Article
Biochemistry & Molecular Biology
Jackson Sira, Xiaodan Zhang, Lin Gao, Therese Martin Cheteu Wabo, Jinyu Li, Caselia Akiti, Wei Zhang, Dianjun Sun
Summary: Some studies have shown that chronic exposure to iAs is associated with an increased risk of diabetes. MiRNA dysfunction has emerged as a potential factor in the development of metabolic phenotypes such as T2DM in response to iAs exposure. However, there is limited research on miRNA profiles during the progression of diabetes after iAs exposure in vivo.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Food Science & Technology
Tongxi Zhou, Guanjun Song, Di Tian, Qinghua Liu, Jinhua Shen, Xinzhou Yang, Ping Zhao
Summary: Nuciferine found in lotus leaves has been shown to improve hyperlipemia and hyperglycemia. In vitro studies revealed that nuciferine stimulates the translocation of glucose transporter 4 (GLUT4) through G protein-PLC-PKC and AMPK pathways, and increases intracellular Ca2+ levels through G protein-PLC-IP3-IP3R pathway, both of which promote glucose uptake. In vivo experiments using KK-Ay mice demonstrated that nuciferine ameliorates symptoms of insulin resistance, abnormal lipid metabolism, and weight gain induced by a high-fat diet. This research highlights the potential of nuciferine in the treatment of type 2 diabetes mellitus.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Environmental Sciences
Mengliang Wu, Chunrong Pang, Shengwen Lu, Thomas H. Hostetter, Xin Hai
Summary: Our study investigated the impact of type 2 diabetes (T2DM) on arsenic metabolism in acute promye-locytic leukemia (APL) patients treated with arsenic trioxide. We discovered that APL patients with T2DM had significantly higher concentrations of arsenic metabolites compared to non-diabetic patients, and this increase was positively correlated with blood glucose levels. Additionally, APL patients with T2DM were more susceptible to liver injury and QTc interval prolongation due to altered arsenic methylation capacity. In in vitro experiments, we cultured HEK293T cells under different glucose concentrations and observed higher concentrations of arsenic metabolites in cells with high glucose. Moreover, high glucose levels significantly increased the expression of the arsenic uptake transporter AQP7 in HEK293T cells at the mRNA and protein levels. Overall, our study demonstrated that T2DM can lead to elevated concentrations of arsenic metabolites in APL patients by increasing AQP7 expression.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Pawel Jan Stanirowski, Dariusz Szukiewicz, Agata Majewska, Mateusz Watroba, Michal Pyzlak, Dorota Bomba-Opon, Miroslaw Wielgos
Summary: This study evaluated the placental expression of glucose transporters in term pregnancies complicated by GDM and PGDM. It found a significant increase in GLUT-1 expression in PGDM patients, while no significant differences were observed in other GLUT isoforms. Positive correlations were noted between fetal birthweight and the expression of GLUT-1 in PGDM group and GLUT-12 in the control group.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Medicine, General & Internal
Daria M. Keller, Natasha Ahmed, Hamza Tariq, Malsha Walgamage, Thilini Walgamage, Azad Mohammed, Jadzia Tin-Tsen Chou, Marta Kaluzna-Oleksy, Maciej Lesiak, Ewa Straburzynska-Migaj
Summary: SGLT2 inhibitors not only show excellent performance in improving glycemic control, but also have a positive impact on cardiovascular and renal outcomes. New guidelines recommend SGLT2 inhibitors as first-line treatment for heart failure patients, bringing new hope for the treatment of heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Maria Anna Bantounou, Panagiotis Sardellis, Rosa Thuemmler, Daniel Black Boada, Justyna Kaczmarek, Ribeya Mahmood, Josip Plascevic, Sam Philip
Summary: This study investigated the renal safety profile of sotagliflozin, a new inhibitor of sodium-glucose co-transporter-1 and -2, in patients with type 1 and type 2 diabetes. The results showed that sotagliflozin did not adversely affect renal function and did not change the risk of key renal outcomes, even in patients with pre-existing renal impairment.
DIABETES OBESITY & METABOLISM
(2023)
Article
Immunology
Xiongfeng Pan, Atipatsa C. Kaminga, Sanjay Kinra, Shi Wu Wen, Hongying Liu, Xinrui Tan, Aizhong Liu
Summary: This study summarized the associations of different chemokines with T1DM, revealing that circulating concentrations of CCL5 and CXCL1 were significantly higher in T1DM patients compared to controls. Circulating CCL5 ranked highest among all the chemokines investigated in T1DM.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Guanjun Song, Yun Huang, Mingrui Xiong, Ziwei Yang, Qinghua Liu, Jinhua Shen, Ping Zhao, Xinzhou Yang
Summary: The study found that Aloperine (ALO) can enhance GLUT4 expression and translocation through multiple pathways, resulting in increased glucose uptake by cells. ALO treatment effectively improves hyperglycemia, insulin resistance, and other issues in type 2 diabetes patients, showing potential hypoglycemic effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Ross Fitzpatrick, Gareth Davison, Jason J. Wilson, Gerard McMahon, Conor McClean
Summary: Exercise has numerous benefits for individuals with type 1 diabetes, but barriers such as post-exercise hypoglycaemia or hyperglycaemia exist. The timing of exercise may be crucial in preventing these blood glucose fluctuations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Eric Pasqualotto, Janine Midori Figueiredo Watanabe, Douglas Mesadri Gewehr, Raphaela da Silva Maintinguer, Simone van de Sande-Lee, Gustavo Neves de Araujo, Fidel Silveira Leal, Carlos Eduardo Andrade Pinheiro
Summary: This study found that bexagliflozin can effectively reduce HbA1c levels, blood pressure, and body weight in patients with T2DM, with similar side effects compared to placebo.
DIABETES OBESITY & METABOLISM
(2023)
Review
Health Care Sciences & Services
Elena Gamarra, Pierpaolo Trimboli
Summary: The correlation between the menstrual cycle and glucose control in type 1 diabetes has been studied since the 1920s. However, due to various factors and heterogeneity in study design, no conclusive evidence on the impact of the menstrual cycle on glycaemic outcomes and insulin sensitivity has been obtained. This systematic review found a lack of consistency in defining menstrual cycle phases, measuring glucose metrics, determining insulin sensitivity, and considering interfering factors, resulting in a high risk of bias. Further research is needed to provide solid evidence and guide clinical management.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Kaat Beunen, Lies Vercauter, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick van den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
Summary: This study aimed to characterize and evaluate the risk of long-term glucose intolerance in women with gestational diabetes mellitus (GDM) positive for type 1 diabetes-related autoimmune antibodies (T1D-related autoantibodies) in pregnancy. The results showed that women with autoantibodies had some adverse characteristics during pregnancy and in their newborns. Long-term follow-up revealed that some women developed glucose intolerance, but only a few still had autoantibodies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Feifei Zhou, Nannan Du, Lulin Zhou, Chenxi Wang, He Ren, Qiang Sun
Summary: This meta-analysis demonstrates that sotagliflozin has an acceptable safety profile in patients with diabetes, with adverse events including genital mycotic infection, related-to-acidosis events, diarrhea, volume depletion, and severe nocturnal hypoglycemia events. The subgroup analysis of sotagliflozin dosage is of great clinical significance for guiding the use of sotagliflozin in patients with diabetes in the future.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Public, Environmental & Occupational Health
Azra Ramezankhani, Ali Siamak Habibi-Moeini, Seyed Saeed Tamehri Zadeh, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the lifetime risk of type 2 diabetes in Iranian adults, specifically looking at the influence of family history of diabetes and body mass index (BMI). It found that both factors independently increased the risk of diabetes and that the risk was even higher when both factors were present. Additionally, the study found that individuals with a positive family history of diabetes and obesity had a significantly higher risk compared to those with a normal weight and no family history of diabetes.
