disc cells and the restraining role of glucosamine sulfate in the TNFα-mediated up-regulation of MMP-3

(2014) Eleni Mavrogonatou et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

TNF and MAP kinase signalling pathways

(2014) Guadalupe Sabio et al.   SEMINARS IN IMMUNOLOGY

Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle

(2012) Corey J. Miller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway

(2011) S. Kant et al.   GENES & DEVELOPMENT

Dysfunctional Nrf2–Keap1 redox signaling in skeletal muscle of the sedentary old

(2010) Adeel Safdar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts

(2010) Suzanne Kapeta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Matrix Metalloproteinases in Skin Ageing

(2009) Miklós Sárdy   CONNECTIVE TISSUE RESEARCH

High osmolality activates the G1 and G2 cell cycle checkpoints and affects the DNA integrity of nucleus pulposus intervertebral disc cells triggering an enhanced DNA repair response

(2009) Eleni Mavrogonatou et al.   DNA REPAIR

Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-α via the p38 mitogen-activated protein kinase pathway

(2009) Yanmin Zhang et al.   FASEB JOURNAL

Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice

(2009) Weisong Duan et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Inhibition and Genetic Deficiency of p38 MAPK Up-Regulates Heme Oxygenase-1 Gene Expression via Nrf2

(2009) S. Naidu et al.   JOURNAL OF IMMUNOLOGY

Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin

(2008) Gary J. Fisher et al.   AMERICAN JOURNAL OF PATHOLOGY

TNF-α production in the skin

(2008) M. M. Bashir et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

The skin: an indispensable barrier

(2008) Ehrhardt Proksch et al.   EXPERIMENTAL DERMATOLOGY

Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: A culture study

(2008) Motoko Sasaki et al.   FREE RADICAL RESEARCH

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY