Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis

Endogenous Damage-Associated Molecular Pattern Molecules at the Crossroads of Inflammation and Cancer

(2015) Geetha Srikrishna et al.   NEOPLASIA

Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures

(2014) S. M. Sacre et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A

(2014) N. Cheng et al.   JOURNAL OF IMMUNOLOGY

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-  Production in Human Monocytes

(2014) J. H. Youn et al.   JOURNAL OF IMMUNOLOGY

Pathogenesis of Joint Destruction in Rheumatoid Arthritis

(2011) Shunichi Shiozawa et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Toll-like receptor modulators: a patent review (2006 – 2010)

(2011) Shaherin Basith et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

Expression of Toll-like Receptors and Their Signaling Pathways in Rheumatoid Synovitis

(2011) YASUNOBU TAMAKI et al.   JOURNAL OF RHEUMATOLOGY

Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model

(2011) Christian Grimstein et al.   Journal of Translational Medicine

Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures

(2011) Sinéad Nic An Ultaigh et al.   ARTHRITIS RESEARCH & THERAPY

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor

(2010) Jeremy Sokolove et al.   ARTHRITIS AND RHEUMATISM

SIGIRR/TIR-8 is an inhibitor of toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis

(2010) Stefan K. Drexler et al.   ARTHRITIS AND RHEUMATISM

Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors

(2010) Sandra Sacre et al.   ARTHRITIS AND RHEUMATISM

Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation

(2010) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM

Etiological role of cigarette smoking in rheumatoid arthritis: Nasal exposure to cigarette smoke condensate extracts augments the development of collagen-induced arthritis in mice

(2010) Shosuke Okamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The cationic amphiphile 3,4-bis(tetradecyloxy)benzylamine inhibits LPS signaling by competing with endotoxin for CD14 binding

(2010) Matteo Piazza et al.   BIOCHEMICAL PHARMACOLOGY

Structure and immunomodulatory property relationship in NapA of Borrelia burgdorferi

(2010) Gaia Codolo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Beyond the enhanceosome: cluster of novel  B sites downstream of the human IFN-  gene is essential for lipopolysaccharide-induced gene activation

(2010) F. G. Goh et al.   BLOOD

9,10-Dihydro-2,5-dimethoxyphenanthrene-1,7-diol, from Eulophia ochreata, inhibits inflammatory signalling mediated by Toll-like receptors

(2010) Praneel Datla et al.   BRITISH JOURNAL OF PHARMACOLOGY

Deciphering the complexity of Toll-like receptor signaling

(2010) Renato Ostuni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

C1q/TNF-Related Protein-3 Represents a Novel and Endogenous Lipopolysaccharide Antagonist of the Adipose Tissue

(2010) Andrea Kopp et al.   ENDOCRINOLOGY

Modulation of toll-like receptor function has therapeutic potential in autoimmune disease

(2010) Felix IL Clanchy et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Novel synthetic gluco-disaccharide RSCL-0409 - a lipopolysaccharide-induced Toll-like receptor-mediated signalling antagonist

(2010) Mani D. Kalluri et al.   FEBS Journal

A synthetic MD-2 mimetic peptide attenuates lipopolysaccharide-induced inflammatory responses in vivo and in vitro

(2010) Guang-Jie Duan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cigarette smoke condensate extracts augment collagen-induced arthritis in mice

(2010) Satomi Chujo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of homodimerization of Toll-like receptor 4 by 4-oxo-4-(2-oxo-oxazolidin-3-yl)-but-2-enoic acid ethyl ester

(2010) Se-Jeong Park et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Novel Toll-like Receptor That Recognizes Vesicular Stomatitis Virus

(2010) Zhongcheng Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling

(2010) Y. Guan et al.   JOURNAL OF IMMUNOLOGY

Endogenous Inflammatory Molecules Engage Toll-Like Receptors in Cardiovascular Disease

(2010) Mihaela G. Ionita et al.   Journal of Innate Immunity

New Insights into the Regulation of Signalling by Toll-Like Receptors and Nod-Like Receptors

(2010) Rebecca C. Coll et al.   Journal of Innate Immunity

DBM1285 Suppresses Tumor Necrosis Factor   Production by Blocking p38 Mitogen-Activated Protein Kinase/Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Signaling Pathway

(2010) J. S. Kang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Benzothiophene Inhibitor of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Inhibits Tumor Necrosis Factor   Production and Has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation

(2010) R. J. Mourey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

(2010) Xiaoxia Z. West et al.   NATURE

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

(2010) Marc Schmidt et al.   NATURE IMMUNOLOGY

Ethnogenetic heterogeneity of rheumatoid arthritis—implications for pathogenesis

(2010) Yuta Kochi et al.   Nature Reviews Rheumatology

Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2

(2010) Michael G Drage et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation

(2010) H D Park et al.   ONCOGENE

Molecular Modeling-Based Evaluation of hTLR10 and Identification of Potential Ligands in Toll-Like Receptor Signaling

(2010) Rajiv Gandhi Govindaraj et al.   PLoS One

Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB

(2010) M. Tanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of toll-like receptor 2-activating lipoprotein IIpA from Vibrio vulnificus

