期刊
NEUROSCIENCE
卷 215, 期 -, 页码 90-97出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2012.04.011
关键词
mTOR; epilepsy; psychiatric comorbidities; rapamycin; seizure
资金
- National Institute of Neurological Disorders and Strokes [NS062068]
- NARSAD
Psychiatric disorders are fairly common comorbidities of epilepsy in humans. Following pilocarpine-induced status epilepticus (SE), experimental animals not only developed spontaneous recurrent seizures, but also exhibited significantly elevated levels of aggressive behavior. The cellular and molecular mechanism triggering these behavioral alterations remains unclear. In the present study, we found that aggression is positively correlated with development of spontaneous seizures. Treatment with rapamycin, a potent mTOR (mammalian target of rapamycin pathway)-pathway inhibitor, markedly diminished aggressive behavior. Therefore, the mTOR pathway may have significance in the underlying molecular mechanism leading to aggression associated with epilepsy. (C) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
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