Review
Multidisciplinary Sciences
Baljit S. Khakh, Steven A. Goldman
Summary: Huntington's disease (HD) is a fatal neurodegenerative disease caused by a mutation in the huntingtin gene. Astrocytes in the striatum, a brain region affected in HD, play a role in the pathology of the disease. Dysfunctions in astrocytes contribute to cellular and metabolic abnormalities in HD, suggesting the potential for therapeutic targeting of these cells to restore normal function.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Clinical Neurology
Carlos Cepeda, Michael S. Levine
Summary: The understanding of the changes in cerebral cortex and basal ganglia in Huntington's disease has greatly improved with the help of genetic animal models. Recent studies have shown that synaptic dysfunction in the cortico-basal ganglia-cortical loop is influenced by cortical maldevelopment and disconnection in the corticostriatal pathway. Additionally, biphasic changes in glutamate and dopamine release in the striatum may explain the different symptoms in early and late stages of the disease.
Article
Neurosciences
Angelica P. Escobar, Jonathan Martinez-Pinto, Francisco Silva-Olivares, Ramon Sotomayor-Zarate, Pablo R. Moya
Summary: EAAT3 overexpression impacts dopamine transmission, making dopamine neurons more sensitive to the effects of amphetamine and leading to an imbalance between the direct and indirect striatal pathways that favors the performance of repetitive behaviors.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ellen T. Koch, Marja D. Sepers, Judy Cheng, Lynn A. Raymond
Summary: This study investigated the correlation between striatal activity and behavior in a Huntington's disease mouse model. Decreased striatal activity was observed during motor learning, with an inverse correlation between latency to fall and striatal activity. At an early stage, the YAC128 mice did not show a deficit in latency to fall but exhibited significant differences in paw kinematics and a weaker correlation between latency to fall and striatal activity. However, at 6 to 7 months, the YAC128 mice showed reduced latency to fall, impaired paw kinematics, and increased striatal activity. In the open field, elevated neuronal activity was observed at rest in the YAC128 mice.
MOVEMENT DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Kathryn Lanza, Christopher Bishop
Summary: Parkinson's Disease (PD) and long-term L-DOPA treatment induce plasticity that contributes to L-DOPA-induced dyskinesia (LID), with the dopamine D3 receptor (D3R) emerging as a promising target in LID management due to its upregulation in LID. D3R undergoes dynamic changes in both PD and LID, and recent genetic and pharmacologic tools have helped clarify its role in LID.
Review
Biochemistry & Molecular Biology
Allen P. F. Chen, Lu Chen, Thomas A. Kim, Qiaojie Xiong
Summary: Dopamine plays a crucial role in controlling CNS function and its dysregulation can lead to various cognitive symptoms associated with neuropsychiatric diseases. Different brain areas have varying functions and roles for dopamine, suggesting potential differential dysregulation in different disease states.
Article
Biochemistry & Molecular Biology
Subramaniam Jayanthi, Bruce Ladenheim, Patricia Sullivan, Michael T. McCoy, Irina N. Krasnova, David S. Goldstein, Jean Lud Cadet
Summary: Perturbations in striatal dopamine homeostasis may contribute to METH use disorder. Rats exposed to footshocks after long-term METH intake showed decreased intake when given a DA D1 receptor antagonist. Compulsive METH takers exhibited abnormal DA metabolism and decreased protein levels. These findings are consistent with studies on human METH users.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Luca Magistrelli, Marco Ferrari, Alessia Furgiuele, Anna Vera Milner, Elena Contaldi, Cristoforo Comi, Marco Cosentino, Franca Marino
Summary: Parkinson's disease is a neurodegenerative disorder caused by loss of dopaminergic neurons. Treatment relies on dopaminergic replacement, but genetic factors can influence the clinical progression and drug response in patients. Understanding the genetic variability of dopaminergic receptors may provide insights into the development of personalized therapies for PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Jayantee Kalita, Abhilasha Tripathi, Mahesh Jadhav, Ravindra S. Thakur, Devendra K. Patel
Summary: Movement disorder is an important manifestation of neurologic Wilson disease, but there is little information on dopaminergic pathways. In this study, we evaluate dopamine and its receptors in patients with NWD and correlate the changes with movement disorder and MRI changes.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Jan Kasper, Simon B. Eickhoff, Svenja Caspers, Jessica Peter, Imis Dogan, Robert Christian Wolf, Kathrin Reetz, Juergen Dukart, Michael Orth
Summary: Kasper et al. found that in Huntington's disease, the functional integrity of the dopamine receptor-rich caudate nucleus plays a crucial role in maintaining network function. Loss of caudate functional integrity leads to motor signs independent of atrophy. This finding may have implications for other neurodegenerative diseases.
Article
Clinical Neurology
Chayaporn Reakkamnuan, Ekkasit Kumarnsit, Dania Cheaha
Summary: Impairments in motor control are the primary feature of Parkinson's disease, which is caused by dopaminergic imbalance in the basal ganglia. Identification of neural biomarkers of dopamine D2 receptor (D2R) suppression would be useful for monitoring the progress of neuropathologies and effects of treatment. The study found that administration of the D2R antagonist HAL led to decreased movement velocity, increased latency to descend, and decreased latency to fall in mice, suggesting these changes as potential biomarkers for monitoring Parkinson's disease.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu, Minming Zhang
Summary: This study found that current coffee consumption is associated with decreased striatal dopamine transporter availability in the caudate. However, the effects of caffeine on dopamine transporter may fade and disappear after quitting coffee consumption.
Article
Nutrition & Dietetics
Gabrielle R. Phillips, Sarah E. Hancock, Andrew M. Jenner, Catriona McLean, Kelly A. Newell, Todd W. Mitchell
Summary: Huntington's disease is a late-onset genetic neurodegenerative disease that leads to cognitive, motor, and psychiatric impairments. It is caused by a polyQ mutation in the HTT gene, resulting in a polyglutamine expansion in the Huntingtin protein. Changes in phospholipids in the HD brain depend on the lipid subclass, species, bond type, and location.
Article
Neurosciences
Nozomi Asaoka, Masakazu Ibi, Hikari Hatakama, Koki Nagaoka, Kazumi Iwata, Misaki Matsumoto, Masato Katsuyama, Shuji Kaneko, Chihiro Yabe-Nishimura
Summary: The study revealed that NOX1 regulates repetitive behavior in mice by facilitating excitatory synaptic inputs in the central striatum. Deficiency or inhibition of NOX1 can significantly reduce repeated D-2 receptor stimulation-induced repetitive behavior without affecting motor responses.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chuan-Ching Lai, Rathinasamy Baskaran, Chih-Yu Tsao, Li-Heng Tuan, Pei-Fen Siow, Mahalakshmi Palani, Lukas Jyuhn-Hsiarn Lee, Chih-Min Liu, Hai-Gwo Hwu, Li-Jen Lee
Summary: Schizophrenia usually manifests during adolescence to young adulthood, providing an opportunity for early intervention. This study investigated the preventive effect of chronic N-acetylcysteine (NAC) treatment on the outbreak of psychosis in Disc1 Het mice and found that NAC can normalize biochemical and morphological features in the striatum. The findings not only support the use of NAC as a dietary supplement for schizophrenia prodromes, but also contribute to our understanding of potential therapeutic targets for treating mental disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Valentina Castiglioni, Andrea Faedo, Marco Onorati, Vittoria Dickinson Bocchi, Zhen Li, Raffaele Iennaco, Romina Vuono, Gaetano P. Bulfamante, Luca Muzio, Gianvito Martino, Nenad Sestan, Roger A. Barker, Elena Cattaneo
Article
Neurosciences
Julia C. Greenland, Caroline H. Williams-Gray, Roger A. Barker
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Review
Neurosciences
Malin Parmar, Olof Torper, Janelle Drouin-Ouellet
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Clinical Neurology
Mayke Oosterloo, Emilia Bijlsma, Sander van Kuijk, Floor Minkes, Raymund Roos, C. E. M. de Die-Smulders
PARKINSONISM & RELATED DISORDERS
(2019)
Editorial Material
Clinical Neurology
Roger Barker, Sarah L. Mason
Article
Neurosciences
Jerome Lamontagne-Proulx, Isabelle St-Amour, Richard Labib, Jeremie Pilon, Helena L. Denis, Nathalie Cloutier, Florence Roux-Dalvai, Antony T. Vincent, Sarah L. Mason, Caroline Williams-Gray, Anne-Claire Duchez, Arnaud Droit, Steve Lacroix, Nicolas Dupre, Melanie Langlois, Sylvain Chouinard, Michel Panisset, Roger A. Barker, Eric Boilard, Francesca Cicchetti
