Prophylactic Antiheparanase Activity by PG545 Is Antiviral In Vitro and Protects against Ross River Virus Disease in Mice

Chondrocytes Contribute to Alphaviral Disease Pathogenesis as a Source of Virus Replication and Soluble Factor Production

(2018) Elisa Lim et al.   Viruses-Basel

Suramin treatment reduces chikungunya pathogenesis in mice

(2016) Szu-Cheng Kuo et al.   ANTIVIRAL RESEARCH

Combined detection of serum CTX-II and COMP concentrations in osteoarthritis model rabbits: an effective technique for early diagnosis and estimation of disease severity

(2016) Bin Bai et al.   Journal of Orthopaedic Surgery and Research

The Cholestanol-Conjugated Sulfated Oligosaccharide PG545 Disrupts the Lipid Envelope of Herpes Simplex Virus Particles

(2015) Joanna S. Said et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples

(2015) Boris Winterhoff et al.   EUROPEAN JOURNAL OF CANCER

Pentosan Polysulfate: a Novel Glycosaminoglycan-Like Molecule for Effective Treatment of Alphavirus-Induced Cartilage Destruction and Inflammatory Disease

(2015) Lara J. Herrero et al.   JOURNAL OF VIROLOGY

Role of Pentraxin 3 in Shaping Arthritogenic Alphaviral Disease: From Enhanced Viral Replication to Immunomodulation

(2015) Suan-Sin Foo et al.   PLoS Pathogens

Ross River Virus: Many Vectors and Unusual Hosts Make for an Unpredictable Pathogen

(2015) Suzi B. Claflin et al.   PLoS Pathogens

Heparanase induces inflammatory cell recruitment in vivo by promoting adhesion to vascular endothelium

(2014) Rebecca Lever et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme

(2014) Ahmed Tayel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Characterization of Barmah Forest virus pathogenesis in a mouse model

(2014) L. J. Herrero et al.   JOURNAL OF GENERAL VIROLOGY

CCR2 Deficiency Promotes Exacerbated Chronic Erosive Neutrophil-Dominated Chikungunya Virus Arthritis

(2014) Y. S. Poo et al.   JOURNAL OF VIROLOGY

Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection

(2014) Weiqiang Chen et al.   JOURNAL OF VIROLOGY

Dengue and chikungunya: long-distance spread and outbreaks in naïve areas

(2014) Giovanni Rezza   Pathogens and Global Health

Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses

(2013) Vito Ferro   EXPERT OPINION ON THERAPEUTIC TARGETS

Discovery of PG545: A Highly Potent and Simultaneous Inhibitor of Angiogenesis, Tumor Growth, and Metastasis

(2012) Vito Ferro et al.   JOURNAL OF MEDICINAL CHEMISTRY

PG545, a Heparan Sulfate Mimetic, Reduces Heparanase Expression In Vivo, Blocks Spontaneous Metastases and Enhances Overall Survival in the 4T1 Breast Carcinoma Model

(2012) Edward Hammond et al.   PLoS One

Potent anti-respiratory syncytial virus activity of a cholestanol-sulfated tetrasaccharide conjugate

(2011) Anna Lundin et al.   ANTIVIRAL RESEARCH

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

(2011) K Dredge et al.   BRITISH JOURNAL OF CANCER

Protection From Arthritis and Myositis in a Mouse Model of Acute Chikungunya Virus Disease by Bindarit, an Inhibitor of Monocyte Chemotactic Protein-1 Synthesis

(2011) Nestor E. Rulli et al.   JOURNAL OF INFECTIOUS DISEASES

Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1

(2010) Joanna Said et al.   ANTIVIRAL RESEARCH

A highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (PI-88) exhibits virucidal activity against herpes simplex virus

(2010) Maria Ekblad et al.   ANTIVIRAL RESEARCH

Chikungunya Virus Arthritis in Adult Wild-Type Mice

(2010) J. Gardner et al.   JOURNAL OF VIROLOGY

Significance of the serum CTX-II level in an osteoarthritis animal model: a 5-month longitudinal study

(2010) M.E. Duclos et al.   OSTEOARTHRITIS AND CARTILAGE

Interaction of E2 Glycoprotein with Heparan Sulfate Is Crucial for Cellular Infection of Sindbis Virus

(2010) Wuyang Zhu et al.   PLoS One

Systematic review of the management of canine osteoarthritis

(2010) R. O. Sandersoln et al.   VETERINARY RECORD

Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis

(2008) Rachel W. Li et al.   ARTHRITIS AND RHEUMATISM

The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis

(2008) Erika H. Noss et al.   IMMUNOLOGICAL REVIEWS