Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation

Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin

(2014) David S. Paul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease

(2014) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

DrosophilaSirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity

(2014) Motiur Rahman et al.   JOURNAL OF CELL BIOLOGY

Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity

(2014) Bharat Jaishy et al.   JOURNAL OF LIPID RESEARCH

Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α

(2013) Yi Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SIRT3 Deacetylates ATP Synthase F1 Complex Proteins in Response to Nutrient- and Exercise-Induced Stress

(2013) Athanassios Vassilopoulos et al.   ANTIOXIDANTS & REDOX SIGNALING

Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity

(2013) Debapriya Dutta et al.   Autophagy

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Cardiac Metabolism in Heart Failure

(2013) Torsten Doenst et al.   CIRCULATION RESEARCH

Evidence for Rapamycin Toxicity in Pancreatic β-Cells and a Review of the Underlying Molecular Mechanisms

(2013) Adam D. Barlow et al.   DIABETES

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

(2013) R. L. Thomas et al.   GENES & DEVELOPMENT

Macrophage Migration Inhibitory Factor Deletion Exacerbates Pressure Overload–Induced Cardiac Hypertrophy Through Mitigating Autophagy

(2013) Xihui Xu et al.   HYPERTENSION

Mechanistic Target of Rapamycin (Mtor) Is Essential for Murine Embryonic Heart Development and Growth

(2013) Yi Zhu et al.   PLoS One

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Glucose Regulation of Load‐Induced mTOR Signaling and ER Stress in Mammalian Heart

(2013) Shiraj Sen et al.   Journal of the American Heart Association

Inducible Overexpression of GLUT1 Prevents Mitochondrial Dysfunction and Attenuates Structural Remodeling in Pressure Overload but Does Not Prevent Left Ventricular Dysfunction

(2013) Renata O. Pereira et al.   Journal of the American Heart Association

Cardiac mTOR protects the heart against ischemia-reperfusion injury

(2012) Toshinori Aoyagi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pressure overload differentially affects respiratory capacity in interfibrillar and subsarcolemmal mitochondria

(2012) Michael Schwarzer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Elevated MTORC1 signaling and impaired autophagy

(2012) Fresnida J. Ramos et al.   Autophagy

Reactivation of autophagy amelioratesLMNAcardiomyopathy

(2012) Jason C. Choi et al.   Autophagy

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Carnitine Palmitoyltransferase-1b Deficiency Aggravates Pressure Overload–Induced Cardiac Hypertrophy Caused by Lipotoxicity

(2012) Lan He et al.   CIRCULATION

Functional Redundancy of SWI/SNF Catalytic Subunits in Maintaining Vascular Endothelial Cells in the Adult Heart

(2012) Monte S. Willis et al.   CIRCULATION RESEARCH

Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction

(2012) Dieter A. Kubli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin protects against myocardial ischemia–reperfusion injury through JAK2–STAT3 signaling pathway

(2012) Anindita Das et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1

(2012) Chong Kiat Goo et al.   PLoS One

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Outlook: membrane junctions enable the metabolic trapping of fatty acids by intracellular acyl-CoA synthetases

(2012) Joachim Füllekrug et al.   Frontiers in Physiology

p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia

(2011) Atsushi Hoshino et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mouse Cardiac Acyl Coenzyme A Synthetase 1 Deficiency Impairs Fatty Acid Oxidation and Induces Cardiac Hypertrophy

(2011) J. M. Ellis et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy

(2010) Xiaoxiao Song et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Rescue of Cardiomyopathy in Peroxisome Proliferator-Activated Receptor-α Transgenic Mice by Deletion of Lipoprotein Lipase Identifies Sources of Cardiac Lipids and Peroxisome Proliferator-Activated Receptor-α Activators

(2010) Jennifer G. Duncan et al.   CIRCULATION

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

(2010) Denghong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure

(2009) Heiko Bugger et al.   CARDIOVASCULAR RESEARCH

Increased Glucose Uptake and Oxidation in Mouse Hearts Prevent High Fatty Acid Oxidation but Cause Cardiac Dysfunction in Diet-Induced Obesity

(2009) Jie Yan et al.   CIRCULATION

Phosphorylation of the F 1 F o ATP Synthase β Subunit

(2009) Lesley A. Kane et al.   CIRCULATION RESEARCH

Post-translational modifications of ATP synthase in the heart: biology and function

(2009) Lesley A. Kane et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Cardiac Restricted Overexpression of Kinase-dead Mammalian Target of Rapamycin (mTOR) Mutant Impairs the mTOR-mediated Signaling and Cardiac Function

(2008) Wei-Hua Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY