PCSK9 Activity Is Potentiated Through HDL Binding

Lipoprotein compartmentalisation as a regulator of PCSK9 activity

(2021) Sean A. Burnap et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles

(2020) Samantha K. Sarkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Density Lipoproteins Are the Main Carriers of PCSK9 in the Circulation

(2020) Sean A. Burnap et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Multi-batch TMT reveals false positives, batch effects and missing values

(2019) Alejandro Brenes et al.   MOLECULAR & CELLULAR PROTEOMICS

Postprandial remodeling of high-density lipoprotein following high saturated fat and high carbohydrate meals

(2019) Michelle Averill et al.   Journal of Clinical Lipidology

Relationship between “LDL-C”, estimated true LDL-C, apolipoprotein B-100, and PCSK9 levels following lipoprotein(a) lowering with an antisense oligonucleotide

(2018) Nicholas J. Viney et al.   Journal of Clinical Lipidology

In a Nutshell: Findings from the Bruneck Study

(2018) Stefan Kiechl et al.   GERONTOLOGY

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

(2018) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Effect of PCSK9 Loss-of-Function Variants on the Postprandial Lipid and ApoB-Lipoprotein Response

(2017) Teik Chye Ooi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques

(2017) Sarah R. Langley et al.   JOURNAL OF CLINICAL INVESTIGATION

Very-Low-Density Lipoprotein–Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III

(2017) Raimund Pechlaner et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor

(2017) Camilla Gustafsen et al.   Nature Communications

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification

(2017) Fan Liu et al.   Nature Communications

Plasma Proteomics for EpidemiologyCLINICAL PERSPECTIVE

(2017) Xiaoke Yin et al.   Circulation-Cardiovascular Genetics

PCSK9 Association With Lipoprotein(a)Novelty and Significance

(2016) Hagai Tavori et al.   CIRCULATION RESEARCH

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors

(2016) Philip L.S.M. Gordts et al.   JOURNAL OF CLINICAL INVESTIGATION

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry

(2015) Fan Liu et al.   NATURE METHODS

MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

(2014) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

Proprotein Convertase Subtilisin Kexin Type 9 Promotes Intestinal Overproduction of Triglyceride-Rich Apolipoprotein B Lipoproteins Through Both Low-Density Lipoprotein Receptor–Dependent and –Independent Mechanisms

(2014) Shirya Rashid et al.   CIRCULATION

Serum Proprotein Convertase Subtilisin/Kexin Type 9 and Cell Surface Low-Density Lipoprotein Receptor

(2013) Hagai Tavori et al.   CIRCULATION

Low Density Lipoprotein Binds to Proprotein Convertase Subtilisin/Kexin Type-9 (PCSK9) in Human Plasma and Inhibits PCSK9-mediated Low Density Lipoprotein Receptor Degradation

(2013) Tanja Kosenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets

(2013) Bertrand Cariou et al.   Nutrition & Metabolism

Proprotein Convertase Subtilisin/Kexin Type 9 Interacts With Apolipoprotein B and Prevents Its Intracellular Degradation, Irrespective of the Low-Density Lipoprotein Receptor

(2012) Hua Sun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Palmitic acid in the sn-2 position of triacylglycerols acutely influences postprandial lipid metabolism

(2011) Thomas AB Sanders et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering drugs and diet network (GOLDN): an interventional study

(2011) Mary K Wojczynski et al.   Lipids in Health and Disease

Metabolism of Very-Low-Density Lipoprotein and Low-Density Lipoprotein Containing Apolipoprotein C-III and Not Other Small Apolipoproteins

(2009) Carlos O. Mendivil et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation

(2009) Steve Poirier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic and Metabolic Determinants of Plasma PCSK9 Levels

(2009) Susan G. Lakoski et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Self-Association of Human PCSK9 Correlates with Its LDLR-Degrading Activity†

(2008) Daping Fan et al.   BIOCHEMISTRY

Plasma PCSK9 levels are significantly modified by statins and fibrates in humans

(2008) Janice Mayne et al.   Lipids in Health and Disease

Molecular basis for LDL receptor recognition by PCSK9

(2008) H. J. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA