Review
Chemistry, Medicinal
Sudipta Paul Bhattacharya, Snigdha Karmakar, Kusumita Acharya, Arijit Bhattacharya
Summary: The development of biofilms is a protective strategy used by bacterial pathogens against the immune response and antimicrobial treatments. Quorum sensing, which alters gene expression profiles, has been identified as a key regulator of biofilm dynamics. With the rapid emergence of antimicrobial resistance, it is urgent to find alternative interventions to control biofilm infections. Exploring phytochemical products has shown promise in inhibiting quorum sensing and preventing biofilm formation. Recent studies have focused on triterpenoids and their derivatives, which have been found to disrupt quorum sensing and impair biofilm formation against bacterial pathogens.
Article
Microbiology
Erika Mulya, Diana Elizabeth Waturangi
Summary: This study investigated Actinomycetes isolates from different regions in Indonesia, revealing their potential to inhibit biofilm formation by food spoilage bacteria through the production of anti-quorum sensing compounds.
Article
Pharmacology & Pharmacy
Abdulrahman S. Bazaid, Ahmed Alsolami, Mitesh Patel, Aiah Mustafa Khateb, Abdu Aldarhami, Mejdi Snoussi, Shekah M. Almusheet, Husam Qanash
Summary: The present study assessed the antimicrobial, antioxidant, and anti-quorum sensing properties of Saudi Sidr honey. The results showed promising antibacterial activity, important antioxidant activities, and the ability to inhibit biofilm formation. The honey also exhibited drug-likeness properties. This highlights the potential of Saudi Sidr honey as a rich source of bioactive compounds.
Article
Environmental Sciences
Dilek Yalcin, Ilkay Acikgoz Erkaya, Belgin Erdem
Summary: In this study, AgNPs were synthesized using Oscillatoria princeps biomass, and the synthesized AgNPs were validated and characterized. The results showed that the AgNPs synthesized from Oscillatoria princeps have the ability to inhibit biofilm formation, indicating their potential therapeutic effect on biofilm-associated infections caused by bacteria and yeasts.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Krishnan Raguvaran, Manickam Kalpana, Thulasiraman Manimegalai, Rajan Maheswaran
Summary: Biogenic AgNPs synthesized using Streptomyces sclerotialus showed potential larvicidal and antibacterial activity, as well as significant inhibition of biofilm formation and quorum sensing in microbial pathogens.
Article
Medicine, Research & Experimental
Amineh Sadat Tajani, Zeinab Amiri Tehranizadeh, Arianoosh Pourmohammad, Armin Pourmohammad, Milad Iranshahi, Faegheh Farhadi, Vahid Soheili, Bibi Sedigheh Fazly Bazzaz
Summary: In this study, several coumarin derivatives were evaluated for their potential as quorum sensing (QS) inhibitors in the management of biofilm-associated infections. The compounds 4-farnesyloxycoumarin and farnesifrol B showed significant reduction in biofilm formation and virulence factor production, as well as synergistic effects with tobramycin. Molecular docking and structural analysis revealed their interaction with the transcriptional regulator protein PqsR, while gene expression analysis demonstrated the significant reduction of PqsR gene expression.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Review
Microbiology
Evgeniya V. Prazdnova, Andrey V. Gorovtsov, Nikita G. Vasilchenko, Maxim P. Kulikov, Varvara N. Statsenko, Anna A. Bogdanova, Alexandr G. Refeld, Yaroslav A. Brislavskiy, Vladimir A. Chistyakov, Michael L. Chikindas
Summary: This review focuses on the mechanisms of quorum-sensing suppression by Gram-positive microorganisms and its practical applications in food fermentation, probiotics, and biotechnology. It also discusses the possible evolutionary role of quorum-quenching mechanisms during the development of interspecies interactions of bacteria.
Article
Food Science & Technology
Yongkai Ma, Qingshan Shi, Qianxian He, Gu Chen
Summary: Methyl N-methylanthranilate (MMA) from Pericarpium Citri Reticulatae Chachiensis exhibited a quorum sensing (QS) inhibition effect against foodborne pathogen Pseudomonas aeruginosa for the first time. MMA disrupted QS-related virulence factor production and biofilm formation, as well as suppressed the expression of QS-related genes. Metabolomics analysis indicated that MMA treatment altered various metabolic pathways in P. aeruginosa, leading to compromised membrane integrity, increased oxidative stress, and ultimately attenuating pathogenicity and biofilm formation. The data suggested that MMA could serve as a novel QS inhibitor and anti-biofilm agent for food safety improvement, providing insights into its mechanism of action and P. aeruginosa response.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Andrea Muras, Ana Parga, Celia Mayer, Ana Otero
Summary: Interfering with quorum sensing systems of bacteria is a promising strategy to control biofilm formation, and the xCELLigence(R) system is proposed as an efficient method for quantifying biofilm formation.
Article
Food Science & Technology
Xiangpeng Han, Qingying Chen, Xingguo Zhang, Xiaolan Chen, Dongsheng Luo, Qingping Zhong
Summary: This study found that Lactiplantibacillus plantarum 2057 can effectively inhibit the formation of Vibrio parahaemolyticus biofilm and interfere with its adhesion ability. In addition, the extract of L. plantarum Z057 significantly reduces the biofilm biomass, metabolic activity, and various important components of V. parahaemolyticus. These findings suggest that L. plantarum 2057 could be a biocontrol strategy alternative to chemical methods against foodborne pathogens.
Article
Chemistry, Medicinal
Abdulrahman S. Bazaid, Abdu Aldarhami, Mitesh Patel, Mohd Adnan, Assia Hamdi, Mejdi Snoussi, Husam Qanash, Mohammed Imam, Mohammad Khalil Monjed, Aiah Mustafa Khateb
Summary: Sumra honey exhibits potential antimicrobial activity against multidrug-resistant bacteria and fungi. It also shows promising antibiofilm, anti-quorum-sensing, and antioxidant activities.
Article
Microbiology
Amal M. Abo Kamer, Ahmed A. Abdelaziz, Khaled B. Al-Monofy, Lamiaa A. Al-Madboly
Summary: This study found that two and a half anthraquinone derivatives were able to significantly inhibit the growth and biofilm formation of MRSA. These compounds were also able to disrupt the signal transduction system of MRSA at low concentrations, reducing the expression of its virulence factors. Experimental evidence has also shown that these compounds can effectively modulate the biofilm and signal transduction system of MRSA in a rat wound infection model.
Article
Microbiology
Zhiyan He, Wei Jiang, Yiting Jiang, Jiachen Dong, Zhongchen Song, Jianrong Xu, Wei Zhou
Summary: This research focused on studying the effect of coumarin on the formation of Porphyromonas gingivalis biofilm, a key pathogen in periodontitis. The results showed that coumarin inhibited the growth of P. gingivalis and caused damage to cell morphology at concentrations above 400 μM. Sub-MIC concentrations of coumarin did not affect cell surface properties, aggregation, attachment, or early-stage biofilm formation. However, it demonstrated anti-biofilm effects on late-stage biofilms and pre-formed biofilm dispersion. The biofilms treated with coumarin became interspersed, and the expression of biofilm-related genes was downregulated. Coumarin also inhibited AI-2 activity and interacted with the HmuY protein through molecular docking analysis.
JOURNAL OF ORAL MICROBIOLOGY
(2022)
Article
Polymer Science
Alfred Ngenge Tamfu, Gokhan Kocak, Ozgur Ceylan, Funda Citak, Vural Butun, Huseyin Cicek
Summary: In this study, antimicrobial polymers with greater applications than traditional antibiotics were developed. The modified polymeric microparticles showed good antibiofilm activity and can be used to reduce the spread of microbial infections and resistance.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Yu-Mei Feng, Pu-Ying Qi, Wan-Lin Xiao, Tai-Hong Zhang, Xiang Zhou, Li-Wei Liu, Song Yang
Summary: This study designed and synthesized a series of compounds that interfere with bacterial quorum sensing (QS), and identified a compound A5 with antibacterial activity. Compound A5 was found to inhibit biofilm formation, suppress bacterial virulence factors, and decrease the expression of QS-related genes. It also showed acceptable control effect against Xanthomonas oryzaepv.oryzae (Xoo) in vivo.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Jose A. Gutierrez-Barranquero, F. Jerry Reen, Maria L. Parages, Ronan McCarthy, Alan D. W. Dobson, Fergal O'Gara
MICROBIAL BIOTECHNOLOGY
(2019)
Review
Plant Sciences
Jose A. Gutierrez-Barranquero, Francisco M. Cazorla, Antonio de Vicente
FRONTIERS IN PLANT SCIENCE
(2019)
Article
Microbiology
F. Jerry Reen, Jose A. Gutierrez-Barranquero, Ronan R. McCarthy, David F. Woods, Sara Scarciglia, Claire Adams, Kristian Fog Nielsen, Lone Gram, Fergal O'Gara
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Stephanie Flynn, F. Jerry Reen, Fergal O'Gara
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Medicine, General & Internal
Jose A. Caparros-Martin, Stephanie Flynn, F. Jerry Reen, David F. Woods, Patricia Agudelo-Romero, Sarath C. Ranganathan, Stephen M. Stick, Fergal O'Gara
Article
Biotechnology & Applied Microbiology
Zaira Heredia-Ponce, Jose Antonio Gutierrez-Barranquero, Gabriela Purtschert-Montenegro, Leo Eberl, Francisco M. Cazorla, Antonio de Vicente
NPJ BIOFILMS AND MICROBIOMES
(2020)
Article
Biotechnology & Applied Microbiology
Francesca Aprile, Zaira Heredia-Ponce, Francisco M. Cazorla, Antonio de Vicente, Jose A. Gutierrez-Barranquero
Summary: Copper resistance mechanisms provide an adaptive advantage to plant-pathogenic bacteria under copper treatments. Studies have shown similar copper resistance mechanisms and distribution of genetic determinants in different geographical populations of Pseudomonas syringae pv. syringae.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Microbiology
Zaira Heredia-Ponce, Jose Antonio Gutierrez-Barranquero, Gabriela Purtschert-Montenegro, Leo Eberl, Antonio de Vicente, Francisco M. Cazorla
Summary: The Fap-like fibre and alginate polysaccharide have secondary roles in biofilm formation of PcPCL1606, while the Psl-like polysaccharide is strongly involved in biofilm architecture and biocontrol activity. These components contribute to early surface attachment and interactions with host plant roots in the biofilm formation process.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Review
Microbiology
Zaira Heredia-Ponce, Antonio de Vicente, Francisco M. Cazorla, Jose Antonio Gutierrez-Barranquero
Summary: Biofilm formation is a result of a multicellular growth mode where bacteria are encased in their own extracellular matrix. Pseudomonas genus bacteria, especially Pseudomonas aeruginosa, have been extensively studied due to their metabolic versatility and ecological significance. The extracellular matrix of P. aeruginosa is primarily composed of exopolysaccharides, such as alginate and Psl polysaccharides, which play crucial roles in biofilm architecture and pathogenic features.
Review
Infectious Diseases
David F. Woods, Stephanie Flynn, Jose A. Caparros-Martin, Stephen M. Stick, F. Jerry Reen, Fergal O'Gara
Summary: The imbalance in respiratory microbiota can lead to lung disease pathogenesis, with bile acids playing a key role in CF cases, associated with inflammation and restructuring of lung microbiota towards a pathogen-dominated state.
Article
Microbiology
Adilah F. Ahmad, Jose A. Caparros-Martin, Silvia Lee, Fergal O'Gara, Bu B. Yeap, Daniel J. Green, Mohammed Ballal, Natalie C. Ward, Girish Dwivedi
Summary: This observational cohort study found that there were no significant differences in gut bacterial diversity between obese patients before and after bariatric surgery compared to a healthy control group. However, there were differences in the abundance of certain bacterial groups between the two cohorts. Additionally, the study observed changes in the levels of specific short chain fatty acids and soluble CD14 and CD163 in obese patients before and after surgery compared to healthy controls.
Article
Microbiology
Stephanie Flynn, F. Jerry Reen, Jose A. Caparros-Martin, David F. Woods, Jorg Peplies, Sarath C. Ranganathan, Stephen M. Stick, Fergal O'Gara
Article
Microbiology
Jose A. Gutierrez-Barranquero, Maria L. Parages, Alan D. W. Dobson, F. Jerry Reen, Fergal O'Gara
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2020)
Article
Microbiology
Jose A. Gutierrez-Barranquero, Maria L. Parages, Alan D. W. Dobson, F. Jerry Reen, Fergal O'Garaa
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2019)