Article
Biochemistry & Molecular Biology
Mohamad Dandan, Julia Han, Sabrina Mann, Rachael Kim, Kelvin Li, Hussein Mohammed, Jen-Chieh Chuang, Kaiyi Zhu, Andrew N. Billin, Ryan S. Huss, Chuhan Chung, Robert P. Myers, Marc Hellerstein
Summary: Treatment with acetyl-CoA carboxylase inhibitors in NASH may increase plasma triglycerides, but its effects on apoB concentrations are variable. This study aimed to determine the effects of firsocostat on LDL-apoB production rates in NASH and the effects of combination therapy with fenofibrate.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Medicine, General & Internal
Jun Yup Kim, Keon-Joo Lee, Jihoon Kang, Beom Joon Kim, Moon-Ku Han, Kyusik Kang, Jong-Moo Park, Tai Hwan Park, Hong-Kyun Park, Yong-Jin Cho, Keun-Sik Hong, Kyung Bok Lee, Myung Suk Jang, Ji Sung Lee, Juneyoung Lee, Hee-Joon Bae
Summary: High levels of fasting and non-fasting triglycerides are prevalent in acute ischemic stroke (AIS) patients, but they do not have a significant impact on subsequent clinical events within one year.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Oncology
Josep Guma, Jose Adria-Cebrian, Belen Ruiz-Aguado, Cinta Albacar, Josefa Girona, Ricardo Rodriguez-Calvo, Neus Martinez-Micaelo, Eric W. F. Lam, Luis Masana, Sandra Guaita-Esteruelas
Summary: The study identified a positive association between TG-enriched particles and certain branched amino acids with breast cancer, suggesting a distinct metabolic signature in BC patients that could aid in improved stratification and treatment. This is the first time advanced NMR profiling has been used to identify relevant lipid and amino acid metabolites in BC serum samples for early and reliable diagnosis and prognosis.
Article
Hematology
Lilli Arndt, Ileana Hernandez-Resendiz, Doreen Moos, Janine Dokas, Silvana Mueller, Franziska Jeromin, Richard Wagner, Uta Ceglarek, Iris M. Heid, Marcus Hoering, Gerhard Liebisch, Sonja C. Stadler, Ralph Burkhardt
Summary: This study demonstrates that deficiency of Trib1 promotes the formation of atherosclerotic lesions and increases plasma cholesterol and triglyceride levels in Ldlr(-/-) mice. It also suggests that Trib1 deficiency alters hepatic lipid metabolism and induces inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marco Roverso, Roberta Seraglia, Raghav Dogra, Denis Badocco, Silvia Pettenuzzo, Luca Cappellin, Paolo Pastore, Sara Bogialli
Summary: This study evaluated the use of single-walled carbon nanohorns (SWCNH) as a specific surface for Surface-Assisted Laser Desorption Ionization (SALDI) analysis. The optimized method provided rapid analysis of amino acids and lipids, and accurately determined the composition of fatty acids in olive oil samples without any sample treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shunji Kato, Yusuke Osuka, Saoussane Khalifa, Takashi Obama, Hiroyuki Itabe, Kiyotaka Nakagawa
Summary: This study developed novel analytical methods using LC-MS/MS to determine the peroxidation mechanisms of plasma lipoproteins in healthy subjects, revealing that PC 16:0/18:2;9OOH, PC 16:0/18:2;13OOH, CE 18:2;9OOH, and CE 18:2;13OOH are the predominant isomers indicating radical and/or enzymatic oxidation. Insights gained from this study could potentially contribute to a more effective suppression of oxidative stress in the human body.
Article
Biochemistry & Molecular Biology
Salvador Sanchez-Vinces, Pedro Henrique Dias Garcia, Alex Ap. Rosini Silva, Anna Maria Alves de Piloto Fernandes, Joyce Aparecida Barreto, Gustavo Henrique Bueno Duarte, Marcia Aparecida Antonio, Alexander Birbrair, Andreia M. Porcari, Patricia de Oliveira Carvalho
Summary: The comprehensive lipidome determined by mass spectrometry is correlated to the serum whole-lipidic profile of adults with different lipidemic conditions. Specifically, serum TAG levels have a positive correlation with certain specific TAGs and ceramides, and a negative correlation with sphingomyelins. HDL-C levels are positively correlated with certain groups of glycerophosphocholine, while LDL-C has a positive correlation with sphingomyelins.
Article
Biochemistry & Molecular Biology
Harley Robinson, Jeffrey Molendijk, Alok K. Shah, Tony Rahman, Gregory J. Anderson, Michelle M. Hill
Summary: This study comprehensively evaluated the accuracy of lipid quantification using Attenuated Total Reflectance (ATR)-Fourier-Transform Infrared Spectroscopy (FTIR) and established a simple workflow for lipidomics sample quantification. The impact of sample extraction method and FTIR spectral processing on lipid quantification was investigated. A Lipid Quality (LiQ) score was developed for sample quality screening. The workflow was validated by comparing with LC-MS quantification results.
