Biosynthetically engineered lipopolysaccharide as vaccine adjuvant

Lipopolysaccharide Engineering inNeisseria meningitidis

(2014) Elder Pupo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Endotoxicity ofShigellaGeneralized Modules for Membrane Antigens (GMMA) by Genetic Lipid A Modifications

(2014) Omar Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meningitis caused by a lipopolysaccharide deficient Neisseria meningitidis

(2014) Jurgen R. Piet et al.   JOURNAL OF INFECTION

Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

(2014) C. Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological Cost of Different Mechanisms of Colistin Resistance and Their Impact on Virulence in Acinetobacter baumannii

(2013) Alejandro Beceiro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

LOS oligosaccharide modification enhances dendritic cell responses to meningococcal native outer membrane vesicles expressing a non-toxic lipid A

(2013) Hannah E. Jones et al.   CELLULAR MICROBIOLOGY

Neisseria meningitidis Native Outer Membrane Vesicles Containing Different Lipopolysaccharide Glycoforms as Adjuvants for Meningococcal and Nonmeningococcal Antigens

(2013) Jerry C. Nagaputra et al.   Clinical and Vaccine Immunology

Live-attenuatedYersinia pestisvaccines

(2013) Xiaoyi Wang et al.   Expert Review of Vaccines

Hexa-Acylated Lipid A Is Required for Host Inflammatory Response to Neisseria gonorrhoeae in Experimental Gonorrhea

(2013) Xiyou Zhou et al.   INFECTION AND IMMUNITY

Adjuvant Activity of Naturally Occurring Monophosphoryl Lipopolysaccharide Preparations from Mucosa-Associated Bacteria

(2013) Paula M. Chilton et al.   INFECTION AND IMMUNITY

Enzymatic Modification of Lipid A by ArnT Protects Bordetella bronchiseptica against Cationic Peptides and Is Required for Transmission

(2013) Olivier Rolin et al.   INFECTION AND IMMUNITY

Lipopolysaccharide Modifications of a Cholera Vaccine Candidate Based on Outer Membrane Vesicles Reduce Endotoxicity and Reveal the Major Protective Antigen

(2013) Deborah R. Leitner et al.   INFECTION AND IMMUNITY

Quantitative Proteomics Reveals Distinct Differences in the Protein Content of Outer Membrane Vesicle Vaccines

(2013) Bas van de Waterbeemd et al.   JOURNAL OF PROTEOME RESEARCH

Construction of Monophosphoryl Lipid A Producing Escherichia coli Mutants and Comparison of Immuno-Stimulatory Activities of Their Lipopolysaccharides

(2013) Yaning Han et al.   Marine Drugs

Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis

(2013) Brittany D. Needham et al.   NATURE REVIEWS MICROBIOLOGY

TRIF Is Required for TLR4 Mediated Adjuvant Effects on T Cell Clonal Expansion

(2013) Siva K. Gandhapudi et al.   PLoS One

Improved Production Process for Native Outer Membrane Vesicle Vaccine against Neisseria meningitidis

(2013) Bas van de Waterbeemd et al.   PLoS One

Intracellular Delivery of Lipopolysaccharide Induces Effective Th1-Immune Responses Independent of IL-12

(2013) Sachiko Watanabe et al.   PLoS One

Modulating the innate immune response by combinatorial engineering of endotoxin

(2013) Brittany D. Needham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Live attenuated tularemia vaccines: Recent developments and future goals

(2013) Mark E. Marohn et al.   VACCINE

Outer membrane vesicles reflect environmental cues in Gallibacterium anatis

(2013) Ragnhild J. Bager et al.   VETERINARY MICROBIOLOGY

Lipid A's Structure Mediates Neisseria gonorrhoeae Fitness during Experimental Infection of Mice and Men

(2013) M. M. Hobbs et al.   mBio

Recognition of lipid A variants by the TLR4-MD-2 receptor complex

(2013) Nina Maeshima et al.   Frontiers in Cellular and Infection Microbiology

Phosphoethanolamine Residues on the Lipid A Moiety of Neisseria gonorrhoeae Lipooligosaccharide Modulate Binding of Complement Inhibitors and Resistance to Complement Killing

(2012) Lisa A. Lewis et al.   INFECTION AND IMMUNITY

Role of Francisella Lipid A Phosphate Modification in Virulence and Long-Term Protective Immune Responses

(2012) Duangjit Kanistanon et al.   INFECTION AND IMMUNITY

Lack of Lipid A Pyrophosphorylation and FunctionallptAReduces Inflammation by Neisseria Commensals

(2012) Constance M. John et al.   INFECTION AND IMMUNITY

New technologies in developing recombinant attenuated Salmonella vaccine vectors

(2012) Shifeng Wang et al.   MICROBIAL PATHOGENESIS

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and optimization of critical process parameters for the production of NOMV vaccine against Neisseria meningitidis

(2012) Bas van de Waterbeemd et al.   VACCINE

The Lipopolysaccharide from Capnocytophaga canimorsus Reveals an Unexpected Role of the Core-Oligosaccharide in MD-2 Binding

(2012) Simon Ittig et al.   PLoS Pathogens

Humanized TLR4/MD-2 Mice Reveal LPS Recognition Differentially Impacts Susceptibility to Yersinia pestis and Salmonella enterica

(2012) Adeline M. Hajjar et al.   PLoS Pathogens

Construction of an Escherichia coli mutant producing monophosphoryl lipid A

(2011) Jiuzhou Chen et al.   BIOTECHNOLOGY LETTERS

Recent clinical experience with vaccines using MPL- and QS-21-containing Adjuvant Systems

(2011) Nathalie Garçon et al.   Expert Review of Vaccines

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Palmitoylation State Impacts Induction of Innate and Acquired Immunity by the Salmonella enterica Serovar TyphimuriummsbBMutant

(2011) Qingke Kong et al.   INFECTION AND IMMUNITY

Effect of Deletion of Genes Involved in Lipopolysaccharide Core and O-Antigen Synthesis on Virulence and Immunogenicity of Salmonella enterica Serovar Typhimurium

(2011) Qingke Kong et al.   INFECTION AND IMMUNITY

Absence of PmrAB-Mediated Phosphoethanolamine Modifications of Citrobacter rodentium Lipopolysaccharide Affects Outer Membrane Integrity

(2011) C. Viau et al.   JOURNAL OF BACTERIOLOGY

Salmonella Synthesizing 1-Monophosphorylated Lipopolysaccharide Exhibits Low Endotoxic Activity while Retaining Its Immunogenicity

(2011) Q. Kong et al.   JOURNAL OF IMMUNOLOGY

Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli

(2011) C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria

(2011) Soumita Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate

(2011) Cristian J.A. Asensio et al.   VACCINE

Adjuvant effect of bacterial outer membrane vesicles with penta-acylated lipopolysaccharide on antigen-specific T cell priming

(2011) Dong Ho Lee et al.   VACCINE

A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression

(2011) P.B. Keiser et al.   VACCINE

A live attenuated strain of Yersinia pestis KIM as a vaccine against plague

(2011) Wei Sun et al.   VACCINE

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

(2010) Adam Kulp et al.   Annual Review of Microbiology

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

(2010) J. H. Moffatt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Transcriptional Repressor FarR Is Not Involved in Meningococcal Fatty Acid Resistance Mediated by the FarAB Efflux Pump and Dependent on Lipopolysaccharide Structure

(2010) S. Schielke et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Coincorporation of LpxL1 and PagL Mutant Lipopolysaccharides into Liposomes with Neisseria meningitidis Opacity Protein: Influence on Endotoxic and Adjuvant Activity

(2010) J. Arenas et al.   Clinical and Vaccine Immunology

Multicenter, Open‐Label, Randomized Phase II Controlled Trial of an Investigational Recombinant Meningococcal Serogroup B Vaccine With and Without Outer Membrane Vesicles, Administered in Infancy

(2010) Jamie Findlow et al.   CLINICAL INFECTIOUS DISEASES

The Structure of Neisseria meningitidis Lipid A Determines Outcome in Experimental Meningococcal Disease

