Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role

A Small Molecule, Odanacatib, Inhibits Inflammation and Bone Loss Caused by Endodontic Disease

(2015) Liang Hao et al.   INFECTION AND IMMUNITY

Rheumatoid arthritis is linked to oral bacteria: etiological association

(2014) Mesut Ogrendik   Modern Rheumatology

Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction

(2014) Sen Yang et al.   Bone Research

Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants

(2013) Lee S. Jacobson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNAi-Mediated Silencing of Atp6i and Atp6i Haploinsufficiency Prevents Both Bone Loss and Inflammation in a Mouse Model of Periodontal Disease

(2013) Hongbing Jiang et al.   PLoS One

C/EBP  regulates osteoclast lineage commitment

(2013) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

(2012) A. Garcia-Cattaneo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoimmune responses in periodontal diseases

(2011) Javed Ali et al.   AUTOIMMUNITY REVIEWS

The RANKL-OPG system in clinical periodontology

(2011) Georgios N. Belibasakis et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

(2011) Sarah E. Ewald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis

(2011) F. G. Goh et al.   RHEUMATOLOGY

Toll-like receptors and their dual role in periodontitis: a review

(2011) Mayank Hans et al.   Journal of Oral Science

Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas

(2010) Yi-Ping Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Periodontitis: a polymicrobial disruption of host homeostasis

(2010) Richard P. Darveau   NATURE REVIEWS MICROBIOLOGY

Periodontitis in RA—the citrullinated enolase connection

(2010) Karin Lundberg et al.   Nature Reviews Rheumatology

RANKL and OPG mRNA Level after Non-Surgical Periodontal Treatment

(2009) Xanthippi E. Dereka et al.   INFLAMMATION

Periodontitis in systemic rheumatic diseases

(2009) Paola de Pablo et al.   Nature Reviews Rheumatology

Dendritic cells as targets for therapy in rheumatoid arthritis

(2009) Shaukat Khan et al.   Nature Reviews Rheumatology

Progression of chronic periodontitis can be predicted by the levels ofPorphyromonas gingivalisandTreponema denticolain subgingival plaque

(2009) S. J. Byrne et al.   Oral microbiology and immunology

Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor–transgenic mice

(2008) Uta Schurigt et al.   ARTHRITIS AND RHEUMATISM

Association Among Rheumatoid Arthritis, Oral Hygiene, and Periodontitis

(2008) N. Pischon et al.   JOURNAL OF PERIODONTOLOGY

Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis

(2008) M. Asagiri et al.   SCIENCE

Immunohistochemical localization of Toll-like receptors 1-10 in periodontitis

(2008) A. Beklen et al.   Oral microbiology and immunology