Article
Chemistry, Analytical
Juan Aspromonte, Patricia Perez Martinez, Kris Wolfs, Erwin Adams
Summary: In this study, two procedures were optimized to diagnose EPI, showing good selectivity for structure confirmation and excellent linearity for purity control. These methods can effectively identify the structure and ensure purity with high accuracy and repeatability.
Article
Agriculture, Multidisciplinary
Xianlin Han, Hongping Ye
Summary: Although triglycerides play important roles in cellular growth, metabolism, and function, accurately identifying their molecular species and quantities remains a challenge.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Ankit Shah, Yujue Wang, Xiaoyang Su, Fredric E. Wondisford
Summary: This study discovered the process of glycerol directly contributing to lactate metabolism. Glycerol's contribution to lactate is higher compared to glucose. This suggests that the importance of glycerol in intermediary metabolism may be underestimated.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemical Research Methods
Pratima Pathak, Anastasia Sarycheva, Matthew A. Baird, Alexandre A. Shvartsburg
Summary: Mass spectrometry and isotopes have been closely linked in scientific research, with stable isotopes playing a crucial role in identification and quantification. Recent studies have successfully differentiated various halogenated aniline isomers through structurally specific splitting methods.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2021)
Article
Hematology
Asier Benito-Vicente, Kepa B. Uribe, Asier Larrea-Sebal, Lourdes Palacios, Ana Cenarro, Xabier Calle, Unai Galicia-Garcia, Shifa Jebari-Benslaiman, Rosa M. Sanchez-Hernandez, Marianne Stef, Gilles Lambert, Fernando Civeira, Cesar Martin
Summary: This study extensively characterized the activities of L8 and L11 variants located in the signal peptide through in vitro experiments. It was found that the L11 variant enhances intracellular degradation of LDLr, which may lead to inefficient LDLr transport and LDLr degradation, resulting in mild hypercholesterolemia.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sean A. Burnap, Katherine Sattler, Raimund Pechlaner, Elisa Duregotti, Ruifang Lu, Konstantinos Theofilatos, Kaloyan Takov, Gerd Heusch, Sotirios Tsimikas, Carlos Fernandez-Hernando, Sarah E. Berry, Wendy L. Hall, Marlene Notdurfter, Gregorio Rungger, Bernhard Paulweber, Johann Willeit, Stefan Kiechl, Bodo Levkau, Manuel Mayr
Summary: This study reveals the relationship between PCSK9 and HDL in humans, showing that HDL acts as a binder of PCSK9 and regulates its function. Using various -omics technologies, the study found that postprandial lipemia drives the release of PCSK9 and apoC3 from HDL.
CIRCULATION RESEARCH
(2021)
Article
Medicine, General & Internal
Jan Boren, Martin Adiels, Elias Bjornson, Niina Matikainen, Sanni Soderlund, Joel Ramo, Marcus Henricsson, Pietari Ripatti, Samuli Ripatti, Aarno Palotie, Rosellina M. Mancina, Mari Ainola, Antti Hakkarainen, Stefano Romeo, Chris J. Packard, Marja-Riitta Taskinen
Summary: Despite the higher liver fat content in PNPLA3-148M homozygotes, there was no increase in VLDL production. Equally, VLDL production was maintained at normal levels despite the putative impairment in cytosolic lipid hydrolysis in these subjects.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Satyawan B. Jadhav, Ryan L. Crass, Sunny Chapel, Michael Kerschnitzki, William J. Sasiela, Maurice G. Emery, Benny M. Amore, P. Hugh R. Barrett, Gerald F. Watts, Alberico L. Catapano
Summary: Combining bempedoic acid with lower doses of statins achieves similar LDL-C lowering compared to statin monotherapy at higher doses, potentially sparing patients from adverse events associated with high statin doses.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Anindita Chakraborty, Jing Pang, Dick C. Chan, Katrina L. Ellis, Amanda J. Hooper, Damon A. Bell, John R. Burnett, Eric K. Moses, Gerald F. Watts
Summary: This study investigated the detection of new cases of elevated Lp(a) during cascade testing of relatives of probands with a definite diagnosis of FH and elevated Lp(a). The findings suggest that a dual approach to cascade testing families for FH and high Lp(a) from appropriate probands can effectively identify new cases of FH and elevated Lp(a).
Article
Medicine, General & Internal
Qidi Ying, Dick C. Chan, Jing Pang, Santica M. Marcovina, Peter Hugh R. Barrett, Gerald F. Watts
Summary: Alirocumab lowers plasma Lp(a) concentration in patients by a dual mode of action, increasing the clearance and decreasing the production of Lp(a) particles. In patients with high apo(a) concentrations, alirocumab primarily reduces apo(a) pool size by increasing the fractional catabolic rate (FCR) of apo(a). By contrast, in patients with very high apo(a) concentrations, alirocumab significantly lowers apo(a) pool size through both increased apo(a) FCR and decreased production rate.
