Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy

FCD Type II and mTOR pathway: Evidence for different mechanisms involved in the pathogenesis of dysmorphic neurons

(2017) Laura Rossini et al.   EPILEPSY RESEARCH

Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections

(2016) Xin You Tai et al.   BRAIN

Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy

(2016) Vikram Puvenna et al.   BRAIN RESEARCH

Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation

(2016) Robert P. Feehan et al.   CELLULAR SIGNALLING

Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain

(2016) Michael S. Hester et al.   EXPERIMENTAL NEUROLOGY

Deletion of mTOR in Reactive Astrocytes Suppresses Chronic Seizures in a Mouse Model of Temporal Lobe Epilepsy

(2016) Xueqin Wang et al.   MOLECULAR NEUROBIOLOGY

PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia

(2015) Laura A. Jansen et al.   BRAIN

Similar PDK1–AKT–mTOR pathway activation in balloon cells and dysmorphic neurons of type II focal cortical dysplasia with refractory epilepsy

(2015) Yuan-xiang Lin et al.   EPILEPSY RESEARCH

Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy

(2015) Ayako Shima et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Activation of extracellular regulated kinase and mechanistic target of rapamycin pathway in focal cortical dysplasia

(2015) Vinit V. Patil et al.   NEUROPATHOLOGY

Activation of AKT/GSK3β pathway by TDZD-8 attenuates kainic acid induced neurodegeneration but not seizures in mice

(2015) Malay Bhowmik et al.   NEUROTOXICOLOGY

TORC2: a novel target for treating age-associated memory impairment

(2015) Jennifer L. Johnson et al.   Scientific Reports

Predicting novel histopathological microlesions in human epileptic brain through transcriptional clustering

(2014) Fabien Dachet et al.   BRAIN

Developmental brain abnormalities in tuberous sclerosis complex: A comparative tissue analysis of cortical tubers and perituberal cortex

(2014) Véronique Ruppe et al.   EPILEPSIA

Decreased interaction between FoxO3a and Akt correlates with seizure-induced neuronal death

(2014) Yoon Sook Kim et al.   EPILEPSY RESEARCH

Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy

(2014) Ruth Yamawaki et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Past and Present Definitions of Epileptogenesis and Its Biomarkers

(2014) Asla Pitkänen et al.   Neurotherapeutics

Growing knowledge of the mTOR signaling network

(2014) Kezhen Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies

(2014) Joan Liu et al.   Acta Neuropathologica Communications

Cell injury and Premature Neurodegeneration in Focal Malformations of Cortical Development

(2013) Anand Iyer et al.   BRAIN PATHOLOGY

AMPA Receptor antagonist NBQX attenuates later-life epileptic seizures and autistic-like social deficits following neonatal seizures

(2013) Jocelyn J. Lippman-Bell et al.   EPILEPSIA

High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy

(2013) Kathleen Heng et al.   EPILEPSIA

International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods

(2013) Ingmar Blümcke et al.   EPILEPSIA

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

(2013) Venus Thomanetz et al.   JOURNAL OF CELL BIOLOGY

Magnesium Lithospermate B Protects Neurons from N-Methyl-d-Aspartic Acid Injury and Attenuates Kainic Acid-Induced Neurodegeration in FVB Mice

(2013) Guodong Xiao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis

(2013) Helen S. Bateup et al.   NEURON

Cell death and survival mechanisms are concomitantly active in the hippocampus of patients with mesial temporal sclerosis

(2013) N. Dericioglu et al.   NEUROSCIENCE

Rapamycin Reverses Status Epilepticus-Induced Memory Deficits and Dendritic Damage

(2013) Amy L. Brewster et al.   PLoS One

Spatiotemporal Characterization of mTOR Kinase Activity Following Kainic Acid Induced Status Epilepticus and Analysis of Rat Brain Response to Chronic Rapamycin Treatment

(2013) Matylda Macias et al.   PLoS One

Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain Injury

(2013) Dongjun Guo et al.   PLoS One

Gene Expression Profiling of a Hypoxic Seizure Model of Epilepsy Suggests a Role for mTOR and Wnt Signaling in Epileptogenesis

(2013) Joachim Theilhaber et al.   PLoS One

Rapamycin suppresses the recurrent excitatory circuits of dentate gyrus in a mouse model of temporal lobe epilepsy

(2012) Haiyun Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

(2012) Erwin A. van Vliet et al.   EPILEPSIA

The mTOR pathway is activated in glial cells in mesial temporal sclerosis

(2012) Alexander A. Sosunov et al.   EPILEPSIA

Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat

(2012) Bo Zhang et al.   EPILEPSIA

The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex

(2012) Sharon W. Way et al.   HUMAN MOLECULAR GENETICS

Multiple Roles for Mammalian Target of Rapamycin Signaling in Both Glutamatergic and GABAergic Synaptic Transmission

(2012) M. C. Weston et al.   JOURNAL OF NEUROSCIENCE

Layer-Specific CREB Target Gene Induction in Human Neocortical Epilepsy

(2012) T. L. Beaumont et al.   JOURNAL OF NEUROSCIENCE

Adaptor Protein APPL1 Couples Synaptic NMDA Receptor with Neuronal Prosurvival Phosphatidylinositol 3-Kinase/Akt Pathway

(2012) Y.-b. Wang et al.   JOURNAL OF NEUROSCIENCE

Time-Dependent Modulation of Mitogen Activated Protein Kinases and AKT in Rat Hippocampus and Cortex in the Pilocarpine Model of Epilepsy

(2012) Mark William Lopes et al.   NEUROCHEMICAL RESEARCH

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy

(2012) X. Huang et al.   NEUROSCIENCE

The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway

(2012) Delia M. Talos et al.   PLoS One

Mapping the Spatio-Temporal Pattern of the Mammalian Target of Rapamycin (mTOR) Activation in Temporal Lobe Epilepsy

(2012) Long-Ze Sha et al.   PLoS One

Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia

(2011) Delia M. Talos et al.   ANNALS OF NEUROLOGY

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Deciphering the Role of Forkhead Transcription Factors in Cancer Therapy

(2011) Jer-Yen Yang et al.   CURRENT DRUG TARGETS

Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscience

(2011) Frances E. Jensen   EPILEPSIA

Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy

(2011) Paul S. Buckmaster et al.   EPILEPSIA

Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function

(2011) H. S. Bateup et al.   JOURNAL OF NEUROSCIENCE

Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

(2011) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

A pulse rapamycin therapy for infantile spasms and associated cognitive decline

(2011) Emmanuel Raffo et al.   NEUROBIOLOGY OF DISEASE

The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1

(2010) Ingmar Blümcke et al.   EPILEPSIA

Synaptic Activity and Nuclear Calcium Signaling Protect Hippocampal Neurons from Death Signal-associated Nuclear Translocation of FoxO3a Induced by ExtrasynapticN-Methyl-d-aspartate Receptors

(2010) Oliver Dick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early Progenitor Cell Marker Expression Distinguishes Type II From Type I Focal Cortical Dysplasias

(2010) Ksenia A. Orlova et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tsc2-Rheb signaling regulates EphA-mediated axon guidance

(2010) Duyu Nie et al.   NATURE NEUROSCIENCE

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

Akt pathway activation and increased neuropeptide Y mRNA expression in the rat hippocampus: Implications for seizure blockade

(2010) Eduardo M. Goto et al.   NEUROPEPTIDES

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

(2009) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

Epileptogenesis in the immature brain: emerging mechanisms

(2009) Sanjay N. Rakhade et al.   Nature Reviews Neurology

Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)

(2009) Eléonore Beurel et al.   TRENDS IN IMMUNOLOGY

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers

(2008) Delia M. Talos et al.   ANNALS OF NEUROLOGY

Tuberous sclerosis complex proteins control axon formation

(2008) Y.-J. Choi et al.   GENES & DEVELOPMENT