Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells

Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT

(2014) Linghe Xi et al.   NUCLEIC ACIDS RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Short Telomeres in ESCs Lead to Unstable Differentiation

(2013) Fabio Pucci et al.   Cell Stem Cell

Mechanisms that Regulate Stem Cell Aging and Life Span

(2013) Robert A.J. Signer et al.   Cell Stem Cell

Enhanced Telomere Rejuvenation in Pluripotent Cells Reprogrammed via Nuclear Transfer Relative to Induced Pluripotent Stem Cells

(2013) Rongrong Le et al.   Cell Stem Cell

Rejuvenation of Human Cardiac Progenitor Cells With Pim-1 Kinase

(2013) Sadia Mohsin et al.   CIRCULATION RESEARCH

Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy

(2013) Foteini Mourkioti et al.   NATURE CELL BIOLOGY

Telomere length and iPSC re-programming: survival of the longest

(2012) Richard Allsopp   CELL RESEARCH

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

(2012) Bruno Bernardes de Jesus et al.   EMBO Molecular Medicine

Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis

(2012) Erez Eitan et al.   EMBO Molecular Medicine

Evidence for premature aging due to oxidative stress in iPSCs from Cockayne syndrome

(2012) Luciana Nogueira de Sousa Andrade et al.   HUMAN MOLECULAR GENETICS

Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin

(2012) Katalin Karikó et al.   MOLECULAR THERAPY

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

Primer3—new capabilities and interfaces

(2012) Andreas Untergasser et al.   NUCLEIC ACIDS RESEARCH

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

(2011) Bruno Bernardes de Jesus et al.   AGING CELL

Walking the Walk from Genes through Telomere Maintenance to Cancer Risk

(2011) E. H. Blackburn   Cancer Prevention Research

Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells

(2011) Fang Wang et al.   CELL RESEARCH

Aging by Telomere Loss Can Be Reversed

(2011) Bruno Bernardes de Jesus et al.   Cell Stem Cell

FGF signalling inhibits neural induction in human embryonic stem cells

(2011) Boris Greber et al.   EMBO JOURNAL

Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia

(2011) R T Calado et al.   LEUKEMIA

Telomerase regulation

(2011) Catherine Cifuentes-Rojas et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

(2011) Luis F. Z. Batista et al.   NATURE

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Human Induced Pluripotent Stem-Derived Retinal Pigment Epithelium (RPE) Cells Exhibit Ion Transport, Membrane Potential, Polarized Vascular Endothelial Growth Factor Secretion, and Gene Expression Pattern Similar to Native RPE

(2011) Maria Kokkinaki et al.   STEM CELLS

Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors

(2010) Eduard Yakubov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Unprecedented Opportunities and Promise for Cancer Prevention Research

(2010) E. H. Blackburn et al.   Cancer Prevention Research

Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice

(2010) Alessandra Sacco et al.   CELL

Quantitative assessment of markers for cell senescence

(2010) Conor Lawless et al.   EXPERIMENTAL GERONTOLOGY

Changes of telomere length with aging

(2010) Kaiyo Takubo et al.   Geriatrics & Gerontology International

mRNA as gene therapeutic: How to control protein expression

(2010) Geertrui Tavernier et al.   JOURNAL OF CONTROLLED RELEASE

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming

(2010) H Vaziri et al.   Regenerative Medicine

A Natural Product Telomerase Activator As Part of a Health Maintenance Program

(2010) Calvin B. Harley et al.   REJUVENATION RESEARCH

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage

(2009) Judith Haendeler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway

(2009) R. Binet et al.   CANCER RESEARCH

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

(2009) Rosa M. Marión et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

Telomere length measurement by a novel monochrome multiplex quantitative PCR method

(2009) R. M. Cawthon   NUCLEIC ACIDS RESEARCH

Telomere Dynamics in Human Cells Reprogrammed to Pluripotency

(2009) Steven T. Suhr et al.   PLoS One

How Telomeres Solve the End-Protection Problem

(2009) T. de Lange   SCIENCE

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

(2008) S. Ahmed et al.   JOURNAL OF CELL SCIENCE