NEUROBIOLOGY OF DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Roger A. Barker, Krista Farrell, Natalie Valle Guzman, Xiaoling He, Stanley E. Lazic, Sarah Moore, Robert Morris, Pamela Tyers, Ruwani Wijeyekoon, Danielle Daft, Sam Hewitt, Viswas Dayal, Thomas Foltynie, Zinovia Kefalopoulou, Philipp Mahlknecht, Nick P. Lao-Kaim, Paola Piccini, Hjalmar Bjartmarz, Anders Bjorklund, Olle Lindvall, Jenny Nelander-Wahlestedt, Malin Parmar, Gesine Paul, Hakan Widner, Alistair Church, Stephen Dunnett, Kathryn Peall, Anne Rosser, Jean Marc Gurruchaga, Stephane Palfi, Tobias Piroth, Christian Winkler
Article
Biochemistry & Molecular Biology
Marcella Birtele, Yogita Sharma, Srisaiyini Kidnapillai, Shong Lau, Thomas B. Stoker, Roger A. Barker, Daniella Rylander Ottosson, Janelle Drouin-Ouellet, Malin Parmar
Article
Clinical Neurology
Romina Vuono, Antonina Kouli, Emilie M. Legault, Lauriane Chagnon, Kieren S. Allinson, Alberto La Spada, Ida Biunno, Roger A. Barker, Janelle Drouin-Ouellet
MOVEMENT DISORDERS
(2020)
Editorial Material
Cell & Tissue Engineering
Janelle Drouin-Ouellet
Summary: The major improvement in generating astrocytes from human fibroblasts will enhance our understanding of the impact of aging on astrocyte function and neurodegenerative disorders.
CELLULAR REPROGRAMMING
(2022)
Article
Cell & Tissue Engineering
Emilie M. Legault, Julie Bouquety, Janelle Drouin-Ouellet
Summary: Understanding CNS-associated neurological diseases is challenging due to limited access to patient brain tissue. However, induced pluripotent stem cell differentiation and direct neural reprogramming offer alternative approaches to generate neural cells for research purposes.
CELLULAR REPROGRAMMING
(2022)
Article
Cell & Tissue Engineering
Janelle Drouin-Ouellet, Dan Li, Yuancheng Ryan Lu, Camila Vazquez Echegaray
Summary: The International Society for Stem Cell Research celebrated its 20th anniversary with a hybrid event that showcased impressive research and promoted collaboration between academia and industry. The event highlighted the significant advancements made in the field over the past two decades.
CELLULAR REPROGRAMMING
(2022)
Article
Cell & Tissue Engineering
Janelle Drouin-Ouellet, Emilie M. Legault, Fredrik Nilsson, Karolina Pircs, Julie Bouquety, Florence Petit, Shelby Shrigley, Marcella Birtele, Maria Pereira, Petter Storm, Yogita Sharma, Andreas Bruzelius, Romina Vuono, Malin Kele, Thomas B. Stoker, Daniella Rylander Ottosson, Anna Falk, Johan Jakobsson, Roger A. Barker, Malin Parmar
Summary: We have developed an efficient approach to generate functional induced dopaminergic neurons from adult human dermal fibroblasts and could specifically detect disease-relevant pathology in patient cells. These patient-derived neurons can serve as a cellular model to study age-related pathology relevant to Parkinson's disease.
Editorial Material
Neurosciences
Janelle Drouin-Ouellet
Summary: In this Journal Club, Janelle Drouin-Ouellet discusses a paper from 1989 that presented the initial evidence of mitochondrial dysfunction in individuals with idiopathic Parkinson's disease.
NATURE REVIEWS NEUROSCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Valentina Gallo, Paolo Vineis, Mariagrazia Cancellieri, Paolo Chiodini, Roger A. Barker, Carol Brayne, Neil Pearce, Roel Vermeulen, Salvatore Panico, Bas Bueno-de-Mesquita, Nicola Vanacore, Lars Forsgren, Silvia Ramat, Eva Ardanaz, Larraitz Arriola, Jesper Peterson, Oskar Hansson, Diana Gavrila, Carlotta Sacerdote, Sabina Sieri, Tilman Kuehn, Verena A. Katzke, Yvonne T. van der Schouw, Andreas Kyrozis, Giovanna Masala, Amalia Mattiello, Robert Perneczky, Lefkos Middleton, Rodolfo Saracci, Elio Riboli
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2019)