The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells

Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice

(2014) Anna M. Pauter et al.   JOURNAL OF LIPID RESEARCH

Diversification of substrate specificities in teleostei Fads2: characterization of Δ4 and Δ6Δ5 desaturases ofChirostoma estor

(2014) Jorge Fonseca-Madrigal et al.   JOURNAL OF LIPID RESEARCH

Fatty acid analysis by high resolution gas chromatography and mass spectrometry for clinical and experimental applications

(2013) J. Thomas Brenna   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Lipid Needs of Preterm Infants: Updated Recommendations

(2013) Alexandre Lapillonne et al.   JOURNAL OF PEDIATRICS

Long chain polyunsaturated fatty acid synthesis in a marine vertebrate: Ontogenetic and nutritional regulation of a fatty acyl desaturase with Δ4 activity

(2012) Sofia Morais et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A novelFADS1isoform potentiatesFADS2-mediated production of eicosanoid precursor fatty acids

(2012) Woo Jung Park et al.   JOURNAL OF LIPID RESEARCH

Maintenance of Arachidonic Acid and Evidence of Δ5 Desaturation in Cats Fed γ-Linolenic and Linoleic Acid Enriched Diets

(2012) Luciano Trevizan et al.   LIPIDS

Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids

(2012) R.A. Gibson et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

FADS2 Function Loss at the Cancer Hotspot 11q13 Locus Diverts Lipid Signaling Precursor Synthesis to Unusual Eicosanoid Fatty Acids

(2011) Woo Jung Park et al.   PLoS One

ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice

(2010) Damir Zadravec et al.   JOURNAL OF LIPID RESEARCH

Vertebrate fatty acyl desaturase with  4 activity

(2010) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicing

(2009) Woo Jung Park et al.   GENE

Fenofibrate Simultaneously Induces Hepatic Fatty Acid Oxidation, Synthesis, and Elongation in Mice

(2009) Maaike H. Oosterveer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration

(2009) Chad K. Stroud et al.   JOURNAL OF LIPID RESEARCH

The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues

(2009) Frédérique Pédrono et al.   JOURNAL OF LIPID RESEARCH

An alternate pathway to long-chain polyunsaturates: theFADS2gene product Δ8-desaturates 20:2n-6 and 20:3n-3

(2009) Woo Jung Park et al.   JOURNAL OF LIPID RESEARCH

Alternative splicing generates a novel FADS2 alternative transcript in baboons

(2009) Woo Jung Park et al.   MOLECULAR BIOLOGY REPORTS

α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans

(2009) J. Thomas Brenna et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

(2008) Young-Ah Moon et al.   JOURNAL OF LIPID RESEARCH

Docosahexaenoic acid synthesis from n-3 fatty acid precursors in rat hippocampal neurons

(2008) Terry L. Kaduce et al.   JOURNAL OF NEUROCHEMISTRY

The Influence of Maternal Early to Mid-Gestation Nutrient Restriction on Long Chain Polyunsaturated Fatty Acids in Fetal Sheep

(2008) Yunhua Zhou et al.   LIPIDS