JOURNAL OF INTERNAL MEDICINE
(2022)
Editorial Material
Endocrinology & Metabolism
Gerald F. Watts, Dick C. Chan
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2022)
Review
Genetics & Heredity
Wann Jia Loh, Dick C. Chan, Pedro Mata, Gerald F. Watts
Summary: This article discusses the incorporation of Lp(a) assessment into cascade testing for FH as a feasible and crucial part of FH care models. We also propose a simple management tool to help physicians identify and manage elevated Lp(a) in FH.
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Medicinal
Claudia Stefanutti, Dick C. Chan, Serafina Di Giacomo, Claudia Morozzi, Gerald F. Watts
Summary: The study demonstrates that evinacumab is a safe and effective treatment for HoFH patients, leading to significant reduction in LDL-C levels, which is maintained even without LA treatment.
Letter
Cardiac & Cardiovascular Systems
Janis M. Nolde, Jing Pang, Dick C. Chan, Natalie C. Ward, Ajmal Mian, Markus P. Schlaich, Gerald F. Watts
HEART LUNG AND CIRCULATION
(2023)
Article
Neurosciences
Emily S. Brook, Zachary J. D'Alonzo, Virginie Lam, Dick C. Chan, Satvinder S. Dhaliwal, Geraldb F. Watts, John C. L. Mamo, Ryusuke Takechi
Summary: Background: Obesity is associated with Alzheimer's disease (AD). Studies show that low plasma amyloid-beta (A beta) 42/40 ratio implies increased AD risk. However, the relationship between body mass index (BMI) and plasma A beta has not been thoroughly studied. Objective: We investigated if high BMI is linked to altered plasma A beta levels and whether reducing BMI through calorie-restriction could normalize A beta concentrations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Peripheral Vascular Disease
Qidi Ying, Mikael Croyal, Dick C. Chan, Valentin Blanchard, Jing Pang, Michel Krempf, Gerald F. Watts
Summary: The study aims to investigate the effect of omega-3 fatty acid supplementation on postprandial apo(a) metabolism in familial hypercholesterolemia (FH) patients. The results showed that omega-3 fatty acid supplementation can reduce the concentration and AUC of postprandial TRL-apo(a) in FH patients, indicating a potential role in reducing ASCVD risk.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Endocrinology & Metabolism
Ryusuke Takechi, Arazu Sharif, Emily Brook, Maimuna Majimbi, Dick C. Chan, Virginie Lam, Gerald F. Watts, John C. L. Mamo
Summary: There is increasing evidence suggesting a positive association between type 2 diabetes and Alzheimer's disease (AD), mainly due to vascular dysfunction, insulin resistance, and accumulation of amyloid-beta protein (A beta) in the brain. Recent studies have found that A beta is secreted in the periphery as nascent triglyceride-rich lipoproteins (TRL's). Elevated levels of TRL-A beta in the blood compromise the blood-brain barrier (BBB), leading to neuroinflammation and cognitive decline. Inhibition of TRL-A beta secretion by peripheral lipogenic organs attenuates the AD phenotype, indicating a causal relationship. Poorly controlled type 2 diabetes often exhibits high triglyceride levels, which contribute to the development of Alzheimer's through increased lipoprotein-A beta and BBB breakdown. This review emphasizes the microvascular axis for dementia in diabetes and discusses potential pharmacotherapies to target insulin resistance, dyslipidemia, and plasma amyloidosis in type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Qidi Ying, Dick C. Chan, Jing Pang, Mikael Croyal, Valentin Blanchard, Michel Krempf, Gerald F. Watts
Summary: This study found that high-dose omega-3 fatty acid ethyl esters (co-3FAEEs) can improve postprandial arterial elasticity in patients with familial hypercholesterolemia (FH). However, further research is needed to confirm these results in a larger population.
CLINICAL NUTRITION ESPEN
(2023)
Review
Pharmacology & Pharmacy
Dick C. Chan, Gerald F. Watts
Summary: High concentrations of LDL and Lp(a) are independent and causal risk factors for ASCVD. Recent advances in gene silencing therapy targeting PCSK9 and Lp(a) offer potential therapeutic options for high-risk patients.
CLINICAL THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Dick C. Chan, Annalisa Ronca, Qidi Ying, Jing Pang, Mikael Croyal, Gerald F. Watts, Elda Favari
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Anindita Chakraborty, Dick C. Chan, Katrina L. Ellis, Jing Pang, Wendy Barnett, Ann Marie Woodward, Mary Vorster, Richard Norman, Eric K. Moses, Gerald F. Watts
Summary: This study found that cascade testing for high Lp(a) is effective in detecting new cases of high Lp(a) in families. The proportion of relatives detected with high Lp(a) is higher when the probands have higher levels of Lp(a).
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Ian W. Li, Rory Watts, Tom Brett, Jan Radford, Clare Heal, Gerard Gill, Charlotte Hespe, Cristian Vargas-Garcia, David R. Sullivan, Alistair W. Vickery, Jing Pang, Diane E. Arnold-Reed, Dick C. Chan, Gerald F. Watts
Summary: Study reveals that screening and management of familial hypercholesterolaemia (FH) in Australian general practice can lead to significant health benefits with relatively modest investments.
AUSTRALIAN JOURNAL OF GENERAL PRACTICE
(2022)