Pathological mutations H187R and E196K facilitate subdomain separation and prion protein conversion by destabilization of the native structure

Heparin binding confers prion stability and impairs its aggregation

(2014) Tuane C. R. G. Vieira et al.   FASEB JOURNAL

Probing Early Misfolding Events in Prion Protein Mutants by NMR Spectroscopy

(2013) Gabriele Giachin et al.   MOLECULES

Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1

(2012) Pravas Kumar Baral et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth

(2012) Alexander K. Buell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity

(2012) Iva Hafner-Bratkovič et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an Intermediate State in Protein Folding and Aggregation

(2012) P. Neudecker et al.   SCIENCE

Introduction of glutamines into the B2–H2 loop promotes prion protein conversion

(2011) Matevž Avbelj et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Globular Domain of the Prion Protein Needs to Be Unlocked by Domain Swapping to Support Prion Protein Conversion

(2011) Iva Hafner-Bratkovič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Population of Nonnative States of Lysozyme Variants Drives Amyloid Fibril Formation

(2011) Alexander K. Buell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of Hydrophobic Mutations in the H2-H3 Subdomain of Prion Protein on Stability and Conversion In Vitro and In Vivo

(2011) Iva Hafner-Bratkovič et al.   PLoS One

Disulfide mapping reveals the domain swapping as the crucial process of the structural conversion of prion protein

(2011) Iva Hafner-Bratkovič et al.   Prion

The H187R Mutation of the Human Prion Protein Induces Conversion of Recombinant Prion Protein to the PrPSc-like Form

(2010) Laszlo L. P. Hosszu et al.   BIOCHEMISTRY

Influence of pH on the Human Prion Protein: Insights into the Early Steps of Misfolding

(2010) Marc W. van der Kamp et al.   BIOPHYSICAL JOURNAL

Tetracysteine-tagged prion protein allows discrimination between the native and converted forms

(2010) Jernej Gašperšič et al.   FEBS Journal

PRNP allelic series from 19 years of prion protein gene sequencing at the MRC Prion Unit

(2010) Jon A. Beck et al.   HUMAN MUTATION

The Unfolded State of the Murine Prion Protein and Properties of Single-point Mutants Related to Human Prion Diseases

(2010) Christian Gerum et al.   JOURNAL OF MOLECULAR BIOLOGY

Pathogenic Mutations in the Hydrophobic Core of the Human Prion Protein Can Promote Structural Instability and Misfolding

(2010) Marc W. van der Kamp et al.   JOURNAL OF MOLECULAR BIOLOGY

Local Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution

(2010) Anne Dhulesia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heparin Binding by Murine Recombinant Prion Protein Leads to Transient Aggregation and Formation of RNA-Resistant Species

(2010) Tuane C. R. G. Vieira et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prion Proteins with Pathogenic and Protective Mutations Show Similar Structure and Dynamics

(2009) Sung-Hun Bae et al.   BIOCHEMISTRY

Identification of an Intracellular Site of Prion Conversion

(2009) Zrinka Marijanovic et al.   PLoS Pathogens

The POM Monoclonals: A Comprehensive Set of Antibodies to Non-Overlapping Prion Protein Epitopes

(2008) Magdalini Polymenidou et al.   PLoS One