JOURNAL OF GLOBAL HEALTH
(2022)
Article
Environmental Sciences
Shenya Xu, Zeyun Yang, Ye Zhi, Shali Yu, Tao Zhang, Junkang Jiang, Jun Tang, Hongsen He, Ming Lu, Xiaoke Wang, Qiyun Wu, Xinyuan Zhao
Summary: The study revealed that exposure to antimony can lead to neuronal apoptosis and increase the risk of Alzheimer's disease. Detection of A beta and NFTs accumulation in the brains of mice exposed to antimony showed A beta accumulation after 4 weeks, A beta accumulation and tau phosphorylation after 8 weeks, and complete AD hallmarks after 1 year.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Toxicology
Yudan Zheng, Wenjie Ding, Tao Zhang, Zixuan Zhao, Rui Wang, Zhijie Li, Shali Yu, Jinlong Li, Xinyuan Zhao, Qiyun Wu
Summary: This study demonstrates that antimony exposure induces astrocyte activation through the promotion of astrocyte proliferation and upregulation of key protein markers iNOS and GFAP. Activation of the p38 MAPK and ERK pathways plays a crucial role in mediating Sb-induced astrocyte activation.
TOXICOLOGY LETTERS
(2021)
Article
Genetics & Heredity
Wenyi Zhang, Ting Chen, Jun Liu, Shali Yu, Lei Liu, Miaosen Zheng, Yifei Liu, Hongbing Zhang, Tingting Bian, Xinyuan Zhao
Summary: This study investigated the expression of RAB11FIP1 in LUAD and its association with prognosis and immune infiltration, finding that RAB11FIP1 is down-regulated in LUAD, associated with survival in lung adenocarcinoma patients, and correlated with multiple pathways and immune cell infiltrates.
FRONTIERS IN GENETICS
(2021)
Article
Environmental Sciences
Shali Yu, Zhijie Li, Qin Zhang, Rui Wang, Zixuan Zhao, Wenjie Ding, Fengxu Wang, Chuan Sun, Juan Tang, Xiaoke Wang, Hongbing Zhang, Rongrong Huang, Qiyun Wu, Junkang Jiang, Xinyuan Zhao
Summary: This study reveals a novel mechanism by which antimony (Sb) triggers neurotoxicity through inducing ferroptosis in neurons by limiting the degradation of the antioxidant glutathione peroxidase 4 (GPX4). The study also found that inhibition of chaperone-mediated autophagy (CMA) can attenuate Sb-induced GPX4 degradation. These findings provide new insights into the understanding of Sb-induced neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Liling Su, Wenpan Fang, Xinyuan Zhao, Longtao Zhu, Lan Gao, Guangdi Chen
Summary: The study found that antimony can disrupt mitochondrial redox homeostasis, leading to the generation of mtROS, thereby inhibiting mitochondrial function and increasing cytotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Immunology
Wenyi Zhang, Pei Xiao, Jiayi Tang, Rui Wang, Xiangdong Wang, Fengxu Wang, Junpu Ruan, Shali Yu, Juan Tang, Rongrong Huang, Xinyuan Zhao
Summary: This study demonstrates the important roles of m6A modification patterns in cervical cancer. Analysis of m6A modification patterns can enhance our understanding of the tumor microenvironment in cervical cancer and facilitate the development of better immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Xiangdong Wang, Rui Wang, Zeyao Zhang, Chao Luo, Zixuan Zhao, Junpu Ruan, Rongrong Huang, Hongbing Zhang, Qiyun Wu, Shali Yu, Juan Tang, Xinyuan Zhao
Summary: This study found a correlation between antimony exposure and cognitive function in older adults. Higher doses of urinary antimony were associated with cognitive impairment, while lower doses were associated with better cognitive performance. Further research is needed to explore the specific mechanisms.
Article
Genetics & Heredity
Li Zeng, Xuehai Wang, Fengxu Wang, Xinyuan Zhao, Yiqian Ding
Summary: This study identifies four CAF-specific genes and constructs a novel prognostic signature, which provides more insights into precise prognostic assessment in ovarian cancer.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Chunyan Gu, Chen Lin, Zheng Zhu, Li Hu, Fengxu Wang, Xuehai Wang, Junpu Ruan, Xinyuan Zhao, Sen Huang
Summary: This study explored the role of IFN-gamma-related genes and long non-coding RNAs in endometrial carcinoma, identifying a prognostic signature and demonstrating significant differences in outcomes and immune microenvironment between high-risk and low-risk groups.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Wenjun Mao, Yun Cai, Danrong Chen, Guanyu Jiang, Yongrui Xu, Ruo Chen, Fengxu Wang, Xuehai Wang, Mingfeng Zheng, Xinyuan Zhao, Jie Mei
Summary: ICB therapy has achieved breakthroughs in treating advanced NSCLC, but the presence of immuno-cold tumors limits its efficacy. Targeting cholesterol synthesis can improve the treatment of immuno-cold tumors. Statin can inhibit the aggressiveness of lung cancer and enhance the response to ICB therapy.
Article
Biotechnology & Applied Microbiology
Erli Gao, Xuehai Wang, Fengxu Wang, Siyuan Deng, Weiyi Xia, Rui Wang, Xiangdong Wang, Xinyuan Zhao, Haixin Qian
Summary: FMNL1 has been identified as a diagnostic marker for tumor-infiltrating immune cells (TIICs) in breast cancer clinical applications through analyzing transcriptional levels and prognostic values.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Oncology
Jinlu Zhao, Jie Mei, Fengxu Wang, Xinyuan Zhao, Yi Ren, Xingyu Zhao, Wang Li, Erli Gao
Summary: This study found that CDCP1 is upregulated in breast cancer and is related to various clinicopathological characteristics and prognosis. Furthermore, CDCP1 is involved in multiple oncogenic pathways and correlated with overexpression of immune checkpoints.
JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Hongyu Zhao, Fengxu Wang, Xuehai Wang, Xinyuan Zhao, Jinfeng Ji
Summary: This study explores the prognostic classification ability of HPV-related signatures in head and neck cancer. Through screening gene expression databases, the researchers identified HPV-related signatures associated with prognosis of HNSCC and developed a prognostic signature. The results demonstrate that the prognostic signature may serve as an important prognostic biomarker for patients with HNSCC.
JOURNAL OF ONCOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Xinyuan Zhao, Tao Zhang, Yudan Zheng, Zixuan Zhao, Wenjie Ding, Ziyang Zhang, Zeyao Zhang, Rui Wang, Man Jiao, Lei Liu, Shali Yu, Xiaoke Wang, Rongrong Huang, Qiyun Wu
Summary: Short-chain chlorinated paraffins (SCCPs) are toxic substances found in food that have been shown to have neurotoxic effects. This study investigated the mechanism by which SCCP exposure activates astrocytes and leads to neuroinflammation. The results showed that SCCP intake caused astrocyte activation and neuronal cell death, accompanied by changes in the gut microbiome and its metabolites. Depleting the gut microbiome through antibiotic treatment reduced astrocyte activation and inflammation induced by SCCPs. Furthermore, fecal microbiota transplantation from SCCP-treated mice to healthy mice resulted in increased astrocyte activation and inflammation. SCCP exposure also led to increased expression of zonulin and damage to tight junctions in the intestinal tract, which were inhibited by antibiotic treatment. These findings suggest that SCCP-induced astrocyte activation and neurotoxicity may be mediated by the gut microbiome-mediated zonulin expression and tight junction impairment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Environmental Sciences
Zhang Tao, Zheng Yu Dan, Jiao Man, Zhi Ye, Xu Shen Ya, Zhu Piao Yu, Zhao Xin Yuan, Wu Qi Yun
Summary: This study found that antimony exposure induced astrocyte activation by upregulating the expression of key protein markers and inflammatory factors. The activation was mediated by the NE-kappa B signaling pathway, as indicated by increased p65 phosphorylation and translocation to the nucleus. Inhibition of NE-kappa B effectively attenuated the antimony-induced astrocyte activation.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