(2010) F. Fransen et al.   INFECTION AND IMMUNITY

Substitution of the Bordetella pertussis Lipid A Phosphate Groups with Glucosamine Is Required for Robust NF- B Activation and Release of Proinflammatory Cytokines in Cells Expressing Human but Not Murine Toll-Like Receptor 4-MD-2-CD14

(2010) N. Marr et al.   INFECTION AND IMMUNITY

Immunization withSalmonella entericaSerovar Typhimurium-Derived Outer Membrane Vesicles Delivering the Pneumococcal Protein PspA Confers Protection against Challenge withStreptococcus pneumoniae

(2010) Maneesha Muralinath et al.   INFECTION AND IMMUNITY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Delivery of foreign antigens by engineered outer membrane vesicle vaccines

(2010) D. J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved OMV vaccine against Neisseria meningitidis using genetically engineered strains and a detergent-free purification process

(2010) Bas van de Waterbeemd et al.   VACCINE

A phase 1 study of a group B meningococcal native outer membrane vesicle vaccine made from a strain with deleted lpxL2 and synX and stable expression of opcA

(2010) Paul B. Keiser et al.   VACCINE

Design and evaluation in mice of a broadly protective meningococcal group B native outer membrane vesicle vaccine

(2010) Wendell D. Zollinger et al.   VACCINE

Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles

(2009) Sang-Hyun Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Salmonella entericaserovar Typhimurium lipopolysaccharide deacylation enhances its intracellular growth within macrophages

(2009) Miyuki Kawano et al.   FEBS LETTERS

Identification of a Novel Lipopolysaccharide Core Biosynthesis Gene Cluster in Bordetella pertussis, and Influence of Core Structure and Lipid A Glucosamine Substitution on Endotoxic Activity

(2009) J. Geurtsen et al.   INFECTION AND IMMUNITY

D27-pLpxL, an Avirulent Strain of Yersinia pestis, Primes T Cells That Protect against Pneumonic Plague

(2009) F. M. Szaba et al.   INFECTION AND IMMUNITY

Regulated Delayed Expression of rfaH in an Attenuated Salmonella enterica Serovar Typhimurium Vaccine Enhances Immunogenicity of Outer Membrane Proteins and a Heterologous Antigen

(2009) Q. Kong et al.   INFECTION AND IMMUNITY

The structurally similar, penta-acylated lipopolysaccharides of Porphyromonas gingivalis and Bacteroides elicit strikingly different innate immune responses

(2009) Alex B. Berezow et al.   MICROBIAL PATHOGENESIS

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens

(2009) V.A. Feodorova et al.   VACCINE

Naturally Occurring Lipid A Mutants in Neisseria meningitidis from Patients with Invasive Meningococcal Disease Are Associated with Reduced Coagulopathy

(2009) Floris Fransen et al.   PLoS Pathogens

Variation of Neisseria gonorrhoeae Lipooligosaccharide Directs Dendritic Cell–Induced T Helper Responses

(2009) Sandra J. van Vliet et al.   PLoS Pathogens

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

(2008) C. R. Casella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Meningococcal Outer Membrane Vesicle Vaccines Derived from Mutant Strains Engineered To Express Factor H Binding Proteins from Antigenic Variant Groups 1 and 2

(2008) O. Koeberling et al.   Clinical and Vaccine Immunology

Modification of Lipooligosaccharide with Phosphoethanolamine by LptA in Neisseria meningitidis Enhances Meningococcal Adhesion to Human Endothelial and Epithelial Cells

(2008) H. Takahashi et al.   INFECTION AND IMMUNITY

Differential Activation of Human and Mouse Toll-Like Receptor 4 by the Adjuvant Candidate LpxL1 of Neisseria meningitidis

(2008) L. Steeghs et al.   INFECTION AND IMMUNITY

Bactericidal Antibody Responses Elicited by a Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Factor H–Binding Protein and Genetically Attenuated Endotoxin

(2008) Oliver Koeberling et al.   JOURNAL OF INFECTIOUS DISEASES

Innate Immune Responses of Synthetic Lipid A Derivatives ofNeisseria meningitidis

(2007) Yanghui Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL