Article
Chemistry, Physical
Yaovi Holade, Hazar Guesmi, Jean-Sebastien Filhol, Qing Wang, Tammy Pham, Jad Rabah, Emmanuel Maisonhaute, Valerie Bonniol, Karine Servat, Sophie Tingry, David Cornu, K. Boniface Kokoh, Teko W. Napporn, Shelley D. Minteer
Summary: In this study, the electrocatalytic oxidation of glucose anomers was investigated using glucose models and optimized gold electrocatalysts. The results show that the electrocatalytic reactivity differs between the alpha-anomer and beta-anomer, depending on the pH environment. These findings have important implications for the electrosynthesis of renewable chemicals.
Article
Chemistry, Multidisciplinary
Brian J. J. Timmer, Arjaan Kooijman, Xander Schaapkens, Tiddo J. Mooibroek
Summary: Galectins are a subclass of carbohydrate binding proteins that play a role in various biological processes. A synthetic galectin mimic with high selectivity for a specific galactoside has been designed and synthesized for the first time, showing a selectivity over 65-fold compared to a glucoside.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
David Lim, Francesca Paradisi
Summary: Glycosylation can improve the pharmacokinetic properties of bioactive molecules, but their syntheses often require tedious protecting group manipulations. In this study, we developed a method for direct aqueous conversion of unprotected sugars into glycosides, and demonstrated its application with various biomolecules including resorcinol, resveratrol, and gimeracil. We also showed that the bioactive drug can be released from the sugar in an oxidatively-triggered manner, making them suitable for medicinal applications. This novel transformation provides access to various selenium-containing glycomimetics and glycoconjugates.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Elena G. Varlamova, Egor A. Turovsky, Ekaterina V. Blinova
Summary: The review highlights the importance of selenium nanoparticles in human health and medicine, detailing their production methods and the potential for creating new drugs or enhancing existing ones. Selenium, a key component in antioxidant enzymes, has been extensively studied in recent years, with a focus on its potential applications in medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Materials Science, Multidisciplinary
Kinshuk Malik, Shruti Sharma, Malti Sharma, Sharda Mahilkar Sonkar, Ayushi Mishra, Lajpreet Kaur, Himanshu Ojha, Mallika Pathak
Summary: In this review, the synthetic strategies and applications of carbon supported copper nanomaterials are discussed. The use of these materials as catalysts and their potential in various applications are explored.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Kristina Lossow, Maria Schwarz, Anna P. Kipp
Summary: Cancer remains a major cause of death worldwide, and early diagnosis is critical for improved survival rates and treatment success. Studies have shown that cancer patients generally have elevated serum copper levels and diminished zinc levels, with inconsistent changes in selenium and iron levels depending on the type of cancer. Further research is needed to investigate whether these element concentrations can predict the survival probability of cancer patients.
Article
Nutrition & Dietetics
Adam Darago, Michal Klimczak, Joanna Stragierowicz, Mateusz Jobczyk, Anna Kilanowicz
Summary: The concentrations of zinc, copper, and selenium in different parts of the prostate gland are associated with men's age and the nature of pathological changes. Zinc levels increase with age in the central part of the prostate, while lower zinc levels in the peripheral part may be linked to the development of prostate adenocarcinoma and benign prostatic hyperplasia. These results suggest a disruption in the homeostasis of essential elements in the etiology of BPH and PCa.
Article
Nutrition & Dietetics
Dorota Skrajnowska, Agata Jagielska, Anna Ruszczynska, Jakub Idkowiak, Barbara Bobrowska-Korczak
Summary: This study investigates the effect of long-term supplementation with selenium and copper on the content of selected elements in rat femoral bones. The results show that a diet enriched with selenium did not significantly reduce the level of these elements, while a diet enriched with copper caused significant changes in the mineral composition of the bones.
Article
Materials Science, Multidisciplinary
Xingwen Wei, Oleksandr Kovtun, Anton Yehorov, Christos G. Aneziris, Olena Volkova
Summary: In this study, selenium was added to the liquid Fe-Cu alloy to test its decopperization possibility. Copper selenide was found to deposit after the addition of selenium, and the addition of secondary metallurgical ladle slag was found to enhance the decopperization efficiency.
Review
Chemistry, Multidisciplinary
Eric Lichtfouse, Nadia Morin-Crini, Corina Bradu, Youssef-Amine Boussouga, Mehran Aliaskari, Andrea Iris Schaefer, Soumya Das, Lee D. Wilson, Michihiko Ike, Daisuke Inoue, Masashi Kuroda, Sebastien Deon, Patrick Fievet, Gregorio Crini
Summary: Contamination of waters by metals, metalloids, and organometallic pollutants is a global health issue. The presence of selenium, particularly at high concentrations in water, is a growing concern, especially in developing countries. Selenium is difficult to remove due to its presence in complex mixtures and competition with other anions. Remediation methods rely on various techniques such as zero-valent iron, nanofiltration, and activated granular sludge.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Review
Toxicology
Cristina W. Nogueira, Nilda V. Barbosa, Joao B. T. Rocha
Summary: Organoselenium compounds have complex pharmacological properties, showing strong anti-inflammatory and antioxidant activities, though the understanding of their specific molecular targets is still unclear.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shuo Zhang, Mauro Sella, Julinton Sianturi, Patricia Priegue, Dacheng Shen, Peter H. Seeberger
Summary: Researchers synthesized oligosaccharides resembling the capsular polysaccharides of Streptococcus suis serotypes and identified lead antigens for the development of semi-synthetic S. suis serotypes 2 and 9 glycoconjugate veterinary vaccines by screening blood from infected pigs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Organic
Sebastian O. Simonetti, Teodoro S. Kaufman, Enrique L. Larghi
Summary: A comprehensive revision on natural and synthetic glycosylated quinolines, including synthesis, applications, natural products, and bioactivity data, is presented.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Bo Ren, Jiaxi Wang, Mengyao Zhang, Yue Chen, Wei Zhao
Summary: A highly site-selective alkylation of trans-diols method has been achieved by chiral copper catalysis, allowing for control over reaction selectivity through adjustment of copper reagents and chiral ligands. This method has a broad substrate scope and has been applied to the site-selective modification of drugs and natural products.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Immunology
Roberto Fuentes, Leire Aguinagalde, Carlo Pifferi, Adrian Plata, Nagore Sacristan, Donatello Castellana, Juan Anguita, Alberto Fernandez-Tejada
Summary: Vaccine adjuvants, particularly saponin adjuvants, play a crucial role in enhancing the effectiveness of vaccines. Despite inherent drawbacks, synthetic derivatives of saponin adjuvants show promise for further optimization. Newly identified saponin oximes demonstrate superior adjuvant activity and hold great potential for the development of next-generation immunotherapeutics.
FRONTIERS IN IMMUNOLOGY
(2022)