(2010) Sangheon Yu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients

(2010) Federica Capolunghi et al.   RHEUMATOLOGY

Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis

(2010) Jingyi Li et al.   ARTHRITIS RESEARCH & THERAPY

Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats

(2010) Liesu Meng et al.   ARTHRITIS RESEARCH & THERAPY

ORIGINAL ARTICLE: Antiphospholipid Antibodies Induce a Pro-Inflammatory Response in First Trimester Trophoblast Via the TLR4/MyD88 Pathway

(2009) Melissa J. Mulla et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Quercetin Prevents LPS-Induced High-Mobility Group Box 1 Release and Proinflammatory Function

(2009) Daolin Tang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy

(2009) R E Alten et al.   ANNALS OF THE RHEUMATIC DISEASES

"Go upstream, young man": lessons learned from the p38 saga

(2009) D Hammaker et al.   ANNALS OF THE RHEUMATIC DISEASES

Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis

(2009) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

Inhibition of NF-κB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis

(2009) Hiroshi Okamoto et al.   ARTHRITIS AND RHEUMATISM

Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-α secretion by macrophage-like cells

(2009) S. L. Zunt et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Targeting Toll-like Receptors in Autoimmunity

(2009) K. Midwood et al.   CURRENT DRUG TARGETS

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1β and caspase-1 in monocytes and dendritic cells

(2009) Julia Hurst et al.   IMMUNOBIOLOGY

Human antiphospholipid antibodies induce TNFα in monocytes via Toll-like receptor 8

(2009) Yvonne Döring et al.   IMMUNOBIOLOGY

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

TLR-3 enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritis

(2009) Kyoung-Woon Kim et al.   IMMUNOLOGY LETTERS

The potential use of toll-like receptor (TLR) agonists and antagonists as prophylactic and/or therapeutic agents

(2009) Amani Makkouk et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

MicroRNA in autoimmunity and autoimmune diseases

(2009) Kaleb M. Pauley et al.   JOURNAL OF AUTOIMMUNITY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resistin competes with lipopolysaccharide for binding to toll-like receptor 4

(2009) Andrej Tarkowski et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Soluble TLR2 Is Present in Human Amniotic Fluid and Modulates the Intraamniotic Inflammatory Response to Infection

(2009) A. T. Dulay et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Cardiac Myosin Activates Innate Immune Responses through TLRs

(2009) P. Zhang et al.   JOURNAL OF IMMUNOLOGY

Sulforaphane Suppresses Oligomerization of TLR4 in a Thiol-Dependent Manner

(2009) Hyung Sun Youn et al.   JOURNAL OF IMMUNOLOGY

Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering

(2009) A.-C. Raby et al.   JOURNAL OF IMMUNOLOGY

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation

(2009) Hulda Sigridur Hreggvidsdottir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo

(2009) Q M Nhu et al.   Mucosal Immunology

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

(2009) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Are new agents needed to treat RA?

(2009) Peter E. Lipsky   Nature Reviews Rheumatology

Treatment of rheumatoid arthritis: state of the art 2009

(2009) Ronald F. van Vollenhoven   Nature Reviews Rheumatology

IL-17 as a future therapeutic target for rheumatoid arthritis

(2009) Wim B. van den Berg et al.   Nature Reviews Rheumatology

Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7

(2009) Tomoko Hayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

(2008) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice

(2008) Marije I. Koenders et al.   ARTHRITIS AND RHEUMATISM

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

(2008) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

(2008) John W. Rice et al.   ARTHRITIS AND RHEUMATISM

A TLR4/MD2 fusion protein inhibits LPS-induced pro-inflammatory signaling in hepatic stellate cells

(2008) Bernd Schnabl et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2

(2008) R. L. He et al.   BLOOD

G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFκB serine 536 phosphorylation in human keratinocytes

(2008) Fui Goon Goh et al.   CELLULAR SIGNALLING

Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein

(2008) Yun Soo Bae et al.   CIRCULATION RESEARCH

TLR accessory molecules

(2008) Sachiko Akashi-Takamura et al.   CURRENT OPINION IN IMMUNOLOGY

Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics

(2008) Marc Feldmann et al.   IMMUNOLOGICAL REVIEWS

Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-κB pathway in adipocytes links nutritional signalling with innate immunity

(2008) Andreas Schaeffler et al.   IMMUNOLOGY

RDP58 inhibits T cell-mediated bladder inflammation in an autoimmune cystitis model

(2008) Wujiang Liu et al.   JOURNAL OF AUTOIMMUNITY

Analysis of Proteinase-activated Receptor 2 and TLR4 Signal Transduction

(2008) Prasad Rallabhandi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

(2008) Shahla Abdollahi-Roodsaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses

(2008) De Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Is serum amyloid A an endogenous TLR4 agonist?

(2008) Silvana Sandri et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Single-Stranded Oligonucleotides Can Inhibit Cytokine Production Induced by Human Toll-Like Receptor 3

(2008) C. T. Ranjith-Kumar et al.   MOLECULAR AND CELLULAR BIOLOGY

Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells

(2008) Noriyuki Hirata et al.   MOLECULAR IMMUNOLOGY

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE

High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

(2008) David S Pisetsky et al.   ARTHRITIS RESEARCH & THERAPY

Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells

(2007) François Vanhoutte et al.   IMMUNOLOGY LETTERS